The effect of smoking on stem cell mobilization in allogeneic donors

Year 2020, Volume: 3 Issue: 3, 291 - 294, 18.06.2020

Tuğçe Nur Yiğenoğlu , Semih Başcı , Derya Şahin , Mehmet Bakırtaş , Ali Kılınc Bahar Uncu Ulu , Hikmetullah Batgi Dicle İskender , Nurgul Ozcan Merih Kızıl Çakır , Sinan Dal , Tuba Hacıbekiroğlu , Fevzi Altuntaş

https://doi.org/10.32322/jhsm.729505

Abstract

Introduction: It has been shown that there is an increase in the number of progenitor cells in the bone marrow after smoking cessation. Adequate number of stem cells should be given to the patients to provide sustained engraftment after allogeneic stem cell transplantation. Therefore, determining the factors affecting the success of peripheral stem cell mobilization in allogenic donors is very important. In this study, we aimed to investigate the effect of smoking on the amount of stem cells collected after peripheral blood stem cell mobilization in allogeneic donors.
Material and Method: The data of 157 allogeneic donors who were performed peripheral stem cell mobilization in our center were analyzed retrospectively. The donors were divided into 2 groups:active smokers (n:80) and non-smokers (n:77). Smokers were divided into two groups as donors who smoked <15 cigarette pack year and those who smoked ≥15 cigarette pack year.
Results: The median CD34+ cell count in the peripheral blood on the 5th day before apheresis was found to be significantly lower in smokers than in non-smokers (p=0.001*). Compared to the donors who smoked <15 cigarette pack year, the median CD34+ cell count in the peripheral blood on the 5th day before apheresis was significantly lower in the donors who smoked ≥15 cigarette pack year (p=0.009*).
Conclusion:During the allogeneic stem cell donor assessment, donors should be questioned for their smoking history. Smoking should be considered as a negative risk factor for peripheral stem cell mobilization, especially in the donors who smoke ≥15 cigarette pack year.

Keywords

cigarette, allogenic donor, stem cell mobilization

Allojenik vericilerde sigaranın kök hücre mobilizasyonu üzerine etkisi

Abstract

Giriş: Sigara kullananlarda, sigaranın bırakılmasından sonra kemik iliğindeki öncü hücre sayısında artış olduğu gösterilmiştir. Allojenik kök hücre nakli sonrası engraftmanın sağlanması için, hastalara yeterli miktarda kök hücre verilmelidir. Bu nedenle, allojenik vericilerde periferik kök hücre mobilizasyonunun başarısını etkileyen faktörlerin belirlenmesi çok önemlidir. Bu çalışmada, sigaranın sağlıklı allojenik vericilerin periferik kan kök hücre mobilizasyonu sonrası toplanan kök hücre miktarı üzerine etkisini araştırmayı amaçladık.
Gereç ve Yöntem:Merkezimizde periferik kök hücre mobilizasyonu yapılan 157 allojenik vericinin verileri retrospektif olarak incelendi. Vericiler aktif sigara içenler (n:80) ve sigara içmeyenler (n:77) olmak üzere 2 kola ayrıldı. Sigara içen vericiler kendi aralarında <15 paket yıl sigara içen ve ≥15 paket yıl sigara içenler olmak üzere 2 gruba ayrılarak incelendi.
Bulgular: Aferez işleminden önceki 5. gün periferik kandaki medyan CD34+ hücre sayısı sigara içen vericilerde sigara içmeyen vericilere göre anlamlı olarak daha düşük saptandı (p=0,001*). Vericilerden ≥15 paket yıl sigara içenlerde; <15 paket yıl sigara içen vericilere kıyasla aferez işleminden önceki 5. gün periferik kandaki medyan CD34+ hücre sayısı, anlamlı olarak daha düşük bulundu (p=0,009*).
Sonuç: Allojenik kök hücre verici değerlendirmesi sırasında, vericiler sigara öyküleri açısından sorgulanmalıdır. Sigara kullanımı, özellikle ≥15 paket yıl sigara içen vericilerde periferik kök hücre mobilizasyonu için negatif bir risk faktörü olarak düşünülmelidir.

Keywords

Sigara, allojenik verici, kök hücre mobilizasyonu

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