Serum levels of ischemic modified albumin (IMA) and prolidase in migraine subjects

Year 2020, , 31 - 35, 15.01.2020

Bahar Say , Nermin Dindar Badem , Ufuk Ergun

https://doi.org/10.32322/jhsm.638466

Abstract

Objective: Migraine is one of the most common neurological diseases with headache
attacks. Although its pathophysiology is still unclear, it is thought to be
multifactorial. Oxidative stress is one of the topics discussed in the
pathophysiology of migraine. The aim of this study was to investigate IMA and prolidase
levels, which are oxidative stress markers in migraine.

Material and Method: In this study, 35
migraine and 35 healthy controls were included. Serum IMA and prolidase levels
were measured in serum obtained after centrifugation from venous blood samples
by ELISA. Prolidase and IMA in migraine patients were compared with the control
group.

Results: The mean age was 40.06±11.14 years in migraine (34 female, 1 male) and
34.31±8.26 in controls (31 female, 4 male). There was no significant difference
between the groups in terms of age and gender (p=0.08, p=0.29). Interictal IMA
and prolidase levels of migraine subjects were significantly higher than the
control group (p=0.02, p<0.001). Prolidase was significantly higher in the attack period
than the control group (p<0.001), but there was no significant difference in
IMA levels (p=0.34). Prolidase and IMA levels during the attack were higher
than interictal period in migraine but there was no significant difference  (p>0.05).

Conclusion: Prolidase and IMA may be an indicator of
oxidative stress in migraine patients. Prolidase, one of the oxidative stress
indicators, also correlates with the frequency of attacks in migraine. It
is thought that these markers may lead to antioxidant agent studies in
prophylactic treatment of migraine.

Keywords

headache, migraine, IMA, prolidase, interictal

Supporting Institution

Scientific Research Projects Coordination Unit of Kirikkale University

Project Number

2018/052

References

• 1. Paraje MG. Oxidative Stress in Biofilms: Causes, Role in Diseases and Biological Effects. İn: Croft C, ed. Oxidative stress causes, role in diseases and biological effects. 978-1-63117-579-4 (eBook). New York. Nova Science Publishers, 2014, 61-93.
• 2.Halliwell B. Free radicals, proteins and DNA: oxidative damage versus redox regulation. Biochem Soc Trans. 1996;24(4):1023-7.
• 3. Reznick, A.Z, Packer, L, 1993. Free radicals and antioxidants in muscular neurological diseases and disorders. In: Poli, G, Albano, E, Dianzani, M.U. (Eds.), Free Radicals: From Basic Science to Medicine. Birkhäuser Verlag, Basel, pp. 425–437.
• 4. Borkum JM. The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory. Headache. 2018; 58(1):118-135. (doi: 10.1111/head.13214).
• 5. Çevik M. U, Yücel Y, Arıkanoğlu A, et al. Multipl sklerozlu hastalarda serum prolidaz ve iskemi modifiye albümin düzeyleri. Journal of Clinical and Experimental Investigations. 2012;3(4):518-20.
• 6. Marta MMF, Duarte A, João BT, et al. Association between ischemia-modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clinical Biochemistry. 2009;42:666-71.
• 7. Zanaboni G, Dyne KM, Rossi A, Monafo V, Cetta G. Prolidase deficiency: biochemical study of erythrocyte and skin fibroblast prolidase activity in Italian patients. Haematologica 1994;79:13-18.
• 8. Palka JA, Phang JM. Prolidase activity in fibroblasts is regulated by interaction of extracellular matrix with cell surface integrin receptors. J Cell Biochem 1997;67:166-175.
• 12. Cohen S, Nadler J. Proline-induced potentiation of glutamate transmission. Brain Research 1997;761:271282.
• 10. Hauptmann M, Wilson DF, Erecinska M. High affinity proline uptake in rat brain synaptosomes. FEBS Lett 1983;161:301-305.
• 11. Crump FT, Fremeau RT, Craig AM. Localization of the brain-specific high-affinity I-proline transporter in cultured hippocampal neurons:molecular heterogenetiy of synaptic terminals. Mol Cell Neurosci 1999;13:2539.
• 13. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia 2018; 38: 1–211.
• 14. Delwing D, Bavaresco CS, Wannmacher CM, Wajner M, Dutra-Filho CS, Wyse AT. Proline induces oxidative stress in cerebral cortex of rats. Int J Dev Neurosci. 2003;21(2):105-10.
• 15. Delwing D, Chiarani F, Bavaresco CS, Wannmacher CM, Wajner M, Dutra-Filho CS, et al. Protective effect of antioxidants on brain oxidative damage caused by proline administration. Neurosci Res. 2005;52(1):69-74.
• 16. Shukla R, Barthwal MK, Srivastava N, et al. Neutrophil-free radical generation and enzymatic antioxidants in migraine patients. Cephalalgia.2004;24:37-43.
• Bolayir E, Celik K, Kugu N, Yilmaz A, Topaktas S, Bakir S. Intraerythrocyte antioxidant enzyme activities in migraine and tension-type headaches. J Chin Med Assoc. 2004;67:263-267.
• 18. Shimomura T, Kowa H, Nahano T, et al. Platelet superoxide dismutase in migraine and tension type headache. Cephalalgia. 1994;14:215-218.
• 19. Cohen SM, Nadler JV. Proline-induced potentiation of glutamate transmission. Brain Res. 1997;761(2):271-82.
• 20. Nam JH, Lee HS, Kim J, Kim J, Chu MK. Salivary glutamate is elevated in individuals with chronic migraine. Cephalalgia. 2018;38(8):1485-1492.
• 21. Zielman R, Wijnen JP, Webb A, et al. Cortical glutamate in migraine. Brain. 2017;140(7):1859-1871
• 22. Eren Y, Dirik E, Neselioglu S, Erel O. Oxidative stress and decreased thiol level in patients with migraine: Cross-sectional study. Acta Neurol Belg. 2015;115:643-649.
• 23. Neri M, Frustaci A, Milic M, et al. A metaanalysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine. Cephalalgia. 2015;35:931-937.
• 24. Aytac¸ B, Coskun O, Alioğlu B, et al. Decreased antioxidant status in migraine patients with brain white matter hyperintensities. Neurol Sci. 2014; 35:1925-1929.
• 25. Borkum JM. The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress: Preliminary Evidence for a Theory. Headache. 2018;58(1):118-135.
• 26. Gupta R, Pathak R, Bhatia MS, Banerjee BD. Comparison of oxidative stress among migraineurs, tension-type headache subjects, and a control group. Ann Indian Acad Neurol 2009;12(3):167-72.
• 27. Karaaslan Ö, Hacımusalar Y, Amuk ÖC. Bal C. Evaluation of ischemia modified albumin levels in major depression patients. J Surg Med. 2019;3(8):557-560.
• 1. Yılmaz G, Sürer H, Üçler S, İnan L, Yücel D. Auralı ve Aurasız Migrende Plazma Malondialdehit Düzeyleri. Turkiye Klinikleri J Med Sci. 2004;24(4):309-15
• 29. Tuncel D, Tolun FI, Gokce M, Imrek S, Ekerbiçer H. Oxidative stress in migraine with and without aura. Biol Trace Elem Res. 2008;126(1-3):92-7.