The frequency and relationship of osteoporosis and vitamin D deficiency in the female geriatric population in Central Anatolia

Year 2021, Volume: 4 Issue: 2, 223 - 227, 28.03.2021

Tekin Yıldırım

https://doi.org/10.32322/jhsm.889207

Cited By: 1

Abstract

Bacground / Aims: The frequency of osteoporosis increases with age and is an important cause of mortality and morbidity due to hip fractures. The aim of our study is to determine the frequency of osteoporosis and vitamin D deficiency in female geriatric population and to investigate the relationship of vertebral and femur bone mineral densities (BMD) with vitamin D level in this population.
Material and Method: The study included 457 women aged 65 years and older. Vertebra and femur bone mineral densities (BMD) and serum 25-hydroxy vitamin D3 (25 (OH) D3) levels were measured.
Results: The mean age was found to be 72.4 ± 5.7 years. The mean L1-L4 and Femur neck BMD values in the participants were -2.74 ± 0.77, -2.31 ± 0.95 respectively, and the rate of osteoporosis was 72.2% (n = 330). There was no statistically significant difference between age groups in respect to frequency of osteaporosis (p = 0.58). Weak negative correlation was found between femur neck BMD value and age (r = -0.26, p <0.001). Vitamin D level was 13.00 ± 8.80 ng / ml and vitamin D deficiency was 87.4% (n = 387). There was no statistically significant difference between age groups in respect to frequency of vitamin D deficiency (p = 0.16). Similarly, no statistically significant relationship was found between osteoporosis and vitamin D deficiency (p = 0.65).
Conclusion: This study suggested that geographic, cultural, and genetic factors are more important determinants in the development of osteoporosis.

Keywords

Bone mineral density, Central Anatolia, female geriatric population, vitamin D

References

• 1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: highlights of the conference. South Med J. 2001;94(6):569-73.
• 2. Duque G, Demontiero O, Troen BR. Prevention and treatment of senile osteoporosis and hip fractures. Minerva medica. 2009;100(1):79-94.
• 3. Bouillon R, Carmeliet G, Daci E, Segaert S, Verstuyf A. Vitamin D metabolism and action. Osteoporos Int. 1998;8 Suppl 2:13-19. doi: 10.1007/pl00022727.
• 4. Holick MF. Vitamin D deficiency. N Engl J M. 2007;357(3):266-81. doi: 10.1056/NEJMra070553.
• 5. Akesson K, Lau KH, Baylink DJ. Rationale for active vitamin D analog therapy in senile osteoporosis. Calcif Tissue Int. 1997;60(1):100-5. doi: 10.1007/s002239900195.
• 6. Girgis CM. Vitamin D and muscle function in the elderly: the elixir of youth? Curr Opin Clin Nutr Metab Care. 2014;17(6):546-50. doi: 10.1097/MCO.0000000000000104.
• 7. Lupsa BC, Insogna K. Bone Health and Osteoporosis. Endocrinology and metabolism clinics of North America. 2015;44(3):517-30. doi: 10.1016/j.ecl.2015.05.002.
• 8. van der Wielen RP, Lowik MR, van den Berg H, de Groot LC, Haller J, et al. Serum vitamin D concentrations among elderly people in Europe. Lancet. 1995;346(8969):207-10. doi: 10.1016/s0140-6736(95)91266-5.
• 9. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004;116(9):634-9. doi: 10.1016/j.amjmed.2003.12.029.
• 10. Hirani V, Primatesta P. Vitamin D concentrations among people aged 65 years and over living in private households and institutions in England: population survey. Age Ageing. 2005;34(5):485-91. doi: 10.1093/ageing/afi153.
• 11. Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of Vitamin D deficiency and effects of ultraviolet light on Vitamin D levels in elderly Turkish population. Arch Gerontol Geriatr. 2005;40(1):53-60. doi: 10.1016/j.archger.2004.05.006.
• 12. Olszynski WP, Shawn Davison K, Adachi JD, Brown JP, Cummings SR, et al. Osteoporosis in men: epidemiology, diagnosis, prevention, and treatment. Clin Ther. 2004;26(1):15-28. doi: 10.1016/s0149-2918(04)90002-1.
• 13. Yendt ER, Kovacs KA, Jones G. Secondary hyperparathyroidism in primary osteoporosis and osteopenia: optimizing calcium and vitamin D intakes to levels recommended by expert panels may not be sufficient for correction. Clin Endocrinol. 2008;69(6):855-63. doi: 10.1111/j.1365-2265.2008.03261.x.
• 14. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;7(5):439-43. doi: 10.1007/s001980050030.
• 15. Allain TJ, Dhesi J. Hypovitaminosis D in older adults. Gerontol. 2003;49(5):273-8. doi: 10.1159/000071707.
• 16. Sahota O, Mundey MK, San P, Godber IM, Lawson N, et al. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone. 2004;35(1):312-9. doi: 10.1016/j.bone.2004.02.003.
• 17. Sahota O, Masud T, San P, Hosking DJ. Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis. Clin Endocrinol. 1999;51(2):217-21. doi: 10.1046/j.1365-2265.1999.00764.x.