KRONİK PERIODONTITISTE BAŞLANGIÇ PERIODONTAL TEDAVİYE E K OLARAK YARA ÖRTÜCÜ AJAN (PERIOFILM®) UYGULAMASININ KLİNİK V E BİYOKİMYASAL ETKİLERİNİN İNCELENMESİ

Year 2011, Volume: 45 Issue: 3, 49 - 57, 26.08.2013

Şebnem Dirikan İpçi Gökser Çakar Gürlüman Nazlı Menemencioğlu Bahar Eren Kuru Ülkü Noyan Selçuk Yılmaz

Abstract

Bu çalışmada, kronik periodontitisli (KP) hastalarda başlangıç periodontal tedaviye destek olarak kullanılan, lokal sodyum
piperasüin (Periofilm®) uygulamasının klinik ve biyokimyasal parametreler üzerindeki etkisi incelendi. Çalışmaya sondalama
derinliği (SD) > 5 mm ve gingival indeksi (Gİ) > 2 olan en az 2 tek köklü dişi bulunan, 20 KP'li hasta dahil edildi. 1. gruba
diş yüzeyi temizliği ve kök yüzeyi düzleştirmesi (SRP), 2. gruba SRP'ye ek olarak Periofilm® (SRP+Periofilm®) uygulandı.
0. ve 90. günde plak indeksi, Gİ, SD, rölatif ataşman ve rölatif dişeti kenarı seviyesi ölçüldü ve dişeti oluğu sıvısı (DOS)
örnekleri toplandı. Biyokimyasal analizler için toplanan DOS örnekleri içerisinde matriks metalloproteinaz-8 (MMP-8) ve
matriks metalloproteinaz doku inhibitörü-1 (TIMP-1) seviyeleri ELISA yöntemi ile değerlendirildi. SRP ve SRP+Periofilm®
gruplarının örnekleme bölgelerinde 90. günde klinik parametrelerde başlangıca göre anlamlı iyileşme saptandı (p < 0.05) ve
sırasıyla 2.2±0.8 mm ve 2.28±0.68 mm SD azalması, 1.49±0.84 mm ve 1.71±1 mm ataşman kazancı, 0.71±0.58 mm ve
0.56±0.92 mm dişeti çekilmesi tespit edildi. DOS, MMP-8 ve TIMP-1 konsantrasyon değerleri SRP ve SRP+Periofilm®
gruplarında klinik parametrelere paralel olarak 90. günde başlangıca göre anlamlı değişim gösterdi (p < 0.001). Tüm
parametrelerde gruplar arası karşılaştırmada istatistiksel olarak anlamlı bir farklılık bulunmadı (p > 0.05). Başlangıç
periodontal tedaviye ek olarak kullanılan Periofilm® in klinik ve biyokimyasal bulgulara herhangi bir ilave katkısının
olmadığı saptandı.

Keywords

Kronik Periodontitis, Lokal Antibiyotik, MMP-8, TIMP-1

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