The role of the C-reactive protein/albumin ratio in determining prognosis of patients diagnosed with small cell lung cancer and the relationship with the diameter and suvmax value of primer mass in PET-CT

Abstract

Introduction: In our study, we aimed to evaluate retrospectively the role of C-reactive protein/ albumin rate (CAR) in determining prognosis of patients diagnosed with SCLC and the relationship with the diameter and SUV max value of primer mass in Positron emission tomography/ computed tomography (PET-CT). Materials and Methods: A total of 70 patients diagnosed with SCLC between January 2008 and December 2015 in this study. Informations of patients were recorded. Results: The mean age of the patients was 57.6±7.5. While 59 patients (84.3%) were dead, 11 patients (15.7%) were still alive. The median follow-up time of the patients was 13. 7 (8.1-30.1) month. The mean life span was found to be 21 month in patients with CAR <0.3, and it was found to be 10 month in patients with CAR≥ 0.3 (p=0.007). Median lifespan was 23 month in patients with LDH <187 and it was 10 month in patients with ≥187 (p= 0.048). Median life span was found as 19 month in patients with NLR <3 and it was found to be 10 month in patients with NLR ≥ 3. The result was evaluated as close to statistical significance (p= 0.073). Conclusion: We detected that male gender, the stage of disease, the increase of SUVmax value of primary mass and increased CAR, NLR and LDH levels were found to be poor prognostic criterias in SCLC patients. We consider that CAR, NLR and LDH levels can be used for forecasting of mortality at the begining of the diagnoses of SCLC

Keywords

• Small cell lung cancer
• C-reactive protein
• albumin
• mortality

Küçük hücreli akciğer kanseri tanısı konulan hastalarda C-reaktif protein/albumin oranının prognoz tayinindeki yeri ile PET-BT’deki primer kitlenin çapı ve suvmax değeri ile ilişkisi

Abstract

Giriş-amaç: Küçük hücreli akciğer kanseri (KHAK) tüm akciğer kanser türlerinin %15’ ini oluşturur. Çalışmamızda KHAK tanısı konulan hastalarda retrospektif olarak ilk tanı anında bakılan C-reaktif protein/ albümin (CAR)’ın prognoz tayinindeki yeri ile primer kitlenin PET-BT’ deki çapı ve SUV max değeri ile ilişkisinin değerlendirilmesini amaçladık. Materyal-metod: Çalışmamızda hastanemiz 8. kliniğinde Ocak 2008- Aralık 2015 tarihleri arasında KHAK tanısı konulan 70 hasta dahil edildi. Hastalara ait bilgiler hasta dosyaları ve hastane bilgi sisteminden retrospektif olarak elde edildi. İlk tanı anında bakılan hemogram, biyokimya değerleri, PET-BT’ deki primer kitlenin çapı, SUVmax değerleri, kanser evresi, sağkalım süreleri kayıt edildi. NLR: nötrofil/lenfosit, CAR: C-reaktif protein/albümin oranları hesaplandı. Bulgular: Hastaların ortalama yaşı 57,6±7,5 olarak hesaplandı. 59 hasta (%84,3) exitus iken, 11 hasta (%15,7) halen sağ idi. Hastaların median izlem süresi 13,7 (8,1-30,1) ay idi. CAR <0,3 olanlarda ortalama yaşam süresi 21 ay iken, ≥ 0,3 olanlar da 10 ay olarak bulundu (p:0,007). LDH<187 olanlarda median ömür 23 ay, ≥187 olanlarda ise 10 ay olarak bulunmuştur (p: 0 ,048). NLR <3 olanlarda median yaşam süresi 19 ay, ≥ 3 olanlarda 10 ay olarak bulunmuştur. Sonuç istatistiksel olarak anlamlılık sınırına yakın olarak değerlendirilmiştir (p:0,073). Sonuç: Erkek cinsiyet, hastalığın evresi ve primer kitlenin SUVmax değerindeki artış, artmış CAR, artmış NLR ve artmış LDH KHAK’lı hastalarda kötü prognoz kriteleri olarak saptadık. CAR, NLR ve LDH düzeylerinin tanı anındaki mortaliteyi öngörmede kullanılabileceklerini düşünmekteyiz.

Keywords

• Küçük hücreli akciğer kanseri
• C-reaktif protein
• albümin
• mortalite

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