Obezitenin endometrioid tip endometrial adenokarsinomlu hastalarda prognoza etkisi

Year 2025, Volume: 8 Issue: 3, 383 - 388, 30.05.2025

Özcan Gül , Guzin Demirağ

https://doi.org/10.32322/jhsm.1658483

Abstract

Amaçlar: Bu çalışmada, tedavi öncesi vücut kitle indeksi (VKİ) ile endometrial kanserle ilişkili, belirlenmiş prognostik faktörler arasındaki ilişki araştırıldı ve bu malignite tanısı konulan hastalarda sağ kalım üzerindeki etkisi değerlendirildi.
Yöntemler: Ocak 2000 ile Haziran 2010 arasında tıbbi onkoloji kliniğinde endometrioid tip endometrial kanser tanısı konulan ve tedavisi ve takibi kliniğimizde devam eden hastalar çalışmaya dahil edildi. Hasta dosyaları ve hastane elektronik veri tabanı retrospektif olarak incelendi. Hastalar obez olmayan (VKİ <30 kg/m²) ve obez (VKİ ≥ 30 kg/m²) gruplara ayrıldı ve ardından klinik özellikler, patolojik sonuçlar ve sağ kalım sonuçları açısından karşılaştırıldı.
Bulgular: Çalışmaya 44'ü obez olmayan grupta ve 82'si obez grupta olmak üzere toplam 126 hasta dahil edildi. İki grup demografik ve klinikopatolojik verilere göre sınıflandırıldığında istatistiksel olarak benzerdi. Evre, tümör derecesi, sitoloji, miyometriyal veya lenfovasküler invazyon derinliği ve lenf nodu metastazı 5 yıllık sağ kalımla anlamlı şekilde ilişkiliydi. 5 yıllık hastalıksız sağ kalım oranı obez olmayan grupta %86,4 ve obez grupta %87,8 idi. Nedene özgü sağ kalım oranları incelendiğinde sırasıyla %86,4 ve %90,2 olarak bulundu ve her iki grup arasında 5 yıllık sağ kalım sonuçları arasında istatistiksel olarak anlamlı bir ilişki gözlenmedi.
Sonuç: Bu çalışma obezite ile hastalığın tanımlanmış prognostik faktörleri ve 5 yıllık sağ kalım sonuçları arasında anlamlı bir ilişki olmadığını göstermiştir.

Keywords

endometrial kanser , obezite , sağkalım

The effect of obesity on prognosis in patients with endometrioid type endometrial adenocarcinoma

Abstract

Aims: This study sought to investigate the relationship between pre-treatment body-mass index (BMI) and established prognostic factors associated with endometrial cancer, as well as to assess its impact on survival in patients diagnosed with this malignancy.
Methods: Patients diagnosed with endometrioid-type endometrial cancer between January 2000 and June 2010 at the medical oncology clinic, and who received treatment and follow-up at our clinic, were included in the study. The patient files and the hospital electronic database were retrospectively reviewed. The patients were divided into non-obese (BMI <30 kg/m2) and obese (BMI ≥30 kg/m2) groups, then compared in terms of clinical characteristics, pathological results, and survival outcomes.
Results: A total of 126 patients, 44 in the non-obese group and 82 in the obese group, were included in the study. The two groups were statistically similar when classified according to demographic and clinicopathological data. Stage, tumour grade, cytology, depth of myometrial or lymphovascular invasion and lymph node metastasis were significantly associated with 5-year survival. The 5-year disease-free survival rate was 86.4% in the non-obese group and 87.8% in the obese group. When examining cause-specific survival rates, they were found to be 86.4% and 90.2%, respectively and no statistically significant association was observed between 5-years survival outcomes between both groups.
Conclusion: This study demonstrated that there was no significant relationship between obesity and the defined prognostic factors of the disease and 5-year survival results.

Keywords

Endometrial cancer , obesity , survival

Ethical Statement

This work as seen and approved by all co-authors has not been published previously and is not currently under consideration for publication elsewhere. The authors declare they have no conflict of interest

Supporting Institution

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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