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Year 2011, Volume: 45 Issue: 3, 49 - 57, 26.08.2013

Abstract

References

  • Offenbacher S. Periodontal diseases: Pathogenesis. Ann Periodontal, 1996; 11: 821ı 78.
  • Loesche WJ, Syed SA, Schmidt E, Morrison EC. Bacterial profiles of subgingival plaques in periodontitis. J Periodontal, 1985; 56 (8): 447ı 56.
  • Mousques T, Listgarten MA, Philips RW. Effect of scaling and root planing on the composition of human subgingival microbial flora. J Periodont Res, 1980; 15: 144-151.
  • Birkedal-Hansen H. Role of matrix metalloproteinases in human periodontal diseases. J Periodontal, 1993; 64 (5 Suppl):
  • Uitto VJ, Overall CM, McCulloch C. Proteolytic host cell enzymes in gingival crevice fluid. Periodontal 2000, 2003; 31: 77ı 104.
  • Ryan ME, Golub LM. Modulation of matrix metalloproteinase activities in periodontitis as a treatment strategy. Periodontal 2000, 2000; 24: 226-38.
  • Ryan ME, Ramamurthy S, Golub LM. Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodontal, 1996; 3: 85-96.
  • Reynolds JJ, Meikle MC. Mechanisms of connective tissue matrix destruction in periodontitis. Periodontal 2000, 1997; 14: 144ı 57.
  • Palosaari H, Wahlgren J, Larmas M, Rônkâ H, Sorsa T, Salo T, Tjâderhane L. The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1. J Dent Res, 2000; 79 (1): 77-84.
  • Golub LM, Suomalainen K, Sorsa T. Host modulation with tetracyclines and their chemically modified analogues. Curr Opin Dent, 1992; 2: 80-90.
  • Golub LM, Sorsa T, Lee HM, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol, 1995; 22 (2): 100-109.
  • Golub LM, Lee HM, Greenwald RA, Ryan ME, Sorsa T, Salo T, Giannobile WV. A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res, 1997; 46 (8): 310-319.
  • Lee W, Aitken S, Sodek J, McCulloch CA. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis. J Periodontal Res, 1995; 30 (1): 23-33.
  • Ingman T, Tervahartiala T, Ding Y, Tschesche H, Haerian A, Kinane DF, Konttinen YT, Sorsa T. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol, 1996; 23 (12): 1127-1132.
  • Ingman T, Sorsa T, Lindy O, Koski H, Konttinen YT. Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients. J Clin Periodontol, 1994; 21 (1): 26ı 31.
  • Chen HY, Cox SW, Eley BM, Mantyla P, Ronka H, Sorsa T. Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients. J Clin Periodontol, 2000; 27 (5): 366ı 369.
  • Mancini S, Romanelli R, Laschinger CA, Overall CM, Sodek J, McCulloch CA. Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases. J Periodontol, 1999; 70 (11): 1292-302.
  • Kiili M, Cox SW, Chen HY, Wahlgren J, Maisi P, Eley BM, Salo T, Sorsa T. Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue. J Clin Periodontol, 2002; 29 (3): 224-232.
  • Sorsa T, Mäntylä P, Rönkä H, Kallio P, Kallis GB, Lundqvist C, Kinane DF, Salo T, Golub LM, Teronen O, Tikanoja S. Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease. Ann N Y Acad Sci, 1999; 30: 130-40.
  • Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA. Activation of neutrophil collagenase in periodontitis. Infect Immun, 1999; 67 (5): 2319-26.
  • Tervahartiala T, Pirilä E, Ceponis A, Maisi P, Salo T, Tuter G, Kallio P, Törnwall J, Srinivas R, Konttinen YT, Sorsa T. The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis. J Dent Res, 2000; 79 (12): 1969-77.
  • Kinane DF, Darby IB, Said S, Luoto H, Sorsa T, Tikanoja S, Mäntylä P. Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance. J Periodontal Res, 2003; 38 (4):
  • Tüter G, Kurtis. B, Serdar M, Yücel A, Ayhan E, Karaduman B, Ozcan G. Effects of phase I periodontal treatment on gingival crevicular fluid levels of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1. J Clin Periodontol, 2005; 32 (9): 1011-5.
  • Kumar MS, Vamsi G, Sripriya R, Sehgal PK. Expression of matrix metalloproteinases (MMP-8 and -9) in chronic periodontitis patients with and without diabetes mellitus. J Periodontol, 2006; 77 (11): 1803-8.
  • Haerian A, Adonogianaki E, Mooney J, Docherty JP, Kinane DF. Gingival crevicular stromelysin, collagenase and tissue inhibitor of matrix metalloproteinase levels in healthy and diseased sites. J Clin Periodontol, 1995; 22: 505-09.
  • Kubota T, Matsuki Y, Nomura T, Hara K. In situ hybridization study on tissue inhibitors of metalloproteinases (TIMPs) mRNA-expressing cells in human inflamed gingival tissue. J Periodont Res, 1997; 32: 467-72.
  • Noyan Ü, Yılmaz S, Kuru B, Kadir T, Acar O, Büget E. A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. J Clin Periodontol, 1997; 24: 158-65.
  • Badersten A, Nilveus R, Egelberg J. Effect of non-surgical periodontal therapy. I. Moderately advanced periodontitis. J Clin Periodontol, 1981; 8: 57-72.
  • Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 2000, 1996; 10: 139-159.
  • Quirynen M, De Soete M, Dierickx K, van Steenberghe D. The intra-oral translocation of periodontopathogens jeopardizes the outcome of periodontal therapy. J Clin Periodontol, 2001; 28: 499-507.
  • Slots J. Selection of antimicrobial agents in periodontal therapy. J Periodontal Res, 2002; 37 (5): 389-98.
  • Ciancio SG. Nonsurgical chemical periodontal therapy. Periodontol 2000, 1995; 9: 27-37.
  • Visconti PC, Capuano A, Parrini S. Local antibiotic therapy with sodium piperacillin. Dental Cadmods, 2003; 04: 73-81.
  • Novak MJ. Classification of diseases and conditions affecting the periodontium. Carranza FA Clinical Periodontology. 10. bs., USA : W.B. Saunders Co., 2009, s: 100-109.
  • Armitage GC. Development of classification system for periodontal diseases and conditions. Ann Periodontol, 1999; 4: 1-6.
  • Joyston-Bechal S, Smales FC, Duckworth R. A follow-up study 3 years after metronidazole therapy for chronic periodontal disease. J Clin Periodontol, 1986; 13: 944- 949.
  • Africa CW, Parker JR, Reddy J. Study of the cultivable flora of subgingival plaque of patients with severe periodontitis. J Dent Assoc S Afr, 1985; 40 (1): 11-4.
  • Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr, Socransky SS. Clinical and microbiological features of subjects with adult periodontitis who responded poorly to scaling and root planing. J Clin Periodontol, 1997; 24 (10): 767-76.
  • O'Conner BC, Newman HN, Wilson M. Susceptibility and resistance of plaque bacteria to minocycline. J Periodontol, 1990; 61: 228ı 33.
  • Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000, 1997; 14: 12-32.
  • Lamont RJ, Oda D, Persson RE, Persson GR. Interaction of Porphyromonas gingivalis with gingival epithelial cellsmaintained in culture. Oral Microbiol Immunol, 1997; 7: 364-367.
  • Rifkin BR, Vernillo AT, Golub LM. Blocking periodontal disease progression by inhibiting tissue destructive enzymes: a potential therapeutic role for tetracyclines and their chemically modified analogs. J Periodontol, 1993; 64 (8 Suppl): 819-27.
  • Slots J, Rams TE. Antibiotics in periodontal therapy: advantages and disadvantages. J Clin Periodontol, 1990; 17 (7): 479-93.
  • Sutter VL, Jones JM, Ghoniem AT. Antimicrobial susceptibilities of bacteria associated with periodontal disesae. Antimicrob Agants Chemother, 1983; 23: 483-486.
  • Walker CB, Pappas JD, Tyler KZ, Cohen S, Gordon JM. Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents. J Periodontol, 1985; 56 (suppl): 67-74.
  • Walker CB, Tyler KT, Low SB, King CJ. Penicillin degrading enzymes in sites associated with adult periodontitis. Oral Microbiol Immunol, 1987; 2: 129-31.
  • Layton JM, Walker CB, Pappas JD. Gingival fluid level of amoxicillin and its MIC's for periodontal bacteria. J Dent Res, 1983; 62 (spec. issue): 290.
  • Kinder SA, Holt SC, Kornman KS. Penicillin resistance in the subgingival microbiota associated with adult periodontitis. J Clin Microbiol, 1986; 23: 1127-1133.
  • Valdes MV, Lobbins PM, Slots J. Beta- lactamase producing bacterian in the human oral cavity. J Oral Pathol, 1982; 11: 58-63.

KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ

Year 2011, Volume: 45 Issue: 3, 49 - 57, 26.08.2013

Abstract

Bu çalışmada, kronik periodontitisli (KP) hastalarda başlangıç periodontal tedaviye destek olarak kullanılan, lokal sodyum
piperasüin (Periofilm®) uygulamasının klinik ve biyokimyasal parametreler üzerindeki etkisi incelendi. Çalışmaya sondalama
derinliği (SD) > 5 mm ve gingival indeksi (Gİ) > 2 olan en az 2 tek köklü dişi bulunan, 20 KP'li hasta dahil edildi. 1. gruba
diş yüzeyi temizliği ve kök yüzeyi düzleştirmesi (SRP), 2. gruba SRP'ye ek olarak Periofilm® (SRP+Periofilm®) uygulandı.
0. ve 90. günde plak indeksi, Gİ, SD, rölatif ataşman ve rölatif dişeti kenarı seviyesi ölçüldü ve dişeti oluğu sıvısı (DOS)
örnekleri toplandı. Biyokimyasal analizler için toplanan DOS örnekleri içerisinde matriks metalloproteinaz-8 (MMP-8) ve
matriks metalloproteinaz doku inhibitörü-1 (TIMP-1) seviyeleri ELISA yöntemi ile değerlendirildi. SRP ve SRP+Periofilm®
gruplarının örnekleme bölgelerinde 90. günde klinik parametrelerde başlangıca göre anlamlı iyileşme saptandı (p < 0.05) ve
sırasıyla 2.2±0.8 mm ve 2.28±0.68 mm SD azalması, 1.49±0.84 mm ve 1.71±1 mm ataşman kazancı, 0.71±0.58 mm ve
0.56±0.92 mm dişeti çekilmesi tespit edildi. DOS, MMP-8 ve TIMP-1 konsantrasyon değerleri SRP ve SRP+Periofilm®
gruplarında klinik parametrelere paralel olarak 90. günde başlangıca göre anlamlı değişim gösterdi (p < 0.001). Tüm
parametrelerde gruplar arası karşılaştırmada istatistiksel olarak anlamlı bir farklılık bulunmadı (p > 0.05). Başlangıç
periodontal tedaviye ek olarak kullanılan Periofilm® in klinik ve biyokimyasal bulgulara herhangi bir ilave katkısının
olmadığı saptandı.

References

  • Offenbacher S. Periodontal diseases: Pathogenesis. Ann Periodontal, 1996; 11: 821ı 78.
  • Loesche WJ, Syed SA, Schmidt E, Morrison EC. Bacterial profiles of subgingival plaques in periodontitis. J Periodontal, 1985; 56 (8): 447ı 56.
  • Mousques T, Listgarten MA, Philips RW. Effect of scaling and root planing on the composition of human subgingival microbial flora. J Periodont Res, 1980; 15: 144-151.
  • Birkedal-Hansen H. Role of matrix metalloproteinases in human periodontal diseases. J Periodontal, 1993; 64 (5 Suppl):
  • Uitto VJ, Overall CM, McCulloch C. Proteolytic host cell enzymes in gingival crevice fluid. Periodontal 2000, 2003; 31: 77ı 104.
  • Ryan ME, Golub LM. Modulation of matrix metalloproteinase activities in periodontitis as a treatment strategy. Periodontal 2000, 2000; 24: 226-38.
  • Ryan ME, Ramamurthy S, Golub LM. Matrix metalloproteinases and their inhibition in periodontal treatment. Curr Opin Periodontal, 1996; 3: 85-96.
  • Reynolds JJ, Meikle MC. Mechanisms of connective tissue matrix destruction in periodontitis. Periodontal 2000, 1997; 14: 144ı 57.
  • Palosaari H, Wahlgren J, Larmas M, Rônkâ H, Sorsa T, Salo T, Tjâderhane L. The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1. J Dent Res, 2000; 79 (1): 77-84.
  • Golub LM, Suomalainen K, Sorsa T. Host modulation with tetracyclines and their chemically modified analogues. Curr Opin Dent, 1992; 2: 80-90.
  • Golub LM, Sorsa T, Lee HM, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol, 1995; 22 (2): 100-109.
  • Golub LM, Lee HM, Greenwald RA, Ryan ME, Sorsa T, Salo T, Giannobile WV. A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res, 1997; 46 (8): 310-319.
  • Lee W, Aitken S, Sodek J, McCulloch CA. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis. J Periodontal Res, 1995; 30 (1): 23-33.
  • Ingman T, Tervahartiala T, Ding Y, Tschesche H, Haerian A, Kinane DF, Konttinen YT, Sorsa T. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol, 1996; 23 (12): 1127-1132.
  • Ingman T, Sorsa T, Lindy O, Koski H, Konttinen YT. Multiple forms of gelatinases/type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients. J Clin Periodontol, 1994; 21 (1): 26ı 31.
  • Chen HY, Cox SW, Eley BM, Mantyla P, Ronka H, Sorsa T. Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients. J Clin Periodontol, 2000; 27 (5): 366ı 369.
  • Mancini S, Romanelli R, Laschinger CA, Overall CM, Sodek J, McCulloch CA. Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases. J Periodontol, 1999; 70 (11): 1292-302.
  • Kiili M, Cox SW, Chen HY, Wahlgren J, Maisi P, Eley BM, Salo T, Sorsa T. Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue. J Clin Periodontol, 2002; 29 (3): 224-232.
  • Sorsa T, Mäntylä P, Rönkä H, Kallio P, Kallis GB, Lundqvist C, Kinane DF, Salo T, Golub LM, Teronen O, Tikanoja S. Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease. Ann N Y Acad Sci, 1999; 30: 130-40.
  • Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA. Activation of neutrophil collagenase in periodontitis. Infect Immun, 1999; 67 (5): 2319-26.
  • Tervahartiala T, Pirilä E, Ceponis A, Maisi P, Salo T, Tuter G, Kallio P, Törnwall J, Srinivas R, Konttinen YT, Sorsa T. The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis. J Dent Res, 2000; 79 (12): 1969-77.
  • Kinane DF, Darby IB, Said S, Luoto H, Sorsa T, Tikanoja S, Mäntylä P. Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance. J Periodontal Res, 2003; 38 (4):
  • Tüter G, Kurtis. B, Serdar M, Yücel A, Ayhan E, Karaduman B, Ozcan G. Effects of phase I periodontal treatment on gingival crevicular fluid levels of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1. J Clin Periodontol, 2005; 32 (9): 1011-5.
  • Kumar MS, Vamsi G, Sripriya R, Sehgal PK. Expression of matrix metalloproteinases (MMP-8 and -9) in chronic periodontitis patients with and without diabetes mellitus. J Periodontol, 2006; 77 (11): 1803-8.
  • Haerian A, Adonogianaki E, Mooney J, Docherty JP, Kinane DF. Gingival crevicular stromelysin, collagenase and tissue inhibitor of matrix metalloproteinase levels in healthy and diseased sites. J Clin Periodontol, 1995; 22: 505-09.
  • Kubota T, Matsuki Y, Nomura T, Hara K. In situ hybridization study on tissue inhibitors of metalloproteinases (TIMPs) mRNA-expressing cells in human inflamed gingival tissue. J Periodont Res, 1997; 32: 467-72.
  • Noyan Ü, Yılmaz S, Kuru B, Kadir T, Acar O, Büget E. A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. J Clin Periodontol, 1997; 24: 158-65.
  • Badersten A, Nilveus R, Egelberg J. Effect of non-surgical periodontal therapy. I. Moderately advanced periodontitis. J Clin Periodontol, 1981; 8: 57-72.
  • Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontol 2000, 1996; 10: 139-159.
  • Quirynen M, De Soete M, Dierickx K, van Steenberghe D. The intra-oral translocation of periodontopathogens jeopardizes the outcome of periodontal therapy. J Clin Periodontol, 2001; 28: 499-507.
  • Slots J. Selection of antimicrobial agents in periodontal therapy. J Periodontal Res, 2002; 37 (5): 389-98.
  • Ciancio SG. Nonsurgical chemical periodontal therapy. Periodontol 2000, 1995; 9: 27-37.
  • Visconti PC, Capuano A, Parrini S. Local antibiotic therapy with sodium piperacillin. Dental Cadmods, 2003; 04: 73-81.
  • Novak MJ. Classification of diseases and conditions affecting the periodontium. Carranza FA Clinical Periodontology. 10. bs., USA : W.B. Saunders Co., 2009, s: 100-109.
  • Armitage GC. Development of classification system for periodontal diseases and conditions. Ann Periodontol, 1999; 4: 1-6.
  • Joyston-Bechal S, Smales FC, Duckworth R. A follow-up study 3 years after metronidazole therapy for chronic periodontal disease. J Clin Periodontol, 1986; 13: 944- 949.
  • Africa CW, Parker JR, Reddy J. Study of the cultivable flora of subgingival plaque of patients with severe periodontitis. J Dent Assoc S Afr, 1985; 40 (1): 11-4.
  • Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr, Socransky SS. Clinical and microbiological features of subjects with adult periodontitis who responded poorly to scaling and root planing. J Clin Periodontol, 1997; 24 (10): 767-76.
  • O'Conner BC, Newman HN, Wilson M. Susceptibility and resistance of plaque bacteria to minocycline. J Periodontol, 1990; 61: 228ı 33.
  • Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000, 1997; 14: 12-32.
  • Lamont RJ, Oda D, Persson RE, Persson GR. Interaction of Porphyromonas gingivalis with gingival epithelial cellsmaintained in culture. Oral Microbiol Immunol, 1997; 7: 364-367.
  • Rifkin BR, Vernillo AT, Golub LM. Blocking periodontal disease progression by inhibiting tissue destructive enzymes: a potential therapeutic role for tetracyclines and their chemically modified analogs. J Periodontol, 1993; 64 (8 Suppl): 819-27.
  • Slots J, Rams TE. Antibiotics in periodontal therapy: advantages and disadvantages. J Clin Periodontol, 1990; 17 (7): 479-93.
  • Sutter VL, Jones JM, Ghoniem AT. Antimicrobial susceptibilities of bacteria associated with periodontal disesae. Antimicrob Agants Chemother, 1983; 23: 483-486.
  • Walker CB, Pappas JD, Tyler KZ, Cohen S, Gordon JM. Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents. J Periodontol, 1985; 56 (suppl): 67-74.
  • Walker CB, Tyler KT, Low SB, King CJ. Penicillin degrading enzymes in sites associated with adult periodontitis. Oral Microbiol Immunol, 1987; 2: 129-31.
  • Layton JM, Walker CB, Pappas JD. Gingival fluid level of amoxicillin and its MIC's for periodontal bacteria. J Dent Res, 1983; 62 (spec. issue): 290.
  • Kinder SA, Holt SC, Kornman KS. Penicillin resistance in the subgingival microbiota associated with adult periodontitis. J Clin Microbiol, 1986; 23: 1127-1133.
  • Valdes MV, Lobbins PM, Slots J. Beta- lactamase producing bacterian in the human oral cavity. J Oral Pathol, 1982; 11: 58-63.
There are 49 citations in total.

Details

Primary Language Turkish
Journal Section Original Research Articles
Authors

Şebnem Dirikan İpçi This is me

Gökser Çakar Gürlüman This is me

Nazlı Menemencioğlu This is me

Bahar Eren Kuru This is me

Ülkü Noyan This is me

Selçuk Yılmaz This is me

Publication Date August 26, 2013
Published in Issue Year 2011 Volume: 45 Issue: 3

Cite

APA Dirikan İpçi, Ş., Çakar Gürlüman, G., Menemencioğlu, N., Eren Kuru, B., et al. (2013). KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ. Journal of Istanbul University Faculty of Dentistry, 45(3), 49-57.
AMA Dirikan İpçi Ş, Çakar Gürlüman G, Menemencioğlu N, Eren Kuru B, Noyan Ü, Yılmaz S. KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ. J Istanbul Univ Fac Dent. August 2013;45(3):49-57.
Chicago Dirikan İpçi, Şebnem, Gökser Çakar Gürlüman, Nazlı Menemencioğlu, Bahar Eren Kuru, Ülkü Noyan, and Selçuk Yılmaz. “KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ”. Journal of Istanbul University Faculty of Dentistry 45, no. 3 (August 2013): 49-57.
EndNote Dirikan İpçi Ş, Çakar Gürlüman G, Menemencioğlu N, Eren Kuru B, Noyan Ü, Yılmaz S (August 1, 2013) KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ. Journal of Istanbul University Faculty of Dentistry 45 3 49–57.
IEEE Ş. Dirikan İpçi, G. Çakar Gürlüman, N. Menemencioğlu, B. Eren Kuru, Ü. Noyan, and S. Yılmaz, “KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ”, J Istanbul Univ Fac Dent, vol. 45, no. 3, pp. 49–57, 2013.
ISNAD Dirikan İpçi, Şebnem et al. “KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ”. Journal of Istanbul University Faculty of Dentistry 45/3 (August 2013), 49-57.
JAMA Dirikan İpçi Ş, Çakar Gürlüman G, Menemencioğlu N, Eren Kuru B, Noyan Ü, Yılmaz S. KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ. J Istanbul Univ Fac Dent. 2013;45:49–57.
MLA Dirikan İpçi, Şebnem et al. “KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ”. Journal of Istanbul University Faculty of Dentistry, vol. 45, no. 3, 2013, pp. 49-57.
Vancouver Dirikan İpçi Ş, Çakar Gürlüman G, Menemencioğlu N, Eren Kuru B, Noyan Ü, Yılmaz S. KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ. J Istanbul Univ Fac Dent. 2013;45(3):49-57.