Synthesis, Antibacterial Activity and QSAR's of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis

Esin Şener; Özlem Temiz; İlkay Ören; İsmail Yalçın; Ahmet Akın; Nejat Uçartürk

doi:10.1501/Eczfak_0000000152

Bazı 5-Sübstitüe-2-(p-Sübstitüebenzil)benzoksazollerin Sentez,A

Year 1995, Volume: 24 Issue: 1, 10 - 20, 01.06.1995

Esin Şener Özlem Temiz İlkay Ören İsmail Yalçın Ahmet Akın Nejat Uçartürk

https://doi.org/10.1501/Eczfak_0000000152

Abstract

Bu çalışmada bazı 5-sübstitüe-2-(p-sübstitüebenzil) benzoksazol türevleri sentezlenmiş ve Staphylococcus aureus'a karşı antibakteriyal etkileri Tüpte Dilüsyon Yöntemi kullanılarak belirlenmiştir. Bileşikler yeterince etkili bulunmuştur (MİK = 6.25-50 ug/mL). Bir seri antimikrobiyal etkili 2-benzilbenzoksazol türevlerinin karşılaştırmalı yapı-etki ilişkileri Free-Wilson analizi yardımıyla incelenmiştir. Çoklu regresyon analizinde yapısal parametreler kullanılmıştır. Free-Wilson analizinin sonucunda 2-benzilbenzoksazollerin 5. konumunun, benzil grubunun para pozisyonuna göre etki için daha önemli olduğu saptanmıştır. Çoklu regresyon analizleri ile 5-CH3 ve p-Cl gruplarının diğerlerine göre daha uygun olduğu bulunmuştur

Keywords

5-Sübslitüc-2-(p-sübstitüebenziI)benzoksazol

Synthesis, Antibacterial Activity and QSAR's of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis

Year 1995, Volume: 24 Issue: 1, 10 - 20, 01.06.1995

Esin Şener Özlem Temiz İlkay Ören İsmail Yalçın Ahmet Akın Nejat Uçartürk

https://doi.org/10.1501/Eczfak_0000000152

Abstract

In this research some 5-substituted-2-(p-substitutedbenzyl) benzoxazole derivatives were synthesized and their antibacterial activity against Staphylococcus aureus was determined using progressive double dilution technique. The compounds were found significantly active (MIC = 6.25-50 μg/mL)

Keywords

5-Substituted-2-(p-substitutedbenzyl)benzox azoles

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Details

Other ID	JA75YF32TE
Journal Section	Research Article
Authors	Esin Şener This is me Özlem Temiz This is me İlkay Ören This is me İsmail Yalçın This is me Ahmet Akın This is me Nejat Uçartürk This is me
Publication Date	June 1, 1995
Submission Date	June 1, 1995
Published in Issue	Year 1995 Volume: 24 Issue: 1

Cite

APA	Şener, E., Temiz, Ö., Ören, İ., Yalçın, İ., et al. (1995). Synthesis, Antibacterial Activity and QSAR’s of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis. Journal of Faculty of Pharmacy of Ankara University, 24(1), 10-20. https://doi.org/10.1501/Eczfak_0000000152
AMA	Şener E, Temiz Ö, Ören İ, Yalçın İ, Akın A, Uçartürk N. Synthesis, Antibacterial Activity and QSAR’s of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis. J. Fac. Pharm. Ankara. June 1995;24(1):10-20. doi:10.1501/Eczfak_0000000152
Chicago	Şener, Esin, Özlem Temiz, İlkay Ören, İsmail Yalçın, Ahmet Akın, and Nejat Uçartürk. “Synthesis, Antibacterial Activity and QSAR’s of Some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles Using the Free-Wilson Analysis”. Journal of Faculty of Pharmacy of Ankara University 24, no. 1 (June 1995): 10-20. https://doi.org/10.1501/Eczfak_0000000152.
EndNote	Şener E, Temiz Ö, Ören İ, Yalçın İ, Akın A, Uçartürk N (June 1, 1995) Synthesis, Antibacterial Activity and QSAR’s of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis. Journal of Faculty of Pharmacy of Ankara University 24 1 10–20.
IEEE	E. Şener, Ö. Temiz, İ. Ören, İ. Yalçın, A. Akın, and N. Uçartürk, “Synthesis, Antibacterial Activity and QSAR’s of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis”, J. Fac. Pharm. Ankara, vol. 24, no. 1, pp. 10–20, 1995, doi: 10.1501/Eczfak_0000000152.
ISNAD	Şener, Esin et al. “Synthesis, Antibacterial Activity and QSAR’s of Some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles Using the Free-Wilson Analysis”. Journal of Faculty of Pharmacy of Ankara University 24/1 (June 1995), 10-20. https://doi.org/10.1501/Eczfak_0000000152.
JAMA	Şener E, Temiz Ö, Ören İ, Yalçın İ, Akın A, Uçartürk N. Synthesis, Antibacterial Activity and QSAR’s of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis. J. Fac. Pharm. Ankara. 1995;24:10–20.
MLA	Şener, Esin et al. “Synthesis, Antibacterial Activity and QSAR’s of Some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles Using the Free-Wilson Analysis”. Journal of Faculty of Pharmacy of Ankara University, vol. 24, no. 1, 1995, pp. 10-20, doi:10.1501/Eczfak_0000000152.
Vancouver	Şener E, Temiz Ö, Ören İ, Yalçın İ, Akın A, Uçartürk N. Synthesis, Antibacterial Activity and QSAR’s of some 5-Substituted-2- (p-Substituted benzyI)benzoxazoles using the Free-Wilson Analysis. J. Fac. Pharm. Ankara. 1995;24(1):10-2.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.