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The Effects of Coffee and Its Components on Gastrointestinal Health

Yıl 2025, Cilt: 7 Sayı: 1, 40 - 46, 18.02.2025
https://doi.org/10.57224/jhpr.1551503

Öz

Coffee consumption is rapidly increasing worldwide, with individuals estimated to consume an average of 2.4 cups per day. It has been suggested that consuming 2-5 cups of coffee daily may support overall health. The potential effects of coffee on the gastrointestinal system have been a topic of debate for many years, and there remains no clear consensus. Coffee contains several bioactive compounds, including phenolic compounds, alkaloids, flavonoids, and diterpenes, which may have various effects on the gastrointestinal system. Among these, caffeine, an alkaloid, is the most well-known and extensively studied for its potential health effects. Coffee, with its caffeine, polyphenols, and bioactive components, may support digestion, enhance intestinal motility, and positively influence the gut microbiota. However, in some individuals, it may increase gastric acid secretion, potentially exacerbating conditions such as gastritis and reflux. Studies examining the effects of coffee on gut health have shown that it enhances motility and may support the microbiota, suggesting potential benefits for conditions such as inflammatory bowel diseases. Although the relationship between coffee consumption and gastrointestinal disorders, such as functional dyspepsia and irritable bowel syndrome, remains unclear, there are indications of potential benefits. In summary, coffee consumption can influence gastrointestinal health. While moderate daily consumption appears to be beneficial, excessive intake may lead to gastrointestinal symptoms. Therefore, it is recommended that coffee intake be adjusted based on individual symptoms and existing health conditions.

Kaynakça

  • Pancsira J. International Coffee Tra-de: a literature review. Journal of Agri-cultural Informatics [Internet]. 2022 Mar 18 [cited 2024 Apr 20];13(1):26–35. Available from: https://magisz.org/journal/index.php/jai/article/view/654.
  • Coffee consumption worldwide from 2012/13 to 2021/22 with a forecast to 2022/23 [Internet]. 2023 [cited 2024 Apr 20]. Available from: https://www.statista.com/statistics/292595/global-coffee-consumption/.
  • Goral M, Yüksel F, Kement Ü, Gü-ner Ç. The meaning and coffee con-sumption habits attributed to coffee by consumers in Turkey. ODÜ Sosyal Bi-limler Araştırmaları Dergisi (ODÜSO-BİAD). 2022 Jul 1;3(2):67–96.
  • Abalo R. Coffee and caffeine con-sumption for human health. Nutrients. 2021;13(9):2918.
  • de Melo Pereira GV, de Carvalho Neto DP, Magalhães Júnior AI, do Prado FG, Pagnoncelli MGB, Karp SG, et al. Chemical composition and health pro-perties of coffee and coffee by-products. Adv Food Nutr Res. 2020;91:65–96.
  • Iriondo-Dehond A, Uranga JA, Del Castillo MD, Abalo R. Effects of coffee and its components on the gastrointesti-nal tract and the brain–gut axis. Nutri-ents. 2021;13(1):1–34.
  • Taborska N, Martyka A, Kubicka Fi-giel M, Ujma P. The impact of consu-med coffee on the digestive system—review of the latest research. J Educ He-alth Sport. 2024;53:32–43.
  • Ambrose L, Popa A, Ilıe L, Balta AA, Fotache PA, Moraru DI, Maftei NM, et al. The influence of nutrition on patients with digestive diseases. Tech-nium BioChemMed. 2023;6:67–72.
  • Song H, Shen X, Chu Q, Zheng X. Coffee consumption is not associated with the risk of gastric cancer: An upda-ted systematic review and meta-analysis of prospective cohort studies. Nutr Res. 2022;102:35–44.
  • Martimianaki G, Bertuccio P, Ali-candro G, Pelucchi C, Bravi F, Carioli G, et al. Coffee consumption and gastric cancer: A pooled analysis from the Sto-mach Cancer Pooling Project consor-tium. Eur J Cancer Prev. 2022;31(2):117–27.
  • Saud S, Salamatullah AM. Relati-onship between the chemical composi-tion and the biological functions of cof-fee. Molecules. 2021;26(24):7634.
  • da Cruz RG, Vieira TMF de S, de Li-ra SP. Potential antioxidant of Brazilian coffee from the region of cerrado. Food Sci Technol (Brazil). 2018;38(3):447–53.
  • Olechno E, Puścion-Jakubik A, Zuj-ko ME, Socha K. Influence of various factors on caffeine content in coffee brews. Foods. 2021;10(6):1–7.
  • Socała K, Szopa A, Serefko A, Po-leszak E, Wlaź P. Neuroprotective ef-fects of coffee bioactive compounds: A review. Int J Mol Sci. 2021;22(1):1–64.
  • Nehlig A. Effects of coffee on the gastrointestinal tract: A narrative review and literature update. Nutrients. 2022;14(1):1–33.
  • Schubert ML. Gastric secretion. Curr Opin Gastroenterol. 2010;26(6):598–603.
  • Barrea L, Pugliese G, Frias-Toral E, El Ghoch M, Castellucci B, Chapela SP, et al. Coffee consumption, health bene-fits and side effects: a narrative review and update for dietitians and nutritio-nists. Crit Rev Food Sci Nutr. 2023;63(1):1238–61.
  • Abd-Elhamid AH, Salem MAE, Mahmoud SM, Abd-Elgalil MM. Histo-logical study of the caffeine effect on intact gastric mucosa and induced gastric ulcer in adult male albino rats. Egypt J Histol. 2021;44(1):163–87.
  • Parra-Lara LG, Mendoza-Urbano DM, Bravo JC, Salamanca CH, Zambra-no ÁR. Coffee consumption and its in-verse relationship with gastric cancer: An ecological study. Nutrients. 2020;12(10):1–8.
  • Kang Y, Yan J. Exploring the con-nection between caffeine intake and constipation: A cross-sectional study using National Health and Nutrition Examination Survey data. BMC Public Health. 2024;24(1):1–9.
  • Hegde S, Shi DW, Johnson JC, Gee-sala R, Zhang K, Lin YM, et al. Mecha-nistic study of coffee effects on gut microbiota and motility in rats. Nutri-ents. 2022;14(22):1–12.
  • González S, Salazar N, Ruiz-Saavedra S, Gómez-Martín M, de los Reyes-Gavilán CG, Gueimonde M. Long-term coffee consumption is asso-ciated with fecal microbial composition in humans. Nutrients. 2020;12(5):1–7.
  • Surdea-Blaga T, Negrutiu DE, Palage M, Dumitrascu DL. Food and gast-roesophageal reflux disease. Curr Med Chem. 2019;26(19):3497–511.
  • Özenoğlu A, Anul N, Özçelikçi B. The relationship of gastroesophageal reflux with nutritional habits and mental disorders. Hum Nutr Metab. 2023;33:200203.
  • Hartoyo FR, Tandarto K, Sidharta V, Tenggara R. The correlation between coffee consumption and gastroesopha-geal reflux disease. Indones J Gastroen-terol Hepatol Dig Endosc [Internet]. 2022 May 15 [cited 2024 Apr 27];23(1):11–16. Available from: https://ina-jghe.com/index.php/jghe/article/view/824.
  • Kim J, Oh SW, Myung SK, Kwon H, Lee C, Yun JM, et al. Association between coffee intake and gastroesop-hageal reflux disease: A meta-analysis. Dis Esophagus [Internet]. 2014;27(4):311–17. Available from: https://doi.org/10.1111/dote.12099.
  • Wei TY, Hsueh PH, Wen SH, Chen CL, Wang CC. The role of tea and cof-fee in the development of gastroesopha-geal reflux disease. Tzu Chi Med J. 2019;31(3):169–76.
  • Mehta RS, Song M, Staller K, Chan AT. Association between beverage inta-ke and incidence of gastroesophageal reflux symptoms. Clin Gastroenterol Hepatol. 2020;18(10):2226–233.e4.
  • Yüksel A. Gastrit ve diyet. Güncel Gastroenteroloji [Internet]. 2016 [cited 2024 Apr 27];(67):218–20. Available from: https://guncel.tgv.org.tr/journal/67/pdf/100470.pdf.
  • Sözen Sİ, Kovancı H, Dalkılıç MS, Sözen S. Nutrition and Helicobacter py-lori infection in gastric disease. World J Adv Res Rev. 2023;18(3):21–30.
  • Mukhaira I, Nurmayanti S, Pujining-tyas S. The relationship between coffee consumption and the incident of gastritis in adolescents at Siere Cendekia Vocati-onal School. J Appl Food Nutr. 2023;4(2):67–71.
  • Miwa H, Watari J, Fukui H, Oshima T, Tomita T, Sakurai J, et al. Current understanding of pathogenesis of func-tional dyspepsia. J Gastroenterol Hepa-tol. 2011;26(Suppl 3):53–60.
  • Duboc H, Latrache S, Nebunu N, Coffin B. The role of diet in functional dyspepsia management. Front Psychi-atry. 2020;11:1–7.
  • Colak H, Gunes FE, Ozen Alahdab Y, Karakoyun B. Investigation of eating habits in patients with functional dyspepsia. Turk J Gastroenterol. 2022;33(8):673–81.
  • Correia H, Peneiras S, Levchook N, Peneiras E, Levchook T, Nayyar J. Ef-fects of a non-caffeinated coffee substi-tute on functional dyspepsia. Clin Nutr ESPEN. 2021;41:412–16.
  • Lee JY, Yau CY, Loh CYL, Lim WS, Teoh SE, Yau CE, et al. Examining the association between coffee intake and the risk of developing irritable bowel syndrome: A systematic review and meta-analysis. Nutrients. 2023;15(1):1–10.
  • Kamp KJ, Cain KC, Utleg A, Burr RL, Raftery D, Luna RA, et al. Bile acids and microbiome among individu-als with irritable bowel syndrome and healthy volunteers. Biol Res Nurs. 2021;23(1):65–74.
  • Georgiou AN, Ntritsos G, Papadimit-riou N, Dimou N, Evangelou E. Cigaret-te smoking, coffee consumption, alco-hol intake, and risk of Crohn’s disease and ulcerative colitis: A Mendelian ran-domization study. Inflamm Bowel Dis. 2021;27(2):162–68.
  • Almofarreh A, Sheerah HA, Arafa A, Alzeer O, Alohali E, Cao J, et al. As-sociation between coffee, tea, and soft drinks consumption and Crohn’s disease in Arab populations: A case-control study. Clin Nutr Open Sci. 2024;55:116–22.
  • Tanaka K, Okubo H, Miyake Y, Na-gata C, Furukawa S, Andoh A, et al. Coffee and caffeine intake reduces risk of ulcerative colitis: A case-control study in Japan. J Gastroenterol Hepatol. 2024;39(3):512–8.
  • Campmans-Kuijpers MJE, Dijkstra G. Food and food groups in inflamma-tory bowel disease (IBD): The design of the Groningen anti-inflammatory diet (GRAID). Nutrients. 2021;13(1):1–9.

Kahve ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri

Yıl 2025, Cilt: 7 Sayı: 1, 40 - 46, 18.02.2025
https://doi.org/10.57224/jhpr.1551503

Öz

Kahve tüketimi Dünya çapında gün geçtikçe hızla artmaktadır. Bireylerin günde ortalama 2.4 fincan kahve içtiği tahmin edilmektedir. Günde içilen ortalama 2-5 fincan kahve tüketiminin bireylerin genel sağlığını desteklemekte olduğu belirtilmektedir. Kahve tüketiminin gastrointestinal sistem üzerine olası etkileri uzun yıllardır tartışılan bir konu olup konu üzerine net bir fikir birliği bulunmamaktadır. Kahve içerisinde fenolik bileşikler, alkaloidler, flavanoidler ve diterpenler gibi pekçok biyoaktif bileşen içermektedir. İçerdiği biyoaktif bileşenlerin gastrointestinal sistem üzerine farklı yönlerden etkileri bulunmaktadır. Biyoaktif bileşenler arasında en iyi bilinen ve potansiyel sağlık etkileri üzerinde daha çok durulan alkoloid grubundan olan kafeindir. Kahve, içeriğindeki kafein, polifenoller ve biyoaktif bileşenlerle sindirimi ve bağırsak hareketliliğini desteklerken, bağırsak mikrobiyotasını da olumlu etkileyebilir. Ancak, bazı bireylerde mide asit salgısını artırarak gastrit ve reflü gibi mide hastalıklarını tetikleyebilmektedir. Kahve tüketiminin bağırsak sağlığı üzerine etkileri incelendiğinde ise motilite üzerine arttırıcı bir etkisinin olduğu ve mikrobiyotayı destekleyebildiği yapılan çalışmalarla gösterilmiştir. Bu özellikleri ile inflamatuar bağırsak hastalıkları üzerine kahvenin potansiyel yararlı etkileri olabileceği belirtilmektedir. Kahve tüketimi ile gastrointestinal sistem hastalıklarından olan fonksiyonel dispepsi ve irritabl bağırsak sendromu arasındaki ilişki için net bir fikir birliğine varılmamakla birlikte olası potansiyel faydalar mevcuttur. Özetle, kahve tüketiminin gastrointestinal sağlığı etkileyebileceğini göstermektedir. Günlük ılımlı miktarda kahve tüketimi faydalı olabildiği görülse de aşırı tüketimi bazı gastrointestinal semptomlara neden olabilmektedir. Sonuç olarak kahve tüketiminin bireysel semptom ve mevcut sağlık durumlarına göre düzenlenmesi önerilmektedir.

Kaynakça

  • Pancsira J. International Coffee Tra-de: a literature review. Journal of Agri-cultural Informatics [Internet]. 2022 Mar 18 [cited 2024 Apr 20];13(1):26–35. Available from: https://magisz.org/journal/index.php/jai/article/view/654.
  • Coffee consumption worldwide from 2012/13 to 2021/22 with a forecast to 2022/23 [Internet]. 2023 [cited 2024 Apr 20]. Available from: https://www.statista.com/statistics/292595/global-coffee-consumption/.
  • Goral M, Yüksel F, Kement Ü, Gü-ner Ç. The meaning and coffee con-sumption habits attributed to coffee by consumers in Turkey. ODÜ Sosyal Bi-limler Araştırmaları Dergisi (ODÜSO-BİAD). 2022 Jul 1;3(2):67–96.
  • Abalo R. Coffee and caffeine con-sumption for human health. Nutrients. 2021;13(9):2918.
  • de Melo Pereira GV, de Carvalho Neto DP, Magalhães Júnior AI, do Prado FG, Pagnoncelli MGB, Karp SG, et al. Chemical composition and health pro-perties of coffee and coffee by-products. Adv Food Nutr Res. 2020;91:65–96.
  • Iriondo-Dehond A, Uranga JA, Del Castillo MD, Abalo R. Effects of coffee and its components on the gastrointesti-nal tract and the brain–gut axis. Nutri-ents. 2021;13(1):1–34.
  • Taborska N, Martyka A, Kubicka Fi-giel M, Ujma P. The impact of consu-med coffee on the digestive system—review of the latest research. J Educ He-alth Sport. 2024;53:32–43.
  • Ambrose L, Popa A, Ilıe L, Balta AA, Fotache PA, Moraru DI, Maftei NM, et al. The influence of nutrition on patients with digestive diseases. Tech-nium BioChemMed. 2023;6:67–72.
  • Song H, Shen X, Chu Q, Zheng X. Coffee consumption is not associated with the risk of gastric cancer: An upda-ted systematic review and meta-analysis of prospective cohort studies. Nutr Res. 2022;102:35–44.
  • Martimianaki G, Bertuccio P, Ali-candro G, Pelucchi C, Bravi F, Carioli G, et al. Coffee consumption and gastric cancer: A pooled analysis from the Sto-mach Cancer Pooling Project consor-tium. Eur J Cancer Prev. 2022;31(2):117–27.
  • Saud S, Salamatullah AM. Relati-onship between the chemical composi-tion and the biological functions of cof-fee. Molecules. 2021;26(24):7634.
  • da Cruz RG, Vieira TMF de S, de Li-ra SP. Potential antioxidant of Brazilian coffee from the region of cerrado. Food Sci Technol (Brazil). 2018;38(3):447–53.
  • Olechno E, Puścion-Jakubik A, Zuj-ko ME, Socha K. Influence of various factors on caffeine content in coffee brews. Foods. 2021;10(6):1–7.
  • Socała K, Szopa A, Serefko A, Po-leszak E, Wlaź P. Neuroprotective ef-fects of coffee bioactive compounds: A review. Int J Mol Sci. 2021;22(1):1–64.
  • Nehlig A. Effects of coffee on the gastrointestinal tract: A narrative review and literature update. Nutrients. 2022;14(1):1–33.
  • Schubert ML. Gastric secretion. Curr Opin Gastroenterol. 2010;26(6):598–603.
  • Barrea L, Pugliese G, Frias-Toral E, El Ghoch M, Castellucci B, Chapela SP, et al. Coffee consumption, health bene-fits and side effects: a narrative review and update for dietitians and nutritio-nists. Crit Rev Food Sci Nutr. 2023;63(1):1238–61.
  • Abd-Elhamid AH, Salem MAE, Mahmoud SM, Abd-Elgalil MM. Histo-logical study of the caffeine effect on intact gastric mucosa and induced gastric ulcer in adult male albino rats. Egypt J Histol. 2021;44(1):163–87.
  • Parra-Lara LG, Mendoza-Urbano DM, Bravo JC, Salamanca CH, Zambra-no ÁR. Coffee consumption and its in-verse relationship with gastric cancer: An ecological study. Nutrients. 2020;12(10):1–8.
  • Kang Y, Yan J. Exploring the con-nection between caffeine intake and constipation: A cross-sectional study using National Health and Nutrition Examination Survey data. BMC Public Health. 2024;24(1):1–9.
  • Hegde S, Shi DW, Johnson JC, Gee-sala R, Zhang K, Lin YM, et al. Mecha-nistic study of coffee effects on gut microbiota and motility in rats. Nutri-ents. 2022;14(22):1–12.
  • González S, Salazar N, Ruiz-Saavedra S, Gómez-Martín M, de los Reyes-Gavilán CG, Gueimonde M. Long-term coffee consumption is asso-ciated with fecal microbial composition in humans. Nutrients. 2020;12(5):1–7.
  • Surdea-Blaga T, Negrutiu DE, Palage M, Dumitrascu DL. Food and gast-roesophageal reflux disease. Curr Med Chem. 2019;26(19):3497–511.
  • Özenoğlu A, Anul N, Özçelikçi B. The relationship of gastroesophageal reflux with nutritional habits and mental disorders. Hum Nutr Metab. 2023;33:200203.
  • Hartoyo FR, Tandarto K, Sidharta V, Tenggara R. The correlation between coffee consumption and gastroesopha-geal reflux disease. Indones J Gastroen-terol Hepatol Dig Endosc [Internet]. 2022 May 15 [cited 2024 Apr 27];23(1):11–16. Available from: https://ina-jghe.com/index.php/jghe/article/view/824.
  • Kim J, Oh SW, Myung SK, Kwon H, Lee C, Yun JM, et al. Association between coffee intake and gastroesop-hageal reflux disease: A meta-analysis. Dis Esophagus [Internet]. 2014;27(4):311–17. Available from: https://doi.org/10.1111/dote.12099.
  • Wei TY, Hsueh PH, Wen SH, Chen CL, Wang CC. The role of tea and cof-fee in the development of gastroesopha-geal reflux disease. Tzu Chi Med J. 2019;31(3):169–76.
  • Mehta RS, Song M, Staller K, Chan AT. Association between beverage inta-ke and incidence of gastroesophageal reflux symptoms. Clin Gastroenterol Hepatol. 2020;18(10):2226–233.e4.
  • Yüksel A. Gastrit ve diyet. Güncel Gastroenteroloji [Internet]. 2016 [cited 2024 Apr 27];(67):218–20. Available from: https://guncel.tgv.org.tr/journal/67/pdf/100470.pdf.
  • Sözen Sİ, Kovancı H, Dalkılıç MS, Sözen S. Nutrition and Helicobacter py-lori infection in gastric disease. World J Adv Res Rev. 2023;18(3):21–30.
  • Mukhaira I, Nurmayanti S, Pujining-tyas S. The relationship between coffee consumption and the incident of gastritis in adolescents at Siere Cendekia Vocati-onal School. J Appl Food Nutr. 2023;4(2):67–71.
  • Miwa H, Watari J, Fukui H, Oshima T, Tomita T, Sakurai J, et al. Current understanding of pathogenesis of func-tional dyspepsia. J Gastroenterol Hepa-tol. 2011;26(Suppl 3):53–60.
  • Duboc H, Latrache S, Nebunu N, Coffin B. The role of diet in functional dyspepsia management. Front Psychi-atry. 2020;11:1–7.
  • Colak H, Gunes FE, Ozen Alahdab Y, Karakoyun B. Investigation of eating habits in patients with functional dyspepsia. Turk J Gastroenterol. 2022;33(8):673–81.
  • Correia H, Peneiras S, Levchook N, Peneiras E, Levchook T, Nayyar J. Ef-fects of a non-caffeinated coffee substi-tute on functional dyspepsia. Clin Nutr ESPEN. 2021;41:412–16.
  • Lee JY, Yau CY, Loh CYL, Lim WS, Teoh SE, Yau CE, et al. Examining the association between coffee intake and the risk of developing irritable bowel syndrome: A systematic review and meta-analysis. Nutrients. 2023;15(1):1–10.
  • Kamp KJ, Cain KC, Utleg A, Burr RL, Raftery D, Luna RA, et al. Bile acids and microbiome among individu-als with irritable bowel syndrome and healthy volunteers. Biol Res Nurs. 2021;23(1):65–74.
  • Georgiou AN, Ntritsos G, Papadimit-riou N, Dimou N, Evangelou E. Cigaret-te smoking, coffee consumption, alco-hol intake, and risk of Crohn’s disease and ulcerative colitis: A Mendelian ran-domization study. Inflamm Bowel Dis. 2021;27(2):162–68.
  • Almofarreh A, Sheerah HA, Arafa A, Alzeer O, Alohali E, Cao J, et al. As-sociation between coffee, tea, and soft drinks consumption and Crohn’s disease in Arab populations: A case-control study. Clin Nutr Open Sci. 2024;55:116–22.
  • Tanaka K, Okubo H, Miyake Y, Na-gata C, Furukawa S, Andoh A, et al. Coffee and caffeine intake reduces risk of ulcerative colitis: A case-control study in Japan. J Gastroenterol Hepatol. 2024;39(3):512–8.
  • Campmans-Kuijpers MJE, Dijkstra G. Food and food groups in inflamma-tory bowel disease (IBD): The design of the Groningen anti-inflammatory diet (GRAID). Nutrients. 2021;13(1):1–9.
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlığın Geliştirilmesi
Bölüm Derleme
Yazarlar

Nur Sena Tutan 0009-0000-4643-4347

İlknur Gökçe Yıldırım 0000-0001-8788-2242

Yayımlanma Tarihi 18 Şubat 2025
Gönderilme Tarihi 17 Eylül 2024
Kabul Tarihi 8 Ocak 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 7 Sayı: 1

Kaynak Göster

APA Tutan, N. S., & Yıldırım, İ. G. (2025). Kahve ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri. Sağlık Profesyonelleri Araştırma Dergisi, 7(1), 40-46. https://doi.org/10.57224/jhpr.1551503
AMA Tutan NS, Yıldırım İG. Kahve ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri. Sağlık Pro Arş Dergisi. Şubat 2025;7(1):40-46. doi:10.57224/jhpr.1551503
Chicago Tutan, Nur Sena, ve İlknur Gökçe Yıldırım. “Kahve Ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri”. Sağlık Profesyonelleri Araştırma Dergisi 7, sy. 1 (Şubat 2025): 40-46. https://doi.org/10.57224/jhpr.1551503.
EndNote Tutan NS, Yıldırım İG (01 Şubat 2025) Kahve ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri. Sağlık Profesyonelleri Araştırma Dergisi 7 1 40–46.
IEEE N. S. Tutan ve İ. G. Yıldırım, “Kahve ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri”, Sağlık Pro Arş Dergisi, c. 7, sy. 1, ss. 40–46, 2025, doi: 10.57224/jhpr.1551503.
ISNAD Tutan, Nur Sena - Yıldırım, İlknur Gökçe. “Kahve Ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri”. Sağlık Profesyonelleri Araştırma Dergisi 7/1 (Şubat 2025), 40-46. https://doi.org/10.57224/jhpr.1551503.
JAMA Tutan NS, Yıldırım İG. Kahve ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri. Sağlık Pro Arş Dergisi. 2025;7:40–46.
MLA Tutan, Nur Sena ve İlknur Gökçe Yıldırım. “Kahve Ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri”. Sağlık Profesyonelleri Araştırma Dergisi, c. 7, sy. 1, 2025, ss. 40-46, doi:10.57224/jhpr.1551503.
Vancouver Tutan NS, Yıldırım İG. Kahve ve Bileşenlerinin Gastrointestinal Sağlık Üzerindeki Etkileri. Sağlık Pro Arş Dergisi. 2025;7(1):40-6.

SAĞLIK PROFESYONELLERİ ARAŞTIRMA DERGİSİ / JOURNAL OF HEALTH PROFESSIONALS RESEARCH /J HEALTH PRO RES