Abstract
Mammalian dentition consist of teeth that develop as discrete organs. From anterior to posterior, the dentition is divided into regions of incisor, canine, premolar and molar tooth types. This rewiev discusses the histologic aspect of tooth development and the coming together of the different tissues that give rise to the form and give shape to the tooth. However, to better understand ‘morphogenesis’, the molecular signals that control cell growth, migration, and ultimately cell fate and differantiation also must be considered. For every developmental event, whether of limb, kidney, or tooth, a complex and intricate cascade of gene expression takes place to direct the cells to the right place and onto the proper differantiation pathway. Hundreads of genes likely are expressed for each developmental pathway, but this rewiev covers the most important signaling molecules and pathways so far described
Keywords
References
- Davis WL. Oral histology: cell structu- re and function. Philadelphia: W.B. Saunders Company, 1986, p.37-54.
- Bei M. Molecular genetics of tooth development. Curr Opin Genet Dev, 2009; 19(5): 504-10.
- Thesleff I. Genetic basis of tooth de- velopment and dental defects. Acta Odontol Scand, 2000; 58(5): 191-94.
- Maas R, Bei M. The genetic control of early tooth development. Crit Rev Oral Biol Med, 1997; 8(1): 4-39.
- Nanci A. Ten Cate’s oral histology: development, structure and function. 6th ed., Saint Louis: Mosby Year Book, 2003, p.79-110.
- Thesleff I. Vaahtokari A, Kettunen P, Aberg T. Epithelial-mesenchymal signaling during tooth development. Connect Tissue Res, 1995; 32(1-4): 9-15.
- Tucker A, Sharpe P. Molecular gene- tics of tooth morphogenesis and patterning: the right shape in the right place. J Dent Res, 1999; 78(4): 826-34.
- Thomas BL, Tucker AS, Qui M, Fer- guson CA, Hardcastle Z, Rubenstein JL, Sharpe PT. Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Deve- lopment, 1997; 124(23): 4811-18.
- Kapadia H, Mues G, D’Souza R. Ge- nes affecting tooth morphogenesis. Orthod Craniofac Res, 2007; 10(4): 237-44.
- Thesleff I. Vaahtokari A, Vainio S, Jowett A. Molecular mechanisms of cell and tissue interactions during early tooth deve- lopment. Anat Rec, 1996; 245(2): 151-61.
- Nieminan P. Gene expression in tooth. (Çevrimiçi)http://bite-it.helsinki.fi/ Erişim Tarihi: 20 Şubat 2007.
- Chen Y, Bei M, Woo I, Satokata I, Maas R. Msx1 controls inductive signaling in mammalian tooth morphogenesis. Deve- lopment, 1996; 122(10): 3035-44.
- Chen J, Lan Y, Baek J, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an es- sential role in activation of odontogenic me- senchyme during early tooth development. Dev Biol, 2009; 334(1): 174-85.
- Ogawa T, Kapadia H, Feng JQ, Rag- how R, Peters H, D’Souza RN. Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth develepment. J Biol Chem, 2006; 281(27): 18363-69.
- Cobourne MT, Hardcastle Z, Sharpe PT. Sonic hedgehog regulates epithelial pro- liferation and cell survival in developing to- oth germ. J Dent Res, 2001; 80(11): 1974-79.
- Jernvall J, Thesleff I. Reiterative signaling and patterning during mammali- an tooth morphogenesis. Mech Dev, 2000; 92(1): 19-29.
- Aberg T, Wang XP, Kim JH, Yamas- hiro T, Bei M, Rice R, Ryoo HM, Thesleff I. Runx2 mediates FGF signaling from epit- helium to mesenchyme during tooth morp- hogenesis. Dev Biol, 2004; 270(1): 76-93.
- Shimo T, Wu C, Billings PC, Pid- dington R, Rosenbloom J, Pacifici M, Ko- yama E. Expression, gene regulation, and roles of Fisp12/CTGF in developing tooth germs. Dev Dyn, 2002; 224(3): 267-78.
- Lesot H, Brook AH. Epithelial histo- genesis during tooth development. Arch Oral Biol, 2009; 54 Suppl 1: S25-33.
- Camilleri S, McDonald F. Runx2 and dental development. Eur J Oral Sci Biol, 2006; 114(5): 361-73.
- Provenza D.V. Fundamentals of oral histology and embryology. Philadelphia: Lippincott Company, 1972, p.65-106.
- Sicher H, Bhaskar S.N. Orban’s oral histology and embryology. 7th ed., Saint Louis: Mosby Company, 1972, p.17-37.
- Avery J. K. Essentials of oral histo- logy and embryology. Saint Louis: Mosby Year Book, 1992, p.51-69.
Abstract
Memeli dişlenme dönemi, farklı bir yapıda gelişmektedir. Ön bölgeden arka bölgeye doğru diş
dizisinde, kesici, kanin, küçük azı ve büyük azı diş çeşitleri yer almaktadır. Bu derleme, diş gelişimi ile
birlikte, dişe şeklini veren diğer dokuların oluşumunu histolojik olarak ele almaktadır. Bunun yanında,
morfogenezisi daha iyi anlayabilmek için, hücre gelişimi ve hücresel migrasyon da dahil, hücrelerin
diferansiyasyon mekanizmaları da ele alınmalıdır. Ekstremite, böbrek veya diş gibi gelişmekte olan
neredeyse her yapıda, birçok gen ekspresyonu, ardarda gelmekte ve bu mekanizma hücrelerin doğru
zamanda doğru yerde olmasını, hücresel diferansiyasyonun doğru bir biçimde meydana gelmesini
sağlamaktadır. Diş gelişiminde yüzlerce gen ekspresyonu görülmekte ancak bu derleme şimdiye kadar
açıklanabilen en önemli sinyal moleküllerini kapsamaktadır.
Keywords
References
- Davis WL. Oral histology: cell structu- re and function. Philadelphia: W.B. Saunders Company, 1986, p.37-54.
- Bei M. Molecular genetics of tooth development. Curr Opin Genet Dev, 2009; 19(5): 504-10.
- Thesleff I. Genetic basis of tooth de- velopment and dental defects. Acta Odontol Scand, 2000; 58(5): 191-94.
- Maas R, Bei M. The genetic control of early tooth development. Crit Rev Oral Biol Med, 1997; 8(1): 4-39.
- Nanci A. Ten Cate’s oral histology: development, structure and function. 6th ed., Saint Louis: Mosby Year Book, 2003, p.79-110.
- Thesleff I. Vaahtokari A, Kettunen P, Aberg T. Epithelial-mesenchymal signaling during tooth development. Connect Tissue Res, 1995; 32(1-4): 9-15.
- Tucker A, Sharpe P. Molecular gene- tics of tooth morphogenesis and patterning: the right shape in the right place. J Dent Res, 1999; 78(4): 826-34.
- Thomas BL, Tucker AS, Qui M, Fer- guson CA, Hardcastle Z, Rubenstein JL, Sharpe PT. Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Deve- lopment, 1997; 124(23): 4811-18.
- Kapadia H, Mues G, D’Souza R. Ge- nes affecting tooth morphogenesis. Orthod Craniofac Res, 2007; 10(4): 237-44.
- Thesleff I. Vaahtokari A, Vainio S, Jowett A. Molecular mechanisms of cell and tissue interactions during early tooth deve- lopment. Anat Rec, 1996; 245(2): 151-61.
- Nieminan P. Gene expression in tooth. (Çevrimiçi)http://bite-it.helsinki.fi/ Erişim Tarihi: 20 Şubat 2007.
- Chen Y, Bei M, Woo I, Satokata I, Maas R. Msx1 controls inductive signaling in mammalian tooth morphogenesis. Deve- lopment, 1996; 122(10): 3035-44.
- Chen J, Lan Y, Baek J, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an es- sential role in activation of odontogenic me- senchyme during early tooth development. Dev Biol, 2009; 334(1): 174-85.
- Ogawa T, Kapadia H, Feng JQ, Rag- how R, Peters H, D’Souza RN. Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth develepment. J Biol Chem, 2006; 281(27): 18363-69.
- Cobourne MT, Hardcastle Z, Sharpe PT. Sonic hedgehog regulates epithelial pro- liferation and cell survival in developing to- oth germ. J Dent Res, 2001; 80(11): 1974-79.
- Jernvall J, Thesleff I. Reiterative signaling and patterning during mammali- an tooth morphogenesis. Mech Dev, 2000; 92(1): 19-29.
- Aberg T, Wang XP, Kim JH, Yamas- hiro T, Bei M, Rice R, Ryoo HM, Thesleff I. Runx2 mediates FGF signaling from epit- helium to mesenchyme during tooth morp- hogenesis. Dev Biol, 2004; 270(1): 76-93.
- Shimo T, Wu C, Billings PC, Pid- dington R, Rosenbloom J, Pacifici M, Ko- yama E. Expression, gene regulation, and roles of Fisp12/CTGF in developing tooth germs. Dev Dyn, 2002; 224(3): 267-78.
- Lesot H, Brook AH. Epithelial histo- genesis during tooth development. Arch Oral Biol, 2009; 54 Suppl 1: S25-33.
- Camilleri S, McDonald F. Runx2 and dental development. Eur J Oral Sci Biol, 2006; 114(5): 361-73.
- Provenza D.V. Fundamentals of oral histology and embryology. Philadelphia: Lippincott Company, 1972, p.65-106.
- Sicher H, Bhaskar S.N. Orban’s oral histology and embryology. 7th ed., Saint Louis: Mosby Company, 1972, p.17-37.
- Avery J. K. Essentials of oral histo- logy and embryology. Saint Louis: Mosby Year Book, 1992, p.51-69.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Review Articles |
| Authors | |
| Publication Date | July 29, 2013 |
| Published in Issue | Year 2013 Volume: 47 Issue: 2 |
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