Role of systemic immune-inflammation index in predicting mortality in cancer patients in palliative care units

Year 2023, Volume: 6 Issue: 2, 223 - 227, 27.03.2023

Duygu Tutan , Fatih Eskin

https://doi.org/10.32322/jhsm.1227572

Cited By: 1

Abstract

Aim: In our study, we aimed to investigate whether the systemic immune-inflammation index (SII) can evaluate mortality in cancer patients treated in the palliative care unit (PCU).
Material and Method: Cancer patients who received palliative care treatments in the PCU were screened retrospectively, and 309 patients were included in the study. The patients were divided into two groups; hospitalizations ending with discharge as Group 1 (n=154) and hospitalizations ending with exitus as Group 2 (n=155). SII values of the two groups were compared. SII was calculated with the formula of neutrophil count x platelet count / lymphocyte count. To determine the best cut-off value for the mortality distinction ability of the SII, a Receiver Operating Curve (ROC) analysis was used.
Results: The mean age and distribution of genders of the two groups were similar (p=0.706, p=0.964). There was a statistically significant difference between the SII values of the two groups (p<0.001). SII was successful in predicting mortality in cancer patients hospitalized in PCU, and the probability of mortality in patients with an SII value of 1426.29 and above at the time of hospitalization was approximately 1.8 times higher than in patients with a value below 1426.29.
Conclusion: We found that high SII values could predict mortality in cancer patients receiving palliative care in PCU. We think that SII, which is inexpensive, easily accessible, and easily calculated with only peripheral blood cell count, will provide clinicians working in PCU with important benefits, such as achieving more accurate prognostic results for the selection of treatment modalities and mortality estimation when combined with their own clinical experience. We recommend that SII be calculated in all cancer patients hospitalized in PCUs and that patients with high SII values should be followed more closely.

Keywords

palliative care, SII, cancer, mortality

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