TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ

Oğuzhan Fırat; İlkay Yıldız

doi:10.33483/jfpau.696349

Review

TOPOISOMERASE II ENZYME INHIBITORS

Year 2020, Volume: 44 Issue: 2, 356 - 372, 31.05.2020

Oğuzhan Fırat , İlkay Yıldız

https://doi.org/10.33483/jfpau.696349

Abstract

Objective: The use of topoisomerase II enzyme inhibitors, which have increased in importance in recent years, has been evaluated in terms of pharmaceutical chemistry and clinical use. In this context, compounds with clinical uses as well as certain compounds which are in the developmental stage are included.

Result and Discussion: Topoisomerase II enzyme inhibition targeted cancer chemotherapy and drug development efforts that are suitable for this mechanism, demonstrating high activity and less adverse effects have been ongoing for many years. As a conclusion, it provides clinical use of many new agents in high activity by making appropriate modifications on the chemical structure of topoisomerase II inhibitors obtained herbally or synthetically. In addition, preventing drug resistance frequently seen in cancer patients, targeted treatment and reduced toxicities can be provided with the discovery of new agents. By ensuring that the use of new agents is among the individualized treatment methods, the most appropriate treatment will be provided to the patients.

Keywords

anticancer, clinical pharmacy, topoisomerase II

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TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ

Year 2020, Volume: 44 Issue: 2, 356 - 372, 31.05.2020

Oğuzhan Fırat , İlkay Yıldız

https://doi.org/10.33483/jfpau.696349

Abstract

Amaç: Son yıllarda önemi daha da artan topoizomeraz II enzim inhibitörleri’nin Farmasötik Kimya bilimi açısından ve klinik kullanımları değerlendirilmiştir. Bu bağlamda, klinik kullanımları olan bileşiklerin yanında geliştirilme aşamasında olan bazı bileşiklere de yer verilmiştir.

Sonuç ve Tartışma: Topoizomeraz II enzimi inhibisyonu hedefli kanser kemoterapisi ve bu mekanizmaya uygun, aktivitesi yüksek olup advers etkileri az olan ilaç geliştirme çabaları uzun yıllardır devam eden bir süreçtir. Sonuç olarak, bitkisel veya sentetik olarak elde edilen topoizomeraz II inhibitörlerinin kimyasal yapıları üzerinde uygun modifikasyonların yapılması, yüksek aktivitede birçok yeni ajanın klinik kullanımını mümkün kılmaktadır. Ayrıca kanser hastalarında sıklıkla görülen ilaç direncinin önüne geçilmesi, hedefe yönelik tedavi ve toksisitelerin azaltılması yeni ajanların keşfiyle sağlanabilecektir.Yeni ajanların kullanımının bireyselleştirilmiş tedavi yöntemleri arasında bulunmasının sağlanması ile hastalara en uygun tedavi sunulabilecektir.

Keywords

antikanser, klinik eczacılık, topoizomeraz II

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21. Van Hasselt, J. G. C., Van Calsteren, K., Heyns, L., Han, S., Mhallem Gziri, M., Schellens, J. H. M., Beijnen J. H., Huitema A. D. R., Amant, F. (2014). Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel. Annals of oncology, 25(10), 2059-2065. https://doi.org/10.1093/annonc/mdu140
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25. Hall, S. W., Friedman, J., Legha, S. S., Benjamin, R. S., Gutterman, J. U., Loo, T. L. (1983). Human pharmacokinetics of a new acridine derivative, 4′-(9-acridinylamino) methanesulfon-m-anisidide (NSC 249992). Cancer research, 43(7), 3422-3426.
26. Rather, M. (2016). A comprehensive review on the phytochemical and pharmacological aspects of Podophyllum hexandrum: a high value medicinal plant. Advances in Biomedicine and Pharmacy, 3(4), 216-226. doi:10.19046/abp.v03i04.06
27. Denny, W. A. (2002). Acridine derivatives as chemotherapeutic agents. Current Medicinal Chemistry, 9(18), 1655-1665. https://doi.org/10.2174/0929867023369277
28. Dittrich, C., Coudert, B., Paz-Ares, L., Caponigro, F., Salzberg, M., Gamucci, T., Paoletti X., Hermans C., Lacombe D., Fumoleau P., European Organization for Research and Treatment of Cancer--Early Clinical Studies Group/New Drug Development Programme (EORTC-ECSG/NDDP) (2003). Phase II study of XR 5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with non-small cell lung cancer. European Journal of Cancer, 39(3), 330-334. https://doi.org/10.1016/S0959-8049(02)00559-2
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Details

Primary Language	Turkish
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Collection
Authors	Oğuzhan Fırat 0000-0002-8726-8530 İlkay Yıldız 0000-0001-9526-0232
Publication Date	May 31, 2020
Submission Date	February 28, 2020
Acceptance Date	May 11, 2020
Published in Issue	Year 2020 Volume: 44 Issue: 2

Cite

APA	Fırat, O., & Yıldız, İ. (2020). TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ. Journal of Faculty of Pharmacy of Ankara University, 44(2), 356-372. https://doi.org/10.33483/jfpau.696349
AMA	Fırat O, Yıldız İ. TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ. J. Fac. Pharm. Ankara. May 2020;44(2):356-372. doi:10.33483/jfpau.696349
Chicago	Fırat, Oğuzhan, and İlkay Yıldız. “TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ”. Journal of Faculty of Pharmacy of Ankara University 44, no. 2 (May 2020): 356-72. https://doi.org/10.33483/jfpau.696349.
EndNote	Fırat O, Yıldız İ (May 1, 2020) TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ. Journal of Faculty of Pharmacy of Ankara University 44 2 356–372.
IEEE	O. Fırat and İ. Yıldız, “TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ”, J. Fac. Pharm. Ankara, vol. 44, no. 2, pp. 356–372, 2020, doi: 10.33483/jfpau.696349.
ISNAD	Fırat, Oğuzhan - Yıldız, İlkay. “TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ”. Journal of Faculty of Pharmacy of Ankara University 44/2 (May 2020), 356-372. https://doi.org/10.33483/jfpau.696349.
JAMA	Fırat O, Yıldız İ. TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ. J. Fac. Pharm. Ankara. 2020;44:356–372.
MLA	Fırat, Oğuzhan and İlkay Yıldız. “TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ”. Journal of Faculty of Pharmacy of Ankara University, vol. 44, no. 2, 2020, pp. 356-72, doi:10.33483/jfpau.696349.
Vancouver	Fırat O, Yıldız İ. TOPOİZOMERAZ II ENZİM İNHİBİTÖRLERİ. J. Fac. Pharm. Ankara. 2020;44(2):356-72.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.