Antimicrobial resistance pattern of Streptococcus agalactiae strains: five years evaluation of single center’

Year 2018, , 25 - 28, 30.06.2018

Ünsal Savcı , Mustafa Şahin , Sezer Toprak Mustafa Sungur

https://doi.org/10.32322/jhsm.425661

Cited By: 3

Abstract

Aim: Streptococcus agalactiae is known to cause severe neonatal and postpartum infections. 
It also affects immunosuppressive patients. Penicillin is the first preferred antimicrobial agent in the treatment of these diseases. However, recent reports of penicillin tolerance and increased resistance to alternative antimicrobial agents in patients with penicillin allergies make treatment more difficult. In this study, we aimed to contribute to more effective treatment by determining antibiotic resistance profiles in GBS strains isolated from various clinical specimens. 

Material and Method: A total of 80 GBS strains isolated from various clinical specimens in clinical microbiology laboratory between 2012 and 2016 were evaluated retrospectively. 


Bacterial identification and antibiotic susceptibility tests were performed using conventional methods and an automated identification analyzer VITEK®-2 (BioMérieux, France).

Results: All GBS isolates
were found as susceptible to penicillin, imipenem, meropenem, linezolid,
trimethoprim sulfamethoxazole, tigecycline, teicoplanin and vancomycin.
The resistance rates of
tetracycline, erythromycin, ciprofloxacin, clindamycin, moxifloxacin and
ampicillin in isolates were 91.5%, 50.0%, 31.0%, 23.7%, 23.3% and 2.9%
respectively.

Conclusion: In our study, penicillin resistance was not
observed in GBS isolates. Penicillin has been using as the first preferred
agent in the treatment of these infections. However, considering the increasing
resistance rates in alternative drugs, antimicrobial susceptibility testing for
the effective treatment and prophylaxis of GBS infections is suggested.

Keywords

Group B streptococcus, penicillin, antimicrobial susceptibility

Streptococcus agalactiae suşlarının antimikrobiyal direnç paterni: beş yıllık tek merkez değerlendirmesi

Abstract

Amaç:
Streptococcus agalactiae’nın ciddi neanatal ve postpartum enfeksiyonlara neden olduğu
bilinmektedir. Ayrıca immünsupresif hastaları da etkilemektedir. Bu
hastalıkların tedavisinde penisilin ilk tercih edilen antimikrobiyal ajandır. Ancak
penisilin alerjisi olan hastalar, son zamanlarda bildirilen penisilin toleransı
ve diğer alternatif antimikrobiyal ajanlara karşı artan direnç oranları
tedaviyi zorlaştırmaktadır. Bu
çalışmada çeşitli klinik örneklerden izole edilen GBS suşlarında antibiyotik
direnç profillerini belirleyerek daha etkili tedaviye katkıda bulunmayı
amaçladık.

Gereç
ve Yöntem:  2012 - 2016 yılları arasında klinik
mikrobiyoloji laboratuvarında çeşitli klinik örneklerden izole edilen toplam 80
GBS suşu retrospektif olarak değerlendirilmiştir. Bakteri identifikasyonu ve
antibiyotik duyarlılık testleri konvansiyonel metodlar ve VITEK^®-2
(BioMérieux, Fransa) otomatize identifkasyon cihazı kullanılarak yapılmıştır.

Bulgular: Tüm GBS izolatları penisilin, imipenem, meropenem, linezolid,
 trimetoprim sulfametoksazol,
tigesiklin, teikoplanin ve vankomisine duyarlı bulunmuştur. İzolatların
tetraksiklin, eritromisin, siprofloksasin, klindamisin, moksifloksasin ve
ampisilin direnç oranları ise sırasıyla %91,5, %50,0, %31,0, %23,7, %23,3 ve
%2,9’dur.

Sonuç: Çalışmamızda
bölgemizde GBS izolatlarında penisiline direnç görülmemiştir.
Penisilin, bu enfeksiyonların tedavisinde ilk
tercih edilen ajan olarak kullanılmaktadır. Ancak alternatif ilaçlarda artan direnç oranları göz önüne
alındığında GBS enfeksiyonlarının etkin tedavi ve profilaksisi
için antimikrobiyal duyarlılık testlerinin yapılması önerilir.

Keywords

Grup B streptokok, penisilin, antimikrobiyal duyarlılık

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