The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.
Conference Paper
Year 2006,
Volume: 35 Issue: 2, 149 - 170, 01.06.2006
Abstract
Genome is under attack of multiple endogenous and exogenous factors which lead to DNA damage. All organisms have DNA repair mechanisms to protect their genetic material from damages caused by environmental factors. DNA repair is an important protective mechanism of cell in the pathway which begins with a single mutation and ends with being formed of damaged DNA and cancer. Many repairing mechanisms which use different biochemical strategies repair a lot of forms of DNA damage. The causal association between genetic alterations and cancer is supported by many experimental and epidemiological data. Genetic instability is the characteristical property of cancer. Mutagenity plays a role either initiation or progression of cancer. DNA repair defects also causes genetic instability and many of cancer types are result of DNA damages which are not repaired
Keywords
Year 2006,
Volume: 35 Issue: 2, 149 - 170, 01.06.2006
Abstract
Genom, DNA hasarına neden olan eksojen veya endojen sayısız farklı etkene maruz kalır. Tüm organizmalar genetik materyallerini bu çevresel etkenlerin oluşturduğu hasarlara karşı korumak amacıyla DNA onarım mekanizması içerirler. DNA onarımı, hücrede tek bir mutasyonla başlayan, hasarlı DNA oluşumu ve kanser tablosuyla son bulabilen yolda, hücreyi koruyan önemli bir mekanizmadır. Farklı biyokimyasal stratejileri kullanan birçok mekanizma DNA hasarının birçok şeklini onarır. Genetik değişiklikler ve kanser arasındaki nedensel bir ilişkinin varlığı birçok deneysel ve epidemiyolojik veri ile desteklenmektedir. Genetik kararsızlık kanserin karakteristik özelliğidir. Mutajenite kanser gelişiminin hem başlangıç hem de gelişme evresinde rol oynar. DNA onarımındaki hatalar da genetik kararsızlığa neden olurlar ve kanserlerin çoğunluğu tamir edilmemiş DNA hasarından kaynaklanır
Keywords
There are 0 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Pharmacology and Pharmaceutical Sciences |
| Other ID | JA82FZ49SZ |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2006 |
| Submission Date | June 1, 2006 |
| Published in Issue | Year 2006 Volume: 35 Issue: 2 |