ODONTOGENIC TUMORS: WHERE ARE WE IN 2017?

Year 2017, Volume: 51 Issue: 3 Suppl 1, 10 - 30, 17.11.2017

John M. Wright Merva Soluk Tekkeşin

Abstract

Odontogenic tumors are a heterogeneous group of lesions of diverse clinical behavior and histopathologic types, ranging from hamartomatous lesions to malignancy. Because odontogenic tumors arise from the tissues which make our teeth, they are unique to the jaws, and by extension almost unique to dentistry.  Odontogenic tumors, as in normal odontogenesis, are capable of inductive interactions between odontogenic ectomesenchyme and epithelium, and the classification of odontogenic tumors is essentially based on this interaction. The last update of these tumors was published in early 2017. According to this classification, benign odontogenic tumors are classified as follows: Epithelial, mesenchymal (ectomesenchymal), or mixed depending on which component of the tooth germ gives rise to the neoplasm. Malignant odontogenic tumors are quite rare and named similarly according to whether the epithelial or mesenchymal or both components is malignant. The goal of this review is to discuss the updated changes to odontogenic tumors and to review the more common types with clinical and radiological illustrations. 

Keywords

Odontogenic tumors, odontogenesis; update; ameloblastoma; odontomas

References

• Nanci A. Ten cate’s oral histology: Development, structure, and function. 7th ed. Mosby Elsevier 2008, p. 79-107.
• Bilodeau EA, Collins BM. Odontogenic cysts and neoplasms. Surg Pathol Clin 2017;10(1):177-222.
• El-Naggar, Chan JKC, Grandis JR, Takata T, Slootweg P, editors. WHO classification of Head and Neck Tumours. Chapter 8: Odontogenic and maxilofacial bone tumours. 4th edition, IARC: Lyon 2017, p.205-260.
• Barnes L, Eveson J, Reichart P, Sidransky D, editors. WHO Head and Neck Tumours. Chapter 6: Odontogenic tumours. 3rd edition, IARC: Lyon 2005, p. 283-327.
• Kramer IR, Pindborg JJ, Shear M. The who histological typing of odontogenic tumours. A commentary on the second edition. Cancer 1992;70(12):2988-2994.
• Sweeney RT, McClary AC, Myers BR, Biscocho J, Neahring L, Kwei KA, Qu K, Gong X, Ng T, Jones CD, Varma S, Odegaard JI, Sugiyama T, Koyota S, Rubin BP, Troxell ML, Pelham RJ, Zehnder JL, Beachy PA, Pollack JR, West RB. Identification of recurrent smo and braf mutations in ameloblastomas. Nat Genet 2014;46(7):722-725.
• Buchner A, Merrell PW, Carpenter WM. Relative frequency of central odontogenic tumors: A study of 1,088 cases from northern california and comparison to studies from other parts of the world. J Oral Maxillofac Surg 2006;64(9):1343-1352.
• Philipsen HP, Reichart PA, Takata T. Desmoplastic ameloblastoma (including "hybrid" lesion of ameloblastoma). Biological profile based on 100 cases from the literature and own files. Oral Oncol 2001;37(5):455-460.
• Philipsen HP, Reichart PA. Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol 1998;34(5):317-325.
• Dissanayake RK, Jayasooriya PR, Siriwardena DJ, Tilakaratne WM. Review of metastasizing (malignant) ameloblastoma (metam): Pattern of metastasis and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111(6):734-741.
• Van Dam SD, Unni KK, Keller EE. Metastasizing (malignant) ameloblastoma: Review of a unique histopathologic entity and report of mayo clinic experience. J Oral Maxillofac Surg 2010;68(12):2962-2974.
• Hertog D, Bloemena E, Aartman IH, van-der-Waal I. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Med Oral Patol Oral Cir Bucal 2012;17(1):e76-82.
• Hertog D, van der Waal I. Ameloblastoma of the jaws: A critical reappraisal based on a 40-years single institution experience. Oral Oncol 2010;46(1):61-64.
• Badni M, Nagaraja A, Kamath V. Squamous odontogenic tumor: A case report and review of literature. J Oral Maxillofac Pathol 2012;16(1):113-117.
• Jones BE, Sarathy AP, Ramos MB, Foss RD. Squamous odontogenic tumor. Head Neck Pathol 2011;5(1):17-19.
• Philipsen HP, Reichart PA. Adenomatoid odontogenic tumour: Facts and figures. Oral Oncol 1999;35(2):125-131.
• Philipsen HP, Reichart PA, Siar CH, Ng KH, Lau SH, Zhang X, Dhanuthai K, Swasdison S, Jainkittivong A, Meer S, Jivan V, Altini M, Hazarey V, Ogawa I, Takata T, Taylor AA, Godoy H, Delgado WA, Carlos-Bregni R, Macias JF, Matsuzaka K, Sato D, Vargas PA, Adebayo ET. An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: A collaborative retrospective study. J Oral Pathol Med 2007;36(7):383-393.
• Rick GM. Adenomatoid odontogenic tumor. Oral Maxillofac Surg Clin North Am 2004;16(3):333-354.
• Murphy CL, Kestler DP, Foster JS, Wang S, Macy SD, Kennel SJ, Carlson ER, Hudson J, Weiss DT, Solomon A. Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles. Amyloid 2008;15(2):89-95.
• Philipsen HP, Reichart PA. Calcifying epithelial odontogenic tumour: Biological profile based on 181 cases from the literature. Oral Oncol 2000;36(1):17-26.
• Kaplan I, Buchner A, Calderon S, Kaffe I. Radiological and clinical features of calcifying epithelial odontogenic tumour. Dentomaxillofac Radiol 2001;30(1):22-28.
• Buchner A, Vered M. Ameloblastic fibroma: A stage in the development of a hamartomatous odontoma or a true neoplasm? Critical analysis of 162 previously reported cases plus 10 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116(5):598-606.
• Chrcanovic BR, Gomez RS. Ameloblastic fibrodentinoma and ameloblastic fibro-odontoma: An updated systematic review of cases reported in the literature. J Oral Maxillofac Surg 2017;75(7):1425-1437.
• Manzon S, Philbert RF, Bush BF, Zola MB, Solomon M. Treatment of a recurrent ameloblastic fibroma. N Y State Dent J 2015;81(1):30-32.
• Mosqueda-Taylor A, Pires FR, Aguirre-Urizar JM, Carlos-Bregni R, de la Piedra-Garza JM, Martinez-Conde R, Martinez-Mata G, Carreno-Alvarez SJ, da Silveira HM, de Barros Dias BS, de Almeida OP. Primordial odontogenic tumour: Clinicopathological analysis of six cases of a previously undescribed entity. Histopathology 2014;65(5):606-612.
• Slater LJ, Eftimie LF, Herford AS. Primordial odontogenic tumor: Report of a case. J Oral Maxillofac Surg 2016;74(3):547-551.
• Soluk Tekkesin M, Pehlivan S, Olgac V, Aksakalli N, Alatli C. Clinical and histopathological investigation of odontomas: Review of the literature and presentation of 160 cases. J Oral Maxillofac Surg 2012;70(6):1358-1361.
• Philipsen HP, Reichart PA, Praetorius F. Mixed odontogenic tumours and odontomas. Considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas. Oral Oncol 1997;33(2):86-99.
• Buchner A, Akrish SJ, Vered M. Central dentinogenic ghost cell tumor: An update on a rare aggressive odontogenic tumor. J Oral Maxillofac Surg 2016;74(2):307-314.
• Candido GA, Viana KA, Watanabe S, Vencio EF. Peripheral dentinogenic ghost cell tumor: A case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108(3):e86-90.
• Sun G, Huang X, Hu Q, Yang X, Tang E. The diagnosis and treatment of dentinogenic ghost cell tumor. Int J Oral Maxillofac Surg 2009;38(11):1179-1183.
• Monteiro LS, Martins M, Pacheco JJ, Salazar F, Magalhaes J, Vescovi P, Meleti M. Er:Yag laser assisted treatment of central odontogenic fibroma of the mandible. Case Rep Dent 2015;2015:230297.
• Mosqueda-Taylor A, Martinez-Mata G, Carlos-Bregni R, Vargas PA, Toral-Rizo V, Cano-Valdez AM, Palma-Guzman JM, Carrasco-Daza D, Luna-Ortiz K, Ledesma-Montes C, de Almeida OP. Central odontogenic fibroma: New findings and report of a multicentric collaborative study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112(3):349-358.
• Olgac V, Koseoglu BG, Aksakalli N. Odontogenic tumours in Istanbul: 527 cases. Br J Oral Maxillofac Surg 2006;44(5):386-388.
• Raubenheimer EJ, Noffke CE. Peripheral odontogenic myxoma: A review of the literature and report of two cases. J Maxillofac Oral Surg 2012;11(1):101-104.
• Martinez-Mata G, Mosqueda-Taylor A, Carlos-Bregni R, de Almeida OP, Contreras-Vidaurre E, Vargas PA, Cano-Valdez AM, Dominguez-Malagon H. Odontogenic myxoma: Clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol 2008;44(6):601-607.
• Noffke CE, Raubenheimer EJ, Chabikuli NJ, Bouckaert MM. Odontogenic myxoma: Review of the literature and report of 30 cases from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104(1):101-109.
• Meleti M, Giovannacci I, Corradi D, Manfredi M, Merigo E, Bonanini M, Vescovi P. Odontogenic myxofibroma: A concise review of the literature with emphasis on the surgical approach. Med Oral Patol Oral Cir Bucal 2015;20(1):e1-6.
• Brannon RB, Fowler CB, Carpenter WM, Corio RL. Cementoblastoma: An innocuous neoplasm? A clinicopathologic study of 44 cases and review of the literature with special emphasis on recurrence. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93(3):311-320.
• Jelic JS, Loftus MJ, Miller AS, Cleveland DB. Benign cementoblastoma: Report of an unusual case and analysis of 14 additional cases. J Oral Maxillofac Surg 1993;51(9):1033-1037.
• El-Mofty SK. Fibro-osseous lesions of the craniofacial skeleton: An update. Head Neck Pathol 2014;8(4):432-444.
• Liu Y, Wang H, You M, Yang Z, Miao J, Shimizutani K, Koseki T. Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol 2010;39(1):57-63.
• Brunner P, Bihl M, Jundt G, Baumhoer D, Hoeller S. Braf p.V600e mutations are not unique to ameloblastoma and are shared by other odontogenic tumors with ameloblastic morphology. Oral Oncol 2015;51(10):e77-78.
• Hall JM, Weathers DR, Unni KK. Ameloblastic carcinoma: An analysis of 14 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103(6):799-807.
• Kruse AL, Zwahlen RA, Gratz KW. New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol 2009;1:31.
• Wright JM, Vered M. Update from the 4th edition of the world health organization classification of head and neck tumours: Odontogenic and maxillofacial bone tumors. Head Neck Pathol 2017;11(1):68-77.
• Thomas G, Pandey M, Mathew A, Abraham EK, Francis A, Somanathan T, Iype M, Sebastian P, Nair MK. Primary intraosseous carcinoma of the jaw: Pooled analysis of world literature and report of two new cases. Int J Oral Maxillofac Surg 2001;30(4):349-355.
• Zwetyenga N, Pinsolle J, Rivel J, Majoufre-Lefebvre C, Faucher A, Pinsolle V. Primary intraosseous carcinoma of the jaws. Arch Otolaryngol Head Neck Surg 2001;127(7):794-797.
• Tiwari M. Primary intraosseous carcinoma of the mandible: A case report with literature review. J Oral Maxillofac Pathol 2011;15(2):205-210.
• Bodner L, Manor E, Shear M, van der Waal I. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: A clinicopathologic analysis of 116 reported cases. J Oral Pathol Med 2011;40(10):733-738.
• Koutlas IG, Allen CM, Warnock GR, Manivel JC. Sclerosing odontogenic carcinoma: A previously unreported variant of a locally aggressive odontogenic neoplasm without apparent metastatic potential. Am J Surg Pathol 2008;32(11):1613-1619.
• Richardson MS, Muller S. Malignant odontogenic tumors: An update on selected tumors. Head Neck Pathol 2014;8(4):411-420.
• Tan SH, Yeo JF, Kheem Pang BN, Petersson F. An intraosseous sclerosing odontogenic tumor predominantly composed of epithelial cells: Relation to (so-called) sclerosing odontogenic carcinoma and epithelial-rich central odontogenic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118(4):e119-125.
• Bilodeau EA, Weinreb I, Antonescu CR, Zhang L, Dacic S, Muller S, Barker B, Seethala RR. Clear cell odontogenic carcinomas show ewsr1 rearrangements: A novel finding and a biological link to salivary clear cell carcinomas. Am J Surg Pathol 2013;37(7):1001-1005.
• Ebert CS, Jr., Dubin MG, Hart CF, Chalian AA, Shockley WW. Clear cell odontogenic carcinoma: A comprehensive analysis of treatment strategies. Head Neck 2005;27(6):536-542.
• Loyola AM, Cardoso SV, de Faria PR, Servato JP, Barbosa de Paulo LF, Eisenberg AL, Dias FL, Gomes CC, Gomez RS. Clear cell odontogenic carcinoma: Report of 7 new cases and systematic review of the current knowledge. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;120(4):483-496.
• Dahiya S, Kumar R, Sarkar C, Ralte M, Sharma MC. Clear cell odontogenic carcinoma: A diagnostic dilemma. Pathol Oncol Res 2002;8(4):283-285.
• Ledesma-Montes C, Gorlin RJ, Shear M, Prae Torius F, Mosqueda-Taylor A, Altini M, Unni K, Paes de Almeida O, Carlos-Bregni R, Romero de Leon E, Phillips V, Delgado-Azanero W, Meneses-Garcia A. International collaborative study on ghost cell odontogenic tumours: Calcifying cystic odontogenic tumour, dentinogenic ghost cell tumour and ghost cell odontogenic carcinoma. J Oral Pathol Med 2008;37(5):302-308.
• Ahmed SK, Watanabe M, deMello DE, Daniels TB. Pediatric metastatic odontogenic ghost cell carcinoma: A multimodal treatment approach. Rare Tumors 2015;7(2):5855.
• Bertoni F, Del Corso G, Bacchini P, Marchetti C, Tarsitano A. Ameloblastic fibrosarcoma of the mandible evolving from a prior ameloblastic fibroma after two years: An unusual finding. Int J Surg Pathol 2016;24(7):656-659.
• Muller S, Parker DC, Kapadia SB, Budnick SD, Barnes EL. Ameloblastic fibrosarcoma of the jaws. A clinicopathologic and DNA analysis of five cases and review of the literature with discussion of its relationship to ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79(4):469-477.
• Kunkel M, Ghalibafian M, Radner H, Reichert TE, Fischer B, Wagner W. Ameloblastic fibrosarcoma or odontogenic carcinosarcoma: A matter of classification? Oral Oncol 2004;40(4):444-449.
• Kim IK, Pae SP, Cho HY, Cho HW, Seo JH, Lee DH, Park IS. Odontogenic carcinosarcoma of the mandible: A case report and review. J Korean Assoc Oral Maxillofac Surg 2015;41(3):139-144.
• DeLair D, Bejarano PA, Peleg M, El-Mofty SK. Ameloblastic carcinosarcoma of the mandible arising in ameloblastic fibroma: A case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103(4):516-520.