Research Article
BibTex RIS Cite

The relationship of erectile dysfunction severity with nocturnal blood pressure pattern and RDW

Year 2024, Volume: 7 Issue: 3, 332 - 336, 27.05.2024
https://doi.org/10.32322/jhsm.1476358

Abstract

Aims: The study aimed to investigate the relationship between the severity of erectile dysfunction (ED), nocturnal blood pressure patterns, and red blood cell width distribution (RDW) in hypertensive patients.
Methods: The study involved 106 hypertensive patients, categorized into non-dippers and dippers based on their nocturnal blood pressure patterns. Key parameters including smoking status, RDW, and International Index of Erectile Function (IIEF) scores, were compared between the groups.
Results: The demographic data of the patients were similar. RDW was significantly higher in patients with non-dipper hypertension (HT) compared to the dipper group. Moderate and severe ED was seen more frequently in the non-dipper HT group (40.4% vs 20.4%; p=0.025). IIEF score was higher in the dipper HT group (17.6±6.9 vs 21.0±4.5; p=0.004). According to logistic regression analysis, age and smoking habit were significant predictors for moderate or severe ED.
Conclusion: The study highlights the significant association between non-dipping blood pressure patterns, elevated RDW, and the severity of ED in hypertensive patients. The findings underscore the importance of monitoring nocturnal blood pressure patterns and RDW in understanding and managing ED in this population.

Ethical Statement

The study received ethical approval from the research committee of Siirt Training and Research Hospital on December 14, 2023, with reference number 94582.

References

  • Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunction. J Urol. 1999;161(1):5-11.
  • Kushiro T, Takahashi A, Saito F, et al. Erectile dysfunction and its influence on quality of life in patients with essential hypertension. Am J Hypertens. 2005;18(3):427-430.
  • Kloner RA. Hypertension as a risk for erectile dysfunction: implications for sildenafil use. J Clin Hypertens. 2000;2(1):33-36.
  • Schwarz ER, Rodriguez J. Sex and the heart. Int J Impot Res. 2005;17(1):S4-S6.
  • Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med. 2007;120(2):151-157.
  • Dursun M, Cimen S, Sulukaya M, Bugday MS, Besiroglu H. The predictive value of red cell distribution width on erectile dysfunction. Andrologia. 2019;51(10):e13374.
  • Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press. 2012;21(3):177-181.
  • Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet. 2007;370(9587):591-603.
  • Altuntas M. Arteriyel hipertansiyon tanısında hasta eğitim düzeyi ve aile hekimliği uygulamasının rolü. Selcuk Med J. 2019; 35(1):31-36
  • Ohkubo T, Hozawa A, Yamaguchi J, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens. 2002;20(11):2183-2189.
  • Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension. 1994;24(6):793-801.
  • Higashi Y, Nakagawa K, Kimura M, et al. Circadian variation of blood pressure and endothelial function in patients with essential hypertension: a comparison of dippers and non-dippers. J Am Coll Cardiol. 2002;40(11):2039-2043.
  • Marinakis AG, Vyssoulis GP, Michaelides AP, Karpanou EA, Cokkinos DV, Toutouzas PK. Impact of abnormal nocturnal blood pressure fall on vascular function. Am J Hypertens. 2003;16(3):209-213.
  • Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822-830.
  • Serefoglu EC, Atmaca AF, Dogan B, Altinova S, Akbulut Z, Balbay MD. Problems in understanding the Turkish translation of the international index of erectile function. J Androl. 2008;29(4):369-373.
  • Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol. 2010;105(3):312-317.
  • Uyarel H, Ergelen M, Cicek G, et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2011;22(3):138-144.
  • Nagajothi N, Braverman A. Elevated red cell distribution width in the diagnosis of thrombotic thrombocytopenic purpura in patients presenting with anemia and thrombocytopenia. South Med J. 2007;100(3):257-259.
  • Isik T, Uyarel H, Tanboga, et al. Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease. Coron Artery Dis. 2012;23(1):51-56.
  • Erdogan A, Keskin E, Sambel M. Red blood cell distribution width values in erectile dysfunction. Rev Int Androl. 2022;20(1):24-30.
  • Sohn MHH. Vascular Erectile Dysfunction. In: Lanzer P, Topol EJ, eds. Pan Vascular Medicine. Springer: 2002:1867-1874. doi: 10.1007/978-3-642-56225-9_133
  • Küçük MF. The relationship between erectile dysfunction and macular and radial peripapillary microvascular densities in Behçet’s patients without ocular involvement. Selcuk Med J. 2022;38(1):8-16.
  • Demir K, Kaya Z, Kayrak M, Bacaksız A, Duman Ç. Orta yaş hipertansif bireylerde kan basıncı kontrolü ve uyku kalitesi arasındaki ilişkinin analizi. Selçuk Üniv Tıp Derg. 2011;27(2):83-87.
  • Costa C, Virag R. The endothelial-erectile dysfunction connection: an essential update. J Sex Med. 2009;6(9):2390-2404.
  • Erden I, Ozhan H, Ordu S, Yalcin S, Caglar O, Kayikci A. The effect of non-dipper pattern of hypertension on erectile dysfunction. Blood Press. 2010;19(4):249-253.
  • Yildirim V, Karakayali M, Uslu M, et al. Association between international index of erectile function-5 scores and circadian patterns of newly diagnosed hypertension in erectile dysfunction patients. Andrologia. 2022;54(1):e14383.
  • Yuvanç E, Simsek V. The effect of nebivolol on erectile dysfunction with Dipper and non Dipper hypertensive patients. Am J Cardiol. 2018;122(4):679-685.
  • Yuvanç E, Dogru MT, Simsek V, Kandemir H, Tuglu D. The effects of nocturnal blood pressure patterns and autonomic alterations on erectile functions in patients with hypertension. Urol J. 2019;16(2):198-204.
  • Ateş İ, Mutlu D, Kaya S, Okutucu M, Sarıer M, Cilingiroglu M. Relationship between masked arterial hypertension and erectile dysfunction. J Mens Health. 2020;16(SP1):e4-e12.
  • Kumaran T, Sujainath N, Rajeshkannan N, Nisahan B. Nocturnal systolic blood pressure pattern of type 2 diabetic hypertensive men with erectile dysfunction: a cross-sectional study from Northern Sri Lanka. BMC Res Notes. 2019;12(1):696.
  • Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 2009;133(4):628-632.
  • Teruhiko I. Detailed association between red blood cell distribution width and heart failure. Clin Cardiol. 2023;46(6):707.
  • Drugescu A, Roca M, Zota IM, et al. Relationships between easily available biomarkers and non-Dipper blood pressure pattern in patients with stable coronary artery disease. Life (Basel). 2023;13(3):640.
  • Latif SB, Das PK, Awal A, et al. Correlation between red cell distribution width and coronary artery disease in patients undergoing elective coronary angiography. Int J Res Med Sci. 2023;11(3):769-774.
  • Buyukkaya E, Erayman A, Karakas, et al. Relation of red cell distribution width with dipper and non-dipper hypertension. Med Glasnik. 2016;13(2):75-81.
Year 2024, Volume: 7 Issue: 3, 332 - 336, 27.05.2024
https://doi.org/10.32322/jhsm.1476358

Abstract

References

  • Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunction. J Urol. 1999;161(1):5-11.
  • Kushiro T, Takahashi A, Saito F, et al. Erectile dysfunction and its influence on quality of life in patients with essential hypertension. Am J Hypertens. 2005;18(3):427-430.
  • Kloner RA. Hypertension as a risk for erectile dysfunction: implications for sildenafil use. J Clin Hypertens. 2000;2(1):33-36.
  • Schwarz ER, Rodriguez J. Sex and the heart. Int J Impot Res. 2005;17(1):S4-S6.
  • Selvin E, Burnett AL, Platz EA. Prevalence and risk factors for erectile dysfunction in the US. Am J Med. 2007;120(2):151-157.
  • Dursun M, Cimen S, Sulukaya M, Bugday MS, Besiroglu H. The predictive value of red cell distribution width on erectile dysfunction. Andrologia. 2019;51(10):e13374.
  • Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press. 2012;21(3):177-181.
  • Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet. 2007;370(9587):591-603.
  • Altuntas M. Arteriyel hipertansiyon tanısında hasta eğitim düzeyi ve aile hekimliği uygulamasının rolü. Selcuk Med J. 2019; 35(1):31-36
  • Ohkubo T, Hozawa A, Yamaguchi J, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens. 2002;20(11):2183-2189.
  • Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension. 1994;24(6):793-801.
  • Higashi Y, Nakagawa K, Kimura M, et al. Circadian variation of blood pressure and endothelial function in patients with essential hypertension: a comparison of dippers and non-dippers. J Am Coll Cardiol. 2002;40(11):2039-2043.
  • Marinakis AG, Vyssoulis GP, Michaelides AP, Karpanou EA, Cokkinos DV, Toutouzas PK. Impact of abnormal nocturnal blood pressure fall on vascular function. Am J Hypertens. 2003;16(3):209-213.
  • Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822-830.
  • Serefoglu EC, Atmaca AF, Dogan B, Altinova S, Akbulut Z, Balbay MD. Problems in understanding the Turkish translation of the international index of erectile function. J Androl. 2008;29(4):369-373.
  • Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol. 2010;105(3):312-317.
  • Uyarel H, Ergelen M, Cicek G, et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2011;22(3):138-144.
  • Nagajothi N, Braverman A. Elevated red cell distribution width in the diagnosis of thrombotic thrombocytopenic purpura in patients presenting with anemia and thrombocytopenia. South Med J. 2007;100(3):257-259.
  • Isik T, Uyarel H, Tanboga, et al. Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease. Coron Artery Dis. 2012;23(1):51-56.
  • Erdogan A, Keskin E, Sambel M. Red blood cell distribution width values in erectile dysfunction. Rev Int Androl. 2022;20(1):24-30.
  • Sohn MHH. Vascular Erectile Dysfunction. In: Lanzer P, Topol EJ, eds. Pan Vascular Medicine. Springer: 2002:1867-1874. doi: 10.1007/978-3-642-56225-9_133
  • Küçük MF. The relationship between erectile dysfunction and macular and radial peripapillary microvascular densities in Behçet’s patients without ocular involvement. Selcuk Med J. 2022;38(1):8-16.
  • Demir K, Kaya Z, Kayrak M, Bacaksız A, Duman Ç. Orta yaş hipertansif bireylerde kan basıncı kontrolü ve uyku kalitesi arasındaki ilişkinin analizi. Selçuk Üniv Tıp Derg. 2011;27(2):83-87.
  • Costa C, Virag R. The endothelial-erectile dysfunction connection: an essential update. J Sex Med. 2009;6(9):2390-2404.
  • Erden I, Ozhan H, Ordu S, Yalcin S, Caglar O, Kayikci A. The effect of non-dipper pattern of hypertension on erectile dysfunction. Blood Press. 2010;19(4):249-253.
  • Yildirim V, Karakayali M, Uslu M, et al. Association between international index of erectile function-5 scores and circadian patterns of newly diagnosed hypertension in erectile dysfunction patients. Andrologia. 2022;54(1):e14383.
  • Yuvanç E, Simsek V. The effect of nebivolol on erectile dysfunction with Dipper and non Dipper hypertensive patients. Am J Cardiol. 2018;122(4):679-685.
  • Yuvanç E, Dogru MT, Simsek V, Kandemir H, Tuglu D. The effects of nocturnal blood pressure patterns and autonomic alterations on erectile functions in patients with hypertension. Urol J. 2019;16(2):198-204.
  • Ateş İ, Mutlu D, Kaya S, Okutucu M, Sarıer M, Cilingiroglu M. Relationship between masked arterial hypertension and erectile dysfunction. J Mens Health. 2020;16(SP1):e4-e12.
  • Kumaran T, Sujainath N, Rajeshkannan N, Nisahan B. Nocturnal systolic blood pressure pattern of type 2 diabetic hypertensive men with erectile dysfunction: a cross-sectional study from Northern Sri Lanka. BMC Res Notes. 2019;12(1):696.
  • Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 2009;133(4):628-632.
  • Teruhiko I. Detailed association between red blood cell distribution width and heart failure. Clin Cardiol. 2023;46(6):707.
  • Drugescu A, Roca M, Zota IM, et al. Relationships between easily available biomarkers and non-Dipper blood pressure pattern in patients with stable coronary artery disease. Life (Basel). 2023;13(3):640.
  • Latif SB, Das PK, Awal A, et al. Correlation between red cell distribution width and coronary artery disease in patients undergoing elective coronary angiography. Int J Res Med Sci. 2023;11(3):769-774.
  • Buyukkaya E, Erayman A, Karakas, et al. Relation of red cell distribution width with dipper and non-dipper hypertension. Med Glasnik. 2016;13(2):75-81.
There are 35 citations in total.

Details

Primary Language English
Subjects Cardiology
Journal Section Original Article
Authors

Muzaffer Aslan 0000-0003-0670-137X

Yunus Emre Yavuz 0000-0002-9901-8141

Dogac Okşen 0000-0003-4548-9543

Erdem Bal 0000-0001-8946-7974

Publication Date May 27, 2024
Submission Date April 30, 2024
Acceptance Date May 20, 2024
Published in Issue Year 2024 Volume: 7 Issue: 3

Cite

AMA Aslan M, Yavuz YE, Okşen D, Bal E. The relationship of erectile dysfunction severity with nocturnal blood pressure pattern and RDW. J Health Sci Med / JHSM. May 2024;7(3):332-336. doi:10.32322/jhsm.1476358

Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS].

The Directories (indexes) and Platforms we are included in are at the bottom of the page.

Note: Our journal is not WOS indexed and therefore is not classified as Q.

You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/2316/file/4905/show







The indexes of the journal are ULAKBİM TR Dizin, Index Copernicus, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, EuroPub, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, etc.

       images?q=tbn:ANd9GcRB9r6zRLDl0Pz7om2DQkiTQXqDtuq64Eb1Qg&usqp=CAU

500px-WorldCat_logo.svg.png

atifdizini.png

logo_world_of_journals_no_margin.png

images?q=tbn%3AANd9GcTNpvUjQ4Ffc6uQBqMQrqYMR53c7bRqD9rohCINkko0Y1a_hPSn&usqp=CAU

doaj.png  

images?q=tbn:ANd9GcSpOQFsFv3RdX0lIQJC3SwkFIA-CceHin_ujli_JrqBy3A32A_Tx_oMoIZn96EcrpLwTQg&usqp=CAU

ici2.png

asos-index.png

drji.png





The platforms of the journal are Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons, etc.

COPE-logo-300x199.jpgimages?q=tbn:ANd9GcQR6_qdgvxMP9owgnYzJ1M6CS_XzR_d7orTjA&usqp=CAU

icmje_1_orig.png

cc.logo.large.png

ncbi.pngimages?q=tbn:ANd9GcRBcJw8ia8S9TI4Fun5vj3HPzEcEKIvF_jtnw&usqp=CAU

ORCID_logo.png

1*mvsP194Golg0Dmo2rjJ-oQ.jpeg


Our Journal using the DergiPark system indexed are;

Ulakbim TR Dizin,  Index Copernicus, ICI World of JournalsDirectory of Research Journals Indexing (DRJI), General Impact FactorASOS Index, OpenAIRE, MIAR,  EuroPub, WorldCat (OCLC)DOAJ,  Türkiye Citation Index, Türk Medline Index, InfoBase Index


Our Journal using the DergiPark system platforms are;

Google, Google Scholar, CrossRef (DOI), ResearchBib, ICJME, COPE, NCBI, ORCID, Creative Commons, Open Access, and etc.


Journal articles are evaluated as "Double-Blind Peer Review". 

Our journal has adopted the Open Access Policy and articles in JHSM are Open Access and fully comply with Open Access instructions. All articles in the system can be accessed and read without a journal user.  https//dergipark.org.tr/tr/pub/jhsm/page/9535

Journal charge policy   https://dergipark.org.tr/tr/pub/jhsm/page/10912


Editor List for 2022

Assoc. Prof. Alpaslan TANOĞLU (MD)  

Prof. Aydın ÇİFCİ (MD)

Prof. İbrahim Celalaettin HAZNEDAROĞLU (MD)

Prof. Murat KEKİLLİ (MD)

Prof. Yavuz BEYAZIT (MD) 

Prof. Ekrem ÜNAL (MD)

Prof. Ahmet EKEN (MD)

Assoc. Prof. Ercan YUVANÇ (MD)

Assoc. Prof. Bekir UÇAN (MD) 

Assoc. Prof. Mehmet Sinan DAL (MD)


Our journal has been indexed in DOAJ as of May 18, 2020.

Our journal has been indexed in TR-Dizin as of March 12, 2021.


17873

Articles published in the Journal of Health Sciences and Medicine have open access and are licensed under the Creative Commons CC BY-NC-ND 4.0 International License.