The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.
Research Article
Year 2003,
Volume: 32 Issue: 2, 99 - 112, 01.06.2003
Abstract
Çalışmanın amacı rat, tavşan, insan ve kopek gibi farklı türlerde plazma fosfolipidlerinin yağ asitlerini tayin etmek ve kiyaslamaktır. Türlerin fosfolipid yağ asitleri başlıca C/e.o, C/8:0, C 8[], Ci8:2 ve (~<2o-4 dir. Fosfolipid yağ asidi bir kaç istisna dışında genellikle şu sekilde azalmaktadır: SFA (doymuş yağ asidi)>MUFA (tekli doymamış yağ asidi)>PUFA (çoklu doymamış yağ asidi). PUFA PE (fosfatidil etanolamin) ve PC (fosfatidil kolin) de yüksek düzeydedir ve tavşan ve insan plazmasında PUFA yüzdesi MUFA ya göre fazladır. Öte yandan PUFA köpekde PC ve PS(fosfatidil serin) de ve ratda ise PI (fosfatidil inozitol), PC ve SPH (sfmgomiyelin) de yüksek bulunmuştur. Cl8:l diğer MUFA ye kiyasla fazlaydı. PUFA içinde Ci8:2 tavşanda diğer türlerle kıyaslanıldığında yüksek ve C20:4 ise düşüktü. Cl8:2 major PUFA olup C20:4 bunu takip etti. Buyağ asitleri bütün türlerde başlıca PC ve PE de ve müteakiben PS, PI ve SPH de konsantre olmustu, Diğer PUFA (Ci8:3, C20:2, C20.-3 ve C20:s) köpekde 0.1 % den azdı ve ratda da cok küçük miktarlardaydı. Bu PUFA tavşanda PE ve PC de ve aynı zamanda insanlarda diğer fosfolipidlerde bulundu. Köpekde LCPUFA (uzun zincirli çoklu doymamış yağ asitleri) yokdu ve rat PC de C22:6 çok azdı
Keywords
Year 2003,
Volume: 32 Issue: 2, 99 - 112, 01.06.2003
Abstract
The purpose of this study was to investigate and compare the fatty acids of plasma phospholipids in rat, rabbit, human and dog. The prominent fatty acids of phospholipids in the species were Ci^.o, C18o, C/s:i, Ci8:2 and C20;4. Fatty acids generally decreased in the following order: SFA (Saturated fatty acids)>MUFA (monounsaturated fatty acid)>PUFA (polyunsaturated fatty acid) with little exceptions. PUFA was higher in PE (phosphatidyl ethanolamine) and PC (phosphatidyl choline) and PUFA>MUFA in rabbit and human plasma, whereas PUFA was higher in PC and PS in dog and in PI, PC and SPH in rat. Cis:i was higher than the other MUFA.. Among PUFA C18:2 was higher and arachidonate (C20:4) was lower in rabbit compared to other species. Cl8:2 was major PUFA and C2o:4 was the second one mainly in PC and PE and followed by PS (phosphatidyl serine), PI (phosphatidyl inositol) and SPH (sphingomyelin) in all of the species. Others (C20:2,Ci8:3, C2o:3 and C20:s) were less than % 0.1 in dog and also present in very small amounts in rat. These PUFA were present in PE and PC in rabbit and as well as in the other phospholipids in human. LCPUFAs (long chain polyunsaturated fatty acids )were not present in dog and rat had small amouts ofC22:4 in PC
Keywords
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Details
| Primary Language | English |
|---|---|
| Subjects | Pharmacology and Pharmaceutical Sciences |
| Other ID | JA32GE49KN |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 2003 |
| Submission Date | June 1, 2003 |
| Published in Issue | Year 2003 Volume: 32 Issue: 2 |