Dapsone can be a new treatment option for reducing the detrimental effect of priapism

Year 2021, Volume: 4 Issue: 6, 800 - 808, 24.09.2021

Engin Kölükçü , Bekir Süha Parlaktaş , Nihat Uluocak , Faik Deresoy , Velid Unsal , Muzaffer Katar

https://doi.org/10.32322/jhsm.963439

Cited By: 1

Abstract

Aim: This study aims to analyze the effect of dapsone against ischaemia-reperfusion injury on corporal tissue in a model of induced-priapism in rats.
Material and Method: A total of 24 rats were randomized into three groups. Group 1 was defined as the control group. Ischaemia-reperfusion injury was evaluated following the priapism model in Group 2. Group 3 had similar procedures to the rats in Group 2. Group 3 additionally had 12.5 mg/kg dapsone administered intraperitoneally 30 minutes after priapism.
Results: Biochemical analysis of blood indicated a significant increase in Group 3 in terms of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and total antioxidant status (TAS) values compared with Group 2 (p:0.002, p:0.029 and p:0.009, respectively). The highest values of malondialdehyde (MDA), protein carbonyl (PC) and total oxidant status (TOS) were recorded in Group 2 (p<0.001). Interleukin 1beta (IL-1beta), Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF alpha) levels were found to be significantly decreased in Group 3 compared with Group 2 (p:0.022, p:0.049 and p<0.001, respectively). Direct microscopic evaluation determined an improvement in inflammation, edema, desquamation and vasocongestion scores in Group 3 compared to Group 2 (p<0.05).
Conclusion: Dapsone has a protective effect on ischaemia-reperfusion injury in corporal tissue.

Keywords

Dapsone, priapism, ischaemia reperfusion injury, treatment

References

• Reddy AG, Alzweri LM, Gabrielson AT, Leinwand G, Hellstrom WJG. Role of Penile Prosthesis in Priapism: A Review. World J Mens Health 2018; 36: 4-14.
• Tay YK, Spernat D, Rzetelski-West K, Appu S, Love C. Acute management of priapism in men. BJU Int 2012; 109: 15-21.
• Ridgley J, Raison N, Sheikh MI, Dasgupta P, Khan MS, Ahmed K. Ischaemic priapism: A clinical review. Turk J Urol 2017; 43: 1-8.
• Yılmaz Y, Taken K, Atar M, Ergün M, Söylemez H. Protective effect of curcumin on priapism and ischemia-reperfusion injury in rats. Eur Rev Med Pharmacol Sci 2015; 19: 4664-70.
• Karaguzel E, Bayraktar C, Kutlu O, et al. The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism. Int Braz J Urol 2016; 42: 146-53.
• Uluocak N, Atılgan D, Erdemir F, et al. An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. Int Urol Nephrol 2010; 42: 889-95.
• Erdemir F, Firat F, Markoc F, et al. The effect of pentoxifylline on penile cavernosal tissues in ischemic priapism-induced rat model. Int Urol Nephrol 2014; 46: 1961-7.
• Ciftci O, Oguz F, Beytur A, Polat F, Altıntas R, Oguzturk H. Lycopene prevents experimental priapism against oxidative and nitrosative damage. Eur Rev Med Pharmacol Sci 2014; 18: 3320-5.
• Çevik Ö, Çadırcı S, Şener TE, et al. Quercetin treatment against ischemia/reperfusion injury in rat corpus cavernosum tissue: a role on apoptosis and oxidative stress. Free Radic Res 2013; 47: 683-91.
• Koca R. Dapsone. Turkiye Klinikleri Dermatology 2014; 7: 43-8.
• Dejban P, Rahimi N, Takzare N, Jahansouz M, Haddadi NS, Dehpour AR. Beneficial effects of dapsone on ischemia/reperfusion injury following torsion/detorsion in ipsilateral and contralateral testes in rat. Theriogenology 2019; 140: 136-42.
• Sheibani M, Nezamoleslami S, Faghir-Ghanesefat H, Hossein Emami A, Dehpour AR. Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats. Cancer Chemother Pharmacol 2020; 85: 563-71.
• Ríos C, Orozco-Suarez S, Salgado-Ceballos H, et al. Anti-Apoptotic Effects of Dapsone After Spinal Cord Injury in Rats. Neurochem Res 2015; 40: 1243-51.
• Wozel G, Blasum C. Dapsone in dermatology and beyond. Arch Dermatol Res 2014; 306: 103-24.
• Liang SE, Hoffmann R, Peterson E, Soter NA. Use of Dapsone in the Treatment of Chronic Idiopathic and Autoimmune Urticaria. JAMA Dermatol 2019; 155: 90-5.
• Diaz-Ruiz A, Mendez-Armenta M, Galván-Arzate S, et al. Antioxidant, anticonvulsive and neuroprotective effects of dapsone and phenobarbital against kainic acid-induced damage in rats. Neurochem Res 2013; 38: 1819-27.
• Abe M, Shimizu A, Yokoyama Y, Takeuchi Y, Ishikawa O. A possible inhibitory action of diaminodiphenyl sulfone on tumour necrosis factor-alpha production from activated mononuclear cells on cutaneous lupus erythematosus. Clin Exp Dermatol 2008; 33: 759-63.
• Nezamoleslami S, Sheibani M, Jahanshahi F, Mumtaz F, Abbasi A, Dehpour AR. Protective effect of dapsone against renal ischemia-reperfusion injury in rat. Immunopharmacol Immunotoxicol 2020; 42: 272-9.
• Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990; 186: 407-21.
• Levine RL, Garland D, Oliver CN, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990; 186: 464-78.
• Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
• Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
• Erel, O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical Biochemistry 2004; 37: 112-9.
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry 2005; 38: 1103-11.
• Senturk GE, Erkanli K, Aydin U, et al. The protective effect of oxytocin on ischemia/reperfusion injury in rat urinary bladder. Peptides 2013; 40: 82-8.
• Levey HR, Segal RL, Bivalacqua TJ. Management of priapism: an update for clinicians. Ther Adv Urol 2014; 6: 230-44.
• El-Bahnasawy MS, Dawood A, Farouk A. Low-flow priapism: risk factors for erectile dysfunction. BJU Int 2002; 89: 285-90.
• Pal DK, Biswal DL, Ghosh B. Outcome and erectile function following treatment of priapism: An institutional experience. Urol Ann 2016; 8: 46-50.
• Kulmala RV, Lehtonen TA, Tammela TL. Preservation of potency after treatment for priapism. Scand J Urol Nephrol 1996; 30: 313-6.
• Sener G, Paskaloğlu K, Sehirli AO, Dülger GA, Alican I. The effects of melatonin on ischemia-reperfusion induced changes in rat corpus cavernosum. J Urol 2002; 167: 2624-7.
• Wu MY, Yiang GT, Liao WT, et al. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem 2018; 46: 1650-67.
• Taati M, Moghadasi M, Dezfoulian O, Asadian P. Effects of ghrelin on testicular ıschemia/reperfusion-ınduced ınjury. Acta Med Iran 2016; 54: 32-8.
• Munarriz R, Park K, Huang YH, et al. Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism. Urology 2003; 62: 760-4.
• Salehzadeh F, Jahangiri S, Mohammadi E. Dapsone as an alternative therapy in children with familial mediterranean Fever. Iran J Pediatr 2012; 22: 23-7.
• Lee JH, Choi SH, Lee CJ, Oh SS. Recovery of dementia syndrome following treatment of brain inflammation. Dement Geriatr Cogn Dis Extra 2020; 10: 1-12.
• Ríos C, Nader-Kawachi J, Rodriguez-Payán AJ, Nava-Ruiz C. Neuroprotective effect of dapsone in an occlusive model of focal ischemia in rats. Brain Res 2004; 999: 212-5.
• Diaz-Ruiz A, Roldan-Valadez E, Ortiz-Plata A, et al. Dapsone improves functional deficit and diminishes brain damage evaluated by 3-Tesla magnetic resonance image after transient cerebral ischemia and reperfusion in rats. Brain Res 2016; 1646: 384-92.