KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ

Abstract

Bu çalışmada, kronik periodontitisli (KP) hastalarda başlangıç periodontal tedaviye destek olarak kullanılan, lokal sodyum piperasüin (Periofilm®) uygulamasının klinik ve biyokimyasal parametreler üzerindeki etkisi incelendi. Çalışmaya sondalama derinliği (SD) > 5 mm ve gingival indeksi (Gİ) > 2 olan en az 2 tek köklü dişi bulunan, 20 KP'li hasta dahil edildi. 1. gruba diş yüzeyi temizliği ve kök yüzeyi düzleştirmesi (SRP), 2. gruba SRP'ye ek olarak Periofilm® (SRP+Periofilm®) uygulandı. 0. ve 90. günde plak indeksi, Gİ, SD, rölatif ataşman ve rölatif dişeti kenarı seviyesi ölçüldü ve dişeti oluğu sıvısı (DOS) örnekleri toplandı. Biyokimyasal analizler için toplanan DOS örnekleri içerisinde matriks metalloproteinaz-8 (MMP-8) ve matriks metalloproteinaz doku inhibitörü-1 (TIMP-1) seviyeleri ELISA yöntemi ile değerlendirildi. SRP ve SRP+Periofilm® gruplarının örnekleme bölgelerinde 90. günde klinik parametrelerde başlangıca göre anlamlı iyileşme saptandı (p < 0.05) ve sırasıyla 2.2±0.8 mm ve 2.28±0.68 mm SD azalması, 1.49±0.84 mm ve 1.71±1 mm ataşman kazancı, 0.71±0.58 mm ve 0.56±0.92 mm dişeti çekilmesi tespit edildi. DOS, MMP-8 ve TIMP-1 konsantrasyon değerleri SRP ve SRP+Periofilm® gruplarında klinik parametrelere paralel olarak 90. günde başlangıca göre anlamlı değişim gösterdi (p < 0.001). Tüm parametrelerde gruplar arası karşılaştırmada istatistiksel olarak anlamlı bir farklılık bulunmadı (p > 0.05). Başlangıç periodontal tedaviye ek olarak kullanılan Periofilm® in klinik ve biyokimyasal bulgulara herhangi bir ilave katkısının olmadığı saptandı.

Keywords

• Kronik Periodontitis, Lokal Antibiyotik, MMP-8, TIMP-1

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