The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.
Karbonmonoksit (CO) Zehirlenmesi ile Ölenlerde ve Sigara İçenlerde Karboksihemoglobin (COHb) ve Methemoglobin (MetHb) Düzeyleri :
Abstract
CO zehirlenmesi sonucu ölen kişilerin (n:18) kanında postmortem karboksihemoglobin (COHb) tayini Dubovvski'nin spektrofotometrik yöntemi ile yapılmıştır. Ayrıca COHb yanında methemoglobin (MetHb) miktarı da spektrofotometrik yöntem ile araştırılmıştır. Postmortem kan Örneklerinde COHb düzeyi % 63-88 arasında (ortalama % 73.11 ± 6.90) ve MetHb düzeyi ise % 0.86-4.20 arasında (ortalama % 3.00 ± 0.87) bulunmuştur. Kan örneklerindeki COHb ve MetHb konsantrasyo alarmda, buzdolabı sıcaklığında 2 ay süreli bekletmenin ve heparin ilavesinin anlamlı bir kayba yol açmadığı gözlenmiştir (P > 0.05). Ayrıca CO'e kronik maruz kalan kişilerde (sigara içenlerde n: 100) COHb ve M e t H b düzeyleri aynı yöntemle yapılmıştır. COHb ve MetHb düzeyleri, günde 1-9 tane içenlerde (n: 44) % 1.94 ± 0.11 COHb, % 1.19 ± 0.05 MetHb, 10-20 tane içenlerde (n: 23) % 3.25 ± 0 . 1 9 COHb, % 1.47 ± 0.06 M e t H b ve > 20 tane içenlerde ise (n: 31) % 4.36 ± 0.14 COHb, % 1.55 ± 0 . 1 4 MetHb belirlenmiştir. COHb düzeyi sigara içen tüm gruplarda içmeyenlere göre ( % 0.86 ± 0.05) anlamlı yüksek bulunmuştur (P < 0.01, P < 0.05). bowski's spectrophotometric method. Occurence of methemoglobin (MetHb) in postmortem blood was also investigated by spectrophotometric method. COHb and MetHb levels of postmortem blood samples were found between 63.00-88.00 % (mean 73.11 ± 6.90 %) and 0.864.20 % (mean 3.00 ± 0.87%) respectively. COHb and MetHb levels of the subjects (cigarette smokers n: 100) who exposed to low CO were also determined by the spectrophotometric method mentioned above. COHb and MetHb levels of the smokers were found 1.94 ± 0.11 % COHb and 1.19 ± 0.05 % MetHb who smoked 1-9 cigarettes daily (n: 44), 3.25 ± 0.19 % COHb and 1.47 ± 0.06 % MetHb who smoked 10-20 cigarettes daily (n: 23), 4.36 ± 0.14 % COHb and 1.55 ± 0 . 1 4 % MetHb who smokers in all groups were found significantly higher than the nonsmokers (P < 0.01, P < 0.05)
Year 1994,
Volume: 23 Issue: 1, 11 - 20, 01.06.1994
Abstract
Postmortem carboxyhemglobin (COHb) levels in the blood of victims (n: 18) suspected of CO poisoning were determined by Dubowski's spectrophotometric method. Occurence of methemoglobin (MetHb) in postmortem blood was also investigated by spectrophotometric method. COHb and MetHb levels of postmortem blood samples were found between 63.00-88.00 % (mean 73.11 ± 6.90 %) and 0.864.20 % (mean 3.00 ± 0.87%) respectively. COHb and MetHb levels of the subjects (cigarette smokers n: 100) who exposed to low CO were also determined by the spectrophotometric method mentioned above. COHb and MetHb levels of the smokers were found 1.94 ± 0.11 % COHb and 1.19 ± 0.05 % MetHb who smoked 1-9 cigarettes daily (n: 44), 3.25 ± 0.19 % COHb and 1.47 ± 0.06 % MetHb who smoked 10-20 cigarettes daily (n: 23), 4.36 ± 0.14 % COHb and 1.55 ± 0 . 1 4 % MetHb who smokers in all groups were found significantly higher than the nonsmokers (P < 0.01, P < 0.05)
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Details
| Other ID | JA85RM27PM |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 1, 1994 |
| Submission Date | June 1, 1994 |
| Published in Issue | Year 1994 Volume: 23 Issue: 1 |