Comparison of demographic and laboratory data of young and elderly patients who deceased due to COVID-19

Year 2022, , 478 - 481, 15.03.2022

Bora Çekmen

https://doi.org/10.32322/jhsm.1047413

Abstract

Introduction: Differences between young and elderly patients who deceased due to COVID-19 require further elucidation. The present study aimed to compare the differences between young and elderly patients who died from COVID-19.
Material and Method: In this single-center cross-sectional study, patients included who had been diagnosed with COVID-19 and had died in the course of hospital follow-up. The following data were recorded. Demographic characteristics of the patients, date of diagnosis, length of diagnosis to death, the first place of hospitalization, duration of hospitalization at the clinical service and intensive care unit, blood parameters. Patients included in the study were divided into 2 groups, i.e., patients aged <65 and ≥65 years, and the relationship between the study data and these two groups were examined.
Results: We included 369 patients. Prevalence of comorbid chronic diseases was significantly higher in the ≥65 years group (81.3% vs. 90.1%, p = 0.034). Prevalence of hypertension and chronic obstructive pulmonary disease was higher in the ≥65 years group (respectively, 72% vs. 84.4%, p = 0.013; 10.7% vs. 30.6%, p < 0.001). Intergroup comparison of laboratory parameters indicated that alanine aminotransferase and lactate dehydrogenase levels were higher in the <65 years group (respectively, p = 0.004; p = 0.020), whereas the creatinine levels were higher in the ≥65 years group (p < 0.001).
Conclusion: This study captured the comorbidities, laboratory parameters, and duration of hospitalization of young and elderly patients, who died due to COVID-19. In the light of the study data, there was no significant intergroup difference.

Keywords

SARS-CoV-2, elderly, young, comorbidity, hematological test

References

• Wu F, Zhao S, Yu B, et al. A new coronavirus associated with human respiratory disease in China. Nature 2020; 579: 265-9.
• Mohamadian M, Chiti H, Shoghli A, Biglari S, Parsamanesh N, Esmaeilzadeh A. COVID-19: Virology, biology and novel laboratory diagnosis. J Gene Med 2021; 23: e3303.
• Abduljali J, Abduljali B. Epidemiology, genome and clinical features of the pandemic SARS‐CoV‐2: a recent view. New Micr New Infect 2020; 35: 100672.
• Yang F, Shi S, Zhu J, Shi J, Dai K, Chen X. Analysis of 92 deceased patients with COVID-19. J Med Virol 2020; 92: 2511-5.
• Grygiel-Górniak B, Oduah MT. COVID-19: what should the general practitioner know? Clin Interv Aging 2021; 16: 43-56
• Carpenter CR, Mudd PA, West CP, Wilber E, Wilber ST. Diagnosing COVID-19 in the emergency department: a scoping review of clinical examinations, laboratory tests, imaging accuracy, and biases. Acad Emerg Med 2020; 27: 653-70
• Li Y, Ji D, Cai W, et al. Clinical characteristics, cause analysis and infectivity of COVID-19 nucleic acid repositive patients: a literature review. J Med Virol 2021; 93: 1288-95.
• Nachtigall I, Lenga P, Jóźwiak K, et al. Clinical course and factors associated with outcomes among 1904 patients hospitalized with COVID-19 in Germany: an observational study. Clin Microbiol Infect 2020; 26: 1663-9.
• Tan X, Zhang S, Xu J, et al. Comparison of clinical characteristics among younger and elderly deceased patients with COVID-19: a retrospective study. Aging (Albany NY) 2020; 13: 16-26.
• Sawalha K, Abozenah M, Kadado AJ, et al. Systematic review of covid-19 related myocarditis: insights on management and outcome. cardiovasc revasc Med 2021; 23: 107-13.
• Arslan K, Baş S. Frequency of troponin elevations in patients with COVID-19 and clinical course in these patients. Anatolian Curr Med J 2022; 4: 95-102.
• Levin AT, Hanage WP, Owusu-Boaitey N, Cochran KB, Walsh SP, Meyerowitz-Katz G. Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications. Eur J Epidemiol 2020; 35: 1123-38.
• Levin AT, Hanage WP, Owusu-Boaitey N, Cochran KB, Walsh SP, Meyerowitz-Katz G. Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications. Eur J Epidemiol 2020; 35: 1123-38
• Manivannan M, Jogalekar MP, Kavitha MS, Maran BAV, Gangadaran P. A mini-review on the effects of COVID-19 on younger individuals. Exp Biol Med (Maywood) 2021; 246: 293-7.
• Parohan M, Yaghoubi S, Seraji A, Javanbakht MH, Sarraf P, Djalali M. Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies. Aging Male 2020; 23: 1416-24.
• Garibaldi BT, Fiksel J, Muschelli J, et al. Patient trajectories among persons hospitalized for COVID-19: a cohort study. Ann Intern Med 2021; 174: 33-41
• Şahin Özdemirel T, Akkurt ES, Ertan Ö, Gökler ME, Akıncı Özyürek B. Complications with moderate-to-severe COVID-19 during hospital admissions in patients with pneumonia. J Health Sci Med 2021; 4: 766-771.
• Velavan TP, Meyer CG. Mild versus severe COVID-19: Laboratory markers. Int J Infect Dis 2020; 95: 304-7.
• Assandri R, Buscarini E, Canetta C, Scartabellati A, Viganò G, Montanelli A. Laboratory biomarkers predicting COVID-19 severity in the emergency room. Arch Med Res 2020; 51: 598-9.
• Ragab D, Salah Eldin H, Taeimah M, Khattab R, Salem R. The COVID-19 cytokine storm; what we know so far. Front Immunol 2020; 11: 1446.
• Al-Omari A, Alhuqbani WN, Zaidi ARZ, et al. Clinical characteristics of non-intensive care unit COVID-19 patients in Saudi Arabia: A descriptive cross-sectional study. J Infect Public Health 2020; 13: 1639-44.