The relationship between serum homocysteine levels and development of coronary collateral circulation in patients with acute coronary syndrome

Year 2020, Volume: 3 Issue: 2, 92 - 96, 19.03.2020

Muhammed Karadeniz , Tuba Karadeniz , Taner Sarak , Çağlar Alp

https://doi.org/10.32322/jhsm.657326

Cited By: 1

Abstract

Aim:
Homocysteine is an amino acid that plays a role in folate metabolism and
inhibits endothelial cell proliferation which is important for angiogenesis. In
this study, we aimed to investigate the relationship between serum homocysteine
levels and coronary collateral development.

Material
and Method: 176
consecutive patients, with acute coronary syndrome and chronic total occlusion,
were divided into two groups according to coronary collateral development. Rentrop
0 and 1 were regarded as group I and Rentrop 2 and 3 as group II.

Results: Plasma homocysteine levels were 18,2 ± 7,0 μmol/L
in the group I and 15,7 ± 5,1 μmol/L in the group II. Univariate logistic regression analysis showed that mean
platelet volume and homocysteine were associated with poor coronary collateral.
Multivariate logistic regression analysis showed that homocysteine level was
independently associated with poor coronary collateral circulation (OR 1,069
[95% CI 1,012-1,130]; P=0,018).

Conclusion: In this study clearly demonstrates that high serum
homocysteine level is associated with poor collateral development in patients
with
acute coronary syndrome.

Keywords

Coronary artery disease, coronary collateral circulation, homocysteine

Akut koroner sendromlu hastalarda serum homosistein düzeyleri ile koroner kollateral dolaşım gelişimi arasındaki ilişki

Abstract

Amaç:
Homosistein, folat metabolizmasında rol oynayan, anjiyogenez için önemli olan
endotelyal hücre proliferasyonunu inhibe eden bir aminoasittir. Bu çalışmada serum
homosistein düzeyiyle koroner kollateral gelişimi arasındaki ilişkiyi
araştırmayı amaçladık.

Gereç
ve Yöntem: 176 kronik total oklüzyonu olan hasta koroner
kollateral gelişimine göre 2 gruba ayrıldı. Rentrop 0 and 1 olanlar grup I
Rentrop 2 ve 3 olanlar grup II olarak kabul edildi.

Sonuç: Plazma
homosistein düzeyleri grup I'de 18,2 ± 7,0 μmol / L ve grup II'de 15,7 ± 5,1 μmol
/ L olarak saptandı. Tek değişkenli lojistik
regresyon analizi ortalama trombosit hacmi ve homosisteinin zayıf koroner kollateral
ile ilişkili olduğunu gösterdi. Çok değişkenli lojistik
regresyon analizi homosistein düzeyinin bağımsız olarak zayıf koroner
kollateral dolaşım ile ilişkili olduğunu göstermiştir  (OR 1,069 [% 95 CI 1,012-1,130];P=0,018).

Keywords

Koroner arter hastalığı, koroner kollateral dolaşım, homosistein

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