Serum amphiregulin level and pancreatic adenocarcinoma relation in patients with chronic pancreatitis

Year 2019, , 110 - 115, 22.09.2019

Bülent Çolak Eylem Karatay

https://doi.org/10.32322/jhsm.533365

Abstract

Background /Aims : We aimed
in our study to determine serum amphiregulin level, which is an indicator of a
malignancy, and to foresee pancreatic carcinoma in chronic pancreatitis.

Materials
and Methods: 42 patients who applied to Department of Gastroenterology  and were diagnosed with chronic
pancreatitis  and 43 healthy patients as
the control group were enrolled in the study. Serum amphiregulin levels were
studied with an Amphiregulin Human ELISA Kit ab99975 (Abcam, Cambridge, UK) by
ELISA(Enzyme-Linked Immunosorbent Assay) method.

Results:
Patients with chronic pancreatitis compared to healthy control group (p : 0.007)
and the group complicated with pseudocyst among chronic pancreatitis patient
group, serum amphiregulin level (p : 0.006) and Ca 19-9 (p : 0.03) level are
high. We also found that the relationship between the long diameter of the
pseudocyst and serum amphiregulin level is statistically significant (p : 0.01)
in the complicated chronic pancreatitis group.

Conclusion:
Patients with chronic pancreatitis and the group complicated with pseudocyst
among chronic pancreatitis patient group must be monitored more closely in
terms of pancreatic cancer since serum amphiregulin level and Ca 19-9 level are
high and the relationship between the long diameter of the pseudocyst and serum
amphiregulin level is statistically significant in such patient groups.

Keywords

Chronic pancreatitis, serum amphiregulin level

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