The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters

Esin Şener; İsmail Yalçın; Seçkin Özden; Tuncel Özden

doi:10.1501/Eczfak_0000000483

Conference Paper

The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters

Year 1986, Volume: 16 Issue: 1, 24 - 30, 01.06.1986

Esin Şener İsmail Yalçın Seçkin Özden Tuncel Özden

https://doi.org/10.1501/Eczfak_0000000483

Abstract

The antifungal active 2-(p-substitutcd-phenyl) benzoxazoles
against C. albicans were studied in a QSAR (quantitative structureactivity
relationships) work using the multiple regression method.
Some of the hydrophobic , electronic ( F, R) and steric (MR,
MW, Pr
) constants were used as physicochemical parameters. The
correlation equations and the best equation obtained from regression
analysis were given.
As a result of quantitative structure-activity relationships of
2-(p-substituted-phenyl) benzoxazoles for C. albicans, it was found
that hydrophobic, electronic or steric parameters were more significant
when they were used in combined forms than they were used separately.

Keywords

2-(p-Substituted-phenyl) benzoxazoles, F, R, MR, MW, Pr , QSAR, Best equation, C. albicans.

Candida Albicans'a Karşı Antifungal Etkili 2-(p-Sübstitüe-Fenil) Benzoksazol Türevleri ile Bazı Hidrofobik, Elektronik, Sterik Parametreler Kombinasyonlarının Kantitatif Yapı-Etki ilişkileri

Year 1986, Volume: 16 Issue: 1, 24 - 30, 01.06.1986

Esin Şener İsmail Yalçın Seçkin Özden Tuncel Özden

https://doi.org/10.1501/Eczfak_0000000483

Abstract

Candida albicans'a karşı antifungal etkili 2-(p-sübstitüe-fenil)-
benzoxazol türevlerinin, çoklu regresyon metodu kullanılarak, kantitatif
yapı-etki ilişkileri (QSAR) çalışılmıştır. Fizikokimyasal para metreler olarak bazı hidrofobik , elektronik ( F, R) ve sterik
(MR, MW, Pr
) sabiteler kullanılmıştır. Regresyon analizleri sonucu
ele geçen korelasyon denklemleri ve ideal denklem çalışmada verilmiş-
tir.
2-(p-Sübstitüe-fenil) benzoksazol türevlerinin kantitatif yapı-etki
ilişkileri incelendiğinde, C. albicans için hidrofobik, elektronik ve
sterik parametrelerin tek tek kullanılmaları yerine, kombinasyonlarının
oldukça dikkate değer sonuçlar verdiği saptanmıştır.

Keywords

Candida, Albicans, Antifungal

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Details

Primary Language	English
Subjects	Pharmacology and Pharmaceutical Sciences
Other ID	JA63PP47JJ
Journal Section	Research Article
Authors	Esin Şener This is me İsmail Yalçın This is me Seçkin Özden This is me Tuncel Özden This is me
Publication Date	June 1, 1986
Submission Date	June 1, 1986
Published in Issue	Year 1986 Volume: 16 Issue: 1

Cite

APA	Şener, E., Yalçın, İ., Özden, S., Özden, T. (1986). The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. Journal of Faculty of Pharmacy of Ankara University, 16(1), 24-30. https://doi.org/10.1501/Eczfak_0000000483
AMA	Şener E, Yalçın İ, Özden S, Özden T. The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. J. Fac. Pharm. Ankara. June 1986;16(1):24-30. doi:10.1501/Eczfak_0000000483
Chicago	Şener, Esin, İsmail Yalçın, Seçkin Özden, and Tuncel Özden. “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”. Journal of Faculty of Pharmacy of Ankara University 16, no. 1 (June 1986): 24-30. https://doi.org/10.1501/Eczfak_0000000483.
EndNote	Şener E, Yalçın İ, Özden S, Özden T (June 1, 1986) The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. Journal of Faculty of Pharmacy of Ankara University 16 1 24–30.
IEEE	E. Şener, İ. Yalçın, S. Özden, and T. Özden, “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”, J. Fac. Pharm. Ankara, vol. 16, no. 1, pp. 24–30, 1986, doi: 10.1501/Eczfak_0000000483.
ISNAD	Şener, Esin et al. “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”. Journal of Faculty of Pharmacy of Ankara University 16/1 (June 1986), 24-30. https://doi.org/10.1501/Eczfak_0000000483.
JAMA	Şener E, Yalçın İ, Özden S, Özden T. The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. J. Fac. Pharm. Ankara. 1986;16:24–30.
MLA	Şener, Esin et al. “The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters”. Journal of Faculty of Pharmacy of Ankara University, vol. 16, no. 1, 1986, pp. 24-30, doi:10.1501/Eczfak_0000000483.
Vancouver	Şener E, Yalçın İ, Özden S, Özden T. The Quantitative Structure-Activity Relationships of AntifungalActive 2- (p-Substituted-Phenyl) Benzoxazole DerivativesAgainst Candida Albicans Using The Combinations of SomeHydrophobic, Electronic And Steric Parameters. J. Fac. Pharm. Ankara. 1986;16(1):24-30.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.