Romatoid artritli hastalarda nöropatik ağrı komponentinin sıklığı ve hastalık aktivitesiyle ilişkisinin değerlendirilmesi: kesitsel bir çalışma

Year 2025, Volume: 8 Issue: 5, 847 - 851, 16.09.2025

Derya Çırakoğlu

https://doi.org/10.32322/jhsm.1730961

Abstract

Amaç: Bu çalışmanın amacı romatoid artritli (RA) hastalarda nöropatik ağrı (NP) kompanentinin sıklığını incelemek ve hastalık aktivitesi, fonksiyonel durum, yaşam kalitesi üzerindeki etkilerini araştırmaktır.
Yöntemler: Çalışmaya RA tanılı altmış hasta ile yaş ve cinsiyet uyumlu altmış kontrol olmak üzere toplam 120 kişi alındı. Hastalık aktivitesi için disease activity score in 28 joints (DAS-28), ağrı için visual analog scale (VAS), nöropatik ağrı için pain-DETECT ağrı anketi (PD-Q), yaşam kalitesi için quality of life-rheumatoid arthritis (RA-QoL), fonksiyenel durum için health assesment questionnaire (HAQ) kullanıldı.
Bulgular: Yaş ve cinsiyet açısından hasta ve kontrol grubu arasında istatistiksel fark saptanmadı (sırasıyla p=0.097, p=0.487). NP oranı hasta grubunda 63.3% (n=38) (kontrol grubunda ise 6.7% (n=4) idi. İki grup arasında istatistiksel anlamlı fark saptandı (p<0.001). RA’lı hastalar PD-Q’ ya göre olası ve muhtemel NP semptomları olanlar (PD-Q≥13) ve NP olası olmayanlar (PD-Q<13) olarak ayrıldı. Olası ve muhtemel NP semptomları olan hasta grubunda VAS-pain, DAS-28, HAQ, RA-QoL açısından olası olmayan gruba kıyasla istatiksel anlamlı fark saptandı (p<0.001). Hastaların PD-Q skorları; DAS-28, VAS-ağrı, RA-QoL, HAQ skorları ile pozitif korelasyon gösterdi (p<0.001).
Sonuç: RA’li hastalarda nosiseptif ağrı yanında azımsanmayacak derecede NP’da mevcuttur. NP yüksek hastalık aktivitesi, düşük yaşam kalitesi ve kısıtlı fonksiyonel kapasite ile ilişkilidir.

Keywords

Romatoid artrit , nöropatik ağrı , pain-DETECT , HAQ

Prevalence of the neuropathic pain component in rheumatoid arthritis patients and its relationship to disease activity: a cross-sectional study

Abstract

Aims: The purpose of this study is to examine the prevalence of the neuropathic pain (NP) component in patients with rheumatoid arthritis (RA) and its effects on disease activity, functional status, and quality of life.
Methods: The sample of the study consisted of 120 individuals, including 60 patients diagnosed with RA and 60 age- and sex-matched controls. The disease activity score-28 (DAS-28) for disease activity, the Visual Analog Scale (VAS) for pain, the painDETECT questionnaire (PDQ) for NP, the Rheumatoid Arthritis Quality of Life Questionnaire (RA-QoL) for quality of life, and the Health Assessment Questionnaire (HAQ) for functional status were used to collect data.
Results: The prevalence of NP was 63.3% (n=38) in the patient group and 6.7% (n=4) in the control group, and the difference between the two groups was statistically significant (p<0.001). The patient group was divided based on their PDQ scores into two subgroups consisting of those with unclear or likely NP symptoms (PDQ≥13) and those without NP symptoms (PDQ<13). The VAS-pain, DAS-28, HAQ, and RA-QoL scores of the subgroups with and without symptoms showed statistically significant differences (p<0.001). The PDQ scores of the patients were positively correlated with their DAS-28, VAS-pain, RA-QoL, and HAQ scores (p<0.001).
Conclusion: In addition to nociceptive pain, RA patients also have non-negligible rates of NP. NP is associated with high disease activity, low quality of life, and limited functional capacity.

Keywords

Rheumatoid arthritis , neuropathic pain , pain-DETECT questionnaire , HAQ

Ethical Statement

Ethical approval: Ordu University Etic Committee: 11 April 2025 decision no: 2025/117 This manuscript has not been published, accepted, or under simultaneous review for publication elsewhere.

Supporting Institution

NO

Thanks

NO

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