Bi-component nanofibröz iskelelerin ve ilaç salım uygulamalarının mini incelemesi

Abstract

İlaç salım sistemleri, ilacın etkinliğini artırmak ve etkilenen bölgeyi iyileştirmek için gerçekleştirir. Elektroçekilmiş nanolifler, yüksek özgül yüzey alanı, kolay işleme, hafif malzeme nedeniyle iskele olarak güçlü ilaç taşıyıcılarıdır. Fonksiyonel biyoaktif maddeleri kapsülleyen lifli iskeleler, ilaç verme uygulamaları için önemlidir ve hidrojeller, mikro / nanobeadler, filmler, geleneksel lifler ve süngerler gibi çeşitli taşıyıcı malzemelere göre daha yüksek kapsülleme verimliliği ve daha yüksek ilaç yükleme kapasitesi gösterirler. İlaç yüklemesinin büyük ölçüde polimer matrisinin yüzeyinde gerçekleşmediği iki bileşenli elektroçekim olan geleneksel elektroçekim ile karşılaştırıldığında, çekirdek kabuklu nanofiberler, ilacın çekirdek katmana yüklenmesi nedeniyle gecikmeli salım ve patlama salınımında azalma gösterir. Bu inceleme makalesinin amacı, ilaç yüklü iki bileşenli nanofiberlerin yapı çekirdeği-kabuğu, yan yana, içi boş nanofiberler ve ayrıca emülsiyon nanofiberlerindeki üretimini ve uygulamalarını eş eksenli nozullar kullanarak araştırmaktır. Ayrıca, çalışma koşulları ve polimer özellikleri gibi bu elektrospinning işleminin yanı sıra elde edilen nanoliflerin ilaç verme profilini etkileyen parametreler kısaca özetlenmiştir. Nanolifler üzerindeki sınırlı klinik çalışmalar tartışılmıştır. Sonunda, elektroçekim prosesindeki ilerlemeler için sorunlara, olasılıklara ve yeni yaklaşımlara ilişkin perspektifler de sunulmuştur.

Keywords

• Bi-component nanolif
• Co-axial elektroçekim
• Side-by-side elektroçekim
• Nanofibröz iskele
• İlaç salım uygulaması

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Abstract

Drug delivery systems perform to improve the drug's efficacy and heal the affected region. Electrospun nanofibers are strong drug carriers as a scaffold due to their high specific surface area, easy processing, lightweight material. Fibrous scaffolds encapsulating functional bioactive agents are important for drug delivery applications, and they show higher encapsulation efficiency and higher drug loading capacity than various types of carrier materials such as hydrogels, micro/nanobeads, films, conventional fibers, and sponges. In comparison to conventional electrospinning, bi-component electrospinning where drug loading does not occur largely on the surface of the polymer matrix, core-shell nanofibers showed delayed release and a decrease in burst release because the drug was loaded into the core layer. The purpose of this mini-review is to investigate the production and applications of the drug-loaded bi-component nanofibers in structure core-shell, side-by-side, hollow nanofibers, and also emulsion nanofibers using co-axial nozzles. Further, the parameters which influence of these electrospinning process, such as working conditions and polymer properties, as well as drug delivery profile of the resulting nanofibers, have been outlined briefly. The limited clinical studies on the nanofibers have been discussed. Eventually, perspectives on the problems, possibilities, and new approaches for electrospinning advancements have been presented, as well.

Keywords

• Bi-component nanofiber
• Co-axial electrospinning
• Side-by-side electrospinning
• Nanofibrous scaffold
• Drug delivery applications

References

1. Lv H, Yu, DG, Wang M, Ning T (2021) Nanofabrication of Janus fibers through side-by-side electrospinning-A mini review. Materials Highlights 2(1-2):18-22. https://doi.org/10.2991/mathi.k.210212.001
2. Walther A, Muller AH (2013) Janus particles: synthesis, self-assembly, physical properties, and applications. Chem Rev 113(7):5194-5261. https://doi.org/10.1021/cr300089t
3. Yu DG, Li JJ, Zhang M, Williams GR (2017) High-quality Janus nanofibers prepared using three-fluid electrospinning. Chem Commun 53(33):4542-4545. https://doi.org/10.1039/C7CC01661A
4. Ciftci F, Duygulu N, Yilmazer Y, Karavelioğlu Z, Çakır Koç R, Gündüz O, Ustündag CB (2023) Antibacterial and cellular behavior of PLA-based bacitracin and zataria multiflora nanofibers produced by electrospinning method. Int J Polym Mater Polym Biomater 72(4):319-334. https://doi.org/10.1080/00914037.2021.2008391
5. Singh M, Chauhan D, Das AK, Iqbal Z, Solanki PR (2021) PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti‐biofilm product. J Appl Polym Sci 138(18):50340. https://doi.org/10.1002/app.50340
6. Xue J, Wu T, Dai Y, Xia Y (2019) Electrospinning and electrospun nanofibers: Methods, materials, and applications. Chem Rev 119(8):5298-5415. https://doi.org/10.1021/acs.chemrev.8b00593
7. Parin FN (2022) Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers. In: Guy LeBlanc J (ed) B-Complex Vitamins: Sources, Intakes and Novel Applications, 1st edn, IntechOpen, United Kingdom, ss 101-122.
8. Zhang X, Shi X, Gautrot JE, Peijs T (2021) Nanoengineered electrospun fibers and their biomedical applications: a review. Nanocomposites 7(1):1-34. https://doi.org/10.1080/20550324.2020.1857121

9. Luraghi A, Peri F, Moroni L (2021) Electrospinning for drug delivery applications: A review. J Controlled Release 334:463-484. https://doi.org/10.1016/j.jconrel.2021.03.033
10. Chien AT, Gulgunje PV, Chae HG, Joshi AS, Moon J, Feng B, Kumar S (2013) Functional polymer–polymer/carbon nanotube bi-component fibers. Polymer 54(22):6210-6217. https://doi.org/10.1016/j.polymer.2013.08.061
11. Zhao P, Chen W, Feng Z, Liu Y, Liu P, Xie Y, Yu DG (2022) Electrospun nanofibers for periodontal treatment: A recent progress. Int J Nanomed 17:4137-4162. https://doi.org/10.2147/IJN.S370340
12. Chen W, Zhao P, Yang Y, Yu DG (2022) Electrospun beads-on-the-string nanoproducts: Preparation and drug delivery application. Curr Drug Deliv 20(9):1224-1240. https://doi.org/10.2174/1567201819666220525095844
13. Liu Y, Chen X, Liu Y, Gao Y, Liu P (2022) Electrospun co-axial fibers to optimize the release of poorly water-soluble drug. Polymers 14(3):469. https://doi.org/10.3390/polym14030469
14. Ning T, Zhou Y, Xu H, Guo S, Wang K, Yu DG (2021) Orodispersible membranes from a modified co-axial electrospinning for fast dissolution of diclofenac sodium. Membranes 11(11):802. https://doi.org/10.3390/membranes11110802
15. Ho CC, Chen WS, Shie TY, Lin JN, Kuo C (2008) Novel fabrication of Janus particles from the surfaces of electrospun polymer fibers. Langmuir 24(11):5663-5666. https://doi.org/10.1021/la800282j
16. Wang M, Yu DG, Williams GR, Bligh SWA (2022) Co-loading of inorganic nanoparticles and natural oil in the electrospun Janus nanofibers for a synergetic antibacterial effect. Pharm. 14(6):1208. https://doi.org/10.3390/pharmaceutics14061208
17. Lin T, Wang H, Wang X (2005) Self‐crimping bicomponent nanofibers electrospun from polyacrylonitrile and elastomeric polyurethane. Adv Mater 17(22):2699-2703. https://doi.org/10.1002/adma.200500901
18. Agarwal S, Jiang S (2015) Nanofibers and Electrospinning. In: Kobayashi S, Müllen K (eds) Encyclopedia of Polymeric Nanomaterials. Springer, Berlin, Heidelberg, ss 1-15
19. Peng L (2018). Bicomponent Porous Fibrous Membranes with Special Fiber Morphologies and Properties. Dissertation, Universitaet Bayreuth
20. Bazilevsky AV, Yarin AL, Megaridis CM (2007) Co-electrospinning of core− shell fibers using a single-nozzle technique. Langmuir 23(5):2311-2314. https://doi.org/10.1021/la063194q
21. Liu W, Graham M, Evans EA, Reneker DH (2002) Poly (meta-phenylene isophthalamide) nanofibers: Coating and post processing. Int J Mater Res 17(12):3206-321.2 https://doi.org/10.1557/JMR.2002.0464
22. Bognitzki M, Hou H, Ishaque M, Frese T, Hellwig M, Schwarte C, ... & Greiner A (2000) Polymer, metal, and hybrid nano‐and mesotubes by coating degradable polymer template fibers (TUFT process). Adv Mater 12(9):637-640. https://doi.org/10.1002/(SICI)1521-4095(200005)12:9<637::AID-ADMA637>3.0.CO;2-W
23. Sun Z, Zussman E, Yarin AL, Wendorff JH, Greiner A (2003) Compound core–shell polymer nanofibers by co‐electrospinning. Adv Mat 15(22):1929-193.2 https://doi.org/10.1002/adma.200305136
24. Li D, Xia Y (2004) Direct fabrication of composite and ceramic hollow nanofibers by electrospinning. Nano Lett 4(5):933-938. https://doi.org/10.1021/nl049590f
25. Reznik SN, Yarin AL, Zussman E, Bercovici L (2006) Evolution of a compound droplet attached to a core-shell nozzle under the action of a strong electric field. Phys Fluids 18(6):062101. https://doi.org/10.1063/1.2206747
26. Zussman E, Yarin AL, Bazilevsky AV, Avrahami R, Feldman M (2006) Electrospun polyaniline/poly (methyl methacrylate)‐derived turbostratic carbon micro‐/nanotubes. Adv Mater 18(3):348-353. https://doi.org/10.1002/adma.200501153
27. Zhang J, Choi SW, Kim SS (2011) Micro-and nano-scale hollow TiO2 fibers by co-axial electrospinning: Preparation and gas sensing. J Solid State Chem 184(11):3008-3013. https://doi.org/10.1016/j.jssc.2011.09.014
28. Li M, Zheng Y, Xin B, Xu Y (2020) Co-axial electrospinning: jet motion, core–shell fiber morphology, and structure as a function of material parameters. Ind Eng Chem Res 59(13):6301-6308. https://doi.org/10.1021/acs.iecr.9b05866
29. Liu X, Yang Y, Yu DG, Zhu MJ, Zhao M, Williams GR (2019) Tunable zero-order drug delivery systems created by modified triaxial electrospinning. Chem Eng J 356:886-894. https://doi.org/10.1016/j.cej.2018.09.096
30. Lin MF, Xiong J, Wang J, Parida K, Lee PS (2018) Core-shell nanofiber mats for tactile pressure sensor and nanogenerator applications. Nano Energy 44:248-255. https://doi.org/10.1016/j.nanoen.2017.12.004
31. He Z, Li M, Li Y, Zhu J, Jiang Y, Meng W, ... & Dai L (2018) Flexible electrospun carbon nanofiber embedded with TiO2 as excellent negative electrode for vanadium redox flow battery. Electrochim Acta 281:601-610. https://doi.org/10.1016/j.electacta.2018.06.011
32. Haider A, Haider S, Kang IK (2018) A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology. Arabian J Chem 11(8):1165-1188. https://doi.org/10.1016/j.arabjc.2015.11.015
33. Moghe AK, Gupta BS (2008) Co‐axial electrospinning for nanofiber structures: preparation and applications. Polym Rev 48(2):353-377. https://doi.org/10.1080/15583720802022257
34. Rathore P, Schiffman JD (2020) Beyond the single-nozzle: Co-axial electrospinning enables innovative nanofiber chemistries, geometries, and applications. ACS Appl Mater Interfaces 13(1):48-66. https://doi.org/10.1021/acsami.0c17706
35. Han D, Steckl AJ (2019) Co-axial electrospinning formation of complex polymer fibers and their applications. Chem Plus Chem 84(10):1453-1497. https://doi.org/10.1002/cplu.201900281
36. Wang J, Windbergs M (2019) Controlled dual drug release by co-axial electrospun fibers–impact of the core fluid on drug encapsulation and release. Int J Pharm 556:363-371. https://doi.org/10.1016/j.ijpharm.2018.12.026
37. Nikmaram N, Roohinejad S, Hashemi S, Koubaa M, Barba FJ, Abbaspourrad, A, Greiner, R. (2017) Emulsion-based systems for fabrication of electrospun nanofibers: Food, pharmaceutical and biomedical applications. RSC Adv 7(46):28951-28964. https://doi.org/10.1039/C7RA00179G
38. Giannetti R, Abraham GA, Rivero G (2019) The role of emulsion parameters in tramadol sustained-release from electrospun mats. Mater Sci Eng C 99:1493-1501. https://doi.org/10.1016/j.msec.2019.02.085
39. Di Gesù R, Merlettini A, Gualandi C, Focarete ML (2018) Advances in multidrug delivery from electrospun nanomaterials. In: Focarete M, Tampieri A (eds) In Core-Shell Nanostructures for Drug Delivery and Theranostics, Woodhead Publishing, Sawston, ss 405-430.
40. Abdullah MF, Nuge T, Andriyana A, Ang BC, Muhamad F (2019) Core–shell fibers: design, roles, and controllable release strategies in tissue engineering and drug delivery. Polymers 11(12):2008. https://doi.org/10.3390/polym11122008
41. Khajavi R, Abbasipour MJSI (2012) Electrospinning as a versatile method for fabricating coreshell, hollow and porous nanofibers. Sci Iran 19(6):2029-2034. https://doi.org/10.3390/polym11122008
42. Yarin AL, Zussman E, Wendorff JH, Greiner A (2007) Material encapsulation and transport in core–shell micro/nanofibers, polymer and carbon nanotubes and micro/nanochannels. J Mater Chem 17(25):2585-2599. https://doi.org/10.1039/B618508
43. İşgen HB, Yılmaz SS, Aytac A (2024) The Production of Hollow Nanofibers from PBS/TPU Blends by Co-axial Electrospinning Method. GU J Sci 37(1):64-73. https://doi.org/10.35378/gujs.1199571
44. Wei Z, Zhang Q, Peng M, Wang X, Long S, Yang J (2014) Preparation and drug delivery study of electrospun hollow PES ultrafine fibers with a multilayer wall. Colloid Polym Sci 292:1339-1345. https://doi.org/10.1007/s00396-014-3187-y
45. Khanna I (2012) Drug discovery in pharmaceutical industry: productivity challenges and trends. Drug Discovery Today 17(19-20):1088-1102. https://doi.org/10.1016/j.drudis.2012.05.007
46. Abu Owida H, Al-Nabulsi JI, Alnaimat F, Al Sharah A, Al-Ayyad M, Turab NM, Abdullah M (2022) Advancement of Nanofibrous Mats and Common Useful Drug Delivery Applications. Adv Pharacol Pharm Sci 2022:9073837. https://doi.org/10.1155/2022/9073837
47. Van Norman GA (2019) Phase II trials in drug development and adaptive trial design. JACC: Basic to Translational Science 4(3):428-437. https://doi.org/10.1016/j.jacbts.2019.02.005
48. Poláková L, Širc J, Hobzová R, Cocârță AI, Heřmánková E (2019) Electrospun nanofibers for local anticancer therapy: Review of in vivo activity. Int J Pharm 558:268-283. https://doi.org/10.1016/j.ijpharm.2018.12.059
49. Zheng Y, Li S, Weng Z, Gao C (2015) Hyperbranched polymers: advances from synthesis to applications. Chem Soc Rev 44(12):4091-4130. https://doi.org/10.1039/C4CS00528G
50. Chevalier Y, Bolzinger MA (2013) Emulsions stabilized with solid nanoparticles: Pickering emulsions. Colloids and Surf A:Physicochemical and Engineering Aspects 439:23-34. https://doi.org/10.1016/j.colsurfa.2013.02.054
51. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE (2001) Biodegradable polymeric nanoparticles as drug delivery devices. J Controlled Release 70(1-2):1-20. https://doi.org/10.1016/S0168-3659(00)00339-4
52. Mickova A, Buzgo M, Benada O, Rampichova M, Fisar Z, Filova E, ... & Amler E (2012) Core/shell nanofibers with embedded liposomes as a drug delivery system. Biomacromolecules 13(4):952-962. https://doi.org/10.1021/bm2018118
53. Kataoka K, Harada A, Nagasaki Y (2012) Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Delivery Rev 64:37-48. https://doi.org/10.1016/S0169-409X(00)00124-1
54. Ulery BT, Nair LS, Laurencin CT (2011) Biomedical applications of biodegradable polymers, J. Polym. Sci. Part B Polym Phys 49:832–864. https://doi.org/ 10.1002/polb.22259
55. Nagarajan S, Bechelany M, Kalkura NS, Miele P, Bohatier CP, Balme S (2019) Electrospun nanofibers for drug delivery in regenerative medicine. In: Mohapatra S, Ranjan S, Dasgupta N, Mishra RK, Thomas S (eds) In Applications of targeted nano drugs and delivery systems, Elsevier, Germany, ss 595-625.
56. Farhaj S, Conway BR, Ghori MU (2023) Nanofibres in Drug Delivery Applications. Fibers 11(2):21. https://doi.org/10.3390/fib11020021
57. URL-1 : https://www.inovenso.com/nanofibers-biomedical-pharmaceutical/ Erişim 26 Kasım 2023
58. Parın FN (2022) Fabrication and novel applications of polymeric biomaterials for tissue scaffolds.
59. Zhang X, Wang C, Liao M, Dai L, Tang Y, Zhang H, ... & Ji P (2019) Aligned electrospun cellulose scaffolds coated with rhBMP-2 for both in vitro and in vivo bone tissue engineering. Carbohydr Polym 213:27-38. https://doi.org/10.1016/j.carbpol.2019.02.038
60. Zhou Y, Zhao Q, Tsai NL, Wang M (2019) Bicomponent nanofibrous scaffolds with dual release of anticancer drugs and biomacromolecules. MRS Communications 9(1):413-420. https://doi.org/10.1557/mrc.2019.23
61. Pilehvar-Soltanahmadi Y, Akbarzadeh A, Moazzez-Lalaklo N, Zarghami N (2016) An update on clinical applications of electrospun nanofibers for skin bioengineering. Artif Cells Nanomed Biotechnol 44(6):1350-1364. https://doi.org/10.3109/21691401.2015.1036999
62. Bian T, Zhao K, Meng Q, Tang Y, Jiao H, Luo J (2019) The construction and performance of multi-level hierarchical hydroxyapatite (HA)/collagen composite implant based on biomimetic bone Haversian motif. Mater Des 162:60-69. https://doi.org/10.1016/j.matdes.2018.11.040
63. Mohamadyar-Toupkanlou F, Vasheghani-Farahani E, Bakhshandeh B, Soleimani M, Ardeshirylajimi A (2015) In Vitro and In Vivo investigations on fibronectin coated and hydroxyapatite incorporated scaffolds. Cell Mol Biol 61(4):1-7. https://doi.org/10.14715/cmb/2015.61.4.1
64. Zhao K, Tang YF, Qin YS, Wei JQ (2011) Porous hydroxyapatite ceramics by ice templating: freezing characteristics and mechanical properties. Ceram Int 37(2):635-639. https://doi.org/10.1016/j.ceramint.2010.10.003
65. Li D, Zhang K, Shi C, Liu L, Yan G, Liu C, ... & Yang B (2018) Small molecules modified biomimetic gelatin/hydroxyapatite nanofibers constructing an ideal osteogenic microenvironment with significantly enhanced cranial bone formation. Int J Nanomed 13:7167-7181. https://doi.org/10.2147/IJN.S174553
66. Chen P, Liu L, Pan J, Mei J, Li C, Zheng Y (2019) Biomimetic composite scaffold of hydroxyapatite/gelatin-chitosan core-shell nanofibers for bone tissue engineering. Mater Sci Eng C 97:325-335. https://doi.org/10.1016/j.msec.2018.12.027.
67. Hou J, Wang Y, Xue H, Dou Y (2018) Biomimetic growth of hydroxyapatite on electrospun CA/PVP core–shell nanofiber membranes. Polymers 10(9):1032. https://doi.org/10.3390/polym10091032
68. Samatya Yılmaz S, Yazıcı Özçelik E, Uzuner H, Kolayli F, Karadenizli A, Aytac A (2023) The PLA-Ag NPs/PU bicomponent nanofiber production for wound dressing applications: Investigation of core/shell displacement effect on antibacterial, cytotoxicity, mechanical, and surface properties. Int J Polym Mater Polym Biomater 73(8):670-687. https://doi.org/10.1080/00914037.2023.2201946
69. Movahedi M, Asefnejad A, Rafienia M, Khorasani MT (2020) Potential of novel electrospun core-shell structured polyurethane/starch (hyaluronic acid) nanofibers for skin tissue engineering: In vitro and in vivo evaluation. Int J Biol Macromol 146:627-637. https://doi.org/10.1016/j.ijbiomac.2019.11.233
70. Chen CH, Chen SH, Chen SH, Chuang ADC, Darshan TG, Chen JP (2023) Hyaluronic acid/platelet rich plasma-infused core-shell nanofiber membrane to prevent postoperative tendon adhesion and promote tendon healing. Int J Biol Macromol 231:123312. https://doi.org/10.1016/j.ijbiomac.2023.123312
71. Yang G, Wang J, Wang Y, Li L, Guo X, Zhou S (2015) An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy. ACS Nano 9(2):1161-1174. https://doi.org/10.1021/nn504573u
72. Ercelik M, Tekin C, Parin FN, Mutlu B, Dogan HY, Tezcan G, ... & Tunca B (2023) Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release. Int J Biol Macromol 253:126722. https://doi.org/10.1016/j.ijbiomac.2023.126722
73. Meng Z, Liu Y, Xu K, Sun X, Yu Q, Wu Z, Zhao Z (2021) Biomimetic polydopamine-modified silk fibroin/curcumin nanofibrous scaffolds for chemo-photothermal therapy of bone tumor. ACS Omega 6(34):22213-22223. https://doi.org/10.1021/acsomega.1c02903
74. Rasouli S, Montazeri M, Mashayekhi S, Sadeghi-Soureh S, Dadashpour M, Mousazadeh H, ... & Pilehvar-Soltanahmadi Y (2020) Synergistic anticancer effects of electrospun nanofiber-mediated codelivery of Curcumin and Chrysin: Possible application in prevention of breast cancer local recurrence. J Drug Delivery Sci Technol 55:101402. https://doi.org/10.1016/j.jddst.2019.101402
75. Dai J, Jin J, Yang S, Li G (2017) Doxorubicin-loaded PLA/pearl electrospun nanofibrous scaffold for drug delivery and tumor cell treatment. Mater Res Express 4(7):075403. https://doi.org/10.1088/2053-1591/aa7479
76. Yang B, Hu Y, Huang CH, Ho WC, Yao CY, Huang CH (2019) Effects of bilayer nanofibrous scaffolds containing curcumin/lithospermi radix extract on wound healing in streptozotocin-induced diabetic rats. Polymers 11(11):1745. https://doi.org/10.3390/polym11111745
77. Khan F, Aldhahri M, Hussain MA, Gauthaman K, Memic A, Abuzenadah A, ... & Aldhaheri RW (2018) Encapsulation of 5-flurouracil into PLGA nanofibers and enhanced anticancer effect in combination with Ajwa-dates-extract (Phoenix dactylifera L.). J Biomed Nanotechnol 14(3):553-563. https://doi.org/10.1166/jbn.2018.2515
78. Sabitha M, Rejinold NS, Nair A, Lakshmanan VK, Nair SV, Jayakumar R (2013) Development and evaluation of 5-fluorouracil loaded chitin nanogels for treatment of skin cancer. Carbohydr Polym 91(1):48-57. https://doi.org/10.1016/j.carbpol.2012.07.060
79. Zhu LF, Zheng Y, Fan J, Yao Y, Ahmad Z, Chang MW (2019) A novel core-shell nanofiber drug delivery system intended for the synergistic treatment of melanoma. Eur J Pharm Sci 137:105002. https://doi.org/10.1016/j.ejps.2019.105002
80. Parin FN, Terzioğlu P (2022) Electrospun Porous Biobased Polymer Mats for Biomedical Applications. In: Uthaman A, Thomas S, Li T, Maria H (eds) Advanced Functional Porous Materials: From Macro to Nano Scale Lengths, Springer Nature, Switzerland, ss 539-586.
81. Maleki H, Doostan M, Shojaei S, Doostan M, Stamatis H, Gkantzou E, Bonkdar A (2023) Nanofiber-based systems against skin cancers: Therapeutic and protective approaches. J Drug Delivery Sci Technol 82:104367. https://doi.org/10.1016/j.jddst.2023.104367
82. Yuan C, Long X, Li J, Cai Q (2021) Coaxially electrospun 5-fluorouracil-loaded PLGA/PVP fibrous membrane for skin tumor treatment. Biomed Mater 16(6):065014. https://doi.org/10.1088/1748-605X/ac2887
83. Lin WC, Yeh IT, Niyama E, Huang WR, Ebara M, Wu CS (2018) Electrospun poly (ε-caprolactone) nanofibrous mesh for imiquimod delivery in melanoma therapy. Polymers 10(3):231. https://doi.org/10.3390/polym10030231
84. Kumar MR, Muzzarelli R, Muzzarelli C, Sashiwa H, Domb AJ (2004) Chitosan chemistry and pharmaceutical perspectives. Chem Rev 104(12):6017-6084. https://doi.org/10.1021/cr030441b
85. Yan E, Jiang J, Yang X, Fan L, Wang Y, An Q, ... & Zhang D (2020) pH-sensitive core-shell electrospun nanofibers based on polyvinyl alcohol/polycaprolactone as a potential drug delivery system for the chemotherapy against cervical cancer. J Drug Delivery Sci Technol 55:101455. https://doi.org/10.1016/j.jddst.2019.101455
86. Vocetkova K, Buzgo M, Sovkova V, Rampichova M, Staffa A, Filova E, ... & Amler E (2017) A comparison of high throughput core–shell 2D electrospinning and 3D centrifugal spinning techniques to produce platelet lyophilisate-loaded fibrous scaffolds and their effects on skin cells. Rsc Advances 7(85):53706-53719. https://doi.org/10.1039/C7RA08728D
87. Li Z, Mei S, Dong Y, She F, Li P, Li Y, & Kong L (2021) Multi-functional core-shell nanofibers for wound healing. Nanomater 11(6):1546. https://doi.org/10.3390/nano11061546
88. Pal P, Srivas PK, Dadhich P, Das B, Maulik D, Dhara S (2017) Nano-/microfibrous cotton-wool-like 3D scaffold with core–shell architecture by emulsion electrospinning for skin tissue regeneration. ACS Biomater Sci Eng 3(12):3563-3575. https://doi.org/10.1021/acsbiomaterials.7b00681
89. Liu C, Li X, Xu F, Cong H, Li Z, Song Y, Wang M (2018) Spatio-temporal release of NGF and GDNF from multi-layered nanofibrous bicomponent electrospun scaffolds. J Mater Sci Mater in Med 29:1-13. https://doi.org/10.1007/s10856-018-6105-x
90. Antaby E, Klinkhammer K, Sabantina L (2021) Electrospinning of chitosan for antibacterial applications—Curr Trends Appl Sci 11(24):11937. https://doi.org/10.3390/app112411937
91. Anisiei A, Oancea F, Marin L (2023) Electrospinning of chitosan-based nanofibers: From design to prospective applications. Rev Chem Eng 39(1):31-70. https://doi.org/10.1515/revce-2021-0003
92. Reddy MSB, Ponnamma D, Choudhary R, Sadasivuni KK (2021) A comparative review of natural and synthetic biopolymer composite scaffolds. Polymers 13(7):1105. https://doi.org/10.3390/polym13071105
93. Zhou Y, Dong Q, Yang H, Liu X, Yin X, Tao Y, ... & Xu W (2017) Photocrosslinked maleilated chitosan/methacrylated poly (vinyl alcohol) bicomponent nanofibrous scaffolds for use as potential wound dressings. Carbohydr Polym 168:220-226. https://doi.org/10.1016/j.carbpol.2017.03.044.
94. Zheng X, Liu X, Zha L (2021) Fabrication of ultrafast temperature‐responsive nanofibrous hydrogel with superelasticity and its' on–off'switchable drug releasing capacity. J Appl Polym Sci 138(17):50280. https://doi.org/10.1002/app.50280
95. Xu R, Zhao H, Muhammad H, Dong M, Besenbacher F, Chen M (2017) Dual-delivery of FGF-2/CTGF from silk fibroin/PLCL-PEO coaxial fibers enhances MSC proliferation and fibrogenesis. Sci Rep 7(1):8509. https://doi.org/10.1038/s41598-017-08226-0
96. Shi Q, Hou J, Zhao C, Xin Z, Jin J, Li C, ... & Yin J (2016) A smart core–sheath nanofiber that captures and releases red blood cells from the blood. Nanoscale 8(4):2022-2029. https://doi.org/10.1039/C5NR07070H
97. Zdraveva E, Mijovic B (2023) Frontier Electrospun Fibers for Nanomedical Applications. In: Villarreal-Gómez LJ, (ed) Biotechnology - Biosensors, Biomaterials and Tissue Engineering Annual 1st edn, IntechOpen, United Kingdom, ss 1-28.
98. Liu C, Li X, Zhao Q, Xie Y, Yao X, Wang M, Cao F (2021) Nanofibrous bicomponent scaffolds for the dual delivery of NGF and GDNF: Controlled release of growth factors and their biological effects. J Mater Sci Mater Med 32:1-19. https://doi.org/10.1007/s10856-020-06479-2
99. Dulnik J, Denis P, Sajkiewicz P, Kołbuk D, Choińska E (2016) Biodegradation of bicomponent PCL/gelatin and PCL/collagen nanofibers electrospun from alternative solvent system. Polym Degrad Stab 130:10-21. https://doi.org/10.1016/j.polymdegradstab.2016.05.022
100. Ramalingam R, Dhand C, Mayandi V, Leung CM, Ezhilarasu H, Karuppannan SK, ... & Arunachalam KD (2021) Core–shell structured antimicrobial nanofiber dressings containing herbal extract and antibiotics combination for the prevention of biofilms and promotion of cutaneous wound healing. ACS Appl Mater Interfaces 13(21):24356-24369. https://doi.org/10.1021/acsami.0c20642.
101. Hadisi Z, Farokhi M, Bakhsheshi‐Rad, HR, Jahanshahi M, Hasanpour S, Pagan E, ... & Akbari M (2020) Hyaluronic acid (HA)‐based silk fibroin/zinc oxide core–shell electrospun dressing for burn wound management. Macromol Biosci 20(4):1900328. https://doi.org/10.1002/mabi.201900328
102. Naeimirad M, Zadhoush A, Kotek R, Esmaeely Neisiany R, Nouri Khorasani S, & Ramakrishna S (2018) Recent advances in core/shell bicomponent fibers and nanofibers: A review. J Appl Polym Sci 135(21):46265. https://doi.org/10.1002/app.46265
103. Niu Q, Zeng L, Mu X, Nie J, Ma G (2016) Preparation and characterization of core-shell nanofibers by electrospinning combined with in situ UV photopolymerization. J Ind Eng Chem 34:337-343. https://doi.org/10.1016/j.jiec.2015.12.006
104. Tawfik EA, Craig DQ, Barker SA (2020) Dual drug-loaded co-axial nanofibers for the treatment of corneal abrasion. Int J Pharm 581:119296. https://doi.org/10.1016/j.ijpharm.2020.119296
105. Bhattarai RS, Bachu RD, Boddu SH, Bhaduri S (2018) Biomedical applications of electrospun nanofibers: Drug and nanoparticle delivery. Pharm 11(1):5. https://doi.org/10.3390/pharmaceutics11010005
106. Martin A, Cai J, Schaedel AL, Van der Plas M, Malmsten M, Rades T, Heinz A. (2022) Zein-polycaprolactone core–shell nanofibers for wound healing. Int J Pharm 621:121809. https://doi.org/10.1016/j.ijpharm.2022.121809
107. Wen S, Hu Y, Zhang Y, Huang S, Zuo Y, Min Y (2019) Dual-functional core-shell electrospun mats with precisely controlled release of anti-inflammatory and anti-bacterial agents. Mater Sci Eng C 100:514-522. https://doi.org/10.1016/j.msec.2019.02.076
108. Li R, Cheng Z, Wen R, Zhao X, Yu X, Sun L, ... & Kang L (2018) Novel SA@ Ca 2+/RCSPs core–shell structure nanofibers by electrospinning for wound dressings. RSC Adv 8(28):15558-15566. https://doi.org/10.1039/c8ra00784e
109. Chen S, Ge L, Mueller A, Carlson MA, Teusink MJ, Shuler FD, Xie J (2017) Twisting electrospun nanofiber fine strips into functional sutures for sustained co-delivery of gentamicin and silver. Nanomed Nanotechnol Biol Med 13(4):1435-1445. https://doi.org/10.1016/j.nano.2017.01.016
110. Fazio E, Ridolfo A, Neri G (2019) Thermally activated noble metal Nanoparticles incorporated in electrospun fiber-based drug delivery systems. Curr Nanomater 4(1):21-31. https://doi.org/10.2174/1573407214666180914121929
111. Yan E, Jiang J, Yang X, Fan L, Wang Y, An Q, ... & Zhang D (2020) pH-sensitive core-shell electrospun nanofibers based on polyvinyl alcohol/polycaprolactone as a potential drug delivery system for the chemotherapy against cervical cancer. J Drug Delivery Sci Technol 55:101455. https://doi.org/10.1016/j.jddst.2019.101455
112. Yousefi P, Dini G, Movahedi B, Vaezifar S, Mehdikhani M (2022) Polycaprolactone/chitosan core/shell nanofibrous mat fabricated by electrospinning process as carrier for rosuvastatin drug. Polym Bull 79:1627-1645. https://doi.org/10.1007/s00289-021-03566-4
113. Baghali M, Ziyadi H, Faridi-Majidi R (2022) Fabrication and characterization of core–shell TiO2-containing nanofibers of PCL-Zein by coaxial electrospinning method as an erythromycin drug carrier. Polym Bull 10(49):41924-41934. https://doi.org/10.1007/s00289-021-03591-3
114. Buzgo M, Rampichova M, Vocetkova K, Sovkova V, Lukasova V, Doupnik M, Mickova A, Rustichelli F, Amler E (2017) Emulsion centrifugal spinning for production of 3D drug releasing nanofibres with core/shell structure. RSC Adv 7:1215–1228. https://doi.org/10.1039/C6RA26606A
115. He P, Zhong Q, Ge Y, Guo Z, Tian J, Zhou Y, ... & Zhou C (2018) Dual drug loaded co-axial electrospun PLGA/PVP fiber for guided tissue regeneration under control of infection. Mater Sci Eng C 90:549-556. https://doi.org/10.1016/j.msec.2018.04.014
116. Balusamy B, Senthamizhan A, Uyar T (2017) In vivo safety evaluations of electrospun nanofibers for biomedical applications. In: Uyar T, Kny E (ed) In Electrospun Materials for Tissue Engineering and Biomedical Applications 1st edn, Woodhead Publishing, Sawston, ss 101-113.
117. Wijeyaratne SM, Kannangara L (2011) Safety and efficacy of electrospun polycarbonate-urethane vascular graft for early hemodialysis access: first clinical results in man. J Vasc Access 12(1):28-35. https://doi.org/10.5301/jva.2011.6278.
118. Kossovich LY, Salkovskiy Y, Kirillova IV (2010) Electrospun chitosan nanofiber materials as burn dressing. In 6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore: In Conjunction with 14th International Conference on Biomedical Engineering (ICBME) and 5th Asia Pacific Conference on Biomechanics (APBiomech) ss. 1212-1214 Springer Berlin Heidelberg.
119. URL-2 https://www.clinicaltrials.gov/ Erişim 26 Kasım 2023
120. Abdul Hameed MM, Mohamed Khan SAP, Thamer BM, Al-Enizi A, Aldalbahi A, El-Hamshary H, El-Newehy MH (2020) Core-shell nanofibers from poly (vinyl alcohol) based biopolymers using emulsion electrospinning as drug delivery system for cephalexin drug. J Macromol Sci Part A 58(2):130-144. https://doi.org/10.1080/10601325.2020.1832517