TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME

Özge Balpınar; Selim Aytaç

doi:10.33483/jfpau.859372

Review

TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME

Year 2021, Volume: 45 Issue: 3, 631 - 651, 27.09.2021

Özge Balpınar , Selim Aytaç

https://doi.org/10.33483/jfpau.859372

Cited By: 2

Abstract

Amaç: Kenevir antik çağlardan bugüne dek tedavi amaçlı kullanılmakta olan bir bitkidir. Her ne kadar kullanımı içerdiği psikoaktif bileşenler dolayısıyla sınırlandırılmış olsa da, kenevirin tıbbi yönüne dair araştırmalar literatürde oldukça yoğundur. Cannabis sativa L., içerdiği fitokannabinoidler ile endokannabinoid sistemde gen düzeyinde pek çok değişikliğe sebep olabilmektedir. Endokannabinoid sistemin pek çok patolojik durumda potansiyel bir terapötik hedef olabileceğine dair kanıtların derlenmesi hedefiyle bu çalışma ortaya koyulmuştur.

Sonuç ve Tartışma: Endokannabinoid sistem içerisinde yer alan reseptörler, endokannabinoidler veya enzimlerin ekspresyon seviyelerinde meydana gelen değişiklikler, Parkinson, Alzheimer, Huntington gibi hastalıkların patolojileriyle ilişkili olabilmektedir. Aynı zamanda endokannabinoid sistemde meydana gelen değişikliklerin kanser hücrelerinin metastazı, yayılımı, proliferasyonunu etkileyebilmektedir. Buna ek olarak kannabinoidlerin, dolayısıyla kenevirin, nöropatik ağrının tedavisinde rol oynadığı gösterilmiştir. Günümüzde kemoterapiye bağlı bulantı ve kusma tedavisinde kullanılan dronabilon ve nabilon kapsülleri gibi bazı kenevir-temelli tedavi preparatları pek çok ülkede onaylanmış, kullanıma sunulmuştur. Δ9tetrahidrocannabinol/ cannabidiol oromukozal sprey gibi preparatlar da pek çok bölgede kanser hastalarında analjezik olarak ya da multiple skleroz hastalarının kas spastisitelerinin giderilmesinde kullanımı onaylanan preparatlardandır. Ancak endokannabinoid sistemin terapötik etkinlik üzerindeki önemi dikkate alındığında, daha pek çok tıbbi durum için kenevirin standardize edilmiş preparatlarına ve bu doğrultuda daha fazla araştırmaya ihtiyaç duyulmaktadır.

Keywords

Kannabinoid, kanser, kenevir, nörodejeneretif hastalıklar

Supporting Institution

Project Number

Thanks

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MEDICAL CANNABIS AND HEALTH: A PHARMACOLOGICAL REVIEW

Year 2021, Volume: 45 Issue: 3, 631 - 651, 27.09.2021

Özge Balpınar , Selim Aytaç

https://doi.org/10.33483/jfpau.859372

Cited By: 2

Abstract

Objective: Cannabis sativa L. is a plant that has been used for therapeutic purposes since ancient times. However, its use has been limited due to its content. Cannabis causes many changes at the gene level in the endocannabinoid system with the phytocannabinoids it contains. The aim of this study was to provide evidence that the endocannabinoid system could be a potential therapeutic target in many pathological conditions.

Result and Discussion: The change in the expression levels of receptors, endocannabinoids or enzymes in the endocannabinoid system may be associated with the pathologies of diseases such as Parkinson, Alzheimer, and Huntington. Besides, changes in the endocannabinoid system can affect the migration, proliferation of cancer cells. Also, cannabinoids, have been shown to play a role in the treatment of neuropathic pain. Today, some cannabis-based treatment preparations such as dronabilon and nabilon capsules used in the treatment of chemotherapy-induced nausea and vomiting have been approved and available in many countries. Preparations such as Δ9tetrahydrocannabinol/cannabidiol oromucosal spray are also among the preparations approved for use as analgesic in cancer patients or for the relief of muscle spasticity in multiple sclerosis patients. However, standardized preparations of cannabis and further research are needed for many other medical conditions.

Keywords

Cannabinoid, Cannabis, cancer, neurodegenerative diseases

Project Number

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Details

Primary Language	Turkish
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Collection
Authors	Özge Balpınar 0000-0003-4235-9241 Selim Aytaç 0000-0003-1786-9725
Project Number	-
Publication Date	September 27, 2021
Submission Date	January 12, 2021
Acceptance Date	June 9, 2021
Published in Issue	Year 2021 Volume: 45 Issue: 3

Cite

APA	Balpınar, Ö., & Aytaç, S. (2021). TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME. Journal of Faculty of Pharmacy of Ankara University, 45(3), 631-651. https://doi.org/10.33483/jfpau.859372
AMA	Balpınar Ö, Aytaç S. TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME. J. Fac. Pharm. Ankara. September 2021;45(3):631-651. doi:10.33483/jfpau.859372
Chicago	Balpınar, Özge, and Selim Aytaç. “TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME”. Journal of Faculty of Pharmacy of Ankara University 45, no. 3 (September 2021): 631-51. https://doi.org/10.33483/jfpau.859372.
EndNote	Balpınar Ö, Aytaç S (September 1, 2021) TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME. Journal of Faculty of Pharmacy of Ankara University 45 3 631–651.
IEEE	Ö. Balpınar and S. Aytaç, “TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME”, J. Fac. Pharm. Ankara, vol. 45, no. 3, pp. 631–651, 2021, doi: 10.33483/jfpau.859372.
ISNAD	Balpınar, Özge - Aytaç, Selim. “TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME”. Journal of Faculty of Pharmacy of Ankara University 45/3 (September 2021), 631-651. https://doi.org/10.33483/jfpau.859372.
JAMA	Balpınar Ö, Aytaç S. TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME. J. Fac. Pharm. Ankara. 2021;45:631–651.
MLA	Balpınar, Özge and Selim Aytaç. “TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME”. Journal of Faculty of Pharmacy of Ankara University, vol. 45, no. 3, 2021, pp. 631-5, doi:10.33483/jfpau.859372.
Vancouver	Balpınar Ö, Aytaç S. TIBBİ KENEVİR VE SAĞLIK: FARMAKOLOJİK BİR DERLEME. J. Fac. Pharm. Ankara. 2021;45(3):631-5.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.