Research Article
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Year 2022, Volume: 5 Issue: 5, 1468 - 1472, 25.09.2022
https://doi.org/10.32322/jhsm.1133573

Abstract

References

  • Varga J, Trojanowska M, Kuwana M. Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities. J Scleroderma Relat Disord 2017; 2: 137-52.
  • Lambova SN. Nailfold Capillaroscopy - Practical Implications for Rheumatology Practice. Curr Rheumatol Rev 2020; 16: 79-83.
  • Ingegnoli F, Ardoino I, Boracchi P, Cutolo M; EUSTAR co-authors. Nailfold capillaroscopy in systemic sclerosis: data from the EULAR scleroderma trials and research etEUSTAR) database. Microvasc Res 2013; 89: 122-28.
  • Lambova SN, Müller-Ladner U. Nailfold capillaroscopy in systemic sclerosis - state of the art: The evolving knowledge about capillaroscopic abnormalities in systemic sclerosis. J Scleroderma Relat Disord 2019; 4: 200-11.
  • Maricq HR, LeRoy EC. Patterns of finger capillary abnormalities in connective tissue disease by “wide-field” microscopy. Arthritis Rheum 1973; 16: 619-28.
  • Maricq HR, LeRoy EC, D’Angelo WA, et al. Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 1980; 23: 183-9.
  • Maricq HR, Harper FE, Khan MM, Tan EM, LeRoy EC. Microvascular abnormalities as possible predictors of disease subsets in Raynaud phenomenon and early connective tissue disease. Clin Exp Rheumatol 1983; 1: 195-205.
  • Cutolo M, Sulli A, Pizzorni C, Accardo S. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 2000; 27: 155-60.
  • Avouac J, Fransen J, Walker UA, et al. Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group. Ann Rheum Dis 2011; 70: 476-81.
  • van den Hoogen F, Khanna D, Fransen J, et al 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 2013; 72: 1747–55.
  • Ruaro B, Sulli A, Smith V, et al. Advances in nailfold capillaroscopic analysis in systemic sclerosis. J Scleroderma Relat Disord 2018; 3: 122-31.
  • Clements P, Lachenbruch P, Siebold J, et al. Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis. J Rheumatol 1995; 22: 1281-5.
  • LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202-5.
  • Fries JF, Spitz P, Kraines RG, Holman HR. Measurement of patient outcome in arthritis. Arthritis Rheum 1980; 23: 137-45.
  • Duruöz MT, Poiraudeau S, Fermanian J, et al. Development and validation of a rheumatoid hand functional disability scale that assesses functional handicap. J Rheumatol 1996; 23: 1167-72.
  • Brower LM, Poole JL. Reliability and validity of the Duruoz Hand Index in persons with systemic sclerosis (scleroderma). Arthritis Rheum 2004; 51: 805-9.
  • Cutolo M, Pizzorni C, Sulli A. Capillaroscopy. Best Pract Res Clin Rheumatol 2005; 19: 437-52.
  • Smith V, Riccieri V, Pizzorni C, et al. Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis. J Rheumatol 2013; 40: 2023-8.
  • Smith V, Decuman S, Sulli A, et al. Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? a pilot study. Ann Rheum Dis 2012; 71: 1636-9.
  • Pizzorni C, Sulli A, Paolino S, et al. Progression of Organ Involvement in Systemic Sclerosis Patients with Persistent “Late” Nailfold Capillaroscopic Pattern of Microangiopathy: A Prospective Study. J Rheumatol 2017; 44: 1941-42.
  • Cutolo M, Herrick AL, Distler O, et al. Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study. Arthritis Rheumatol 2016; 68: 2527-39.
  • Hofstee HM, Vonk Noordegraaf A, Voskuyl AE, et al. Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis. Ann Rheum Dis 2009; 68: 191-5.
  • Peytrignet S, Denton CP, Lunt M, et al. Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study. Rheumatology 2018; 57: 370-81.
  • Rannou F, Poiraudeau S, Berezné A, et al. Assessing disability and quality of life in systemic sclerosis: construct validities of the Cochin Hand Function Scale, Health Assessment Questionnaire (HAQ), Systemic Sclerosis HAQ, and Medical Outcomes Study 36-Item Short Form Health Survey. Arthritis Rheum 2007; 57: 94-102.
  • Erol K, Gok K, Cengiz G, Ozgocmen S. Hand functions in systemic sclerosis and rheumatoid arthritis and influence on clinical variables. Int J Rheum Dis 2018; 21: 249-52.
  • Hughes M, Pauling JD. Exploring the patient experience of digital ulcers in systemic sclerosis. Semin Arthritis Rheum 2019; 48: 888-94.

The relationship of nailfold capillaroscopy patterns with clinical features, functional status, pain and fatigue in patients with systemic sclerosis

Year 2022, Volume: 5 Issue: 5, 1468 - 1472, 25.09.2022
https://doi.org/10.32322/jhsm.1133573

Abstract

Aim: To identify the frequency of scleroderma-type capillaroscopic patterns and evaluate the association of capillaroscopic patterns with clinical parameters, functional status, fatigue, and pain in systemic sclerosis (SSc).
Material and Method: This cross-sectional study included SSc patients consecutively between January 2017 and January 2019. Cutaneous involvement was evaluated with the modified Rodnan skin score (mRSS). The presence of digital ulcers, Raynaud phenomenon, interstitial lung disease, pulmonary hypertension, cardiac, gastrointestinal system (GIS), renal, joint and muscle involvement were recorded. The severity of the Raynaud phenomenon, fatigue, pain, and patient global assessment (PGA) was assessed on the Visual Analogue Scale (VAS). The Health Assessment Questionnaire (HAQ) and the Duruoz Hand Index (DHI) were used to assess physical disability and hand function, respectively. Nailfold videocapillaroscopic examinations of the patients were performed, and they were classified into four groups, including normal/non-specific, early, active, and late scleroderma patterns.
Results: The mean age of 32 patients with SSc (31 female, one male) was 48.93±12.77. Anormal capillaroscopic examination findings were detected in 93.7% of the patients, and the most common capillaroscopic pattern was the active pattern. The comparison of scleroderma pattern groups revealed no difference in age (p=0.224), but disease duration was shorter in the early pattern group (p=0.005). The duration and severity of the Raynaud phenomenon, and mean mRSS were lower in the early pattern group (p=0.004, p=0.009, and p=0.001, respectively). The digital ulcer (p=0.011) and diffuse cutaneous SSc (p=0.016) were more common in the late pattern group. The percentage of pulmonary hypertension (p=0.011), GIS involvement (p<0.001), and arthralgia (p=0.027) were higher in the late pattern group. Fatigue (p=0.575), pain (p=0.536), PGA (p=0.861), HAQ (p=0.164) and DHI (p=0.064) scores were not different between the capillaroscopy pattern groups.
Conclusion: Digital ulcer, pulmonary hypertension, and GIS involvement were more common in SSc patients with the late pattern. The fatigue, pain, physical disability, and hand function were similar between capillaroscopy pattern groups.

References

  • Varga J, Trojanowska M, Kuwana M. Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities. J Scleroderma Relat Disord 2017; 2: 137-52.
  • Lambova SN. Nailfold Capillaroscopy - Practical Implications for Rheumatology Practice. Curr Rheumatol Rev 2020; 16: 79-83.
  • Ingegnoli F, Ardoino I, Boracchi P, Cutolo M; EUSTAR co-authors. Nailfold capillaroscopy in systemic sclerosis: data from the EULAR scleroderma trials and research etEUSTAR) database. Microvasc Res 2013; 89: 122-28.
  • Lambova SN, Müller-Ladner U. Nailfold capillaroscopy in systemic sclerosis - state of the art: The evolving knowledge about capillaroscopic abnormalities in systemic sclerosis. J Scleroderma Relat Disord 2019; 4: 200-11.
  • Maricq HR, LeRoy EC. Patterns of finger capillary abnormalities in connective tissue disease by “wide-field” microscopy. Arthritis Rheum 1973; 16: 619-28.
  • Maricq HR, LeRoy EC, D’Angelo WA, et al. Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 1980; 23: 183-9.
  • Maricq HR, Harper FE, Khan MM, Tan EM, LeRoy EC. Microvascular abnormalities as possible predictors of disease subsets in Raynaud phenomenon and early connective tissue disease. Clin Exp Rheumatol 1983; 1: 195-205.
  • Cutolo M, Sulli A, Pizzorni C, Accardo S. Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 2000; 27: 155-60.
  • Avouac J, Fransen J, Walker UA, et al. Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research Group. Ann Rheum Dis 2011; 70: 476-81.
  • van den Hoogen F, Khanna D, Fransen J, et al 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 2013; 72: 1747–55.
  • Ruaro B, Sulli A, Smith V, et al. Advances in nailfold capillaroscopic analysis in systemic sclerosis. J Scleroderma Relat Disord 2018; 3: 122-31.
  • Clements P, Lachenbruch P, Siebold J, et al. Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis. J Rheumatol 1995; 22: 1281-5.
  • LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202-5.
  • Fries JF, Spitz P, Kraines RG, Holman HR. Measurement of patient outcome in arthritis. Arthritis Rheum 1980; 23: 137-45.
  • Duruöz MT, Poiraudeau S, Fermanian J, et al. Development and validation of a rheumatoid hand functional disability scale that assesses functional handicap. J Rheumatol 1996; 23: 1167-72.
  • Brower LM, Poole JL. Reliability and validity of the Duruoz Hand Index in persons with systemic sclerosis (scleroderma). Arthritis Rheum 2004; 51: 805-9.
  • Cutolo M, Pizzorni C, Sulli A. Capillaroscopy. Best Pract Res Clin Rheumatol 2005; 19: 437-52.
  • Smith V, Riccieri V, Pizzorni C, et al. Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis. J Rheumatol 2013; 40: 2023-8.
  • Smith V, Decuman S, Sulli A, et al. Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? a pilot study. Ann Rheum Dis 2012; 71: 1636-9.
  • Pizzorni C, Sulli A, Paolino S, et al. Progression of Organ Involvement in Systemic Sclerosis Patients with Persistent “Late” Nailfold Capillaroscopic Pattern of Microangiopathy: A Prospective Study. J Rheumatol 2017; 44: 1941-42.
  • Cutolo M, Herrick AL, Distler O, et al. Nailfold Videocapillaroscopic Features and Other Clinical Risk Factors for Digital Ulcers in Systemic Sclerosis: A Multicenter, Prospective Cohort Study. Arthritis Rheumatol 2016; 68: 2527-39.
  • Hofstee HM, Vonk Noordegraaf A, Voskuyl AE, et al. Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis. Ann Rheum Dis 2009; 68: 191-5.
  • Peytrignet S, Denton CP, Lunt M, et al. Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study. Rheumatology 2018; 57: 370-81.
  • Rannou F, Poiraudeau S, Berezné A, et al. Assessing disability and quality of life in systemic sclerosis: construct validities of the Cochin Hand Function Scale, Health Assessment Questionnaire (HAQ), Systemic Sclerosis HAQ, and Medical Outcomes Study 36-Item Short Form Health Survey. Arthritis Rheum 2007; 57: 94-102.
  • Erol K, Gok K, Cengiz G, Ozgocmen S. Hand functions in systemic sclerosis and rheumatoid arthritis and influence on clinical variables. Int J Rheum Dis 2018; 21: 249-52.
  • Hughes M, Pauling JD. Exploring the patient experience of digital ulcers in systemic sclerosis. Semin Arthritis Rheum 2019; 48: 888-94.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Didem Erdem Gürsoy 0000-0003-4962-0385

Halise Hande Gezer 0000-0001-8790-304X

Sevtap Acer 0000-0002-4805-0555

Hatice Şule Baklacıoğlu This is me 0000-0001-9062-8675

Mehmet Tuncay Duruöz 0000-0003-3584-2788

Publication Date September 25, 2022
Published in Issue Year 2022 Volume: 5 Issue: 5

Cite

AMA Erdem Gürsoy D, Gezer HH, Acer S, Baklacıoğlu HŞ, Duruöz MT. The relationship of nailfold capillaroscopy patterns with clinical features, functional status, pain and fatigue in patients with systemic sclerosis. J Health Sci Med / JHSM. September 2022;5(5):1468-1472. doi:10.32322/jhsm.1133573

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