The prevalence of contrast nephropathy in patients undergoing percutaneous coronary intervention in acute coronary syndrome

An Erratum to this article was published on January 5, 2026. https://dergipark.org.tr/en/pub/jhsm/article/1857316

Abstract

Objective: Contrast nephropathy (KMN) is defined as an acute renal injury due to intravenous contrast agents applied in diagnostic or therapeutic interventions and is an important cause of hospitalization due to acute renal failure. In this study, the frequency of coronary intervention and contrast agent nephropathy was investigated in acute coronary syndrome.

Material and Method: According to the European Urogenital Radiology Society Guide, "An increase of 25 or 0.5 mg/dl in serum creatinine within 3 days after administration of contrast medium without any other etiological cause". After approval of the Ethics Committee, 336 patients who met the inclusion criteria were included in the study. Patients younger than 18 years of age with chronic renal insufficiency, heart failure, coronary by-pass history, serum creatinine control after the procedure and patients without percutaneous coronary intervention were excluded from the study.

Results: BMD was detected in 11.9% of the 336 patients included in the study. The mean age of 40 patients who developed CMN was 73.9±10.2 / year, and the mean age of 296 patients who did not have CMN was 59.4±12.3 /year. The mean age was significantly higher in the DM group (p <0.001). The mean body mass index (BMI) was 28.2 ± 4.7kg / m² in the non-developing group, while the BMI average was 26.5 ± 3.3kg / m². The mean VKI was lower in the DM group (p = 0.044). The mean SYNTAX score was 16.6 ± 8.3 in the non-developing group, whereas the mean in the group with the improved KMN was 22.5 ± 10.3. The SYNTAX score was higher in the KMN-developing group than in the non-KMN group (p=0.001). There was no difference between two groups in terms of AKS type, DM, HT and sex (p=0.713, p=0.317, p=0.055, p=0.589).

Conclusion: Strategies should be implemented to prevent other CMD developments, provided that hydration is absolute before and after the procedure in groups at risk for which contrast media should be given.

Keywords

• Contrast nephropathy,acute coronary syndrome,percutaneous coronary intervention

Akut koroner sendromda perkütan koroner girişim yapılan hastalarda kontrast nefropati prevalansı

An Erratum to this article was published on January 5, 2026. https://dergipark.org.tr/en/pub/jhsm/article/1857316

Abstract

Amaç: Kontrast madde nefropatisi (KMN), tanı veya tedavi amaçlı yapılan girişimlerde uygulanan intravenöz kontrast ajanlara bağlı olarak gelişen akut böbrek hasarı olarak tanımlanmıştır ve akut böbrek yetersizliğine bağlı olarak hastaneye yatışlarda önemli bir nedendir. Bu çalışmada akut koroner sendromda koroner girişim ve kontrast madde nefropatisi sıklığı araştırılmıştır.

Gereç ve Yöntem: Avrupa Ürogenital Radyoloji Cemiyeti Kılavuzu’na göre KMN tanımı; “başka bir etiyolojik sebep olmaksızın, kontrast madde verilmesinden sonraki 3 gün içinde serum kreatinin düzeyinde başl25 veya 0.5 mg/dl artış olması” olarak kabul edilmiştir. Etik Kurul onayı sonrası dahil edilme kriterlerine uyan 336 hasta çalışmaya alındı. 18 yaşından küçük, kronik böbrek yetersizliği olan, kalp yetmezliği olan, koroner by-pass öyküsü olan, işlem sonrası serum kreatinini kontrol edilemeyen hastalar ve perkütan koroner girişim yapılmayan hastalar çalışma dışı bırakıldı.

Sonuçlar: Çalışmaya dahil edilen 336 hastanın %11,9’unda KMN saptandı. KMN gelişen 40 hastanın yaş ortalaması 73,9±10,2/yıl, KMN gelişmeyen 296 hastanın yaş ortalaması 59,4±12,3/yıl idi. KMN gelişen grupta yaş ortalaması istatistiksel olarak anlamlı derecede yüksek bulundu (p<0.001). KMN gelişmeyen hasta grubunda vücut kitle indeksi (VKİ) ortalaması 28,2±4,7kg/m² iken, KMN gelişen grupta VKİ ortalaması 26,5±3.3kg/m² idi. KMN gelişen grupta VKİ ortalaması daha düşük bulundu (p=0.044). KMN gelişmeyen hasta grubunda SYNTAX skoru ortalama 16,6±8,3 iken, KMN gelişen hasta grubunda ortalama 22,5±10,3 idi. KMN gelişen grupta SYNTAX skoru KMN gelişmeyen gruba göre daha yüksek bulundu (p=0.001). AKS tipi, DM, HT ve cinsiyet açısından iki grup arasında fark bulunmadı (p=0.713, p=0.317,p=0.055, p=0.589).

Sonuç: Kontrast madde verilmesi gereken risk altındaki gruplarda işlem öncesinde ve sonrasında hidrasyon mutlak olması şartıyla diğer KMN gelişmesini önleyici stratejiler uygulanmalıdır.

Keywords

• Kontrast nefropati,akut koroner sendrom,perkütan koroner girişim

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