E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER

Gülhan Cengiz; Nergiz Aksoy; Göknur Aktay; Tülin Söylemezoğlu

doi:10.1501/Eczfak_0000000331

E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER

Year 1999, Volume: 28 Issue: 1, 47 - 60, 01.06.1999

Gülhan Cengiz Nergiz Aksoy Göknur Aktay Tülin Söylemezoğlu

https://doi.org/10.1501/Eczfak_0000000331

Abstract

In order to investigate the role of lipid peroxidation in the paracetamol and aspirin hepatotoxicity, toxic doses of paracetamol (500 mg/kg) and aspirin (200 mg/kg) were given IP to rats. Malondialdehyde (MDA), a product of lipid peroxidation, was tested in both plasma and liver. Plasma MDA levels were found to be 16.33 0.92 in control group, 24.25. 0.86 in paracetamol group and 20.27 0.73 nmol MDA/ml in aspirin group. Hepatic MDA levels were found to be 348 15.8 in control group, 425 8.17 in paracetamol group and 406. 10.27 nmol MDA/g wet weight in aspirin group. Paracetamol and aspirin caused significantly increases in MDA levels in both plasma and liver (p<0.05). According to our results, lipid peroxidation may conclude an indicator of paracetamol and aspirin hepatotoxicity

Keywords

Paracetamol, aspirin, lipid peroxidation, hepatotoxicity

PARASETAMOL VE ASPİRİNİN PLAZMA VE KARACİĞERDE LİPİD PEROKSİDASYONA ETKİSİ

Year 1999, Volume: 28 Issue: 1, 47 - 60, 01.06.1999

Gülhan Cengiz Nergiz Aksoy Göknur Aktay Tülin Söylemezoğlu

https://doi.org/10.1501/Eczfak_0000000331

Abstract

Parasetamol ve aspirin hepatotoksisitesinde lipid peroksidasyonun rolünü araştırmak amacıyla sıçanlara toksik dozda İP parasetamol (500 mg/kg) ve aspirin (200 mg/kg) verildi. Lipid peroksidasyon son ürünü olan malondialdehid (MDA), plazma ve karaciğerde ölçüldü. Plazma MDA düzeyi; kontrol grubunda 16.33 0.92, parasetamol grubunda 24.25 0.86 ve aspirin grubunda 20.27. 0.73 nmol MDA/ml olarak bulundu. Karaciğer MDA düzeyi; kontrol grubunda 348. 15.8, parasetamol grubunda 425. S.17 ve aspirin grubunda 406 10.27 nmol MDA/g yaş ağırlık olarak bulundu. Parasetamol ve aspirin, plazma ve karaciğer MDA düzeylerinde önemli bir artışa neden oldu (p<0.05). Bulgularımıza göre, lipid peroksidasyonun parasetamol ve aspirin hepatotoksisitesinin bir göstergesi olarak değerlendirilebileceği sonucuna varıldı

Keywords

Parasetamol, aspirin, lipid peroksidasyonu, hepatotoksisite

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Details

Other ID	JA99KN52FE
Journal Section	Research Article
Authors	Gülhan Cengiz This is me Nergiz Aksoy This is me Göknur Aktay This is me Tülin Söylemezoğlu This is me
Publication Date	June 1, 1999
Submission Date	June 1, 1999
Published in Issue	Year 1999 Volume: 28 Issue: 1

Cite

APA	Cengiz, G., Aksoy, N., Aktay, G., Söylemezoğlu, T. (1999). E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER. Journal of Faculty of Pharmacy of Ankara University, 28(1), 47-60. https://doi.org/10.1501/Eczfak_0000000331
AMA	Cengiz G, Aksoy N, Aktay G, Söylemezoğlu T. E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER. J. Fac. Pharm. Ankara. June 1999;28(1):47-60. doi:10.1501/Eczfak_0000000331
Chicago	Cengiz, Gülhan, Nergiz Aksoy, Göknur Aktay, and Tülin Söylemezoğlu. “E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER”. Journal of Faculty of Pharmacy of Ankara University 28, no. 1 (June 1999): 47-60. https://doi.org/10.1501/Eczfak_0000000331.
EndNote	Cengiz G, Aksoy N, Aktay G, Söylemezoğlu T (June 1, 1999) E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER. Journal of Faculty of Pharmacy of Ankara University 28 1 47–60.
IEEE	G. Cengiz, N. Aksoy, G. Aktay, and T. Söylemezoğlu, “E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER”, J. Fac. Pharm. Ankara, vol. 28, no. 1, pp. 47–60, 1999, doi: 10.1501/Eczfak_0000000331.
ISNAD	Cengiz, Gülhan et al. “E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER”. Journal of Faculty of Pharmacy of Ankara University 28/1 (June 1999), 47-60. https://doi.org/10.1501/Eczfak_0000000331.
JAMA	Cengiz G, Aksoy N, Aktay G, Söylemezoğlu T. E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER. J. Fac. Pharm. Ankara. 1999;28:47–60.
MLA	Cengiz, Gülhan et al. “E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER”. Journal of Faculty of Pharmacy of Ankara University, vol. 28, no. 1, 1999, pp. 47-60, doi:10.1501/Eczfak_0000000331.
Vancouver	Cengiz G, Aksoy N, Aktay G, Söylemezoğlu T. E F F E C T S O F P A R A C E T A M O L A N D ASPIRIN O N LIPID P E R O X I D A T I O N I N P L A S M A A N D LIVER. J. Fac. Pharm. Ankara. 1999;28(1):47-60.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.