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Yaygın olarak kullanılan pediatrik demir takviyelerinin restoratif materyallerin renk stabilitesi üzerine etkisi

Year 2025, Volume: 8 Issue: 5, 919 - 925, 16.09.2025
https://doi.org/10.32322/jhsm.1764625

Abstract

Amaç: Bu in vitro çalışmanın amacı, yaygın olarak reçete edilen pediatrik demir takviyelerinin—ferrik polimaltoz (Ferrum®) ve demir sülfat (Ferro Sanol B®)—farklı restoratif materyallerin renk stabilitesi (ΔE) üzerindeki etkisini değerlendirmektir.
Yöntemler: Kompozit rezin, kompomer, akışkan kompozit rezin ve cam iyonomer simanlardan oluşan toplam 180 örnek, distile su (kontrol), ferrik polimaltoz veya demir sülfat gruplarına (n=15) ayrıldı. Tüm örnekler 37 °C’de saklandı, test solüsyonlarına günde 2 dakika daldırıldı ve başlangıç, 7. gün ve 28. günlerde değerlendirildi. Daldırmalar arasında örnekler distile suda muhafaza edildi. Renk ölçümleri, CIE Lab* sistemi kullanılarak bir spektrofotometre (VITA Easyshade, Almanya) ile yapıldı ve ΔE değerleri hesaplandı. Veriler Kruskal–Wallis ve Mann–Whitney U testleri ile analiz edildi (p < 0,05).
Bulgular: Her iki demir takviyesi de tüm restoratif materyallerde kontrol grubuna kıyasla anlamlı renklenmeye neden oldu (p < 0,05). En yüksek renk değişimi cam iyonomer simanda gözlenirken, en düşük renk değişimi kompozit rezinde görüldü. Ferrik polimaltoz, başta cam iyonomer siman olmak üzere çoğu materyal grubunda demir sülfata kıyasla daha fazla renk değişimine yol açtı.
Sonuç: Pediatrik demir takviyeleri, restoratif materyallerin renklenmesi açısından yüksek potansiyele sahiptir ve demirin kimyasal formu renklenme derecesini etkiler. Renklenme potansiyeli azaltılmış formülasyonların geliştirilmesi, pediatrik diş tedavisinde estetik sonuçların iyileştirilmesine katkı sağlayabilir.

References

  • American Academy of Pediatric Dentistry. Pediatric restorative dentistry. In: The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry; 2024:452-465.
  • American Academy of Pediatric Dentistry. Best practices for restorative dentistry. In: The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry; 2019:340-352.
  • Mutluay MS. Süt dişlerinde restoratif materyal seçimi ve etkileyen faktörler. Selcuk Dent J. 2016;3(3):151-158. doi:10.15311/1441.300071
  • Genç G, Toz T. A review of the color stability of resin composites: the etiology, classification and the treatment of composite staining. Ege Univ Dent Fac J. 2017;38(2):68-79. doi:10.5505/eudfd.2017.43265
  • Yamanel K. Farklı içeceklerin diş rengindeki restoratif materyallerin renk stabiliteleri üzerine etkisi. Süleyman Demirel Univ Saglik Bilim Derg. 2018;9(2):26-31. doi:10.22312/sdusbed.409547
  • Tüzüner T, Turgut S, Baygin O, Yıldız M. Effects of different pediatric drugs on the color stability of various restorative materials applicable in pediatric dentistry. BioMed Res Int. 2017;1:9684193. doi:10.1155/2017/ 9684193
  • Özdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk Pediatri Ars. 2015;50(1):11-19. doi:10.5152/tpa.2015.2331
  • Yılmaz R, Aral YZ, Dallar Y. The comparison of the efficiency of once, twice or three times daily oral doses of ferrous sulphate in the treatment of iron deficiency anemia among children. J Child Health Dis. 2011;11(3): 102-107. doi:10.5222/jchild.2011.102
  • Babaei N, Molaei T, Belyad S, et al. Relationship of pH and the viscosity of five different iron supplements with the absorption of iron ions and enamel discoloration in the anterior primary teeth (an in vitro study). Dent Res J (Isfahan). 2021;18:7.
  • İnci MA, Özer H, Ercan VB. Diş rengindeki restoratif materyallerin farklı içeceklerde bekletilmesi sonrası renk stabilitelerinin ve yüzey pürüzlülüklerinin değerlendirilmesi. Ege Univ Dis Hekim Fak Derg. 2023;44(2):93-99.
  • Singh A, Grover C, Raina D, Pandey A, Krishna ASC. Color stability of pediatric restorative material over pediatric drug formulation. Cureus. 2023;15(8):e42953. doi:10.7759/cureus.42953
  • Lokhande RS, Nagarathna PJ, Deoghare A, Chhatani N, Busi S, Malladi S. Effect of different iron supplements on color stability of nanocomposite restorative materials. Int J Clin Pediatr Dent. 2024;17(3):274-278. doi:10. 5005/jp-journals-10005-2790
  • Harza Y, Rao A, Natarajan S, Srikrishna SB. Effect of herbal toothpaste on the colour stability, surface roughness, and microhardness of aesthetic restorative materials-an in vitro study. BDJ Open. 2024;10(1):95. doi:10. 1038/s41405-024-00280-x
  • Paravina RD, Pérez MM, Ghinea R. Acceptability and perceptibility thresholds in dentistry: a comprehensive review of clinical and research applications. J Esthet Restor Dent. 2019;31(2):103-112. doi:10.1111/jerd. 12465
  • Paravina RD. Critical appraisal. Color in dentistry: match me, match me not. J Esthet Restor Dent. 2009;21(2):133-139. doi:10.1111/j.1708-8240. 2009.00259.x
  • International Organization for Standardization. Dentistry-Guidance on Color Measurement. ISO/TR 28642. Geneva, Switzerland: ISO; 2016.
  • Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988.
  • Tomczak M, Tomczak E. The need to report effect size estimates revisited: an overview of some recommended measures of effect size. Trends Sport Sci. 2014;21(1):19-25.
  • Kaya E. The effect of surface sealants on discoloration of primary teeth related to iron syrups. Yeditepe J Dent. 2021;17(3):171-176. doi:10.5505/yeditepe.2021.64426
  • Pani SC, Alenazi FM, Alotain AM, Alanazi HD, Alasmari AS. Extrinsic tooth staining potential of high dose and sustained release iron syrups on primary teeth. BMC Oral Health. 2015;15:90. doi:10.1186/s12903-015-0075-6
  • Janisch FAS, Aguilar MF, Aguiar FHB, França FMG, Bastos RT, Vieira-Junior WF. Surface roughness and color stability of conventional and bulk-fill resin composite with S-PRG fillers after coffee exposure: an in-vitro study. Clin Cosmet Investig Dent. 2025;17:21-29. doi:10.2147/CCIDE.S507164
  • Aktaş N, Akın Y, Bal C, Bani M, Bankoğlu Güngör M. Effect of the different dietary supplements on the average surface roughness and color stability of direct restorative materials used in pediatric dentistry. Children (Basel). 2024;11(6):645. doi:10.3390/children11060645
  • Yılmaz N, Baygin O, Tüzüner T, Turgut SN, Erbek SM. Evaluation of the effect of pediatric drugs and an oral rinse on primary teeth discoloration. Dent Med Probl. 2022;59(2):225-231. doi:10.17219/dmp/133406
  • Valera B, Bhatt R, Patel M, Patel C, Makwani D, Goyal S. Effect of different pediatric medications on various tooth colored restorative materials used in pediatric dentistry: a comparative study. Int J Health Sci. 2022;6(S3):578-591. doi:10.53730/ijhs.v6nS3.5318
  • Kale YJ, Lingayat SD, Dadpe MV, et al. Assessment of detrimental effects of pediatric drug syrups on different esthetic dental restorative materials used in children: a systematic review. World J Dent. 2025;16(4):391-399. doi:10.5005/jp-journals-10015-2631

The effect of commonly used pediatric iron supplements on the color stability of restorative materials

Year 2025, Volume: 8 Issue: 5, 919 - 925, 16.09.2025
https://doi.org/10.32322/jhsm.1764625

Abstract

Aims: This in vitro study aimed to evaluate the effect of commonly prescribed pediatric iron supplements-ferric polymaltose (Ferrum®) and ferrous sulfate (Ferro Sanol B®)-on the color stability (ΔE) of different restorative materials.
Methods: One hundred eighty specimens from composite resin, compomer, flowable composite resin, and glass ionomer cement were assigned to distilled water (control), ferric polymaltose, or ferrous sulfate groups (n=15). All samples were stored at 37°C, immersed in the test solutions for 2 minutes daily, and evaluated at baseline, 7 days, and 28 days. Between immersions, specimens were kept in distilled water. Color measurements were performed using a spectrophotometer (VITA Easyshade, Germany) in the CIE Lab* system and ΔE values were calculated. Data were analyzed using Kruskal-Wallis and Mann-Whitney U tests (p<0.05).
Results: Both iron supplements caused significant discoloration in all restorative materials compared to the control (p<0.05). GIC exhibited the highest color change, while composite resin showed the lowest. Ferric polymaltose produced greater discoloration than ferrous sulfate in most material groups, particularly in GIC.
Conclusion: Pediatric iron supplements have a high potential for discoloration of restorative materials, with the iron’s chemical form influencing the extent of staining. The development of formulations with reduced staining potential may contribute to improved esthetic outcomes in pediatric dental care.

References

  • American Academy of Pediatric Dentistry. Pediatric restorative dentistry. In: The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry; 2024:452-465.
  • American Academy of Pediatric Dentistry. Best practices for restorative dentistry. In: The Reference Manual of Pediatric Dentistry. Chicago, IL: American Academy of Pediatric Dentistry; 2019:340-352.
  • Mutluay MS. Süt dişlerinde restoratif materyal seçimi ve etkileyen faktörler. Selcuk Dent J. 2016;3(3):151-158. doi:10.15311/1441.300071
  • Genç G, Toz T. A review of the color stability of resin composites: the etiology, classification and the treatment of composite staining. Ege Univ Dent Fac J. 2017;38(2):68-79. doi:10.5505/eudfd.2017.43265
  • Yamanel K. Farklı içeceklerin diş rengindeki restoratif materyallerin renk stabiliteleri üzerine etkisi. Süleyman Demirel Univ Saglik Bilim Derg. 2018;9(2):26-31. doi:10.22312/sdusbed.409547
  • Tüzüner T, Turgut S, Baygin O, Yıldız M. Effects of different pediatric drugs on the color stability of various restorative materials applicable in pediatric dentistry. BioMed Res Int. 2017;1:9684193. doi:10.1155/2017/ 9684193
  • Özdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk Pediatri Ars. 2015;50(1):11-19. doi:10.5152/tpa.2015.2331
  • Yılmaz R, Aral YZ, Dallar Y. The comparison of the efficiency of once, twice or three times daily oral doses of ferrous sulphate in the treatment of iron deficiency anemia among children. J Child Health Dis. 2011;11(3): 102-107. doi:10.5222/jchild.2011.102
  • Babaei N, Molaei T, Belyad S, et al. Relationship of pH and the viscosity of five different iron supplements with the absorption of iron ions and enamel discoloration in the anterior primary teeth (an in vitro study). Dent Res J (Isfahan). 2021;18:7.
  • İnci MA, Özer H, Ercan VB. Diş rengindeki restoratif materyallerin farklı içeceklerde bekletilmesi sonrası renk stabilitelerinin ve yüzey pürüzlülüklerinin değerlendirilmesi. Ege Univ Dis Hekim Fak Derg. 2023;44(2):93-99.
  • Singh A, Grover C, Raina D, Pandey A, Krishna ASC. Color stability of pediatric restorative material over pediatric drug formulation. Cureus. 2023;15(8):e42953. doi:10.7759/cureus.42953
  • Lokhande RS, Nagarathna PJ, Deoghare A, Chhatani N, Busi S, Malladi S. Effect of different iron supplements on color stability of nanocomposite restorative materials. Int J Clin Pediatr Dent. 2024;17(3):274-278. doi:10. 5005/jp-journals-10005-2790
  • Harza Y, Rao A, Natarajan S, Srikrishna SB. Effect of herbal toothpaste on the colour stability, surface roughness, and microhardness of aesthetic restorative materials-an in vitro study. BDJ Open. 2024;10(1):95. doi:10. 1038/s41405-024-00280-x
  • Paravina RD, Pérez MM, Ghinea R. Acceptability and perceptibility thresholds in dentistry: a comprehensive review of clinical and research applications. J Esthet Restor Dent. 2019;31(2):103-112. doi:10.1111/jerd. 12465
  • Paravina RD. Critical appraisal. Color in dentistry: match me, match me not. J Esthet Restor Dent. 2009;21(2):133-139. doi:10.1111/j.1708-8240. 2009.00259.x
  • International Organization for Standardization. Dentistry-Guidance on Color Measurement. ISO/TR 28642. Geneva, Switzerland: ISO; 2016.
  • Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1988.
  • Tomczak M, Tomczak E. The need to report effect size estimates revisited: an overview of some recommended measures of effect size. Trends Sport Sci. 2014;21(1):19-25.
  • Kaya E. The effect of surface sealants on discoloration of primary teeth related to iron syrups. Yeditepe J Dent. 2021;17(3):171-176. doi:10.5505/yeditepe.2021.64426
  • Pani SC, Alenazi FM, Alotain AM, Alanazi HD, Alasmari AS. Extrinsic tooth staining potential of high dose and sustained release iron syrups on primary teeth. BMC Oral Health. 2015;15:90. doi:10.1186/s12903-015-0075-6
  • Janisch FAS, Aguilar MF, Aguiar FHB, França FMG, Bastos RT, Vieira-Junior WF. Surface roughness and color stability of conventional and bulk-fill resin composite with S-PRG fillers after coffee exposure: an in-vitro study. Clin Cosmet Investig Dent. 2025;17:21-29. doi:10.2147/CCIDE.S507164
  • Aktaş N, Akın Y, Bal C, Bani M, Bankoğlu Güngör M. Effect of the different dietary supplements on the average surface roughness and color stability of direct restorative materials used in pediatric dentistry. Children (Basel). 2024;11(6):645. doi:10.3390/children11060645
  • Yılmaz N, Baygin O, Tüzüner T, Turgut SN, Erbek SM. Evaluation of the effect of pediatric drugs and an oral rinse on primary teeth discoloration. Dent Med Probl. 2022;59(2):225-231. doi:10.17219/dmp/133406
  • Valera B, Bhatt R, Patel M, Patel C, Makwani D, Goyal S. Effect of different pediatric medications on various tooth colored restorative materials used in pediatric dentistry: a comparative study. Int J Health Sci. 2022;6(S3):578-591. doi:10.53730/ijhs.v6nS3.5318
  • Kale YJ, Lingayat SD, Dadpe MV, et al. Assessment of detrimental effects of pediatric drug syrups on different esthetic dental restorative materials used in children: a systematic review. World J Dent. 2025;16(4):391-399. doi:10.5005/jp-journals-10015-2631
There are 25 citations in total.

Details

Primary Language English
Subjects Paedodontics
Journal Section Original Article
Authors

Hülya Çerçi Akçay 0000-0002-3589-7511

Çağan Taş 0009-0007-2675-5689

Eda Sır 0009-0005-4174-6380

Nefise Şeker 0000-0003-4722-3087

Publication Date September 16, 2025
Submission Date August 13, 2025
Acceptance Date September 1, 2025
Published in Issue Year 2025 Volume: 8 Issue: 5

Cite

AMA Çerçi Akçay H, Taş Ç, Sır E, Şeker N. The effect of commonly used pediatric iron supplements on the color stability of restorative materials. J Health Sci Med / JHSM. September 2025;8(5):919-925. doi:10.32322/jhsm.1764625

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