Relationship between the ABO blood group and mortality among the COVID-19 patients

Year 2021, , 441 - 444, 15.07.2021

Fatih Doğanay , Rohat Ak

https://doi.org/10.32322/jhsm.915047

Abstract

Objective: Differences in blood group antigen expression may increase or decrease the sensitivity of the host to many infections. Our aim in this study is to examine the relationship between ABO and Rh blood groups of COVID-19 patients and their mortality.
Material and Method: This retrospective observational study was conducted with patients who were diagnosed with COVID-19 in the emergency department of a tertiary hospital between May 1, 2020, and November 1, 2020. Patients who had a positive COVID-19 RT-PCR test and had blood group information in the HIMS database were included in the study. Blood groups, age, and gender information of the patients who included in the study were recorded on a form.
Results: The population of this study consists of 356 patients, of which 171 were women and 185 were men. There were 94 people in the O blood group, 185 people in the A blood group, 48 people in the B blood group, 29 people in the AB blood group, 37 people in the Rh-negative blood group, 319 people in the Rh-positive blood group. When the mortality status between blood groups is examined, it was observed that COVID-19 was less mortal in men with O blood group (p= 0.002).
Conclusion: COVID-19 infection is more common in those with the A blood group compared to the other groups. Additionally, we concluded that being in the O blood group is a factor that reduces mortality in men. More studies with a larger sample size are needed to confirm the results of our study.

Keywords

Blood groups, COVID-19, Mortality

References

• Topcu AC, Ozturk-Altunyurt G, Akman D, Batirel A, Demirhan R. Acute Limb Ischemia in Hospitalized COVID-19 Patients. Ann Vasc Surg 2021; S0890-5096(21)00233-8.
• Ahn DG, Shin HJ, Kim MH, et al. Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel coronavirus disease 2019 (COVID-19). J Microbiol Biotechnol 2020; 30: 313-24.
• Shi Y, Yu X, Zhao H, Wang H, Zhao R, Sheng J. Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan. Crit Care 2020; 24: 108.
• Li B, Yang J, Zhao F, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol 2020; 109: 531-8.
• Seyhan AU, Doganay F, Yilmaz E, Topal NP, Ak R. Investigation of QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID-19. J Coll Physicians Surg Pak 2020; 30: 153-7.
• Tian S, Hu N, Lou J, et al. Characteristics of COVID-19 infection in Beijing. J Infect 2020; 80: 401-6.
• Meng J, Xiao G, Zhang J, et al. Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. Emerg Microbes Infect 2020; 9: 757-60.
• Doğanay F, Elkonca F, Seyhan AU, Yılmaz E, Batırel A, Ak R. Shock index as a predictor of mortality among the COVID-19 patients. Am J Emerg Med 2021; 40: 106-9.
• Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395: 1054-62.
• Zhao J, Yang Y, Huang H, et al. Relationship between the ABO blood group and the COVID-19 susceptibility. Clin Infect Dis 2020; ciaa1150.
• Seyhan AU, Doğanay F, Yılmaz E, Aydıner Ö, Ak R, Tekol SD. The comparison of chest CT and RT-PCR during the diagnosis of COVID-19. J Clin Med Kaz 2021; 18: 53-6.
• Batool Z, Durrani SH, Tariq S. Association of AB0 and rh blood group types to hepatitis B, hepatitis C, HIV and syphilis infection, a five year’ experience in healthy blood donors in a tertiary care hospital. J Ayub Med Coll Abbottabad 2017; 29: 90-2.
• Lindesmith L, Moe C, Marionneau S, et al. Human susceptibility and resistance to Norwalk virus infection. Nat Med 2003; 9: 548-53.
• Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta 2020; 509: 220-223.
• Göker H, Aladağ Karakulak E, Demiroğlu H, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci 2020; 50: 679-83.
• McGonagle D, O’Donnell JS, Sharif K, Emery P, Bridgewood C. Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet Rheumatol 2020; 2: 437-45.
• Solmaz İ, Araç S. ABO blood groups in COVID-19 patients; Cross-sectional study. Int J Clin Pract 2021; 75: e13927.
• Cooling L. Blood groups in infection and host susceptibility. Clin Microbiol Rev 2015; 28: 801-70.