Research Article
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Year 2022, , 45 - 48, 17.01.2022
https://doi.org/10.32322/jhsm.993320

Abstract

References

  • Clarke BL, Collins MT, Bilezikian JP- Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab 2016; 101: 2284-99.
  • Shoback D. Clinical practice. Hypoparathyroidism. N Engl J Med 2008; 359: 391-403.
  • Bilezikian JP. Hypoparathyroidism. J Clin Endocrinol Metab 2020; 105: 1722–36.
  • Genç M, Gültekin K, Önal A, Güngüneş A, Arıkan Durmaz Ş. A case of autoimmune polyglandular syndrome type 1 with ectodermal dystrophy in her nail. J Health Sci Med 2018; 1: 22-4.
  • Cipriani C, Bilezikian JP. Clinical Presentation of hypoparathyroidism. J Endocr Soc 2021 Jan 22; 5: bvab003.
  • Shoback DM, Bilezikian JP, Costa AG, et al. Presentation of hypoparathyroidism: etiologies and clinical features. J Clin Endocrinol Metab 2016; 101: 2300-12.
  • Lopes MP, Kliemann BS, Bini IB, et al. hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features, and complications. Arch Endocrinol Metab 2016; 60: 532-6.
  • Büttner M, Musholt TJ, Singer S. Quality of life in patients with hypoparathyroidism receiving standard treatment: a systematic review. Endocrine 2017; 58: 14-20.
  • Sikjaer T, Moser E, Rolighed L, et al. Concurrent hypoparathyroidism is associated with impaired physical function and quality of life in hypothyroidism. J Bone Miner Res 2016; 31: 1440-8.
  • Al-Azem H, Khan AA. Hypoparathyroidism. Best Pract Res Clin Endocrinol Metab 2012; 26: 517-22.
  • Ito Y, Kihara M, Kobayashi K, Miya A, Miyauchi A. Permanent hypoparathyroidism after completion total thyroidectomy as a second surgery: How do we avoid it? Endocr J 2014; 61: 403-8.
  • Rao SD. Epidemiology of parathyroid disorders. Best Pract Res Clin Endocrinol Metab 2018; 32: 773-80.
  • Powers J, Joy K, Ruscio A, Lagast H. Prevalence and incidence of hypoparathyroidism in the United States using a large claims database. J Bone Miner Res 2013; 28: 2570–6.
  • Gafni RI, Collins MT. Hypoparathyroidism. N Engl J Med 2019; 380: 1738-47.
  • Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study. J Bone Miner Res 2013; 28: 2277-85.
  • Mitchell DM, Regan S, Cooley MR, et al. Long-term follow-up of patients with hypoparathyroidism. J Clin Endocrinol Metab 2012; 97: 4507-14.
  • Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. The epidemiology of non-surgical hypoparathyroidism in Denmark: A nationwide case finding study. J Bone Miner Res 2015; 30: 1738-44.

Real-life data of patients with hypoparathyroidism: a case-control study

Year 2022, , 45 - 48, 17.01.2022
https://doi.org/10.32322/jhsm.993320

Abstract

Objective: This study aims to investigate real-life data of patients with hypoparathyroidism.
Material and Method: This retrospective case-control study was carried out in a tertiary endocrine center between 1 January 2010 and 31 December 2019. Patients with a confirmed diagnosis of persistent hypoparathyroidism and healthy controls were included. Demographic characteristics of the patients, laboratory findings, etiologies of hypoparathyroidism, treatments they received, reasons for hospitalization, and complications were investigated.
Results: Sixty-five patients (mean age 42.80±13.4 years, 91% female) with hypoparathyroidism, and 54 healthy controls (mean age 33.58±11.9 years, 65% female) were included. Mean calcium level 7.95±0.92 mg/dl, and mean PTH level 9.99±6.30 pg/ml in hypoparathyroidism. Regarding the etiology of HypoPT, 51 (78%) patients had hypoPT due to surgery; 14 (22%) patients developed HypoPT due to non-surgical causes. In patients with hypoPT who underwent surgery, the mean calcium value was 8.03±0.93 mg/dl; the mean calcium value in patients with non-surgical HypoPT was 7.67±0.85 mg/dl. The mean PTH levels in non-surgical group, other group 10.16±6.21 pg/ml and 9.36±6.82 pg/ml, respectively. The most common surgery was due to multinodular goiter (72%). In 46 percent, the most common treatment was calcitriol 0.5 mcg/day and calcium 2000 mg/day. Nearly half of the patients had treatment non-compliance (46%). Eighteen percent of patients had kidney stones. Forty-three percent of the patients had been hospitalized in the last year. The most common reason for the hospitalization of patients with hypoparathyroidism was hypocalcemia, and the most common reason for this was treatment non-compliance.
Conclusion: In our study, the most common cause of hypoparathyroidism is surgery due to multinodular goiter. The most common reason for hospitalization is treatment non-compliance. Up to one-fifth of patients had kidney stones.

References

  • Clarke BL, Collins MT, Bilezikian JP- Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab 2016; 101: 2284-99.
  • Shoback D. Clinical practice. Hypoparathyroidism. N Engl J Med 2008; 359: 391-403.
  • Bilezikian JP. Hypoparathyroidism. J Clin Endocrinol Metab 2020; 105: 1722–36.
  • Genç M, Gültekin K, Önal A, Güngüneş A, Arıkan Durmaz Ş. A case of autoimmune polyglandular syndrome type 1 with ectodermal dystrophy in her nail. J Health Sci Med 2018; 1: 22-4.
  • Cipriani C, Bilezikian JP. Clinical Presentation of hypoparathyroidism. J Endocr Soc 2021 Jan 22; 5: bvab003.
  • Shoback DM, Bilezikian JP, Costa AG, et al. Presentation of hypoparathyroidism: etiologies and clinical features. J Clin Endocrinol Metab 2016; 101: 2300-12.
  • Lopes MP, Kliemann BS, Bini IB, et al. hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features, and complications. Arch Endocrinol Metab 2016; 60: 532-6.
  • Büttner M, Musholt TJ, Singer S. Quality of life in patients with hypoparathyroidism receiving standard treatment: a systematic review. Endocrine 2017; 58: 14-20.
  • Sikjaer T, Moser E, Rolighed L, et al. Concurrent hypoparathyroidism is associated with impaired physical function and quality of life in hypothyroidism. J Bone Miner Res 2016; 31: 1440-8.
  • Al-Azem H, Khan AA. Hypoparathyroidism. Best Pract Res Clin Endocrinol Metab 2012; 26: 517-22.
  • Ito Y, Kihara M, Kobayashi K, Miya A, Miyauchi A. Permanent hypoparathyroidism after completion total thyroidectomy as a second surgery: How do we avoid it? Endocr J 2014; 61: 403-8.
  • Rao SD. Epidemiology of parathyroid disorders. Best Pract Res Clin Endocrinol Metab 2018; 32: 773-80.
  • Powers J, Joy K, Ruscio A, Lagast H. Prevalence and incidence of hypoparathyroidism in the United States using a large claims database. J Bone Miner Res 2013; 28: 2570–6.
  • Gafni RI, Collins MT. Hypoparathyroidism. N Engl J Med 2019; 380: 1738-47.
  • Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study. J Bone Miner Res 2013; 28: 2277-85.
  • Mitchell DM, Regan S, Cooley MR, et al. Long-term follow-up of patients with hypoparathyroidism. J Clin Endocrinol Metab 2012; 97: 4507-14.
  • Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. The epidemiology of non-surgical hypoparathyroidism in Denmark: A nationwide case finding study. J Bone Miner Res 2015; 30: 1738-44.
There are 17 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Vedat Tan This is me 0000-0002-8482-313X

Alparslan Kemal Tuzcu 0000-0002-1814-9773

Zafer Pekkolay 0000-0002-5323-2257

Publication Date January 17, 2022
Published in Issue Year 2022

Cite

AMA Tan V, Tuzcu AK, Pekkolay Z. Real-life data of patients with hypoparathyroidism: a case-control study. J Health Sci Med /JHSM /jhsm. January 2022;5(1):45-48. doi:10.32322/jhsm.993320

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