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Alerjik rinit ve astım olan hastalarda prick testi sonuçlarımız

Year 2020, Volume: 3 Issue: 3, 245 - 249, 18.06.2020
https://doi.org/10.32322/jhsm.710017

Abstract

Amaç: Çalışmamızda astım ve alerjik rinit tanısı konulmuş on üç yaş üzerindeki hastaların alerjenlere olan duyarlılıkları, total ve spesifik serum immunoglobulin E düzeylerini değerlendirmeyi amaçladık.
Gereç ve Yöntem: Çocuk alerji ve dahiliye bölümüne 1 Ocak 2017 ve 30 mayıs 2018 tarihleri arasında başvuran alerjik rinit ve astım tanısı almış 133 hastaya uygulanan deri prick testleri ile total ve spesifik serum immunoglobulin E sonuçları retrospektif olarak incelenmiştir.
Bulgular: Çalışmaya 36 (%27,1) erkek,97(%72,9) kadın olmak üzere 133 hasta dahil edildi. Çalışma grubunun yaş ortalaması 15,34±1,50 idi. Hastalardan 42’sinde (%31,6) bronşiyal astım,29’unda (%21,8) alerjikrinit,61’inde (%45,9) ise alerjik rinit ve bronşiyal astım birlikteliği mevcuttu. Deri prick testlerinde 65(%48,8) hastada en az bir alerjene hassasiyet tespit edilmiştir. En sık karışık ot poleni (41 [%30,8] hasta) hassasiyeti tespit edilmiştir. Astım ve rinit birlikteliğinde en az bir alerjene karşı pozitiflik sıklığı anlamlı olarak yüksekti (p=0,01) Üç (%2,4) hastada gıda alerjisi tespit edilmiştir. Total serum immunoglobulin E düzeyi ile ev tozu akarları hassasiyeti arasında istatiksel olarak anlamlı ilişki saptanmıştır (p=0,000).
Sonuç: Çalışmamızda en sık karışık ot poleni ve ev tozu akarlarına karşı hassasiyet saptanmıştır. Astım ve rinit birlikteliğinde alerjen pozitifliği sıklığı yüksekti. İklim, çevresel koşullar, sosyoekonomik şartlar bu sonuçlara etki etmiş olabilir.

References

  • 1. Abrams, Elissa M., and Scott Sicherer. Cutaneous sensitization to peanut in children with atopic dermatitis: a window to prevention of peanut allergy. JAMA Dermatology 2019; 155: 13-4.
  • 2. Bıçakçı A, Tosunoğlu A. Allergenic pollens in Turkey Asthma Allergy Immunol 2019; 17: 7-24.
  • 3. McWilliam V, Peters RL, Allen KJ, et al. Skin prick test predictive values for the outcome of cashew challenges in children. J Allergy Clin Immunol Pract 2020; 8: 141‐8.e2.
  • 4. Farrokhi S, Gheybi MK, Movahed A, et al.Common aero allergens in patients with asthma and allergic rhinitis living in South western part of Iran: based on skin prick test reactivity. Iran J Allergy Asthma Immunol. 2015; 14: 133-8.
  • 5. Arslan S, Şenel E, Öztekin A, Gülhan M, Koşar N, Özkan AT. Çorum’da göğüs hastalıkları ve dermatoloji kliniklerinde solunum alerjenlerine yönelik deri prick testi sonuçları: 2 yıllık retrospektif çalışma. Hitit Med J 2019; 1: 12-4.
  • 6. Agache I, Bilò M, Braunstahl GJ, et al. Invivo diagnosis of allergic diseases—allergen provocation tests. Allergy 2015; 70: 355-65.
  • 7. Nacaroglu HT, Erdem SB, Sumer O, et al. Local and systemic reactions to subcutaneous allergen immunotherapy: Ten years’ experience in a pediatric clinic. An 2016; 116: 349-53.
  • 8. Jackola DR, Pierson-Mullany L, Blumenthal MN, Rosenberg A. Allergen skin test reactionpatterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early life. Int Arch Allergy Immunol 2003; 132: 364-72.
  • 9. Hua T, Silverberg JI. Atopic dermatitis in US adults: epidemiology, association with marital status, and atopy. Ann Allergy Asthma Immunol 2018; 121: 622-4.
  • 10. Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab 2015; 66 (Suppl 1): 8-16.
  • 11. Galili E, Barzilai A, Twig G, et al. Allergic rhinitis and asthma among adolescents with psoriasis: a population-based cross-sectional study. Acta Derm Venereol 2020; 100(10): adv00133. doi:10.2340/00015555-3485
  • 12. Wahn U, Bachert C, Heinrich J, Richter H, Zielen S. Real-world benefits of allergen immunotherapy for birch pollen-associated allergic rhinitis and asthma. Allergy 2019; 74: 594‐604.
  • 13. Kalyoncu AF. Perennial and seasonal rhinitis in Ankara, Turkey. Allergy 1997; 52: 1040-1.
  • 14. Kolokotroni O, Middleton N, Gavatha M, Lamnisos D, Priftis KN, Yiallouros PK. Asthma and atopy in children born bycaesareansection: effect modification by family history of allergies - a population based cross-sectional study. BMC Pediatr 2012; 12: 179.
  • 15. Çiçek D, Kandi B, Dertlioğlu SB, Uçak H. Elazığ yöresinde alerjik astma, alerjik rinit, alerjik konjunktivit, kronik ürtiker ve atopik dermatitli olgularda prick test sonuçlarının değerlendirilmesi. Fırat Üniv Sağ Bil Derg 2008: 22: 193 – 6.
  • 16. Nalbantoğlu A, Nalbantoğlu B, Donma MM, Samancı N. Tekirdağ ilinde yaşayan alerjik rinit hastalarda alerji deri testi sonuçlarının değerlendirilmesi. Namık Kemal Tıp Derg 2017; 5: 122-6.
  • 17. Ceylan E, Gencer M, Şan İ, İyinen İ. Alerjik rinitli olgularımızda prick testlerde saptanan aero alerjenlerin dağılımı. Türkiye Klinikleri J Med Sci 2006; 26: 370–4.
  • 18. Uzaslan EK, Yüksel EG, Özyardımcı N. Astma polikliniğimizde izlenmekte olan atopik bronşial astmalı olgularda prick, intradermal deri testleri ve rast yöntemi sonuçlarının değerlendirilmesi. Van Tıp Derg 1999; 6:13-8.
  • 19. D, Babayiğit A, Uzuner N, Karaman Ö, Tezcan D, Köze S. Ev tozu alerjisi saptanan hastaların retrospektif değerlendirilmesi. DEÜ Tıp Fakültesi Derg 2005; 19: 77 – 83.
  • 20. Barlay F. Denizli ili çevresindeki alerjik rinit ön tanı olgularda deri prick testi sonuçlarımız; 15 yıllık retrospektif çalışma. Pamukkale Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı Uzmanlık Tezi, 2019, Denizli.
  • 21. Mungan D, Celik G, Sin B, Bavbek S, Demirel Y, Misirligil Z. Characteristic features of cockroach hypersensitivity in Turkish asthmatic patients. Allergy 1998; 53: 870-3.
  • 22. Yılmaz N, Can D, Asilsoy S, Gülle S, The diagnostic value of specific IgE in allergic diseases. Asthma Allergy Immunol 2009; 7: 111-7.
  • 23. Araújo IMS, Bena MGP, de Brito POL, et al. Socio-environmental profile of child and adolescents sensitized by house dust mite in northeast of Brazil. Allergol Immunopathol (Madr) 2019; 47: 417‐24.
  • 24. Hameed RM, Ahmed MM, Abood HA, Hussein AM. To evaluate total serum immunglobulin E level and factors that effect on this level in İraqı astmatic children. Biome Biotechonol Res J 2019; 3: 240-4.

Prick test results in patients with allergic rhinitis and asthma

Year 2020, Volume: 3 Issue: 3, 245 - 249, 18.06.2020
https://doi.org/10.32322/jhsm.710017

Abstract

Introduction: In our study, we aimed to evaluate the sensitivity, total and specific serum immunoglobulin E levels of patients over the age of thirteen, who were diagnosed with asthma and allergic rhinitis.
Material and Method: Skin prick tests and total and specific serum immunoglobulin E results of 133 patients with allergic rhinitis and asthma who applied to the department of Child Allergy and Internal Medicine between January 1, 2017 and May 30, 2018 were evaluated retrospectively.
Results: A total of 133 patients (36 (27.1%) male and 97 (72.9%) female) were included in the study. The mean age of the study group was 15.34±1.50. Forty-two patients (31.6%) had asthma bronchiole, 29 (21.8%) had allergic rhinitis, and 61 (45.9%) had allergic rhinitis and asthma bronchiole. In skin prick tests, 65 (48.8%) patients had sensitivity to at least one allergen. The most common mixed herb pollen was (41 (30.8%) patients) sensitivity. The prevalence of positivity against at least one allergen in asthma and rhinitis was significantly higher (p=0.01). Food allergy was detected in three (2.4%) patients. A statistically significant relationship was found between total serum immunoglobulin E and house dust mites sensitivity (p=0.000).
Conclusions: In our study, sensitivity to mixed grass pollen and house dust mites was found most frequently. The prevalence of allergen positivity was high in asthma and rhinitis group. Climate, environmental conditions, socioeconomic conditions may have an impact on these results.

References

  • 1. Abrams, Elissa M., and Scott Sicherer. Cutaneous sensitization to peanut in children with atopic dermatitis: a window to prevention of peanut allergy. JAMA Dermatology 2019; 155: 13-4.
  • 2. Bıçakçı A, Tosunoğlu A. Allergenic pollens in Turkey Asthma Allergy Immunol 2019; 17: 7-24.
  • 3. McWilliam V, Peters RL, Allen KJ, et al. Skin prick test predictive values for the outcome of cashew challenges in children. J Allergy Clin Immunol Pract 2020; 8: 141‐8.e2.
  • 4. Farrokhi S, Gheybi MK, Movahed A, et al.Common aero allergens in patients with asthma and allergic rhinitis living in South western part of Iran: based on skin prick test reactivity. Iran J Allergy Asthma Immunol. 2015; 14: 133-8.
  • 5. Arslan S, Şenel E, Öztekin A, Gülhan M, Koşar N, Özkan AT. Çorum’da göğüs hastalıkları ve dermatoloji kliniklerinde solunum alerjenlerine yönelik deri prick testi sonuçları: 2 yıllık retrospektif çalışma. Hitit Med J 2019; 1: 12-4.
  • 6. Agache I, Bilò M, Braunstahl GJ, et al. Invivo diagnosis of allergic diseases—allergen provocation tests. Allergy 2015; 70: 355-65.
  • 7. Nacaroglu HT, Erdem SB, Sumer O, et al. Local and systemic reactions to subcutaneous allergen immunotherapy: Ten years’ experience in a pediatric clinic. An 2016; 116: 349-53.
  • 8. Jackola DR, Pierson-Mullany L, Blumenthal MN, Rosenberg A. Allergen skin test reactionpatterns in children (</=10 years old) from atopic families suggest age-dependent changes in allergen-IgE binding in early life. Int Arch Allergy Immunol 2003; 132: 364-72.
  • 9. Hua T, Silverberg JI. Atopic dermatitis in US adults: epidemiology, association with marital status, and atopy. Ann Allergy Asthma Immunol 2018; 121: 622-4.
  • 10. Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab 2015; 66 (Suppl 1): 8-16.
  • 11. Galili E, Barzilai A, Twig G, et al. Allergic rhinitis and asthma among adolescents with psoriasis: a population-based cross-sectional study. Acta Derm Venereol 2020; 100(10): adv00133. doi:10.2340/00015555-3485
  • 12. Wahn U, Bachert C, Heinrich J, Richter H, Zielen S. Real-world benefits of allergen immunotherapy for birch pollen-associated allergic rhinitis and asthma. Allergy 2019; 74: 594‐604.
  • 13. Kalyoncu AF. Perennial and seasonal rhinitis in Ankara, Turkey. Allergy 1997; 52: 1040-1.
  • 14. Kolokotroni O, Middleton N, Gavatha M, Lamnisos D, Priftis KN, Yiallouros PK. Asthma and atopy in children born bycaesareansection: effect modification by family history of allergies - a population based cross-sectional study. BMC Pediatr 2012; 12: 179.
  • 15. Çiçek D, Kandi B, Dertlioğlu SB, Uçak H. Elazığ yöresinde alerjik astma, alerjik rinit, alerjik konjunktivit, kronik ürtiker ve atopik dermatitli olgularda prick test sonuçlarının değerlendirilmesi. Fırat Üniv Sağ Bil Derg 2008: 22: 193 – 6.
  • 16. Nalbantoğlu A, Nalbantoğlu B, Donma MM, Samancı N. Tekirdağ ilinde yaşayan alerjik rinit hastalarda alerji deri testi sonuçlarının değerlendirilmesi. Namık Kemal Tıp Derg 2017; 5: 122-6.
  • 17. Ceylan E, Gencer M, Şan İ, İyinen İ. Alerjik rinitli olgularımızda prick testlerde saptanan aero alerjenlerin dağılımı. Türkiye Klinikleri J Med Sci 2006; 26: 370–4.
  • 18. Uzaslan EK, Yüksel EG, Özyardımcı N. Astma polikliniğimizde izlenmekte olan atopik bronşial astmalı olgularda prick, intradermal deri testleri ve rast yöntemi sonuçlarının değerlendirilmesi. Van Tıp Derg 1999; 6:13-8.
  • 19. D, Babayiğit A, Uzuner N, Karaman Ö, Tezcan D, Köze S. Ev tozu alerjisi saptanan hastaların retrospektif değerlendirilmesi. DEÜ Tıp Fakültesi Derg 2005; 19: 77 – 83.
  • 20. Barlay F. Denizli ili çevresindeki alerjik rinit ön tanı olgularda deri prick testi sonuçlarımız; 15 yıllık retrospektif çalışma. Pamukkale Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı Uzmanlık Tezi, 2019, Denizli.
  • 21. Mungan D, Celik G, Sin B, Bavbek S, Demirel Y, Misirligil Z. Characteristic features of cockroach hypersensitivity in Turkish asthmatic patients. Allergy 1998; 53: 870-3.
  • 22. Yılmaz N, Can D, Asilsoy S, Gülle S, The diagnostic value of specific IgE in allergic diseases. Asthma Allergy Immunol 2009; 7: 111-7.
  • 23. Araújo IMS, Bena MGP, de Brito POL, et al. Socio-environmental profile of child and adolescents sensitized by house dust mite in northeast of Brazil. Allergol Immunopathol (Madr) 2019; 47: 417‐24.
  • 24. Hameed RM, Ahmed MM, Abood HA, Hussein AM. To evaluate total serum immunglobulin E level and factors that effect on this level in İraqı astmatic children. Biome Biotechonol Res J 2019; 3: 240-4.
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Article
Authors

Gülşah Duyuler Ayçin 0000-0001-9560-3661

Muharrem Bayrak 0000-0003-2760-4181

Kenan Çadırcı 0000-0002-2765-4288

Publication Date June 18, 2020
Published in Issue Year 2020 Volume: 3 Issue: 3

Cite

AMA Duyuler Ayçin G, Bayrak M, Çadırcı K. Alerjik rinit ve astım olan hastalarda prick testi sonuçlarımız. J Health Sci Med / JHSM. June 2020;3(3):245-249. doi:10.32322/jhsm.710017

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