EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES

Özlem Öztürk Ceylan; Beyza Yılmaz; Sibel Süzen

doi:10.33483/jfpau.1504455

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EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES

Year 2024, Volume: 48 Issue: 3, 1281 - 1292, 10.09.2024

Özlem Öztürk Ceylan , Beyza Yılmaz Sibel Süzen

https://doi.org/10.33483/jfpau.1504455

Abstract

Objective: Melatonin (MLT) is largely produced within the pinealocytes from tryptophan, happening during the dark. MLT’s binding sites have been established in numerous parts of the brain but also in the cells of the immune system, gonads, kidney, and cardiovascular system. MLT may directly or indirectly affect the thyroid gland and its activities. It can also prevent thyroid cell proliferation and interfere with thyroid hormone synthesis. The underlying mechanisms need to be carefully interpreted.
Result and Discussion: In this review the typical inhibitory effects of MLT on the thyroid gland and hormone secretion, as well as its antioxidant effects and relationship with thyroid diseases is investigated.

Keywords

Hypothyroidism, melatonin, melatonin receptors, thyroid cancer, thyroid physiology

Ethical Statement

Bu çalışmanın, özgün bir çalışma olduğunu; çalışmanın hazırlık, veri toplama, analiz ve bilgilerin sunumu olmak üzere tüm aşamalarından bilimsel etik ilke ve kurallarına uygun davrandığımı; bu çalışma kapsamında elde edilmeyen tüm veri ve bilgiler için kaynak gösterdiğimi ve bu kaynaklara kaynakçada yer verdiğimi; kullanılan verilerde herhangi bir değişiklik yapmadığımı, etik görev ve sorumluluklara riayet ettiğimi beyan ederim.

Supporting Institution

ANKARA ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ

Project Number

19L0237007 NUMARALI ANKARA ÜNİVERSİTESİ BAP PROJESİ

Thanks

Doktora çalışmalarına başlamak istediğimde, tüm sevgisi ile kucaklayan, bilgi birikimi ve tecrübeleri ile ışık tutan, her adımımda desteğini eksik etmeyen, uzun yıllar süren çalışmalarıma gösterdiği sabırdan dolayı danışman hocam Sayın Prof. Dr. Sibel Süzen’e, çalışmalarımızın temelini oluşturmamızda bize desteğini esirgemeyen tüm çalışmalarımın aydınlatılmasında A.Ü Eczacılık Fakültesi Merkez Laboratuvarı cihaz ve ekipmanları ile gece gündüz çalışan Sayın Prof. Dr. Hakan Göker’e, mikrobiyolojik çalışmalarımı gerçekleştiren Sayın Prof. Dr. Nurten Altanlar’a, deneylerimi tamamladığım Farmasötik Kimya Anabilim Dalı’nın değerli Öğretim Üyelerine, Araştırma Görevlileri ve Yüksek Lisans/ Doktora öğrencilerine, tüm çalışmalarımda bana kendiyle geçecek anne saatinden özveri de ve fedakarlıkta bulunup başarıma başarı katan ve yardım eden Sevgili Kızım İrem Ceylan’a, sabırla akademik çalışmalarıma destek veren Sevgili Eşim Selim Ceylan’a, doğduğum günden beri sevgilerini her konuda hissettiren verdiğim her kararda motive edici desteklerini esirgemeyen biricik annem ve babama, bu süreçte hayatıma dokunan tüm dostlarıma sonsuz sevgi ve saygılarımla teşekkür ederim.

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MELATONİNİN TİROİD FİZYOLOJİ VE HASTALIKLARI ÜZERİNDEKİ ROLÜNÜN DEĞERLENDİRİLMESİ

Year 2024, Volume: 48 Issue: 3, 1281 - 1292, 10.09.2024

Özlem Öztürk Ceylan , Beyza Yılmaz Sibel Süzen

https://doi.org/10.33483/jfpau.1504455

Abstract

Amaç: Melatonin (MLT) büyük ölçüde triptofandan pinealositler içinde üretilir. Karanlıkta serotonin-N-asetiltransferaz aktivitesinde büyük bir artış olduğunda gerçekleşir ve serotoninin N-asetilserotonine dönüşmesine neden olur. MLT'nin bağlanma bölgeleri beynin birçok yerinde ve aynı zamanda bağışıklık sistemi, gonadlar, böbrek ve kardiyovasküler sistem hücrelerinde tespit edilmiştir. MLT, MT1 ve MT2 membran reseptörleri aracılığıyla birçok farmakolojik ve fizyolojik aktiviteyi etkiler. Ayrıca, reseptör aracılı olmayan etkileri ile antioksidan aktivite gösterir. MLT doğrudan veya dolaylı olarak tiroid bezini ve faaliyetlerini etkileyebilir. Altta yatan mekanizmaların dikkatle yorumlanması gerekmektedir.
Sonuç ve Tartışma: Bu derlemede, MLT'nin tiroid bezi ve hormon salgısı üzerindeki tipik inhibitör etkilerinin yanı sıra antioksidan etkileri ve tiroid hastalıkları ile ilişkisi incelenmiştir.

Keywords

Hipotiroidizm, melatonin, melatonin reseptörleri, tiroid kanseri, tiroid fizyolojisi

Project Number

19L0237007 NUMARALI ANKARA ÜNİVERSİTESİ BAP PROJESİ

References

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2. Shirinzadeh, H., Ince, E., Westwell, A.D., Gurer-Orhan, H., Suzen, S. (2016). Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: Studies on their antioxidant, chemopreventive and cytotoxic activities. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1312-1321. [CrossRef]
3. Srinivasan, V., Gobbi, G., Shillcutt, S.D., Suzen, S. (2014). Melatonin: Therapeutic value and neuroprotection, CRC Press, New York, p.573.
4. Reiter R.J., Tan D.X., Rosales-Corral S., Galano A., Zhou X.J., Xu B. (2018). Mitochondria: Central organelles for melatonin's antioxidant and anti-aging actions. Molecules. 23 (2), 509. [CrossRef]
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Details

Primary Language	English
Subjects	Pharmaceutical Chemistry
Journal Section	Collection
Authors	Özlem Öztürk Ceylan 0000-0002-5749-0595 Beyza Yılmaz This is me 0009-0001-6355-2182 Sibel Süzen This is me 0000-0003-3413-6152
Project Number	19L0237007 NUMARALI ANKARA ÜNİVERSİTESİ BAP PROJESİ
Early Pub Date	August 22, 2024
Publication Date	September 10, 2024
Submission Date	June 24, 2024
Acceptance Date	August 14, 2024
Published in Issue	Year 2024 Volume: 48 Issue: 3

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APA	Öztürk Ceylan, Ö., Yılmaz, B., & Süzen, S. (2024). EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES. Journal of Faculty of Pharmacy of Ankara University, 48(3), 1281-1292. https://doi.org/10.33483/jfpau.1504455
AMA	Öztürk Ceylan Ö, Yılmaz B, Süzen S. EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES. J. Fac. Pharm. Ankara. September 2024;48(3):1281-1292. doi:10.33483/jfpau.1504455
Chicago	Öztürk Ceylan, Özlem, Beyza Yılmaz, and Sibel Süzen. “EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES”. Journal of Faculty of Pharmacy of Ankara University 48, no. 3 (September 2024): 1281-92. https://doi.org/10.33483/jfpau.1504455.
EndNote	Öztürk Ceylan Ö, Yılmaz B, Süzen S (September 1, 2024) EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES. Journal of Faculty of Pharmacy of Ankara University 48 3 1281–1292.
IEEE	Ö. Öztürk Ceylan, B. Yılmaz, and S. Süzen, “EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES”, J. Fac. Pharm. Ankara, vol. 48, no. 3, pp. 1281–1292, 2024, doi: 10.33483/jfpau.1504455.
ISNAD	Öztürk Ceylan, Özlem et al. “EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES”. Journal of Faculty of Pharmacy of Ankara University 48/3 (September 2024), 1281-1292. https://doi.org/10.33483/jfpau.1504455.
JAMA	Öztürk Ceylan Ö, Yılmaz B, Süzen S. EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES. J. Fac. Pharm. Ankara. 2024;48:1281–1292.
MLA	Öztürk Ceylan, Özlem et al. “EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES”. Journal of Faculty of Pharmacy of Ankara University, vol. 48, no. 3, 2024, pp. 1281-92, doi:10.33483/jfpau.1504455.
Vancouver	Öztürk Ceylan Ö, Yılmaz B, Süzen S. EVALUATING THE ROLE OF MELATONIN ON THYROID PHYSIOLOGY AND DISEASES. J. Fac. Pharm. Ankara. 2024;48(3):1281-92.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.