DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER

Ezgi Aydın; Ali Aydın; Gizem Çetiner; Gülşah Erel Akbaba

doi:10.33483/jfpau.1033286

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DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER

Year 2022, Volume: 46 Issue: 2, 551 - 575, 29.05.2022

Ezgi Aydın Ali Aydın Gizem Çetiner Gülşah Erel Akbaba

https://doi.org/10.33483/jfpau.1033286

Abstract

Amaç: Sentetik, biyolojik ve biyoteknolojik ilaç araştırmalarında sıklıkla kullanılan polimerik ve lipidik yapıdaki nanopartiküler sistemler klinik beklentileri halen istenilen düzeyde karşılayamamaktadır. Yenilikçi bir yaklaşım olarak geliştirilen doğadan ilham alan, biyomimetik nanotaşıyıcılar sahip oldukları yüksek biyouyumluluk, düşük toksisisite ve doğal hedefleme yetenekleri nedeniyle gittikçe artan şekilde çalışmalara dahil edilmektedir. Bu derlemenin amacı biyomimetik nanotaşıyıcılar alanında yapılan güncel çalışmaları ele alarak farmasötik yenilikçi taşıyıcı system geliştirme çabasına katkıda bulunmaktır.

Sonuç ve Tartışma: En sık kullanılan biyomimetik sistemler arasında virüs temelli, memeli hücresi temelli ve bakteri-mantar temelli nanotaşıyıcı sistemler bulunmaktadır. Doğanın bize sunduğu bu sistemleri anlama çabası taşıyıcı sistem araştırmalarında bizi daha ileriye götürebilir. Bununla birlikte, kontrol edilebilirlik ve seri üretim gibi sentetik sistemlerin avantajları ile biyolojik sistemlerin yüksek hücresel alım ve biyouyumluluk işlevlerinin birleştirmesi ile daha başarılı nanotaşıyıcı sistemlerin geliştirilme potansiyeli olabilecektir. Böylece, biyomimetik sistemlerin protein, gen ve diğer terapötik ajanların taşınmasındaki rolü artacaktır.

Keywords

Bakteri, biyomimetik, memeli hücreleri, nanopartiküller, virüs

Supporting Institution

Tübitak

Project Number

218S840

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NATURE-INSPIRED BIOMIMETIC NANOCARRIER SYSTEMS

Year 2022, Volume: 46 Issue: 2, 551 - 575, 29.05.2022

Ezgi Aydın Ali Aydın Gizem Çetiner Gülşah Erel Akbaba

https://doi.org/10.33483/jfpau.1033286

Abstract

Objective: Nanoparticular systems such as polymeric and lipidic nanoparticles, which are frequently used in synthetic, biological and biotechnological drug delivery, struggle to meet clinical expectations at the desired level. Nature-inspired biomimetic nanocarriers developed as an innovative approach, are increasingly included in studies due to their high biocompatibility, low toxicity, and natural targeting capabilities. The aim of this review is to contribute to the development of innovative pharmaceutical carrier system by addressing the current studies in the field of biomimetic nanocarriers.

Result and Discussion: Among the most commonly used biomimetic systems are virus-based, mammalian cell-based and bacteria-fungi-based nanocarrier systems. The effort to understand these systems that nature offers us could take us further in carrier system research. Moreover, there may be potential for more successful nanocarrier systems to be developed by combining the advantages of synthetic systems such as controllability and mass production with the high cellular uptake and biocompatibility functions of biological systems. Thus, the role of biomimetic systems in the transport of proteins, genes and other therapeutic agents will increase.

Keywords

Bacteria, biomimetic, mammalian cells, nanoparticle, virus

Project Number

218S840

References

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Details

Primary Language	Turkish
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Collection
Authors	Ezgi Aydın This is me 0000-0003-0593-8586 Ali Aydın This is me 0000-0001-7656-0969 Gizem Çetiner This is me 0000-0001-9557-9008 Gülşah Erel Akbaba 0000-0003-3287-5277
Project Number	218S840
Publication Date	May 29, 2022
Submission Date	December 6, 2021
Acceptance Date	March 31, 2022
Published in Issue	Year 2022 Volume: 46 Issue: 2

Cite

APA	Aydın, E., Aydın, A., Çetiner, G., Erel Akbaba, G. (2022). DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER. Journal of Faculty of Pharmacy of Ankara University, 46(2), 551-575. https://doi.org/10.33483/jfpau.1033286
AMA	Aydın E, Aydın A, Çetiner G, Erel Akbaba G. DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER. J. Fac. Pharm. Ankara. May 2022;46(2):551-575. doi:10.33483/jfpau.1033286
Chicago	Aydın, Ezgi, Ali Aydın, Gizem Çetiner, and Gülşah Erel Akbaba. “DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER”. Journal of Faculty of Pharmacy of Ankara University 46, no. 2 (May 2022): 551-75. https://doi.org/10.33483/jfpau.1033286.
EndNote	Aydın E, Aydın A, Çetiner G, Erel Akbaba G (May 1, 2022) DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER. Journal of Faculty of Pharmacy of Ankara University 46 2 551–575.
IEEE	E. Aydın, A. Aydın, G. Çetiner, and G. Erel Akbaba, “DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER”, J. Fac. Pharm. Ankara, vol. 46, no. 2, pp. 551–575, 2022, doi: 10.33483/jfpau.1033286.
ISNAD	Aydın, Ezgi et al. “DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER”. Journal of Faculty of Pharmacy of Ankara University 46/2 (May 2022), 551-575. https://doi.org/10.33483/jfpau.1033286.
JAMA	Aydın E, Aydın A, Çetiner G, Erel Akbaba G. DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER. J. Fac. Pharm. Ankara. 2022;46:551–575.
MLA	Aydın, Ezgi et al. “DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER”. Journal of Faculty of Pharmacy of Ankara University, vol. 46, no. 2, 2022, pp. 551-75, doi:10.33483/jfpau.1033286.
Vancouver	Aydın E, Aydın A, Çetiner G, Erel Akbaba G. DOĞADAN İLHAM ALAN BİYOMİMETİK NANOTAŞIYICI SİSTEMLER. J. Fac. Pharm. Ankara. 2022;46(2):551-75.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.