Human papillomavirus prevalence in unexplained infertile women with chronic endometritis

Year 2022, , 1124 - 1127, 20.07.2022

Mehmet Ağar , Asena Ayar Madenli , Tuğba Gürbüz

https://doi.org/10.32322/jhsm.1111517

Abstract

Introduction: This study investigates unexplained infertile women with or without chronic endometritis (CE) and examines the prevalence of the human papillomavirus (HPV) in this population.
Material and Method: This study was done with a cross-sectional and retrospective method. The prevalence of HPV infection and related cases in the participants were examined. In this study, 15 infertile women with CE and 64 infertile women without CE were and analyzed from four perspectives: negative HPV, low-risk HPV, probable high-risk HPV, and the presence of high-risk HPV.
Results: The participants have mean age of 32.89 years ±3.95. High-risk HPV infection was detected in 3 (20%) and 11 (17%) of the patients with and without CE, respectively (p>0.05). The negative HPV (2 (13%) and 17 (26%)), low-risk HPV (3 (20%) and 20 (31%)), and probable high-risk HPV (7 (46%) and 16 (25%)) in infertile women with CE and infertile women had no significantly different prevalence (p>0.05). The two studied groups had no significantly different mean age, body mass index (BMI), and Infertility duration were not in (P=0.08, P=0.932, and P=0.283, respectively).
Conclusion: HPV has no significantly different prevalence in unexplained infertile women with and without CE. It is recommended that this study be repeated with more unexplained infertile women with CE.

Keywords

Human papillomaviruses, chronic endometritis, infertility, the prevalence of HPV

References

• Bouvard V, Wentzensen N, Mackie A, et al. The IARC perspective on cervical cancer screening. N Engl J Med 2021; 385: 1908-18.
• McBride AA. Human papillomaviruses: diversity, infection and host interactions. Nat Rev Microbiol 2022; 20: 95-108.
• Ge Y, Zhong S, Ren M, et al. Prevalence of human papillomavirus infection of 65,613 women in East China. BMC Public Health 2019; 19: 178.
• Haedicke J, Iftner T. Human papillomaviruses and cancer. Radiother Oncol 2013; 108: 397-402.
• Hoffmann M, Quabius ES. Relevance of human papillomaviruses in head and neck cancer-what remains in 2021 from a clinician's point of view? Viruses 2021; 13: 1173.
• Rocha RM, Souza RP, Gimenes F, Consolaro MEL. The high-risk human papillomavirus continuum along the female reproductive tract and its relationship to infertility and endometriosis. Reprod Biomed Online 2019; 38: 926-37.
• Özdemir E. , Kaplan S. İnfertilite ve Hemşirelik Yaklaşımı. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi 2021; 4: 79-89.
• World Health Organization. WHO fact sheet on infertility 2021; 52. Available online: https: //www.who.int/news-room/fact-sheets/detail/infertility
• Sarac M, Koc I. Prevalence and risk factors of infertility in turkey: evidence from demographic and health surveys, 1993-2013. J Biosoc Sci 2018; 50: 472-90.
• Lundy SD, Sangwan N, Parekh NV, et al. Functional and Taxonomic Dysbiosis of the Gut, Urine, and Semen Microbiomes in Male Infertility. Eur Urol 2021; 79: 826-36.
• Mol BW, Tjon-Kon-Fat R, Kamphuis E, van Wely M. Unexplained infertility: Is it over-diagnosed and over-treated?. Best Pract Res Clin Obstet Gynaecol 2018; 53: 20-9.
• Park HJ, Kim YS, Yoon TK, Lee WS. Chronic endometritis and infertility. Clin Exp Reprod Med 2016; 43: 185-92.
• Ravel J, Moreno I, Simón C. Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. Am J Obstet Gynecol 2021; 224: 251-7.
• Espinós JJ, Fabregues F, Fontes J, et al. Impact of chronic endometritis in infertility: a SWOT analysis. Reprod Biomed Online 2021; 42: 939-51.
• Dokuzeylül Güngör N. , Gürbüz T. , Yurci A. Hysteroscopic evaluation of chronic endometritis incidence in unexplained infertile women with recurrent implantation failure: six years experience. Ahi Evran Med J 2022; 6: 64-70.
• Puente E, Alonso L, Laganà AS, Ghezzi F, Casarin J, Carugno J. Chronic endometritis: old problem, novel insights and future challenges. Int J Fertil Steril 2020; 13: 250-6.
• Wang S, Zhao H, Li F, Xu Y, Bao H, Zhao D. Higher chronic endometritis incidences within infertile polycystic ovary syndrome clinical cases. J Healthcare Engineering 2022; 2022: 1-6.
• Bouet PE, El Hachem H, Monceau E, Gariépy G, Kadoch IJ, Sylvestre C. Chronic endometritis in women with recurrent pregnancy loss and recurrent implantation failure: prevalence and role of office hysteroscopy and immunohistochemistry in diagnosis. Fertil Steril 2016; 105: 106-10.
• Moreno-Sepulveda J, Rajmil O. Seminal human papillomavirus infection and reproduction: a systematic review and meta-analysis. Andrology 2021; 9: 478-502.
• Ouh YT, Min KJ, Cho HW, et al. Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the Republic of Korea, 2014-2016. J Gynecol Oncol 2018; 29: e14.
• Jaworek H, Zborilova B, Koudelakova V, et al. Prevalence of human papillomavirus infection in oocyte donors and women treated for infertility: An observational laboratory-based study. Eur J Obstet Gynecol Reprod Biol X 2019; 4: 100068.
• Heidarpour M, Derakhshan M, Derakhshan-Horeh M, Kheirollahi M, Dashti S. Prevalence of high‐risk human papillomavirus infection in women with ovarian endometriosis. J Obstetr Gynaecol Res 2017, 43: 135-39.