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Year 2013, Volume: 47 Issue: 2, 81 - 88, 29.07.2013

Abstract

The purpose of modern dentistry is the early prevention of tooth decay rather than invasive restorative therapy. In recent years, remineralization of the demineralised enamel without using any restorative treatment becomes more important. Nano-sized particles have similarity to the apatite crystals of tooth enamel in morphology and crystal structure. Recently, some reports have shown that nano-hydroxyapatite has some potential to remineralize of enamel lesions. In this review, the effects of nano-hydroxyapatite toothpastes on remineralization were examined and studies on this subject were explained with details.

References

  • Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nat Nanotechnol, 2010; 5(8): 565-69. Elliott JC. Structure, crystal chemistry and density of enamel apatites. Ciba Found
  • Symp, 1997; 205: 54-67. Featherstone JD. The continuum of dental caries-evidence for a dynamic disease process. J Dent Res, 2004; 83 Spec No C: C39- Featherstone JD. The science and practice of caries prevention. J Am Dent Assoc, 2000; 131(7): 887-99. Silverstone M, Jahnson NW, Hardie
  • JM, Williams R. Dental caries: aetiology, pathology and prevention. Hong Kong: The Mac Millian Press, 1981, p.71-97. Thylstrup A, Feverskov O, Larsen MJ.
  • Polarized light microscopy of enamel structure in incisors from newborn infants. Scand J Dent Res, 1976; 84(5): 243-54. Hicks J, Garcia-Godoy F, Flaitz C.
  • Biological factors in dental caries: role of remineralization and fluoride in the dynamic process of demineralization and remineralization: part 3. J Clin Ped Dent, 2004; 28(3): 203- Ten Cate JM. In vitro studies on the effects of fluoride on de- and remineralization. J Dent Res, 1990; 69 Spec No: 614-19. Featherstone JD. Prevention and reversal of dental caries: role of low level fluoride. Community Dent Oral Epidemiol, 1999; 27(1): 31-40.
  • Erickson RL, Glasspoole EA. Model investigations of caries inhibition by fluoride releasing dental materials. Adv Dent Res, 1995; 3(9): 315-23.
  • Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC. Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptideamorphous calcium phosphate. J Dent Res, 2001; 80(12): 2066-70.
  • Sjögren K, Birkhed D, Ruben J, Arends J. Effect of post-brushing water rinsing on caries-like lesions at approximal and buccal sites. Caries Res, 1995; 29(5): 337Featherstone JD. Remineralization, the natural caries repair process-the need for new approaches. Adv Dent Res 2009; 21(1): 4-7.
  • Silverstone LM, Hicks MJ, Featherstone MJ. Dynamic factors affecting lesion initiation and progression in human dental enamel. Part I. The dynamic nature of enamel caries. Quintessence Int, 1988; 19(10): 683-7
  • Walker G, Cai F, Shen P, Reynolds C, Ward B, Fone C, Honda S, Koganei M, Oda M, Reynolds E. Increased remineralization of tooth enamel by milk containing added casein phosphopeptide- amorphus calcium phosphate. J Diary Res, 2006; 73(1): 74-78. Tschoppe P, Zandim DL, Martus P, Kielbassa AM. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J Dent, 2011; 39(6): 430-37.
  • Peters MC. Strategies for noninvasive demineralized tissue repair. Dent Clin North Am, 2010; 54(3): 507-25.
  • Pearce EI, Moore AJ. Remineralization of softened bovine enamel following tretment of overlying plaque with a mineralenriching solution. J Dent Res,1985; 64(3): 416- Murray JJ, Rugg-Gunn AJ, Jenkins
  • GN. Fluoride in caries prevention. 3rd ed., Oxford: Buttrtworth-Heinemann,1991. Brambilla E. Fluoride - is it capable of fighting old and new dental diseases? An overview of existing fluoride compounds and their clinical applications. Caries Res, 2001; 35 Suppl 1: 6-9. US Department of Health and Human
  • Services, Public and Health Service. Washington: DC Government Printing Office, 19 Newbrun E. Current regulations and recommendations concerning water fluoridation, fluoride supplements, and topical fluoride agents. J Dent Res, 1992; 71(5): 1255 Bowen WH, Pearson SK. The effects of sucralose, xylitol, and sorbitol on remineralization of caries lesions in rats. J Dent
  • Res, 1992; 71(5): 1166-68. Featherstone JD. Delivery challenges for fluoride, chlorhexidine and xylitol. BMC
  • Oral Health, 2006; 6 Suppl 1: S8. Gmür R, Giertsen E, van der Veen
  • MH, de Josselin de Jong E, Ten Cate JM, Guggenheim B. In vitro quantitative lightinduced fluorescence to measure changes in enamel mineralization. Clin Oral Investig, 2006; 10(3): 187-95. Tanzer JM. Xylitol chewing gum and dental caries. Int Dent J, 1995; 45(1 Suppl 1): 65-76. Zhao H, He W, Wang Y, Zhang X, Li Z, Yan S, Zhou W, Wang G. Biomineralization of large hydroxyapatite particles using ovalbumin as biosurfactant. Mater Lett, 2008; 62: 3603–05.
  • Roveri N, Foresti E, Lelli M, Lesci IG. Recent advances in preventing teeth health hazard: The daily use of hydroxyapatite instead of fluoride. Recent Pat Biomed Eng, 2009; 2: 197–215.
  • Lu KL, Zhang JX, Meng XC, Li XY. Remineralization effect of the nano-HA toothpaste on artificial caries. Key Eng Mater,2007; 330-332: 267-70.
  • Yamagishi K, Onuma K, Suzuki T, Okada F, Tagami J, Otsuki M, Senawangse P. Materials chemistry: a synthetic enamel for rapid tooth repair. Nature, 2005; 433(7028): 8
  • Chiu CY, Ruan L, Huang Y. Biomolecular specificity controlled nanomaterial synthesis. Chem Soc Rev, 2013; 42(7): 2512King NM, Itthagarun A, Cheung M. Remineralization by nanohydroxyapatitecontaining dentifrice: a pH cycling study using slurry. J Dent Res, 2006; 85 (Spec Iss B) Abstract no:0186.
  • Mielnik-Błaszczak M, Krawczyk D, Pels E. The application of synthetic hydroxyapatite in children and adolescents in various clinical cases. Ann Univ Mariae Curie Sklodowska Med, 2001; 56: 95-98.
  • Gao W. The remineralization research of nano-hydroxypatite. MsD Thesis, Sichuan University West China College of Stomatology, 2004, p.4-11.
  • Kınsun S. Nano-hidroksiapatit esaslı materyallarin mine remineralizasyonu üzerine etkilerinin incelenmesi. Doktora Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü Pedodonti Anabilim Dalı, 2007.
  • Nishimura K, Yamaguchi Y, Yoshitake K. Demineralized enamel surface microstructure after brushing using toothpaste containing medical hydroxyapatite under FE-SEM observation. J Japan Stomatolog Soc, 1999; 48(3): 199-210. Najibfard K, Ramalingam K, Chedjieu I, Amaechi BT. Remineralization of early caries by a nano-hydroxyapatite dentifrice.
  • J Clin Dent, 2011; 22(5): 139-43. Roveri N, Battistella E, Bianchi
  • CL, Foltran I, Foresti E, Iafisco M, Lelli M, Naldoni A, Palazzo B, Rimondini L. Surface enamel remineralization: biomimetic apatite nanocrystals and fluoride ions different effects. J Nanomater, 2009; doi:1155/2009/746383. Huang S, Gao S, Cheng L, Yu H. Remineralization potential of nano-hydroxyapatite on initial enamel lesions: an in vitro study. Caries Res, 2011; 45(5): 460-68. Yamazaki H, Margolis HC. Enhanced enamel remineralization under acidic conditions in vitro. J Dent Res, 2008; 87(6): 569- Li L, Pan H, Tao J, Xu X, Mao C, Gu X, Tang R. Repair of enamel by using hydroxyapatite nanoparticles as the building blocks. J Mater Chem, 2008; 18: 4079-84. Onuma K, Yamagishi K, Oyane A.
  • Nucleation and growth of hydroxyapatite nanocrystals for nondestructive repair of early caries lesions. J Cryst Growth, 2005; 282(1-2): 199-207. Yazışma Adresi Feyza Nur Görken
  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Pedodonti A.D. 34093-Çapa-Fatih/İstanbul Tel: 0212 414 20 20/ 30317 e-posta: feyzag@gmail.com

NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ

Year 2013, Volume: 47 Issue: 2, 81 - 88, 29.07.2013

Abstract

Modern diş hekimliğinin amacı; diş çürüğünün invaziv restoratif girişimlerle tedavisi yerine erken
dönemde önlenmesidir. Son zamanlarda demineralize olmuş mine dokusunun herhangi bir restoratif
tedavi uygulamadan remineralize edilebilmesi büyük önem kazanmıştır. Nano hidroksiapatit partikülleri
diş minesindeki apatit kristalleriyle morfolojik ve yapısal olarak benzerlik göstermektedir. Son
zamanlarda yapılan araştırmalarda nano hidroksiapatitin mine çürük lezyonlarını remineralize edici
etkisi olduğu ortaya konmuştur. Bu derleme çalışmasında nano hidroksiapatit içeren diş macunlarının
remineralizasyon üzerine etkileri detaylı olarak incelenmiş ve bu konuda yapılmış olan çalışmalar
hakkında bilgiler verilmiştir.

References

  • Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nat Nanotechnol, 2010; 5(8): 565-69. Elliott JC. Structure, crystal chemistry and density of enamel apatites. Ciba Found
  • Symp, 1997; 205: 54-67. Featherstone JD. The continuum of dental caries-evidence for a dynamic disease process. J Dent Res, 2004; 83 Spec No C: C39- Featherstone JD. The science and practice of caries prevention. J Am Dent Assoc, 2000; 131(7): 887-99. Silverstone M, Jahnson NW, Hardie
  • JM, Williams R. Dental caries: aetiology, pathology and prevention. Hong Kong: The Mac Millian Press, 1981, p.71-97. Thylstrup A, Feverskov O, Larsen MJ.
  • Polarized light microscopy of enamel structure in incisors from newborn infants. Scand J Dent Res, 1976; 84(5): 243-54. Hicks J, Garcia-Godoy F, Flaitz C.
  • Biological factors in dental caries: role of remineralization and fluoride in the dynamic process of demineralization and remineralization: part 3. J Clin Ped Dent, 2004; 28(3): 203- Ten Cate JM. In vitro studies on the effects of fluoride on de- and remineralization. J Dent Res, 1990; 69 Spec No: 614-19. Featherstone JD. Prevention and reversal of dental caries: role of low level fluoride. Community Dent Oral Epidemiol, 1999; 27(1): 31-40.
  • Erickson RL, Glasspoole EA. Model investigations of caries inhibition by fluoride releasing dental materials. Adv Dent Res, 1995; 3(9): 315-23.
  • Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC. Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptideamorphous calcium phosphate. J Dent Res, 2001; 80(12): 2066-70.
  • Sjögren K, Birkhed D, Ruben J, Arends J. Effect of post-brushing water rinsing on caries-like lesions at approximal and buccal sites. Caries Res, 1995; 29(5): 337Featherstone JD. Remineralization, the natural caries repair process-the need for new approaches. Adv Dent Res 2009; 21(1): 4-7.
  • Silverstone LM, Hicks MJ, Featherstone MJ. Dynamic factors affecting lesion initiation and progression in human dental enamel. Part I. The dynamic nature of enamel caries. Quintessence Int, 1988; 19(10): 683-7
  • Walker G, Cai F, Shen P, Reynolds C, Ward B, Fone C, Honda S, Koganei M, Oda M, Reynolds E. Increased remineralization of tooth enamel by milk containing added casein phosphopeptide- amorphus calcium phosphate. J Diary Res, 2006; 73(1): 74-78. Tschoppe P, Zandim DL, Martus P, Kielbassa AM. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J Dent, 2011; 39(6): 430-37.
  • Peters MC. Strategies for noninvasive demineralized tissue repair. Dent Clin North Am, 2010; 54(3): 507-25.
  • Pearce EI, Moore AJ. Remineralization of softened bovine enamel following tretment of overlying plaque with a mineralenriching solution. J Dent Res,1985; 64(3): 416- Murray JJ, Rugg-Gunn AJ, Jenkins
  • GN. Fluoride in caries prevention. 3rd ed., Oxford: Buttrtworth-Heinemann,1991. Brambilla E. Fluoride - is it capable of fighting old and new dental diseases? An overview of existing fluoride compounds and their clinical applications. Caries Res, 2001; 35 Suppl 1: 6-9. US Department of Health and Human
  • Services, Public and Health Service. Washington: DC Government Printing Office, 19 Newbrun E. Current regulations and recommendations concerning water fluoridation, fluoride supplements, and topical fluoride agents. J Dent Res, 1992; 71(5): 1255 Bowen WH, Pearson SK. The effects of sucralose, xylitol, and sorbitol on remineralization of caries lesions in rats. J Dent
  • Res, 1992; 71(5): 1166-68. Featherstone JD. Delivery challenges for fluoride, chlorhexidine and xylitol. BMC
  • Oral Health, 2006; 6 Suppl 1: S8. Gmür R, Giertsen E, van der Veen
  • MH, de Josselin de Jong E, Ten Cate JM, Guggenheim B. In vitro quantitative lightinduced fluorescence to measure changes in enamel mineralization. Clin Oral Investig, 2006; 10(3): 187-95. Tanzer JM. Xylitol chewing gum and dental caries. Int Dent J, 1995; 45(1 Suppl 1): 65-76. Zhao H, He W, Wang Y, Zhang X, Li Z, Yan S, Zhou W, Wang G. Biomineralization of large hydroxyapatite particles using ovalbumin as biosurfactant. Mater Lett, 2008; 62: 3603–05.
  • Roveri N, Foresti E, Lelli M, Lesci IG. Recent advances in preventing teeth health hazard: The daily use of hydroxyapatite instead of fluoride. Recent Pat Biomed Eng, 2009; 2: 197–215.
  • Lu KL, Zhang JX, Meng XC, Li XY. Remineralization effect of the nano-HA toothpaste on artificial caries. Key Eng Mater,2007; 330-332: 267-70.
  • Yamagishi K, Onuma K, Suzuki T, Okada F, Tagami J, Otsuki M, Senawangse P. Materials chemistry: a synthetic enamel for rapid tooth repair. Nature, 2005; 433(7028): 8
  • Chiu CY, Ruan L, Huang Y. Biomolecular specificity controlled nanomaterial synthesis. Chem Soc Rev, 2013; 42(7): 2512King NM, Itthagarun A, Cheung M. Remineralization by nanohydroxyapatitecontaining dentifrice: a pH cycling study using slurry. J Dent Res, 2006; 85 (Spec Iss B) Abstract no:0186.
  • Mielnik-Błaszczak M, Krawczyk D, Pels E. The application of synthetic hydroxyapatite in children and adolescents in various clinical cases. Ann Univ Mariae Curie Sklodowska Med, 2001; 56: 95-98.
  • Gao W. The remineralization research of nano-hydroxypatite. MsD Thesis, Sichuan University West China College of Stomatology, 2004, p.4-11.
  • Kınsun S. Nano-hidroksiapatit esaslı materyallarin mine remineralizasyonu üzerine etkilerinin incelenmesi. Doktora Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü Pedodonti Anabilim Dalı, 2007.
  • Nishimura K, Yamaguchi Y, Yoshitake K. Demineralized enamel surface microstructure after brushing using toothpaste containing medical hydroxyapatite under FE-SEM observation. J Japan Stomatolog Soc, 1999; 48(3): 199-210. Najibfard K, Ramalingam K, Chedjieu I, Amaechi BT. Remineralization of early caries by a nano-hydroxyapatite dentifrice.
  • J Clin Dent, 2011; 22(5): 139-43. Roveri N, Battistella E, Bianchi
  • CL, Foltran I, Foresti E, Iafisco M, Lelli M, Naldoni A, Palazzo B, Rimondini L. Surface enamel remineralization: biomimetic apatite nanocrystals and fluoride ions different effects. J Nanomater, 2009; doi:1155/2009/746383. Huang S, Gao S, Cheng L, Yu H. Remineralization potential of nano-hydroxyapatite on initial enamel lesions: an in vitro study. Caries Res, 2011; 45(5): 460-68. Yamazaki H, Margolis HC. Enhanced enamel remineralization under acidic conditions in vitro. J Dent Res, 2008; 87(6): 569- Li L, Pan H, Tao J, Xu X, Mao C, Gu X, Tang R. Repair of enamel by using hydroxyapatite nanoparticles as the building blocks. J Mater Chem, 2008; 18: 4079-84. Onuma K, Yamagishi K, Oyane A.
  • Nucleation and growth of hydroxyapatite nanocrystals for nondestructive repair of early caries lesions. J Cryst Growth, 2005; 282(1-2): 199-207. Yazışma Adresi Feyza Nur Görken
  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Pedodonti A.D. 34093-Çapa-Fatih/İstanbul Tel: 0212 414 20 20/ 30317 e-posta: feyzag@gmail.com
There are 29 citations in total.

Details

Primary Language Turkish
Journal Section Review Articles
Authors

Feyza Görken This is me

Arzu Erdem This is me

Gökşen Ikıkarakayalı This is me

Elif Sepet This is me

Publication Date July 29, 2013
Published in Issue Year 2013 Volume: 47 Issue: 2

Cite

APA Görken, F., Erdem, A., Ikıkarakayalı, G., Sepet, E. (2013). NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ. Journal of Istanbul University Faculty of Dentistry, 47(2), 81-88.
AMA Görken F, Erdem A, Ikıkarakayalı G, Sepet E. NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ. J Istanbul Univ Fac Dent. July 2013;47(2):81-88.
Chicago Görken, Feyza, Arzu Erdem, Gökşen Ikıkarakayalı, and Elif Sepet. “NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ”. Journal of Istanbul University Faculty of Dentistry 47, no. 2 (July 2013): 81-88.
EndNote Görken F, Erdem A, Ikıkarakayalı G, Sepet E (July 1, 2013) NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ. Journal of Istanbul University Faculty of Dentistry 47 2 81–88.
IEEE F. Görken, A. Erdem, G. Ikıkarakayalı, and E. Sepet, “NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ”, J Istanbul Univ Fac Dent, vol. 47, no. 2, pp. 81–88, 2013.
ISNAD Görken, Feyza et al. “NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ”. Journal of Istanbul University Faculty of Dentistry 47/2 (July 2013), 81-88.
JAMA Görken F, Erdem A, Ikıkarakayalı G, Sepet E. NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ. J Istanbul Univ Fac Dent. 2013;47:81–88.
MLA Görken, Feyza et al. “NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ”. Journal of Istanbul University Faculty of Dentistry, vol. 47, no. 2, 2013, pp. 81-88.
Vancouver Görken F, Erdem A, Ikıkarakayalı G, Sepet E. NANO-HİDROKSİAPATİTLİ (n-HAp) DİŞ MACUNLARININ MİNE REMİNERALİZASYONU ÜZERİNE ETKİLERİ. J Istanbul Univ Fac Dent. 2013;47(2):81-8.