EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS

Burcu Sezgin; Murat Soyseven

doi:10.33483/jfpau.1425350

Research Article

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EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS

Year 2024, Volume: 48 Issue: 2, 535 - 543, 20.05.2024

Burcu Sezgin , Murat Soyseven

https://doi.org/10.33483/jfpau.1425350

Abstract

Objective: In our study, it was aimed to make a comparative analysis of the environmental impact profiles of two approaches including Gas Chromatography (GC) and Liquid Chromatography (LC) methods, which are frequently used techniques for the determination of non-steroidal anti-inflammatory drugs (NSAIDs) and their metabolites in environmental water samples.
Material and Method: The evaluation of the methods' environmental impact was performed using National Environmental Methods Index Label (NEMI), Analytical Eco-scale, Analytical GREEnness Metric (AGREE), and Green Analytical Procedure Index (GAPI).
Result and Discussion: The routine analysis of NSAIDs in environmental waters is carried out, resulting in a significant volume of chemical waste. In recent times, there has been a growing significance attributed to environmentally conscious analytical methodologies and the evaluation of methodologies through a green lens to confront this challenge. There is no statistically significant difference in terms of environmental impact profile was observed between the two methods compared.

Keywords

Environmental waters, green chemistry, greenness assessment, nonsteroidal anti-inflammatory drugs (NSAIDs)

References

1. Zuccato, E., Calamari, D., Natangelo, M., Fanelli, R. (2000). Presence of therapeutic drugs in the environment, Lancet, 355. [CrossRef]
2. Farré, M., Petrovic, M., Barceló, D. (2007). Recently developed GC/MS and LC/MS methods for determining NSAIDs in water samples. Analytical and Bioanalytical Chemistry, 387, 1203-1214. [CrossRef]
3. Kosjek, T., Heath, E., Krbavčič, A. (2005). Determination of non-steroidal anti-inflammatory drug (NSAIDs) residues in water samples. Environment International, 31(5), 679-685. [CrossRef]
4. Noguera-Oviedo, K., Aga, D. S. (2016). Lessons learned from more than two decades of research on emerging contaminants in the environment. Journal of Hazardous Materials, 316, 242-251. [CrossRef]
5. Bindu, S., Mazumder, S., Bandyopadhyay, U. (2020). Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochemical Pharmacology, 180, 114147. [CrossRef]
6. Rao, C.V., Rivenson, A., Simi, B., Zang, E., Kelloff, G., Steele, V., Reddy, B.S. (1995). Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Research, 55(7), 1464-1472.
7. Bjarnason, I., Scarpignato, C., Holmgren, E., Olszewski, M., Rainsford, K.D., Lanas, A. (2018). Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs. Gastroenterology, 154(3), 500-514. [CrossRef]
8. Petrie, B., Barden, R., Kasprzyk-Hordern, B. (2015). A review on emerging contaminants in wastewaters and the environment: current knowledge, understudied areas and recommendations for future monitoring. Water Research, 72, 3-27. [CrossRef]
9. Rodrıguez, I., Quintana, J.B., Carpinteiro, J., Carro, A.M., Lorenzo, R.A., Cela, R. (2003). Determination of acidic drugs in sewage water by gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives. Journal of Chromatography A, 985(1-2), 265-274. [CrossRef]
10. Öllers, S., Singer, H.P., Fässler, P., Müller, S.R. (2001). Simultaneous quantification of neutral and acidic pharmaceuticals and pesticides at the low-ng/l level in surface and waste water. Journal of Chromatography A, 911(2), 225-234. [CrossRef]
11. Moeder, M., Schrader, S., Winkler, M., Popp, P. (2000). Solid-phase microextraction–gas chromatography–mass spectrometry of biologically active substances in water samples. Journal of Chromatography A, 873(1), 95-106. [CrossRef]
12. Weigel, S., Berger, U., Jensen, E., Kallenborn, R., Thoresen, H., Hühnerfuss, H. (2004). Determination of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with emphasis on ibuprofen and its metabolites. Chemosphere, 56(6), 583-592. [CrossRef]
13. Lee, H.B., Peart, T.E., Svoboda, M.L. (2005). Determination of endocrine-disrupting phenols, acidic pharmaceuticals, and personal-care products in sewage by solid-phase extraction and gas chromatography–mass spectrometry. Journal of Chromatography A, 1094(1-2), 122-129. [CrossRef]
14. Tauxe-Wuersch, A., De Alencastro, L.F., Grandjean, D., Tarradellas, J. (2005). Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. Water Research, 39(9), 1761-1772. [CrossRef]
15. Hanafiah, Z.M., Mohtar, W.H.M.W., Abd Manan, T.S.B., Bachi, N.A., Abdullah, N.A., Abd Hamid, H.H., Rasdi, N.W. (2022). The occurrence of non-steroidal anti-inflammatory drugs (NSAIDs) in Malaysian urban domestic wastewater. Chemosphere, 287, 132134. [CrossRef]
16. Samaras, V.G., Thomaidis, N.S., Stasinakis, A.S., Gatidou, G., Lekkas, T.D. (2010). Determination of selected non-steroidal anti-inflammatory drugs in wastewater by gas chromatography-mass spectrometry. International Journal of Environmental and Analytical Chemistry, 90(3-6), 219-229. [CrossRef]
17. Hashim, N.H., Khan, S.J. (2011). Enantioselective analysis of ibuprofen, ketoprofen and naproxen in wastewater and environmental water samples. Journal of Chromatography A, 1218(29), 4746-4754. [CrossRef]
18. Shanmugam, G., Sampath, S., Selvaraj, K.K., Larsson, D.J., Ramaswamy, B.R. (2014). Non-steroidal anti-inflammatory drugs in Indian rivers. Environmental Science and Pollution Research, 21, 921-931. [CrossRef]
19. Ferrer, I., Ginebreda, A., Figueras, M., Olivella, L., Tirapu, L., Vilanova, M., Barceló, D. (2001). Determination of drugs in surface water and wastewater samples by liquid chromatography–mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. Journal of Chromatography A, 938(1-2), 187-197. [CrossRef]
20. Miao, X.S., Koenig, B.G., Metcalfe, C.D. (2002). Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Chromatography A, 952(1-2), 139-147. [CrossRef]
21. González-Barreiro, C., Lores, M., Casais, M.C., Cela, R. (2003). Simultaneous determination of neutral and acidic pharmaceuticals in wastewater by high-performance liquid chromatography-post-column photochemically induced fluorimetry. Journal of Chromatography A, 993(1-2), 29-37. [CrossRef]
22. Löffler, D., Ternes, T. A. (2003). Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1021(1-2), 133-144. [CrossRef]
23. Vanderford, B.J., Pearson, R.A., Rexing, D.J., Snyder, S.A. (2003). Analysis of endocrine disruptors, pharmaceuticals, and personal care products in water using liquid chromatography/tandem mass spectrometry. Analytical Chemistry, 75(22), 6265-6274. [CrossRef]
24. Quintana, J.B., Reemtsma, T. (2004). Sensitive determination of acidic drugs and triclosan in surface and wastewater by ion‐pair reverse‐phase liquid chromatography/tandem mass spectrometry. Rapid Communications In Mass Spectrometry, 18(7), 765-774. [CrossRef]
25. Santos, J.L., Aparicio, I., Alonso, E., Callejón, M. (2005). Simultaneous determination of pharmaceutically active compounds in wastewater samples by solid phase extraction and high-performance liquid chromatography with diode array and fluorescence detectors. Analytica Chimica Acta, 550(1-2), 116-122. [CrossRef]
26. Debska, J., Kot‐Wasik, A., Namiesnik, J. (2005). Determination of nonsteroidal antiinflammatory drugs in water samples using liquid chromatography coupled with diode‐array detector and mass spectrometry. Journal of Separation Science, 28(17), 2419-2426. [CrossRef]
27. Madikizela, L.M., Chimuka, L. (2017). Simultaneous determination of naproxen, ibuprofen and diclofenac in wastewater using solid-phase extraction with high performance liquid chromatography. Water Sa, 43(2), 264-274. [CrossRef]
28. Márta, Z., Bobály, B., Fekete, J., Magda, B., Imre, T., Szabó, P.T. (2018). Simultaneous determination of ten nonsteroidal anti-inflammatory drugs from drinking water, surface water and wastewater using micro UHPLC-MS/MS with on-line SPE system. Journal of Pharmaceutical and Biomedical Analysis, 160, 99-108. [CrossRef]
29. Jindal, K., Narayanam, M., Singh, S. (2015). A systematic strategy for the identification and determination of pharmaceuticals in environment using advanced LC-MS tools: Application to ground water samples. Journal of Pharmaceutical and Biomedical Analysis, 108, 86-96. [CrossRef]
30. Paíga, P., Santos, L.H.M.L.M., Delerue-Matos, C. (2017). Development of a multi-residue method for the determination of human and veterinary pharmaceuticals and some of their metabolites in aqueous environmental matrices by SPE-UHPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 135, 75-86. [CrossRef]
31. Zgoła-Grześkowiak, A. (2010). Application of DLLME to isolation and concentration of non-steroidal anti-inflammatory drugs in environmental water samples. Chromatographia, 72, 671-678. [CrossRef]
32. Macià, A., Borrull, F., Aguilar, C., Calull, M. (2003). Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples. Electrophoresis, 24(16), 2779-2787. [CrossRef]
33. Macià, A., Borrull, F., Calull, M., Aguilar, C. (2006). Different sample stacking strategies to analyse some nonsteroidal anti-inflammatory drugs by micellar electrokinetic capillary chromatography in mineral waters. Journal of Chromatography A, 1117(2), 234-245. [CrossRef]
34. Macià, A., Borrull, F., Aguilar, C., Calull, M. (2004). Application of capillary electrophoresis with different sample stacking strategies for the determination of a group of nonsteroidal anti‐inflammatory drugs in the low μg·L−1 concentration range. Electrophoresis, 25(3), 428-436. [CrossRef]
35. Macià, A., Borrull, F., Calull, M., Benavente, F., Hernández, E., Sanz‐Nebot, V., Barbosa, J., Aguilar, C. (2008). Sensitivity enhancement for the analysis of naproxen in tap water by solid‐phase extraction coupled in‐line to capillary electrophoresis. Journal of Separation Science, 31(5), 872-880. [CrossRef]
36. Macià, A., Borrull, F., Calull, M., Aguilar, C. (2006). Analysis of nonsteroidal anti-inflammatory drugs in water samples using microemulsion electrokinetic capillary chromatography under pH-suppressed electroosmotic flow with an on-column preconcentration technique. Chromatographia, 63, 149-154. [CrossRef]
37. Gentili, A. (2007). Determination of non-steroidal anti-inflammatory drugs in environmental samples by chromatographic and electrophoretic techniques. Analytical and Bioanalytical Chemistry, 387(4), 1185-1202. [CrossRef]
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39. Fitch, B.N., Gray, R., Beres, M., Hicks, M.B., Farrell, W., Aurigemma, C., Olesik, S.V. (2022). Life cycle analysis and sustainability comparison of reversed phase high performance liquid chromatography and carbon dioxide-containing chromatography of small molecule pharmaceuticals. Green Chemistry, 24(11), 4516-4532. [CrossRef]
40. Gaber, Y., Törnvall, U., Kumar, M.A., Amin, M.A., Hatti-Kaul, R. (2011). HPLC-EAT (Environmental Assessment Tool): a tool for profiling safety, health and environmental impacts of liquid chromatography methods. Green Chemistry, 13(8), 2021-2025. [CrossRef]
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SIK KULLANILAN NONSTEROİD ANTİ-İNFLAMATUVAR İLAÇLARIN (NSAİİ) ÇEVRESEL SULARDA TAYİNİ İÇİN GELİŞTİRİLMİŞ ÇEŞİTLİ YÖNTEMLERİN YEŞİLLİK PROFİLLERİNİN DEĞERLENDİRİLMESİ

Year 2024, Volume: 48 Issue: 2, 535 - 543, 20.05.2024

Burcu Sezgin , Murat Soyseven

https://doi.org/10.33483/jfpau.1425350

Abstract

Amaç: Çalışmamızda, çevresel su örneklerinde steroid olmayan antiinflamatuar ilaçların (NSAİİ) ve bunların metabolitlerinin tayininde sıklıkla kullanılan teknikler olan Gaz Kromatografisi (GK) ve Sıvı Kromatografisi (SK) yöntemlerini içeren iki yaklaşımın çevresel etki profillerinin karşılaştırmalı bir analizinin yapılması amaçlanmıştır.
Gereç ve Yöntem: Yöntemlerin çevresel etkisinin değerlendirilmesi, Ulusal Çevresel Yöntemler İndeks Etiketi (NEMI), Analitik Eko-ölçek, Analitik Yeşillik Metriği (AGREE) ve Yeşil Analitik Prosedür İndeksi (GAPI) kullanılarak gerçekleştirilmiştir.
Sonuç ve Tartışma: Çevresel sularda NSAİİ'lerin rutin analizi gerçekleştirilmekte ve bunun sonucunda önemli miktarda kimyasal atık ortaya çıkmaktadır. Son zamanlarda, çevreye duyarlı analitik metodolojilere ve bu zorluğun üstesinden gelmek için metodolojilerin yeşil bir mercekle değerlendirilmesine atfedilen önem giderek artmaktadır. Karşılaştırılan iki yöntem arasında çevresel etki profili açısından istatistiksel olarak anlamlı bir fark olmadığı gözlenmiştir.

Keywords

Çevresel sular, nonsteroid anti-inflamatuvar ilaçlar (NSAİİ), yeşil kimya, yeşillik değerlendirmesi

References

1. Zuccato, E., Calamari, D., Natangelo, M., Fanelli, R. (2000). Presence of therapeutic drugs in the environment, Lancet, 355. [CrossRef]
2. Farré, M., Petrovic, M., Barceló, D. (2007). Recently developed GC/MS and LC/MS methods for determining NSAIDs in water samples. Analytical and Bioanalytical Chemistry, 387, 1203-1214. [CrossRef]
3. Kosjek, T., Heath, E., Krbavčič, A. (2005). Determination of non-steroidal anti-inflammatory drug (NSAIDs) residues in water samples. Environment International, 31(5), 679-685. [CrossRef]
4. Noguera-Oviedo, K., Aga, D. S. (2016). Lessons learned from more than two decades of research on emerging contaminants in the environment. Journal of Hazardous Materials, 316, 242-251. [CrossRef]
5. Bindu, S., Mazumder, S., Bandyopadhyay, U. (2020). Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochemical Pharmacology, 180, 114147. [CrossRef]
6. Rao, C.V., Rivenson, A., Simi, B., Zang, E., Kelloff, G., Steele, V., Reddy, B.S. (1995). Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Research, 55(7), 1464-1472.
7. Bjarnason, I., Scarpignato, C., Holmgren, E., Olszewski, M., Rainsford, K.D., Lanas, A. (2018). Mechanisms of damage to the gastrointestinal tract from nonsteroidal anti-inflammatory drugs. Gastroenterology, 154(3), 500-514. [CrossRef]
8. Petrie, B., Barden, R., Kasprzyk-Hordern, B. (2015). A review on emerging contaminants in wastewaters and the environment: current knowledge, understudied areas and recommendations for future monitoring. Water Research, 72, 3-27. [CrossRef]
9. Rodrıguez, I., Quintana, J.B., Carpinteiro, J., Carro, A.M., Lorenzo, R.A., Cela, R. (2003). Determination of acidic drugs in sewage water by gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives. Journal of Chromatography A, 985(1-2), 265-274. [CrossRef]
10. Öllers, S., Singer, H.P., Fässler, P., Müller, S.R. (2001). Simultaneous quantification of neutral and acidic pharmaceuticals and pesticides at the low-ng/l level in surface and waste water. Journal of Chromatography A, 911(2), 225-234. [CrossRef]
11. Moeder, M., Schrader, S., Winkler, M., Popp, P. (2000). Solid-phase microextraction–gas chromatography–mass spectrometry of biologically active substances in water samples. Journal of Chromatography A, 873(1), 95-106. [CrossRef]
12. Weigel, S., Berger, U., Jensen, E., Kallenborn, R., Thoresen, H., Hühnerfuss, H. (2004). Determination of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with emphasis on ibuprofen and its metabolites. Chemosphere, 56(6), 583-592. [CrossRef]
13. Lee, H.B., Peart, T.E., Svoboda, M.L. (2005). Determination of endocrine-disrupting phenols, acidic pharmaceuticals, and personal-care products in sewage by solid-phase extraction and gas chromatography–mass spectrometry. Journal of Chromatography A, 1094(1-2), 122-129. [CrossRef]
14. Tauxe-Wuersch, A., De Alencastro, L.F., Grandjean, D., Tarradellas, J. (2005). Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. Water Research, 39(9), 1761-1772. [CrossRef]
15. Hanafiah, Z.M., Mohtar, W.H.M.W., Abd Manan, T.S.B., Bachi, N.A., Abdullah, N.A., Abd Hamid, H.H., Rasdi, N.W. (2022). The occurrence of non-steroidal anti-inflammatory drugs (NSAIDs) in Malaysian urban domestic wastewater. Chemosphere, 287, 132134. [CrossRef]
16. Samaras, V.G., Thomaidis, N.S., Stasinakis, A.S., Gatidou, G., Lekkas, T.D. (2010). Determination of selected non-steroidal anti-inflammatory drugs in wastewater by gas chromatography-mass spectrometry. International Journal of Environmental and Analytical Chemistry, 90(3-6), 219-229. [CrossRef]
17. Hashim, N.H., Khan, S.J. (2011). Enantioselective analysis of ibuprofen, ketoprofen and naproxen in wastewater and environmental water samples. Journal of Chromatography A, 1218(29), 4746-4754. [CrossRef]
18. Shanmugam, G., Sampath, S., Selvaraj, K.K., Larsson, D.J., Ramaswamy, B.R. (2014). Non-steroidal anti-inflammatory drugs in Indian rivers. Environmental Science and Pollution Research, 21, 921-931. [CrossRef]
19. Ferrer, I., Ginebreda, A., Figueras, M., Olivella, L., Tirapu, L., Vilanova, M., Barceló, D. (2001). Determination of drugs in surface water and wastewater samples by liquid chromatography–mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. Journal of Chromatography A, 938(1-2), 187-197. [CrossRef]
20. Miao, X.S., Koenig, B.G., Metcalfe, C.D. (2002). Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of Chromatography A, 952(1-2), 139-147. [CrossRef]
21. González-Barreiro, C., Lores, M., Casais, M.C., Cela, R. (2003). Simultaneous determination of neutral and acidic pharmaceuticals in wastewater by high-performance liquid chromatography-post-column photochemically induced fluorimetry. Journal of Chromatography A, 993(1-2), 29-37. [CrossRef]
22. Löffler, D., Ternes, T. A. (2003). Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1021(1-2), 133-144. [CrossRef]
23. Vanderford, B.J., Pearson, R.A., Rexing, D.J., Snyder, S.A. (2003). Analysis of endocrine disruptors, pharmaceuticals, and personal care products in water using liquid chromatography/tandem mass spectrometry. Analytical Chemistry, 75(22), 6265-6274. [CrossRef]
24. Quintana, J.B., Reemtsma, T. (2004). Sensitive determination of acidic drugs and triclosan in surface and wastewater by ion‐pair reverse‐phase liquid chromatography/tandem mass spectrometry. Rapid Communications In Mass Spectrometry, 18(7), 765-774. [CrossRef]
25. Santos, J.L., Aparicio, I., Alonso, E., Callejón, M. (2005). Simultaneous determination of pharmaceutically active compounds in wastewater samples by solid phase extraction and high-performance liquid chromatography with diode array and fluorescence detectors. Analytica Chimica Acta, 550(1-2), 116-122. [CrossRef]
26. Debska, J., Kot‐Wasik, A., Namiesnik, J. (2005). Determination of nonsteroidal antiinflammatory drugs in water samples using liquid chromatography coupled with diode‐array detector and mass spectrometry. Journal of Separation Science, 28(17), 2419-2426. [CrossRef]
27. Madikizela, L.M., Chimuka, L. (2017). Simultaneous determination of naproxen, ibuprofen and diclofenac in wastewater using solid-phase extraction with high performance liquid chromatography. Water Sa, 43(2), 264-274. [CrossRef]
28. Márta, Z., Bobály, B., Fekete, J., Magda, B., Imre, T., Szabó, P.T. (2018). Simultaneous determination of ten nonsteroidal anti-inflammatory drugs from drinking water, surface water and wastewater using micro UHPLC-MS/MS with on-line SPE system. Journal of Pharmaceutical and Biomedical Analysis, 160, 99-108. [CrossRef]
29. Jindal, K., Narayanam, M., Singh, S. (2015). A systematic strategy for the identification and determination of pharmaceuticals in environment using advanced LC-MS tools: Application to ground water samples. Journal of Pharmaceutical and Biomedical Analysis, 108, 86-96. [CrossRef]
30. Paíga, P., Santos, L.H.M.L.M., Delerue-Matos, C. (2017). Development of a multi-residue method for the determination of human and veterinary pharmaceuticals and some of their metabolites in aqueous environmental matrices by SPE-UHPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 135, 75-86. [CrossRef]
31. Zgoła-Grześkowiak, A. (2010). Application of DLLME to isolation and concentration of non-steroidal anti-inflammatory drugs in environmental water samples. Chromatographia, 72, 671-678. [CrossRef]
32. Macià, A., Borrull, F., Aguilar, C., Calull, M. (2003). Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples. Electrophoresis, 24(16), 2779-2787. [CrossRef]
33. Macià, A., Borrull, F., Calull, M., Aguilar, C. (2006). Different sample stacking strategies to analyse some nonsteroidal anti-inflammatory drugs by micellar electrokinetic capillary chromatography in mineral waters. Journal of Chromatography A, 1117(2), 234-245. [CrossRef]
34. Macià, A., Borrull, F., Aguilar, C., Calull, M. (2004). Application of capillary electrophoresis with different sample stacking strategies for the determination of a group of nonsteroidal anti‐inflammatory drugs in the low μg·L−1 concentration range. Electrophoresis, 25(3), 428-436. [CrossRef]
35. Macià, A., Borrull, F., Calull, M., Benavente, F., Hernández, E., Sanz‐Nebot, V., Barbosa, J., Aguilar, C. (2008). Sensitivity enhancement for the analysis of naproxen in tap water by solid‐phase extraction coupled in‐line to capillary electrophoresis. Journal of Separation Science, 31(5), 872-880. [CrossRef]
36. Macià, A., Borrull, F., Calull, M., Aguilar, C. (2006). Analysis of nonsteroidal anti-inflammatory drugs in water samples using microemulsion electrokinetic capillary chromatography under pH-suppressed electroosmotic flow with an on-column preconcentration technique. Chromatographia, 63, 149-154. [CrossRef]
37. Gentili, A. (2007). Determination of non-steroidal anti-inflammatory drugs in environmental samples by chromatographic and electrophoretic techniques. Analytical and Bioanalytical Chemistry, 387(4), 1185-1202. [CrossRef]
38. Macià, A., Borrull, F., Calull, M., Aguilar, C. (2007). Capillary electrophoresis for the analysis of non-steroidal anti-inflammatory drugs. TrAC Trends in Analytical Chemistry, 26(2), 133-153. [CrossRef]
39. Fitch, B.N., Gray, R., Beres, M., Hicks, M.B., Farrell, W., Aurigemma, C., Olesik, S.V. (2022). Life cycle analysis and sustainability comparison of reversed phase high performance liquid chromatography and carbon dioxide-containing chromatography of small molecule pharmaceuticals. Green Chemistry, 24(11), 4516-4532. [CrossRef]
40. Gaber, Y., Törnvall, U., Kumar, M.A., Amin, M.A., Hatti-Kaul, R. (2011). HPLC-EAT (Environmental Assessment Tool): a tool for profiling safety, health and environmental impacts of liquid chromatography methods. Green Chemistry, 13(8), 2021-2025. [CrossRef]
41. Armenta, S., Garrigues, S., de la Guardia, M. (2008). Green analytical chemistry. TrAC Trends in Analytical Chemistry, 27(6), 497-511. [CrossRef]
42. Anastas, P.T. (1999). Green chemistry and the role of analytical methodology development. Critical Reviews In Analytical Chemistry, 29(3), 167-175. [CrossRef]
43. Soyseven, M., Sezgin, B., Arli, G. (2023). The development and validation of a novel, green, sustainable and eco-friendly HPLC-ELSD method approach for the simultaneous determination of seven artificial sweeteners in various food products: An assessment of the greenness profile of the developed method with an analytical eco-scale, NEMI, GAPI and AGREE. Microchemical Journal, 193, 109225. [CrossRef]
44. Keith, L.H., Gron, L.U., Young, J.L. (2007). Green analytical methodologies. Chemical Reviews, 107(6), 2695-2708. [CrossRef]
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There are 49 citations in total.

Details

Primary Language	English
Subjects	Pharmaceutical Analytical Chemistry
Journal Section	Research Article
Authors	Burcu Sezgin 0000-0003-0279-4839 Murat Soyseven 0000-0002-6433-2392
Early Pub Date	April 2, 2024
Publication Date	May 20, 2024
Submission Date	January 25, 2024
Acceptance Date	March 14, 2024
Published in Issue	Year 2024 Volume: 48 Issue: 2

Cite

APA	Sezgin, B., & Soyseven, M. (2024). EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS. Journal of Faculty of Pharmacy of Ankara University, 48(2), 535-543. https://doi.org/10.33483/jfpau.1425350
AMA	Sezgin B, Soyseven M. EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS. J. Fac. Pharm. Ankara. May 2024;48(2):535-543. doi:10.33483/jfpau.1425350
Chicago	Sezgin, Burcu, and Murat Soyseven. “EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS”. Journal of Faculty of Pharmacy of Ankara University 48, no. 2 (May 2024): 535-43. https://doi.org/10.33483/jfpau.1425350.
EndNote	Sezgin B, Soyseven M (May 1, 2024) EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS. Journal of Faculty of Pharmacy of Ankara University 48 2 535–543.
IEEE	B. Sezgin and M. Soyseven, “EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS”, J. Fac. Pharm. Ankara, vol. 48, no. 2, pp. 535–543, 2024, doi: 10.33483/jfpau.1425350.
ISNAD	Sezgin, Burcu - Soyseven, Murat. “EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS”. Journal of Faculty of Pharmacy of Ankara University 48/2 (May 2024), 535-543. https://doi.org/10.33483/jfpau.1425350.
JAMA	Sezgin B, Soyseven M. EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS. J. Fac. Pharm. Ankara. 2024;48:535–543.
MLA	Sezgin, Burcu and Murat Soyseven. “EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS”. Journal of Faculty of Pharmacy of Ankara University, vol. 48, no. 2, 2024, pp. 535-43, doi:10.33483/jfpau.1425350.
Vancouver	Sezgin B, Soyseven M. EVALUATION OF GREENNESS PROFILES OF VARIOUS DEVELOPED METHODS FOR THE DETERMINATION OF COMMONLY USED NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ENVIRONMENTAL WATERS. J. Fac. Pharm. Ankara. 2024;48(2):535-43.

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Scope and Aim

The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.