Research Article
BibTex RIS Cite
Year 2022, Volume: 5 Issue: 6, 1512 - 1517, 25.10.2022
https://doi.org/10.32322/jhsm.1160392

Abstract

References

  • World Health Organization. WHO Coronavirus (COVID-19) Dashboard. https //covid19.who.int/ (accessed date: 19 April 2022).
  • Marin BG, Aghagoli G, Lavine K, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol 2021; 31:1-10.
  • Qi J, He D, Yang D, et al. Severity-associated markers and assessment model for predicting the severity of COVID-19: a retrospective study in Hangzhou, China. BMC Infect Dis 2021; 21: 774.
  • Hou H, Zhang B, Huang H, et al. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Clin Exp Immunol 2020; 201: 76-84.
  • Smilowitz NR, Kunichoff D, Garshick M, et al. C-reactive protein and clinical outcomes in patients with COVID-19. Eur Heart J 2021; 42: 2270-9.
  • Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med 2020; 58: 1021-8.
  • Wang S, Sheng Y, Tu J, Zhang L. Association between peripheral lymphocyte count and the mortality risk of COVID-19 inpatients. BMC Pulm Med 2021; 21: 55.
  • Vardon-Bounes F, Gratacap MP, Groyer S, et al. Kinetics of mean platelet volume predicts mortality in patients with septic shock. PLoS One 2019; 14: e0223553.
  • Güçlü E, Kocayiğit H, Okan HD, et al. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras (1992) 2020; 66: 1122-7.
  • Vélez-Páez JL, Legua P, Vélez-Páez P, et al. Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis. PLoS One 2022; 17: e0262356.
  • Zhang Z, Xu X, Ni H, Deng H. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 2014; 29: 885.
  • Liu Y, Sun W, Guo Y, et al. Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets 2020; 31: 490-6.
  • Larsen JB, Pasalic L, Hvas AM. Platelets in coronavirus disease 2019. Semin Thromb Hemost 2020; 46: 823-5.
  • Pujani M, Raychaudhuri S, Verma N, et al. Association of Hematologic biomarkers and their combinations with disease severity and mortality in COVID-19- an Indian perspective. Am J Blood Res 2021; 11: 180-90.
  • Ostadi Z, Shadvar K, Sanaie S, Mahmoodpoor A, Saghaleini SH: Thrombocytopenia in the intensive care unit. Pak J Med Sci 2019; 35: 282-7.
  • Shankaralingappa A, Tummidi S, Arun Babu T. Diagnostic value of platelet indices in COVID 19 infection: a case-control study from a single tertiary care center. Egypt J Intern Med 2022; 34: 35.
  • Golwala ZM, Shah H, Gupta N, Sreenivas V, Puliyel JM. Mean platelet volume (MPV), platelet distribution width (PDW), platelet count and plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study. Afr Health Sci 2016; 16: 356-62.
  • Mobarki AA, Dobie G, Saboor M, et al. MPR and NLR as prognostic markers in ICU-admitted patients with COVID-19 in Jazan, Saudi Arabia. Infect Drug Resist 2021; 14: 4859-64.
  • Yardımcı AC, Yıldız S, Ergen E, et al. Association between platelet indices and the severity of the disease and mortality in patients with COVID-19. Eur Rev Med Pharmacol Sci 2021; 25: 6731-40.
  • Shen Y, Huang X, Zhang W. Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: interaction effect with disease severity-a retrospective study. BMJ Open 2019; 9: e022896.
  • Damar Çakırca T, Torun A, Çakırca G, Portakal RD. Role of NLR, PLR, ELR and CLR in differentiating COVID-19 patients with and without pneumonia. Int J Clin Pract 2021; 75: e14781.
  • Sarkar S, Kannan S, Khanna P, Singh AK. Role of platelet-to-lymphocyte count ratio (PLR), as a prognostic indicator in COVID-19: a systematic review and meta-analysis. J Med Virol 2022; 94: 211-21.
  • Gao YD, Ding M, Dong X, et al. Risk factors for severe and critically ill COVID-19 patients: a review. Allergy 2021; 76: 428-55.
  • Wang J, Jiang M, Chen X, Montaner LJ. Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. J Leukoc Biol 2020; 108: 17-41.
  • Han Q, Wen X, Wang L, et al. Role of hematological parameters in the diagnosis of influenza virus infection in patients with respiratory tract infection symptoms. J Clin Lab Anal 2020; 34: e23191.
  • Wang X, Li X, Shang Y, et al. Ratios of neutrophil-to-lymphocyte and platelet-to-lymphocyte predict all-cause mortality in inpatients with coronavirus disease 2019 (COVID-19): a retrospective cohort study in a single medical centre. Epidemiol Infect 2020; 148: e211.
  • Simadibrata DM, Calvin J, Wijaya AD, Ibrahim NAA. Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis. Am J Emerg Med 2021; 42: 60-9.

Platelet-to-lymphocyte ratio and mean platelet volume-to-platelet count ratio for predicting mortality in critical COVID-19 patients

Year 2022, Volume: 5 Issue: 6, 1512 - 1517, 25.10.2022
https://doi.org/10.32322/jhsm.1160392

Abstract

Introduction: Defining the markers that can be used in clinical practice for predicting the mortality of critical patients will be cautionary for taking necessary measures in high-risk cases. Although there are a large number of studies conducted during the pandemic, no mortality marker to predict the prognosis of intensive care unit (ICU) patients with COVID-19 has yet been defined. Platelet indices can be easily evaluated with a complete blood count (CBC) analysis, one of the most accessible tests worldwide. This study aimed to evaluate the role of platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet-to-lymphocyte ratio (PLR), and MPV-to-platelet count ratio (MPV/PLT) in predicting the mortality of ICU patients with COVID-19.
Material and Method: This single-center, retrospective, cross-sectional study included 201 critical COVID-19 patients over 18 years of age who were hospitalized in ICU between August 2020 and February 2021. Patients were divided into two groups as survivors and non-survivors. The relationship of MPV, PDW, PCT, PLR, and MPV/PLT parameters evaluated at ICU admission with mortality was investigated.
Results: There was no significant difference between the survivor and non-survivor groups in terms of platelet count, MPV, PCT, and PDW. The comparison of the platelet ratios revealed higher PLR and MPV/PLT ratio in the non-survivor group than in the survivor group (p<0.05). The cut-off value of PLR for predicting mortality was found to be 292.20 (AUC: 0.601 [95% CI 0.522-0.681]) (p<0.05), while the cut-off of MPV/PLT was found to be 0.0289 (AUC: 0.590 [95% CI 0.510-0.671]) (p<0.05).
Conclusion: The results of this study demonstrated PLR and MPV/PLT ratio were associated with mortality. The use of ratios such as MPV/PLT and PLR as an early prognostic indicator instead of platelet indices alone, like MPV in ICU patients with COVID-19, may help identify high-risk patients early.

References

  • World Health Organization. WHO Coronavirus (COVID-19) Dashboard. https //covid19.who.int/ (accessed date: 19 April 2022).
  • Marin BG, Aghagoli G, Lavine K, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol 2021; 31:1-10.
  • Qi J, He D, Yang D, et al. Severity-associated markers and assessment model for predicting the severity of COVID-19: a retrospective study in Hangzhou, China. BMC Infect Dis 2021; 21: 774.
  • Hou H, Zhang B, Huang H, et al. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Clin Exp Immunol 2020; 201: 76-84.
  • Smilowitz NR, Kunichoff D, Garshick M, et al. C-reactive protein and clinical outcomes in patients with COVID-19. Eur Heart J 2021; 42: 2270-9.
  • Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med 2020; 58: 1021-8.
  • Wang S, Sheng Y, Tu J, Zhang L. Association between peripheral lymphocyte count and the mortality risk of COVID-19 inpatients. BMC Pulm Med 2021; 21: 55.
  • Vardon-Bounes F, Gratacap MP, Groyer S, et al. Kinetics of mean platelet volume predicts mortality in patients with septic shock. PLoS One 2019; 14: e0223553.
  • Güçlü E, Kocayiğit H, Okan HD, et al. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras (1992) 2020; 66: 1122-7.
  • Vélez-Páez JL, Legua P, Vélez-Páez P, et al. Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis. PLoS One 2022; 17: e0262356.
  • Zhang Z, Xu X, Ni H, Deng H. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 2014; 29: 885.
  • Liu Y, Sun W, Guo Y, et al. Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets 2020; 31: 490-6.
  • Larsen JB, Pasalic L, Hvas AM. Platelets in coronavirus disease 2019. Semin Thromb Hemost 2020; 46: 823-5.
  • Pujani M, Raychaudhuri S, Verma N, et al. Association of Hematologic biomarkers and their combinations with disease severity and mortality in COVID-19- an Indian perspective. Am J Blood Res 2021; 11: 180-90.
  • Ostadi Z, Shadvar K, Sanaie S, Mahmoodpoor A, Saghaleini SH: Thrombocytopenia in the intensive care unit. Pak J Med Sci 2019; 35: 282-7.
  • Shankaralingappa A, Tummidi S, Arun Babu T. Diagnostic value of platelet indices in COVID 19 infection: a case-control study from a single tertiary care center. Egypt J Intern Med 2022; 34: 35.
  • Golwala ZM, Shah H, Gupta N, Sreenivas V, Puliyel JM. Mean platelet volume (MPV), platelet distribution width (PDW), platelet count and plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study. Afr Health Sci 2016; 16: 356-62.
  • Mobarki AA, Dobie G, Saboor M, et al. MPR and NLR as prognostic markers in ICU-admitted patients with COVID-19 in Jazan, Saudi Arabia. Infect Drug Resist 2021; 14: 4859-64.
  • Yardımcı AC, Yıldız S, Ergen E, et al. Association between platelet indices and the severity of the disease and mortality in patients with COVID-19. Eur Rev Med Pharmacol Sci 2021; 25: 6731-40.
  • Shen Y, Huang X, Zhang W. Platelet-to-lymphocyte ratio as a prognostic predictor of mortality for sepsis: interaction effect with disease severity-a retrospective study. BMJ Open 2019; 9: e022896.
  • Damar Çakırca T, Torun A, Çakırca G, Portakal RD. Role of NLR, PLR, ELR and CLR in differentiating COVID-19 patients with and without pneumonia. Int J Clin Pract 2021; 75: e14781.
  • Sarkar S, Kannan S, Khanna P, Singh AK. Role of platelet-to-lymphocyte count ratio (PLR), as a prognostic indicator in COVID-19: a systematic review and meta-analysis. J Med Virol 2022; 94: 211-21.
  • Gao YD, Ding M, Dong X, et al. Risk factors for severe and critically ill COVID-19 patients: a review. Allergy 2021; 76: 428-55.
  • Wang J, Jiang M, Chen X, Montaner LJ. Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. J Leukoc Biol 2020; 108: 17-41.
  • Han Q, Wen X, Wang L, et al. Role of hematological parameters in the diagnosis of influenza virus infection in patients with respiratory tract infection symptoms. J Clin Lab Anal 2020; 34: e23191.
  • Wang X, Li X, Shang Y, et al. Ratios of neutrophil-to-lymphocyte and platelet-to-lymphocyte predict all-cause mortality in inpatients with coronavirus disease 2019 (COVID-19): a retrospective cohort study in a single medical centre. Epidemiol Infect 2020; 148: e211.
  • Simadibrata DM, Calvin J, Wijaya AD, Ibrahim NAA. Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis. Am J Emerg Med 2021; 42: 60-9.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Hayriye CANKAR DAL 0000-0003-4744-9959

Kudret Yasemin YALNIZ 0000-0002-4312-7867

Damla TOSUN 0000-0002-5656-3940

Bilge GÖZÜKARA 0000-0003-2661-7028

Hülya ŞİRİN 0000-0001-8489-5005

Cihangir DOĞU 0000-0003-2581-541X

Dilek ÖZTÜRK KAZANCI 0000-0002-8021-1451

Sema TURAN 0000-0003-2443-0390

Publication Date October 25, 2022
Published in Issue Year 2022 Volume: 5 Issue: 6

Cite

AMA CANKAR DAL H, YALNIZ KY, TOSUN D, GÖZÜKARA B, ŞİRİN H, DOĞU C, ÖZTÜRK KAZANCI D, TURAN S. Platelet-to-lymphocyte ratio and mean platelet volume-to-platelet count ratio for predicting mortality in critical COVID-19 patients. J Health Sci Med / JHSM. October 2022;5(6):1512-1517. doi:10.32322/jhsm.1160392

Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS].

The Directories (indexes) and Platforms we are included in are at the bottom of the page.

Note: Our journal is not WOS indexed and therefore is not classified as Q.

You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/2316/file/4905/show







The indexes of the journal are ULAKBİM TR Dizin, Index Copernicus, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, EuroPub, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, etc.

       images?q=tbn:ANd9GcRB9r6zRLDl0Pz7om2DQkiTQXqDtuq64Eb1Qg&usqp=CAU

500px-WorldCat_logo.svg.png

atifdizini.png

logo_world_of_journals_no_margin.png

images?q=tbn%3AANd9GcTNpvUjQ4Ffc6uQBqMQrqYMR53c7bRqD9rohCINkko0Y1a_hPSn&usqp=CAU

doaj.png  

images?q=tbn:ANd9GcSpOQFsFv3RdX0lIQJC3SwkFIA-CceHin_ujli_JrqBy3A32A_Tx_oMoIZn96EcrpLwTQg&usqp=CAU

ici2.png

asos-index.png

drji.png





The platforms of the journal are Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons, etc.

COPE-logo-300x199.jpgimages?q=tbn:ANd9GcQR6_qdgvxMP9owgnYzJ1M6CS_XzR_d7orTjA&usqp=CAU

icmje_1_orig.png

cc.logo.large.png

ncbi.pngimages?q=tbn:ANd9GcRBcJw8ia8S9TI4Fun5vj3HPzEcEKIvF_jtnw&usqp=CAU

ORCID_logo.png

1*mvsP194Golg0Dmo2rjJ-oQ.jpeg


Our Journal using the DergiPark system indexed are;

Ulakbim TR Dizin,  Index Copernicus, ICI World of JournalsDirectory of Research Journals Indexing (DRJI), General Impact FactorASOS Index, OpenAIRE, MIAR,  EuroPub, WorldCat (OCLC)DOAJ,  Türkiye Citation Index, Türk Medline Index, InfoBase Index


Our Journal using the DergiPark system platforms are;

Google, Google Scholar, CrossRef (DOI), ResearchBib, ICJME, COPE, NCBI, ORCID, Creative Commons, Open Access, and etc.


Journal articles are evaluated as "Double-Blind Peer Review". 

Our journal has adopted the Open Access Policy and articles in JHSM are Open Access and fully comply with Open Access instructions. All articles in the system can be accessed and read without a journal user.  https//dergipark.org.tr/tr/pub/jhsm/page/9535

Journal charge policy   https://dergipark.org.tr/tr/pub/jhsm/page/10912


Editor List for 2022

Assoc. Prof. Alpaslan TANOĞLU (MD)  

Prof. Aydın ÇİFCİ (MD)

Prof. İbrahim Celalaettin HAZNEDAROĞLU (MD)

Prof. Murat KEKİLLİ (MD)

Prof. Yavuz BEYAZIT (MD) 

Prof. Ekrem ÜNAL (MD)

Prof. Ahmet EKEN (MD)

Assoc. Prof. Ercan YUVANÇ (MD)

Assoc. Prof. Bekir UÇAN (MD) 

Assoc. Prof. Mehmet Sinan DAL (MD)


Our journal has been indexed in DOAJ as of May 18, 2020.

Our journal has been indexed in TR-Dizin as of March 12, 2021.


17873

Articles published in the Journal of Health Sciences and Medicine have open access and are licensed under the Creative Commons CC BY-NC-ND 4.0 International License.