The relationship between levels of apolipoprotein A1 and B in aqueous and serum with stage of diabetic retinopathy

Year 2023, Volume: 6 Issue: 2, 546 - 551, 27.03.2023

İnci Elif Erbahçeci Timur , Kemal Örnek , Osman Çağlayan

https://doi.org/10.32322/jhsm.1253299

Abstract

Aim: To determine the association between serum and aqueous apolipoprotein (Apo) A1 and Apo B levels and Apo B/A1 ratio in diabetic retinopathy.
Material and Method: This cross-sectional prospective study included 63 diabetic patients with or without retinopathy and 38 control subjects who underwent cataract surgery. The study groups were as follows; healthy subjects (Group 1), diabetic patients without retinopathy (Group 2), with non-proliferative diabetic retinopathy (Group 3), and with proliferative diabetic retinopathy (Group 4). Serum and aqueous Apo A1 and Apo B levels were determined by using an enzyme-linked immunosorbent assay.
Results: The amount of Apo B was determined in aqueous samples of all (100%) patients in Group 4 and 77.7% of patients in Group 3.The mean serum Apo B/A1 ratio was significantly higher in Group 2, Group 3 and Group 4 compared with Group 1 (p=0.002, p=0.037 and p<0.001, respectively). The aqueous Apo B level, aqueous and serum Apo B/A1 levels were significantly correlated with the severity of retinopathy in diabetic patients (all p<0.001).
Conclusion: Higher serum and aqueous Apo B/A1 ratio were significantly associated with the stage of diabetic retinopathy.

Keywords

aqueous humor, diabetic retinopathy, apolipoprotein A1, apolipoprotein B

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