The relationship of laboratory parameters and mortality of patients followed in intensive care units with COVID-19

Year 2022, Volume: 5 Issue: 4, 1015 - 1022, 20.07.2022

Meltem Karacan Gölen , Dilek Yılmaz Okuyan , Ömür İlban , Mahmut Sami Tutar , Şaziye Melike Işık

https://doi.org/10.32322/jhsm.1106106

Abstract

Aim: We aimed to evaluate the parameters associated with mortality in COVID-19 patients followed up in the intensive care unit.
Material and Method: Three hundred twenty-one patients followed up with the diagnosis of COVID-19 were included in the study. Demographic characteristics, laboratory and clinical parameters were compared in patients with and without mortality.
Results: A higher intubation rate (98.6% vs. 10.9%) and longer hospitalization (10.0 vs. 8.0 days) were detected in the non-survivor group (p<0.001). The neutrophil count, ferritin, troponin I, INR, PT, LDH, urea, creatinine, procalcitonin, WBC, CRP, AST, neutrophil/lymphocyte ratio, and CRP/albumin ratio were significantly higher in the non-survivor group, whereas the lymphocyte count, albumin, monocyte, and platelet counts were significantly lower. A multivariate logistic regression model identified endotracheal intubation, high platelet count, low LDH, low albumin, and decreased CRP/albumin ratio as risk factors associated with intensive care unit mortality. Albumin had the highest prognostic accuracy with an AUC of 0.681 (95% CI: 0.621-0.742) and the highest sensitivity (84.5%), and the platelet count had the highest specificity (69.2%).
Conclusion: Advanced age, intubation status, and duration of intubation were associated with mortality, and it was thought that an increase in LDH levels and CRP/albumin ratio and a decrease in albumin levels and platelet counts had predictive value in predicting mortality

Keywords

COVID-19, intensive care, mortality, laboratory parameters

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