Intralesional epidermal growth factor treatment on diabetic foot ulcers: one centre experience

Year 2018, Volume: 1 Issue: 1, 1 - 3, 05.04.2018

Aydın Çifci Birhan Oktaş Şenay Arıkan Durmaz Aşkın Güngüneş İrfan Karahan Taner Sarak

https://doi.org/10.32322/jhsm.397000

Abstract

Introduction:
The intralesional injection of
recombinant human epidermal growth factor (EGF-IL) is a new approach for
reducing amputations. In this study we aimed to show efficacy of EGF-IL with
cases.
Material and Method: EGF-IL 75 μg application to 8 diabetic foot ulcers
(6 males, 2 females; mean age: 60.3±9.3 years) was evaluated. Patients had
history of prior standard treatments.
Results:  In all
eight patients’ completely healing was observed diabetic foot ulcers after the
intralesional EGF treatment.

Conclusion: In our experience our patients’
wounds wish priorly have healing problems, improved with intralesional EGF.
This treatment is expensive and caused of some allergic reactions. Relation
with malignancies are not known for long-term.

Keywords

Diabetes, foot ulcer, EGF, wound healing

Diyabetik ayakta intralezyonel epidermal growth faktör kullanımı: bir merkezin deneyimi

Abstract

Giriş: Rekombinant insan epidermal
büyüme faktörü (EGF-IL) intralezyonel enjeksiyonu amputasyonları azaltmak için
yeni bir yaklaşımdır. Bu çalışmada EGF-IL'nin olgularla etkinliğini göstermeyi
amaçladık.

Gereç ve Yöntem: Sekiz diyabetik ayak ülserine (6
erkek, 2 kadın; ortalama yaş: 60.3 ± 9.3 yıl) EGF-IL 75 μg uygulandı. Hastalar
daha önce standart tedaviler geçmişi vardı.

Bulgular: Sekiz hastanın tamamında,
intralezyonel EGF tedavisinden sonra diyabetik ayak ülserleri iyileşti.

Sonuç: Tecrübelerimize göre,
hastalarımızın yaraları önceden intralezyonal EGF ile iyileşen iyileşme
problemlerine sahip olmak istemektedir. Bu tedavi pahalıdır ve bazı alerjik
reaksiyonlara neden olur. Malignitelerle olan ilişki uzun süredir
bilinmemektedir.

Keywords

Diyabet, ayak ülseri, EGF, yara iyileşmesi

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