REJENERATİF ENDODONTİ

Year 2012, Volume: 46 Issue: 3, 91 - 98, 19.12.2012

Ayça Yılmaz

Abstract

Rejeneratif tıp ve doku mühendisliğinin son yıllardaki hızlı gelişimi; tıbbın bütün dallarında olduğu
gibi, diş hekimliğinde de rejeneratif uygulamaların gündeme gelmesini sağlamıştır. Diş hekimliğinde
uygulanan ilk rejeneratif tedavinin 1952 yılında Hermann tarafından uygulanan vital amputasyon tedavisi
olduğu kabul edilmektedir. Bunu takiben, yönlendirilmiş doku ve kemik rejenerasyonları, distraksiyon
osteogenezi, kemik ogmentasyonu ve periodontal doku rejenerasyonu uygulamaları gibi çok çeşitli
rejeneratif tedaviler gerçekleştirilmiştir. Günümüzde doku mühendisliğinin geldiği noktada, ektopik
olarak diş dokusunun oluşturulabildiği bildirilmiştir. Bu derlemenin amacı, rejeneratif tedavilerdeki
temel kavramların tanımlanması ve diş hekimliğindeki, özellikle de endodontik tedavilerdeki rejeneratif
uygulamalar hakkında güncel literatür çalışma sonuçlarının değerlendirilmesidir.

Keywords

Kök hücre, kök kanalı revaskülarizasyonu, üçlü antibiyotik patı

References

• Şenel F. Kök hücre. Bilim ve Teknik, 2002; 2: 1-15.
• http://tr.wikipedia.org/wiki/Doku_ mühendisliği, Erişim tarihi: 05.11.2011.
• http://www.biltek.tubitak.gov.tr/bil- gipaket/klonlama/klonlama_uygulamalari. html, Erişim tarihi: 05.11.2011.
• Hermann BW. On the reaction of the dental pulp to vital amputation and calyxl capping. Dtsch Zahnarztl Z, 1952; 7: 1446ı 47.
• Murray PE, Garcia-Godoy F, Harg- reaves K M . Regenerative endodontics: a review of current status and a call for action. J Endod, 2007; 33: 377-90.
• Ohazama A. The possibility of tooth regenerative therapy. Clin Calcium, 2005; 15: 81-85.
• Banchs F, TropeM. Revascularization of immature permanent teeth with apical pe­ riodontitis: new treatment protocol. J Endod, 2004; 30: 196-200.
• Iwaya S, Ikawa M , Kubota M . Revas­ cularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol, 2001; 17: 185-87.
• Sato I , Ando-Kurihara N, Kota K, Iwa- ku M , Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole techniques for tracking transplanted stem and minocycline in situ. Int Endod J, 1996; 29: 118 -24.
• Sato T, Hoshino E, Uematsu H, No- da T. In vitro antimicrobial susceptibility use in endodontic theraphy. Cytokine Growth to combinations of drugs on bacteria from Factor Rev 2005; 16: 369-76. carious and endodontic lesions of human deciduous teeth. Oral Microbiol Immunol, 1993; 8: 172-76.
• Ritter AL, Ritter AV, Murrah V, Si- gurdsson A, Trope M . Pulp revasculariza- tion of replanted immature dog teeth after treatment with minocycline and doxycycline assessed by laser doppler flowmetry, radiog- raphy, and histology. Dent Traumatol, 2004; 20: 75- 84.
• Yanpiset K, Trope M . Pulp revascu- larization of replanted immature dog teeth terial improves bone formation and scaffold after different treatment methods. Endod degradation-a long-term histological study. J Dent Traumatol, 2000; 16: 211-17.
• Hoshino E, Kurihara-Ando N , Sato I et al. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J, 1996; 29: 125-30.
• Kling M , Cvek M , Mejare I . Rate and predictability of pulp revascularisation in therapeutically reimplanted permanent inci- sors. Endod Dent Traumatol, 1986; 2: 83-89.
• Jung I , Lee S and Hargreaves K M . Biologically based treatment of immature permanent teeth with pulpal necrosis: a case series. J Endod, 2008; 34: 876-87.
• Kindler V. Postnatal stem cell survi- val: does the niche, a rare harbor where the resist the ebb tide of differentiation, also cells in an injectable hydroxypropylmethy- provide lineage-specific instructions? J Le- lcellulose hydrogel. Biomaterials, 2005; 26: ukoc Biol, 2005; 78: 836-44.
• Nakashima M , Akamine A. The appı lication of tissue engineering to regeneration of pulp and dentin in endodontics. J Endod, 2005; 31: 711-18.
• Brazelton TR, Blau H M . Optimizing cells in vivo. Stem Cells, 2005; 23: 1251-65.
• Nakashima M . Bone morphogenetic proteins in dentin regeneration for potential
• Helmlinger G, Yuan F, Dellian M , Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution me- asurements reveal a lack of correlation. Nat Med, 1997; 3: 177-82.
• Nakashima M . Tissue engineering in endodontics. Aust Endod J, 2005; 31: 111-13.
• Schopper C, Ziya-Ghazvini F, Gori- woda W, Moser D, Wanschitz F, Spassova E, Lagogiannis G, Auterith A, Ewers R. HA/ TCP compounding of a porous CaP biomaı Biomed Mater Res B Appl Biomater, 2005; 74: 458-67.
• Sachlos E, Czernuszka JT. Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue en- gineering scaffolds. Eur Cell Mater, 2003; 30: 29-39.
• Elisseeff J, Puleo C, Yang F, Sharma B. Advances in skeletal tissue engineering with hydrogels. Orthod Craniofac Res, 2005; 8: 150-61.
• Trojani C, Weiss P, Michiels JF, Vi- natier C, Guicheux J, Daculsi G, Gaudray P, Carle GF, Rochet N. Three-dimensional cul- ture and differentiation of human osteogenic 5509-17.
• Alhadlaq A, Mao JJ. Tissue-enginee- red osteochondral constructs in the shape of an articular condyle. J Bone Joint Surg Am, 2005; 87: 936-44.
• Şanjana NE, Fuller SB. A fast fle­ xible ink-jet printing method for patterning dissociated neurons in culture. J Neurosci Methods, 2004; 136: 151-63.