Case Report
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Year 2021, Volume: 4 Issue: 6, 967 - 969, 24.09.2021
https://doi.org/10.32322/jhsm.888191

Abstract

References

  • Rodbard D. Continuous glucose monitoring: a review of recent studies demonstrating improved glycemic outcomes. Diabetes Technol Ther 2017; 19: 25–37.
  • Blum A. Freestyle libre glucose monitoring system. Clin Diabetes 2018; 36: 203–4.
  • Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus–infected pneumonia in Wuhan, China. JAMA 2020; 323: 1061.
  • Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507–13.
  • Tang Z, Du X, Louie RF, Kost GJ. Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer. Am J Clin Pathol 2000; 113: 75–86.
  • Boretti A, Banik BK. Intravenous Vitamin C for reduction of cytokines storm in acute respiratory distress syndrome. PharmaNutrition 2020; 12: 100190.
  • Cheng RZ. Can early and a high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Med Drug Discov 2020; 5: 100028.
  • Hecker L. Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace. Am J Physiol Cell Mol Physiol 2018; 314: 642–53.
  • Basu A, Slama MQ, Nicholson WT, et al. Continuous glucose monitor interference with commonly prescribed medications: a pilot study. J Diabetes Sci Technol 2017; 11: 936–41.
  • Calhoun P, Johnson TK, Hughes J, Price D, Balo AK. Resistance to acetaminophen interference in a novel continuous glucose monitoring system. J Diabetes Sci Technol 2018; 12: 393–6.
  • Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GD. Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diabetes Obes Metab 2019; 21: 674–82.
  • Ashor AW, Werner AD, Lara J, Willis ND, Mathers JC, Siervo M. Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr 2017; 71: 1371–80.
  • Doupis J, Avramidis K. Managing diabetes during the COVID-19 pandemic. Eur Endocrinol 2020; 16: 85.

Interference of high dose intravenous vitamin C with blood glucose testing in a patient with COVID-19 infection

Year 2021, Volume: 4 Issue: 6, 967 - 969, 24.09.2021
https://doi.org/10.32322/jhsm.888191

Abstract

Flash glucose monitoring system (FGMs) is an option for patients to monitor their glucose however, the presence of interfering substances can result in false blood glucose readings. The COVID-19 (SARS-2-Cov) pandemic has resulted in substantial damage to the public and currently, no effective treatment is available for this deadly disease. Intravenous vitamin C (VC) has been shown to attenuate the cytokine storm in COVID-19 infection. Studies suggest that vitamin C supplementation reduces blood glucose in diabetic patients. On the other hand, VC can affect glucose readings obtained by devices in varying degrees. Here, we present a diabetic patient diagnosed with COVID-19 infection, who had false increased blood glucose readings on FGM after VC treatment. A 45-year-old woman with T2DM was diagnosed with a COVID-19 infection. Intravenous VC at a dose of 2500mg five times was added to the standard treatment protocol due to COVID-19 pneumonia. Her flash glucose levels were consistently elevated during intravenous VC infusion and returned to her normal average values after cessation of infusion. Insulin was not given at the time of fluctuations in blood glucose readings because both fingerstick and venous blood glucose measurements at the time of VC infusion were not consistent with the FGM readings. False increase in blood glucose readings due to interfering substances should be kept in mind since correction with insulin or antidiabetics may lead to a potential for dangerous life-threatening hypoglycemic events.

References

  • Rodbard D. Continuous glucose monitoring: a review of recent studies demonstrating improved glycemic outcomes. Diabetes Technol Ther 2017; 19: 25–37.
  • Blum A. Freestyle libre glucose monitoring system. Clin Diabetes 2018; 36: 203–4.
  • Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus–infected pneumonia in Wuhan, China. JAMA 2020; 323: 1061.
  • Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507–13.
  • Tang Z, Du X, Louie RF, Kost GJ. Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer. Am J Clin Pathol 2000; 113: 75–86.
  • Boretti A, Banik BK. Intravenous Vitamin C for reduction of cytokines storm in acute respiratory distress syndrome. PharmaNutrition 2020; 12: 100190.
  • Cheng RZ. Can early and a high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Med Drug Discov 2020; 5: 100028.
  • Hecker L. Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace. Am J Physiol Cell Mol Physiol 2018; 314: 642–53.
  • Basu A, Slama MQ, Nicholson WT, et al. Continuous glucose monitor interference with commonly prescribed medications: a pilot study. J Diabetes Sci Technol 2017; 11: 936–41.
  • Calhoun P, Johnson TK, Hughes J, Price D, Balo AK. Resistance to acetaminophen interference in a novel continuous glucose monitoring system. J Diabetes Sci Technol 2018; 12: 393–6.
  • Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GD. Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diabetes Obes Metab 2019; 21: 674–82.
  • Ashor AW, Werner AD, Lara J, Willis ND, Mathers JC, Siervo M. Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr 2017; 71: 1371–80.
  • Doupis J, Avramidis K. Managing diabetes during the COVID-19 pandemic. Eur Endocrinol 2020; 16: 85.
There are 13 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Engin Karagoz This is me 0000-0003-1131-3590

Muhammed Kizilgul 0000-0002-8468-9196

Publication Date September 24, 2021
Published in Issue Year 2021 Volume: 4 Issue: 6

Cite

AMA Karagoz E, Kizilgul M. Interference of high dose intravenous vitamin C with blood glucose testing in a patient with COVID-19 infection. J Health Sci Med / JHSM. September 2021;4(6):967-969. doi:10.32322/jhsm.888191

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