Toxicology Study the Acute effects of Diethanolamine in Mice Blood and Liver (Oral study)

Year 2017, Volume: 12 Issue: 1, 14 - 23, 30.03.2017

Hamsa Tariq Abdl-razzaq Muhammed Nafea Ali Al- Azzawi

Abstract

The
most important goals of this study is screening effects of Diethanolamine (DEA) which is consider one of the most
important ingredients in cosmetic products in some tissues of female albino
mice (blood and liver) as laboratory models;(DEA) which using for neutralizing
the pH through the industry  of cosmetic
product or adding to make the product fatty or more sudsy; and as a
preservative in vegetables and meat, also in some Pharmaceutical preparations
as  one of the ingredients of medicine
for patients of Pulmonary Arterial Hypertension (PHA); and in industry of
intravenous solutions and preservative solution for contact lenses. Thirty mice
at the average age of (40 days) and weight (21- 24 gm); were divided into 6
groups (control, 603, 1250, 2500, 5000, 10000 ppm), each group includes five
mice were treated for two weeks; weight gain except the higher concentrations,
ruffled fur, pale foot pads and abortions were recorded. Water consumption was
increased in mice groups which treated with low concentrations and decreased in
higher concentrations resulting in severe dehydration which cause death. The
hematological results showed decreasing in Hemoglobin, Packed Cell Volume and
platelets count; but the White Blood Cells were recorded increasing in their
count with the increasing in concentrations and exposure period. Monocytes,
Neutrophils and Lymphocytes were increased also because the decreasing immunity
for mice. The histopathological sections showed the increasing in liver weight
and showed hepatocytes degeneration, congestion of the central vein, sinusoid
dilation, necrosis and lysis of hepatocytes, sever fatty changes, nuclear
pyknosis and karyorrhexis and infiltration of inflammatory cells.

Keywords

Diethanolamine, acute effect, toxicity

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