Does the presence of comorbidities in rheumatoid arthritis patients impact initial tumor necrosis factor inhibitor treatment response and retention rates?

Year 2025, Volume: 8 Issue: 2, 292 - 297, 21.03.2025

Tuba Yüce İnel , Sinem Burcu Kocaer , Hüseyin Ediz Dalkılıç , Servet Akar , Süleyman Serdar Koca , Soner Şenel , Abdurrahman Tufan , Sema Yılmaz , Ayşe Çefle , Sadettin Uslu , Ali Karakaş , Yeşim Erez , Aydan Köken Avşar , İsmail Sarı , Merih Birlik , Haner Direşkeneli , Şükran Erten , Fatoş Önen

https://doi.org/10.32322/jhsm.1591510

Abstract

Aims: We aimed to evaluate the effect of comorbidities on the first tumor necrosis factor inhibitor (TNFi) treatment response and retention in patients with rheumatoid arthritis (RA).
Methods: The study included adult RA patients (with M05 and M06 ICD codes) registered in the TURKBIO database and receiving their first TNFi treatment. Data on demographic, clinical, and laboratory features, disease activity scores, and other follow-up parameters (at the beginning and months 6 and 12) were collected. The Log-Rank test and Kaplan-Meier curve were used to determine the TNFi retention rates.
Results: There were 1172 bio-naive RA patients who initiated their first TNFi treatments. The median age (IQR) of the patients was 53 (51-61), and 79.8% (n=935) were women. The most commonly used TNFi was etanercept (38.9%), followed by adalimumab (27.9%), certolizumab (13.8%), golimumab (10.8%), and infliximab (8.7%). The most prevalent comorbidities in patients were hypertension (32.6%), obesity (32.6%), osteoporosis (22.3%), asthma/COPD (17.9%), and diabetes mellitus (15.7%). The presence of comorbidities at the beginning of TNFi treatment did not affect DAS28 CRP responses at months 6 and 12 (p=0.18 and p=0.83, respectively) and the continuation rates of the first TNFi drug. After conducting a thorough analysis that factored in variables including gender, age over 60 years, smoking, serologic status, presence of erosion, and basal disease activity scores, it was determined that there were no statistically significant hazard ratios (HR) for the first TNFi persistence. However, there was a 5% decrease in adherence to the first TNFi drug with an increase in median disease duration (HR 0.95, 95% CI=0.90-1.00, p=0.048).
Conclusion: It has been observed that the presence of comorbidities in patients with RA does not significantly affect the TNFi treatment response and retention rate. However, evidence suggests that as the duration of the disease increases, the continuation of the first TNFi drug may decrease.

Keywords

Comorbidity, rheumatoid arthritis, first TNFi drug survival

Romatoid artrit hastalarında eşlik eden hastalıkların varlığı, başlangıç ​​tümör nekroz faktörü inhibitörü tedavisine yanıtı ve tedavi devam oranlarını etkiler mi?

Abstract

Amaçlar: Romatoid artritli (RA) hastalarda komorbiditelerin ilk tümör nekroz faktörü inhibitörü (TNFi) tedavi yanıtı ve retansiyonu üzerindeki etkisini değerlendirmeyi amaçladık.
Yöntemler: Çalışmaya TURKBIO veri tabanında kayıtlı ve ilk TNFi tedavilerini alan yetişkin RA hastaları (M05 ve M06 ICD kodlu) dahil edildi. Demografik, klinik ve laboratuvar özellikleri, hastalık aktivite skorları ve diğer takip parametreleri (başlangıçta ve 6. ve 12. aylarda) hakkında veriler toplandı. TNFi retansiyon oranlarını belirlemek için Log-Rank testi ve Kaplan-Meier eğrisi kullanıldı.
Bulgular: İlk TNFi tedavilerine başlayan 1172 biyo-naif RA hastası vardı. Hastaların medyan yaşı (IQR) 53 (51-61) idi ve %79,8'i (n=935) kadındı. En sık kullanılan TNFi etanersept (%38,9) iken bunu adalimumab (%27,9), sertolizumab (%13,8), golimumab (%10,8) ve infliksimab (%8,7) izledi. Hastalarda en sık görülen eşlik eden hastalıklar hipertansiyon (%32,6), obezite (%32,6), osteoporoz (%22,3), astım/KOAH (%17,9) ve diabetes mellitus (%15,7) idi. TNFi tedavisinin başlangıcında eşlik eden hastalıkların varlığı 6. ve 12. aylardaki DAS28 CRP yanıtlarını (sırasıyla p=0,18 ve p=0,83) ve ilk TNFi ilacının devam oranlarını etkilemedi. Cinsiyet, 60 yaş üstü olma, sigara içme, serolojik durum, erozyon varlığı ve bazal hastalık aktivite skorları gibi değişkenleri hesaba katan kapsamlı bir analiz yürütüldükten sonra, ilk TNFi kalıcılığı için istatistiksel olarak anlamlı tehlike oranları (HR) olmadığı belirlendi. Ancak, medyan hastalık süresinde artışla birlikte ilk TNFi ilacına uyumda %5'lik bir azalma oldu (HR 0,95, %95 CI=0,90-1,00, p=0,048).
Sonuç: RA hastalarında eşlik eden hastalıkların varlığının TNFi tedavi yanıtını ve tutma oranını önemli ölçüde etkilemediği gözlemlenmiştir. Ancak, kanıtlar hastalığın süresi arttıkça ilk TNFi ilacına devam etmenin azalabileceğini göstermektedir.

Keywords

Eşlik eden hastalık, romatoid artrit, ilk TNFi ilacı sağ kalımı

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