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İnfantil hipertrofik pilor stenozu olgularının klinik ve laboratuar bulgularının incelenmesi

Year 2025, Volume: 8 Issue: 6, 1030 - 1033, 25.10.2025
https://doi.org/10.32322/jhsm.1773064

Abstract

Giriş: İnfantil hipertrofik pilor stenozu (İHPS), bebeklerde yaşamın erken döneminde cerrahi müdahale gerektiren en sık gastrointestinal hastalıktır. Etyolojisi tam olarak bilinmemekle birlikte erkek cinsiyet, biberonla beslenme ve ilk çocuk olma gibi risk faktörleri tanımlanmıştır. Bu çalışmada, İHPS’li hastaların klinik ve laboratuvar bulgularını değerlendirmek ve literatüre katkıda bulunmak amaçlanmıştır.
Metodoloji: 2012-2024 yılları arasında Düzce Üniversitesi Araştırma ve Uygulama Hastanesi, çocuk sağlığı ve hastalıkları kliniklerinde İHPS tanısı alan 19 olgu retrospektif olarak incelenmiştir. Olguların demografik özellikleri, başvuru şikayetleri, laboratuvar sonuçları ve doğum öyküleri analiz edilmiştir. Tanımlayıcı istatistikler ve korelasyon analizleri SPSS 25 programı kullanılarak yapılmıştır.
Sonuçlar: Olguların %78,9’u erkekti, median tanı yaşı 42 gündü. Olguların %47,4’ü biberonla besleniyordu ve %47,4’ü ilk çocuktu. Kusma tüm hastalarda görülürken, %68,4’ünde kilo alamama şikayeti vardı. Hipokloremi oranı %42,1 olarak saptandı. Anne yaşı ile semptom süresi arasında orta düzeyde negatif korelasyon bulundu.
Sonuç: İHPS tanı ve tedavisinde erken farkındalık hayati öneme sahiptir. Sağlık çalışanlarının bu konuda eğitilmesi, erken tanı ve tedavi başarısını artıracaktır. Çalışmamız, İHPS’nin risk faktörleri ve klinik özelliklerine dair değerli bilgiler sunmaktadır.

Ethical Statement

Çalışmaya Düzce Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurulu’nun onayı (Tarih: 16.12.2024, Karar No: 2024/257) alınarak başlandı.

References

  • Zampieri N, Corato V, Scirè G, Camoglio FS. Hypertrophic pyloric stenosis: 10 years’ experience with standard open and laparoscopic approach. Pediatr Gastroenterol Hepatol Nutr. 2021;24(3):265-272. doi:10.5223/pghn.2021.24.3.265
  • Sakharkar S, Tiwari D, Yemul R, Kabra N. The enigma of infantile hypertrophic pyloric stenosis in preterm neonate. Clin Pediatr (Phila). 2025:99228251342391. doi:10.1177/00099228251342391
  • van den Bunder FA, Derikx JP, Kiblawi R, van Rijn RR, Dingemann J. Diagnostic accuracy of palpation and ultrasonography for diagnosing infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. Br J Radiol. 2022;95(1139):20211251. doi:10.1259/bjr.20211251
  • Oetzmann von Sochaczewski C, Muensterer OJ. The incidence of infantile hypertrophic pyloric stenosis nearly halved from 2005 to 2017: analysis of German administrative data. Pediatr Surg Int. 2021;37(5):579-585. doi:10.1007/s00383-020-04810-0
  • Obaid YY, Toubasi AA, Albustanji FH, Al-Qawasmeh AR. Perinatal risk factors for infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. J Pediatr Surg. 2023;58(3):458-466. doi:10.1016/j.jpedsurg.2022.08.016
  • Hernanz-Schulman M. Infantile hypertrophic pyloric stenosis. Radiology. 2003;227(2):319-331. doi:10.1148/radiol.2272011329
  • Muse AI, Hussein BO, Adem BM, Osman MO, Abdulahi ZB, Ibrahim MA. Treatment outcome and associated factors of infantile hypertrophic pyloric stenosis at eastern Ethiopia public hospitals. BMC Surg. 2024;24(1):262. doi:10.1186/s12893-024-02567-0
  • Kozak M. What is strong correlation? Teaching Statistics. 2009;31(3):85-86. doi:10.1111/j.1467-9639.2009.00387.x
  • Chuang YH, Chao HC, Yeh HY, Lai MW, Chen CC. Factors associated with pyloric hypertrophy severity and post-operative feeding and nutritional recovery in infantile hypertrophic pyloric stenosis. Biomed J. 2022;45(6):948-956. doi:10.1016/j.bj.2021.12.011
  • Acker SN, Garcia AJ, Ross JT, Somme S. Current trends in the diagnosis and treatment of pyloric stenosis. Pediatr Surg Int. 2015;31(4):363-366. doi:10.1007/s00383-015-3682-3
  • Fawkner-Corbett D, McHoney M. Infantile hypertrophic pyloric stenosis. Paediatr Child Health. 2024;34(4):126-129. doi:10.1016/j.paed.2024.01.004
  • Taylor ND, Cass DT, Holland AJ. Infantile hypertrophic pyloric stenosis: has anything changed? J Paediatr Child Health. 2013;49(1):33-37. doi:10.1111/jpc.12027
  • Bundak R, Neyzi O, Günöz H, Darendeliler F. Pediatri Cilt 1. 3. Baskı. Nobel Tıp Kitabevleri; 2002. Büyüme-gelişme ve bozuklukları; 79-99.
  • Kaya B, Akduman H, Dilli D, et al. Pyloric Index, a new parameter: predicting perioperative prognosis in neonates with hypertrophic pyloric stenosis. Scand J Gastroenterol. 2024;59(12):1272-1276. doi:10.1080/00365521.2024.2425982
  • Zhu J, Zhu T, Lin Z, Qu Y, Mu D. Perinatal risk factors for infantile hypertrophic pyloric stenosis: a meta-analysis. J Pediatr Surg. 2017;52(9):1389-1397. doi:10.1016/j.jpedsurg.2017.02.017
  • Krogh C, Biggar RJ, Fischer TK, et al. Bottle-feeding and the risk of pyloric stenosis. Pediatrics. 2012;130(4):e943-e949. doi:10.1542/peds.2011-2785
  • Gotley LM, Blanch A, Kimble R, Frawley K, Acworth JP. Pyloric stenosis: a retrospective study of an Australian population. Emerg Med Australas. 2009;21(5):407-13. doi:10.1111/j.1742-6723.2009.01218.x
  • Feng Z, Nie Y, Zhang Y, et al. The clinical features of infantile hypertrophic pyloric stenosis in Chinese Han population: analysis from 1998 to 2010. PLoS One. 2014;9(2):e88925. doi:10.1371/journal.pone.0088925
  • Broom BL. Impact of marital quality and psychological well-being on parental sensitivity. Nurs Res. 1994;43(3):138-143. doi:10.1371/journal.pone.0088925

Evaluation of clinical and laboratory findings in cases of infantile hypertrophic pyloric stenosis

Year 2025, Volume: 8 Issue: 6, 1030 - 1033, 25.10.2025
https://doi.org/10.32322/jhsm.1773064

Abstract

Aims: Infantile hypertrophic pyloric stenosis (IHPS) is the most common gastrointestinal disorder in early infancy that requires surgical intervention. Although its etiology is not fully understood, several risk factors have been identified, including male sex, bottle feeding, and being a first-born child. The aim of this study was to evaluate the clinical and laboratory findings of patients with IHPS and to contribute to the existing literature.
Methods: This study retrospectively analyzed 19 cases of IHPS diagnosed from 2012 to 2024 at the Department of Pediatrics, Düzce University Research and Training Hospital. Demographic characteristics, presenting complaints, laboratory results, and birth histories of the patients were analyzed. Descriptive statistics and correlation analyses were performed using SPSS version 25.
Results: Of the patients, 78.9% were male, with a median age at diagnosis of 42 days. Bottle feeding was observed in 47.4% of cases, and 47.4% were first-born children. Vomiting was present in all patients, while 68.4% had complaints of poor weight gain. The rate of hypochloremia was 42.1%. A moderate negative correlation was found between maternal age and the duration of symptoms.
Conclusion: Early recognition is crucial in the diagnosis and management of IHPS. Training healthcare professionals on this condition may improve early diagnosis and treatment outcomes. Our study provides valuable insights into the risk factors and clinical characteristics of IHPS.

Ethical Statement

The study was initiated with the approval of the Duzce University Medical Faculty Clinical Researches Ethics Committee (Date: 16.12.2024, Decision No: 2024/257).

References

  • Zampieri N, Corato V, Scirè G, Camoglio FS. Hypertrophic pyloric stenosis: 10 years’ experience with standard open and laparoscopic approach. Pediatr Gastroenterol Hepatol Nutr. 2021;24(3):265-272. doi:10.5223/pghn.2021.24.3.265
  • Sakharkar S, Tiwari D, Yemul R, Kabra N. The enigma of infantile hypertrophic pyloric stenosis in preterm neonate. Clin Pediatr (Phila). 2025:99228251342391. doi:10.1177/00099228251342391
  • van den Bunder FA, Derikx JP, Kiblawi R, van Rijn RR, Dingemann J. Diagnostic accuracy of palpation and ultrasonography for diagnosing infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. Br J Radiol. 2022;95(1139):20211251. doi:10.1259/bjr.20211251
  • Oetzmann von Sochaczewski C, Muensterer OJ. The incidence of infantile hypertrophic pyloric stenosis nearly halved from 2005 to 2017: analysis of German administrative data. Pediatr Surg Int. 2021;37(5):579-585. doi:10.1007/s00383-020-04810-0
  • Obaid YY, Toubasi AA, Albustanji FH, Al-Qawasmeh AR. Perinatal risk factors for infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. J Pediatr Surg. 2023;58(3):458-466. doi:10.1016/j.jpedsurg.2022.08.016
  • Hernanz-Schulman M. Infantile hypertrophic pyloric stenosis. Radiology. 2003;227(2):319-331. doi:10.1148/radiol.2272011329
  • Muse AI, Hussein BO, Adem BM, Osman MO, Abdulahi ZB, Ibrahim MA. Treatment outcome and associated factors of infantile hypertrophic pyloric stenosis at eastern Ethiopia public hospitals. BMC Surg. 2024;24(1):262. doi:10.1186/s12893-024-02567-0
  • Kozak M. What is strong correlation? Teaching Statistics. 2009;31(3):85-86. doi:10.1111/j.1467-9639.2009.00387.x
  • Chuang YH, Chao HC, Yeh HY, Lai MW, Chen CC. Factors associated with pyloric hypertrophy severity and post-operative feeding and nutritional recovery in infantile hypertrophic pyloric stenosis. Biomed J. 2022;45(6):948-956. doi:10.1016/j.bj.2021.12.011
  • Acker SN, Garcia AJ, Ross JT, Somme S. Current trends in the diagnosis and treatment of pyloric stenosis. Pediatr Surg Int. 2015;31(4):363-366. doi:10.1007/s00383-015-3682-3
  • Fawkner-Corbett D, McHoney M. Infantile hypertrophic pyloric stenosis. Paediatr Child Health. 2024;34(4):126-129. doi:10.1016/j.paed.2024.01.004
  • Taylor ND, Cass DT, Holland AJ. Infantile hypertrophic pyloric stenosis: has anything changed? J Paediatr Child Health. 2013;49(1):33-37. doi:10.1111/jpc.12027
  • Bundak R, Neyzi O, Günöz H, Darendeliler F. Pediatri Cilt 1. 3. Baskı. Nobel Tıp Kitabevleri; 2002. Büyüme-gelişme ve bozuklukları; 79-99.
  • Kaya B, Akduman H, Dilli D, et al. Pyloric Index, a new parameter: predicting perioperative prognosis in neonates with hypertrophic pyloric stenosis. Scand J Gastroenterol. 2024;59(12):1272-1276. doi:10.1080/00365521.2024.2425982
  • Zhu J, Zhu T, Lin Z, Qu Y, Mu D. Perinatal risk factors for infantile hypertrophic pyloric stenosis: a meta-analysis. J Pediatr Surg. 2017;52(9):1389-1397. doi:10.1016/j.jpedsurg.2017.02.017
  • Krogh C, Biggar RJ, Fischer TK, et al. Bottle-feeding and the risk of pyloric stenosis. Pediatrics. 2012;130(4):e943-e949. doi:10.1542/peds.2011-2785
  • Gotley LM, Blanch A, Kimble R, Frawley K, Acworth JP. Pyloric stenosis: a retrospective study of an Australian population. Emerg Med Australas. 2009;21(5):407-13. doi:10.1111/j.1742-6723.2009.01218.x
  • Feng Z, Nie Y, Zhang Y, et al. The clinical features of infantile hypertrophic pyloric stenosis in Chinese Han population: analysis from 1998 to 2010. PLoS One. 2014;9(2):e88925. doi:10.1371/journal.pone.0088925
  • Broom BL. Impact of marital quality and psychological well-being on parental sensitivity. Nurs Res. 1994;43(3):138-143. doi:10.1371/journal.pone.0088925
There are 19 citations in total.

Details

Primary Language English
Subjects Paediatrics (Other)
Journal Section Original Article
Authors

Fatih Kurt 0000-0003-1975-6492

Murat Kaya 0000-0001-6650-0145

Publication Date October 25, 2025
Submission Date August 28, 2025
Acceptance Date September 24, 2025
Published in Issue Year 2025 Volume: 8 Issue: 6

Cite

AMA Kurt F, Kaya M. Evaluation of clinical and laboratory findings in cases of infantile hypertrophic pyloric stenosis. J Health Sci Med / JHSM. October 2025;8(6):1030-1033. doi:10.32322/jhsm.1773064

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