DİŞ HEKİMLİĞİNDE DOKU MÜHENDİSLİĞİNİN YERİ

Year 2012, Volume: 46 Issue: 2, 47 - 57, 04.09.2012

Z. Sırık Selen Ergin Gülbahar Işık

Abstract

Doku mühendisliği hasarlı doku ve organların yeniden restore edilmesini amaçlayan bir mühendislik
dalıdır. Bu mühendislik dalı, hücrelerin doğal veya sentetik yapı iskelelerine spesifik sinyallerle
entegre edilmesi üzerine kurulmuştur. Bu kısa derlemede diş hekimliğinde doku mühedisliği stratejiler
ve uygulama alanları olarak iki başlık altında incelenmiştir. Doku mühendisliği stratejilerinde doku
kondüksiyonu, doku indüksiyonu, kök hücre nakli ve gen terapisi tanımlanmış, doku mühendisliği
uygulama alanlarında da oral kavitenin kemik, kıkırdak, dentin, dental pulpa ve tükürük bezi gibi çe­
şitli dokularında yapılan rejeneratif çalışmalar incelenmiştir. Doku mühendisliği stratejileri ile bugün,
deri, kıkırdak gibi dokular laboratuvarda işlendikten sonra bazı medikal uygulamalarda kullanılabil¬
mektedir. Oral kavitenin çeşitli dokularında çok geniş uygulama alanları bulunan doku mühendisliği,
diş hekimliğinde devrim niteliğinde olsa da kompleks doku defektlerinin tedavisi üzerine daha çok
araştırma yapılmasına ihtiyaç vardır.

Keywords

Doku mühendisliği, prostodonti, diş hekimliği, kök hücre, rejenerasyon

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