QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS

Özlem Temiz Arpacı; İlkay Yıldız Ören; Esin Akı Şener; İsmail Yalçın; Betül Tekiner

doi:10.1501/Eczfak_0000000477

BAZI ANTİBAKTERİYAL ETKİLİ BENZOKSAZOLLERİN B. SUBTİLİS'E KARŞI KANTİTATİF YAPI-ETKİ İLİŞKİLERİ

Year 2002, Volume: 31 Issue: 2, 73 - 81, 01.06.2002

Özlem Temiz Arpacı İlkay Yıldız Ören Esin Akı Şener İsmail Yalçın Betül Tekiner

https://doi.org/10.1501/Eczfak_0000000477

Abstract

Bu kantitatif yapı-etki ilişkileri analizinde önceden sentezleri gerçekleştirilmiş ve B. subtilis'e karşı in vitro gelişimlerini inhibe etme aktiviteleri test edilmiş olan 5-sübstitüebenzamido- ve 5sübstitüefenilasetamido-2-(p-sübstitüefenil)benzoksazol türevlerine basamaklı çoklu regresyon analizi uygulandı. Kantitatif yapı-etki ilişkileri analiz sonuçları, R2 konumunun R ve R1 'den antibakteriyal aktivite için daha önemli olduğunu ortaya koymuştur. R2'nin hidrofobik ve sterik etkileri antibakteriyal aktivitenin artması için diğer parametrelerden daha önemlidir

Keywords

kantitatif yapı-etki ilişkileri, antibakteriyal etki, benzoksazoller

QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS

Year 2002, Volume: 31 Issue: 2, 73 - 81, 01.06.2002

Özlem Temiz Arpacı İlkay Yıldız Ören Esin Akı Şener İsmail Yalçın Betül Tekiner

https://doi.org/10.1501/Eczfak_0000000477

Abstract

The QSAR analysis of a set of previously synthesized 5-substitutedbenzamido- and 5substitutedphenylacetamido-2-(p-substituted-phenyl)benzoxazole derivatives, which were tested in vitro, for their growth inhibitory activity against Bacillus subtilis, was performed by using the stepwise multiple regression analysis. The resulting QSAR revealed that the substitution at position R is more significant than R and R1 to improve the antibacterial activity. Hydrophobic and steric effects of substituents at R2 have an important role for increasing the antibacterial activity compared to other parameters

Keywords

QSAR, Antibacterial activity, Benzoxazoles

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Details

Other ID	JA88YU28CM
Journal Section	Research Article
Authors	Özlem Temiz Arpacı This is me İlkay Yıldız Ören This is me Esin Akı Şener This is me İsmail Yalçın This is me Betül Tekiner This is me
Publication Date	June 1, 2002
Submission Date	June 1, 2002
Published in Issue	Year 2002 Volume: 31 Issue: 2

Cite

APA	Temiz Arpacı, Ö., Yıldız Ören, İ., Akı Şener, E., Yalçın, İ., et al. (2002). QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS. Journal of Faculty of Pharmacy of Ankara University, 31(2), 73-81. https://doi.org/10.1501/Eczfak_0000000477
AMA	Temiz Arpacı Ö, Yıldız Ören İ, Akı Şener E, Yalçın İ, Tekiner B. QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS. J. Fac. Pharm. Ankara. June 2002;31(2):73-81. doi:10.1501/Eczfak_0000000477
Chicago	Temiz Arpacı, Özlem, İlkay Yıldız Ören, Esin Akı Şener, İsmail Yalçın, and Betül Tekiner. “QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS”. Journal of Faculty of Pharmacy of Ankara University 31, no. 2 (June 2002): 73-81. https://doi.org/10.1501/Eczfak_0000000477.
EndNote	Temiz Arpacı Ö, Yıldız Ören İ, Akı Şener E, Yalçın İ, Tekiner B (June 1, 2002) QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS. Journal of Faculty of Pharmacy of Ankara University 31 2 73–81.
IEEE	Ö. Temiz Arpacı, İ. Yıldız Ören, E. Akı Şener, İ. Yalçın, and B. Tekiner, “QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS”, J. Fac. Pharm. Ankara, vol. 31, no. 2, pp. 73–81, 2002, doi: 10.1501/Eczfak_0000000477.
ISNAD	Temiz Arpacı, Özlem et al. “QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS”. Journal of Faculty of Pharmacy of Ankara University 31/2 (June 2002), 73-81. https://doi.org/10.1501/Eczfak_0000000477.
JAMA	Temiz Arpacı Ö, Yıldız Ören İ, Akı Şener E, Yalçın İ, Tekiner B. QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS. J. Fac. Pharm. Ankara. 2002;31:73–81.
MLA	Temiz Arpacı, Özlem et al. “QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS”. Journal of Faculty of Pharmacy of Ankara University, vol. 31, no. 2, 2002, pp. 73-81, doi:10.1501/Eczfak_0000000477.
Vancouver	Temiz Arpacı Ö, Yıldız Ören İ, Akı Şener E, Yalçın İ, Tekiner B. QSARs OF SOME ANTIBACTERIAL ACTIVE BENZOXAZOLES AGAINST B. SUBTILIS. J. Fac. Pharm. Ankara. 2002;31(2):73-81.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.