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Year 2013, Volume: 47 Issue: 2, 50 - 56, 29.07.2013

Abstract

Leukoplakia considered as the most common premalignant oral lesion of the oral cavity and defined as, “a white patch or plaque that cannot be characterized clinically as any other disease”. Precancerous lesions including oral leukoplakia have a benign biological, but the histopathological examination demonstrates atypical cells confined to the epidermis. These lesions have carcinogenic potential. Patients should be followed up in terms of malignancy risk. In this case transformation of leukoplakia into oral squamous cell carcinoma is reported.

References

  • Liu W, Wang YF, Zhou HW, Shi P, Zhou ZT, Tang GY, Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients. BMC Cancer, 2010; 10: 685. Papadimitrakopoulou VA, Hong WK, Lee JS, Martin JW, Lee JJ, Batsakis JG, Lippman SM. Low-dose isotretinoin versus beta-carotene to prevent oral carcinogenesis: long-term follow-up. J Natl Cancer Inst, 1997; 89(3): 257–58. Mithani SK, Mydlarz WK, Grumbine
  • FL, Smith IM, Califano JA. Molecular genetics of premalignant oral lesions. Oral Dis, 2007; 13(2): 126-33. Reibel J. Prognosis of oral premalignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med, 2003; 14(1): 47-62. Sciubba JJ. Oral cancer. The importance of early diagnosis and treatment. Am
  • J Clin Dermatol, 2001; 2(4): 239-51. van der Waal I, Schepman KP, van der Meij EH, Smeele LE. Oral leukoplakia: a clinicopathological review. Oral Oncol, 1997; 33(5): 291-301. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med, 2007; 36(10): 575–80. Petti S. Pooled estimate of world leukoplakia prevalence: a systematic review.
  • Oral Oncol, 2003; 39(8): 770-80. Saito T, Sugiura C, Hirai A, Notani K, Totsuka Y, Shindoh M, Fukuda H. Development of squamous cell carcinoma from pre-existent oral leukoplakia: with respect to treatment modality. Int J Oral Maxillofac Surg, 2001; 30(1): 49–53.
  • Fischer DJ, Epstein JB, Morton TH, Schwartz SM. Interobserver reliability in the histopathologic diagnosis of oral premalignant and malignant lesions. J Oral Pathol Med, 2004; 33(2): 65-70.
  • Sarp JP, Eversole LR, Wysocki GP. Contemporary oral and maxillofacial pathology. St. Louis: Mosby, 1997, p.156-95. Ma N, Tagawa T, Hiraku Y, Murata M, Ding X, Kawanishi S. 8-Nitroguanine formation in oral leukoplakia a premalignant lesion. Nitric Oxide, 2006; 14(2): 137–43.
  • Huber MA. White oral lesions, actinic cheilitis, and leukoplakia: confusions in terminology and definition: facts and controversies. Clin Dermatol, 2010; 28(3): 262–68. Öztürk B, Coşkun U, Yaman E, Kaya AO, Yıldız R, Benekli M, Büyükberber S. Oral kavite kanserlerinde risk faktörleri, premalign lezyonlar ve kemoprevensiyon. UHOD, 2009; 19(2): 117-26.
  • Waldron CA, Shafer WG. Leukoplakia revisited: a clinicopathologic study 3256 oral leukoplakias. Cancer, 1975; 36(4): 1386Martorell-Calatayud A, Botella-Estrada R, Bagán-Sebastián JV, SanmartínJiménez O, Guillén-Baronaa C. Oral leukoplakia: clinical, histopathologic and molecular features and therapeutic approach. Actas Dermosifiliogr, 2009; 100(8): 669-84. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral & maxillofacial pathology. Philadelphia: Saunders, 2002.
  • Maserejian NN, Joshipura KJ, Rosner BA, Giovannucci E, Zavras AI. Prospective study of alcohol consumption and risk of oral premalignant lesions in men. Cancer Epidemiol Biomarkers Prev, 2006; 15(4): 774–81. Ünür M, Dogan Onur Ö. Ağız hastalıklarının teşhis ve tedavisi. İstanbul: Quintessence Yayıncılık, 2003. Cawson RA, Odell EW. Essentials of oral pathology and medicine. 6th ed., Edinburgh: Churchill Livingstone, 1998. Longshore SJ, Camisa C. Detection and management of premalignant oral leukoplakia. Dermatologic Theraphy, 2002; 15(3): 229-35. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin, 2002; 52(4): 195–215. Sciubba JJ. Oral leukoplakia. Crit Rev
  • Oral Biol Med, 1995; 6(2): 147-60. Haya-Fernandez MC, Bagan JV, Murillo-Cortes J, Poveda-Roda R, Calabuig C.
  • The prevalence of oral leukoplakia in 138 patients with oral squamous cell carcinoma. Oral Disease, 2004; 10(6): 346-48. Ak G, Ünür M. Lökoplaki kökenli epidermoid karsinom (2 vaka nedeni ile). İstanbul Üniv Diş Hek Fak Derg, 1998; 32(1): 34- Lodi G, Sardella A, Bez C, Demarosi
  • F, Carrassi A. Interventions for treating oral leukoplakia (review). The Cochrane Library, 2007; 4: 1-24. Holmstrup P, Vedtofte P, Reibel J, Stoltze K. Long-term treatment outcome of oral premalignant lesions. Oral Oncol, 2006; 42(5): 461-74. Yazışma Adresi Alp Saruhanoğlu
  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Ağız Diş ve Çene Cerrahisi A. D. 34093 Çapa- Fatih / İstanbul Telefon : 0212 4142020/ 30353 e-posta: saruhanoglualp@yahoo.com

ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report

Year 2013, Volume: 47 Issue: 2, 50 - 56, 29.07.2013

Abstract

ÖZ

Oral lökoplaki, oral mukozada en sık görülen premalign lezyon olup klinik ya da patolojik olarak herhangi bir hastalığa ait olmayan beyaz-gri plaklar ile karakterizedir. Lökoplakinin de dahil olduğu premalign lezyonlar, biyolojik davranışı selim olan ancak histopatolojik olarak hücrelerde atipi kriterleri ve maligniteye dönüşme potansiyeli taşıyan lezyonlardır. Premalign lezyonların başlangıcından itibaren düşük dereceli maligniteler olarak değerlendirilerek belirli aralıklarla takip edilmeleri önerilmektedir. Bu olguda oral lökoplaki tanısıyla takip edilen hastada lökoplakinin malign transformasyon ile oral skuamoz hücreli karsinom gelişimi göstermesi rapor edilmiştir.

Anahtar kelimeler: Lökoplaki, malign transformasyon, oral kanser

ABSTRACT

Leukoplakia considered as the most common premalignant oral lesion of the oral cavity and defined as, "a white patch or plaque that cannot be characterized clinically as any other disease". Precancerous lesions including oral leukoplakia have a benign biological, but the histopathological examination demonstrates atypical cells confined to the epidermis. These lesions have carcinogenic potential. Patients should be followed up in terms of malignancy risk. In this case transformation of leukoplakia into oral squamous cell carcinoma is reported.

Keywords: Leukoplakia, malign transformation, oral cancer

References

  • Liu W, Wang YF, Zhou HW, Shi P, Zhou ZT, Tang GY, Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients. BMC Cancer, 2010; 10: 685. Papadimitrakopoulou VA, Hong WK, Lee JS, Martin JW, Lee JJ, Batsakis JG, Lippman SM. Low-dose isotretinoin versus beta-carotene to prevent oral carcinogenesis: long-term follow-up. J Natl Cancer Inst, 1997; 89(3): 257–58. Mithani SK, Mydlarz WK, Grumbine
  • FL, Smith IM, Califano JA. Molecular genetics of premalignant oral lesions. Oral Dis, 2007; 13(2): 126-33. Reibel J. Prognosis of oral premalignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med, 2003; 14(1): 47-62. Sciubba JJ. Oral cancer. The importance of early diagnosis and treatment. Am
  • J Clin Dermatol, 2001; 2(4): 239-51. van der Waal I, Schepman KP, van der Meij EH, Smeele LE. Oral leukoplakia: a clinicopathological review. Oral Oncol, 1997; 33(5): 291-301. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med, 2007; 36(10): 575–80. Petti S. Pooled estimate of world leukoplakia prevalence: a systematic review.
  • Oral Oncol, 2003; 39(8): 770-80. Saito T, Sugiura C, Hirai A, Notani K, Totsuka Y, Shindoh M, Fukuda H. Development of squamous cell carcinoma from pre-existent oral leukoplakia: with respect to treatment modality. Int J Oral Maxillofac Surg, 2001; 30(1): 49–53.
  • Fischer DJ, Epstein JB, Morton TH, Schwartz SM. Interobserver reliability in the histopathologic diagnosis of oral premalignant and malignant lesions. J Oral Pathol Med, 2004; 33(2): 65-70.
  • Sarp JP, Eversole LR, Wysocki GP. Contemporary oral and maxillofacial pathology. St. Louis: Mosby, 1997, p.156-95. Ma N, Tagawa T, Hiraku Y, Murata M, Ding X, Kawanishi S. 8-Nitroguanine formation in oral leukoplakia a premalignant lesion. Nitric Oxide, 2006; 14(2): 137–43.
  • Huber MA. White oral lesions, actinic cheilitis, and leukoplakia: confusions in terminology and definition: facts and controversies. Clin Dermatol, 2010; 28(3): 262–68. Öztürk B, Coşkun U, Yaman E, Kaya AO, Yıldız R, Benekli M, Büyükberber S. Oral kavite kanserlerinde risk faktörleri, premalign lezyonlar ve kemoprevensiyon. UHOD, 2009; 19(2): 117-26.
  • Waldron CA, Shafer WG. Leukoplakia revisited: a clinicopathologic study 3256 oral leukoplakias. Cancer, 1975; 36(4): 1386Martorell-Calatayud A, Botella-Estrada R, Bagán-Sebastián JV, SanmartínJiménez O, Guillén-Baronaa C. Oral leukoplakia: clinical, histopathologic and molecular features and therapeutic approach. Actas Dermosifiliogr, 2009; 100(8): 669-84. Neville BW, Damn DD, Allen CM, Bouquot JE. Oral & maxillofacial pathology. Philadelphia: Saunders, 2002.
  • Maserejian NN, Joshipura KJ, Rosner BA, Giovannucci E, Zavras AI. Prospective study of alcohol consumption and risk of oral premalignant lesions in men. Cancer Epidemiol Biomarkers Prev, 2006; 15(4): 774–81. Ünür M, Dogan Onur Ö. Ağız hastalıklarının teşhis ve tedavisi. İstanbul: Quintessence Yayıncılık, 2003. Cawson RA, Odell EW. Essentials of oral pathology and medicine. 6th ed., Edinburgh: Churchill Livingstone, 1998. Longshore SJ, Camisa C. Detection and management of premalignant oral leukoplakia. Dermatologic Theraphy, 2002; 15(3): 229-35. Neville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin, 2002; 52(4): 195–215. Sciubba JJ. Oral leukoplakia. Crit Rev
  • Oral Biol Med, 1995; 6(2): 147-60. Haya-Fernandez MC, Bagan JV, Murillo-Cortes J, Poveda-Roda R, Calabuig C.
  • The prevalence of oral leukoplakia in 138 patients with oral squamous cell carcinoma. Oral Disease, 2004; 10(6): 346-48. Ak G, Ünür M. Lökoplaki kökenli epidermoid karsinom (2 vaka nedeni ile). İstanbul Üniv Diş Hek Fak Derg, 1998; 32(1): 34- Lodi G, Sardella A, Bez C, Demarosi
  • F, Carrassi A. Interventions for treating oral leukoplakia (review). The Cochrane Library, 2007; 4: 1-24. Holmstrup P, Vedtofte P, Reibel J, Stoltze K. Long-term treatment outcome of oral premalignant lesions. Oral Oncol, 2006; 42(5): 461-74. Yazışma Adresi Alp Saruhanoğlu
  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Ağız Diş ve Çene Cerrahisi A. D. 34093 Çapa- Fatih / İstanbul Telefon : 0212 4142020/ 30353 e-posta: saruhanoglualp@yahoo.com
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Case Reports
Authors

Alp Saruhanoğlu This is me

Nazlı Altın This is me

Sertan Ergun This is me

Hakkı Tanyeri This is me

Publication Date July 29, 2013
Published in Issue Year 2013 Volume: 47 Issue: 2

Cite

APA Saruhanoğlu, A., Altın, N., Ergun, S., Tanyeri, H. (2013). ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report. Journal of Istanbul University Faculty of Dentistry, 47(2), 50-56.
AMA Saruhanoğlu A, Altın N, Ergun S, Tanyeri H. ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report. J Istanbul Univ Fac Dent. July 2013;47(2):50-56.
Chicago Saruhanoğlu, Alp, Nazlı Altın, Sertan Ergun, and Hakkı Tanyeri. “ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report”. Journal of Istanbul University Faculty of Dentistry 47, no. 2 (July 2013): 50-56.
EndNote Saruhanoğlu A, Altın N, Ergun S, Tanyeri H (July 1, 2013) ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report. Journal of Istanbul University Faculty of Dentistry 47 2 50–56.
IEEE A. Saruhanoğlu, N. Altın, S. Ergun, and H. Tanyeri, “ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report”, J Istanbul Univ Fac Dent, vol. 47, no. 2, pp. 50–56, 2013.
ISNAD Saruhanoğlu, Alp et al. “ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report”. Journal of Istanbul University Faculty of Dentistry 47/2 (July 2013), 50-56.
JAMA Saruhanoğlu A, Altın N, Ergun S, Tanyeri H. ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report. J Istanbul Univ Fac Dent. 2013;47:50–56.
MLA Saruhanoğlu, Alp et al. “ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report”. Journal of Istanbul University Faculty of Dentistry, vol. 47, no. 2, 2013, pp. 50-56.
Vancouver Saruhanoğlu A, Altın N, Ergun S, Tanyeri H. ORAL LÖKOPLAKİNİN MALİGN TRANSFORMASYONU: OLGU SUNUMU-Malign Transformation of Oral Leukoplakia: A Case Report. J Istanbul Univ Fac Dent. 2013;47(2):50-6.